REACTOME_FRS_MEDIATED_FGFR1_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [1] -0.18[2] 0.12[3] -0.20[4] -0.07[5] 0.51[6] 0.70[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.57[9] 0.28[10] 0.12[11] -0.41[12] -0.55[13] -0.26[14]
3 NRAS GTPase NRas [15] 0.00[16] 0.31[17] 0.44[18] 0.04[19] -0.45[20] -0.81[21]
4 HRAS GTPase HRas [22] -1.63[23] -2.47[24] -3.54[25] -1.91[26] -2.18[27] -3.22[28]
5 KRAS GTPase KRas [29] -1.14[30] -1.29[31] 0.03[32] -0.16[33] -0.55[34] 0.12[35]
6 SOS1 Son of sevenless homolog 1 [36] -0.72[37] 0.68[38] -0.10[39] -0.12[40] -0.94[41] -0.02[42]
7 FGF2 Fibroblast growth factor 2 [43] -7.31[44] -7.19[45] -3.31[46] -0.03[47] 1.50[48] -2.22[49]
8 FRS2 Fibroblast growth factor receptor substrate 2 [50] 0.66[51] 1.63[52] 1.85[53] 1.94[54] 1.51[55] 2.78[56]
9 FRS3 Fibroblast growth factor receptor substrate 3 [57] 0.00[58] -0.30[59] -1.59[60] -0.67[61] -1.07[62] -1.47[63]
10 FGFR1 Fibroblast growth factor receptor 1 [64] 3.95[65] 2.14[66] 3.51[67] 4.10[68] 3.31[69] 1.10[70]
11 KL Klotho [71] -6.68[72] [73] [74] -2.35[75] -7.66[76] -0.31[77]
12 FGF5 Fibroblast growth factor 5 [78] -1.62[79] -0.42[80] -0.78[81] 0.52[82] 0.15[83] 2.58[84]
13 FGF1 Fibroblast growth factor 1 [85] -3.39[86] -2.73[87] -7.47[88] -0.37[89] 1.15[90] -0.52[91]
14 FGF8 Fibroblast growth factor 8 [92] -3.95[93] -3.73[94] 0.48[95] -2.88[96] [97] 2.14[98]
15 FGF9 Fibroblast growth factor 9 [99] 1.63[100] -2.15[101] [102] 1.82[103] -3.35[104] -0.46[105]
16 FGF6 Fibroblast growth factor 6 [106] [107] [108] [109] [110] [111] [112]
17 FGF4 Fibroblast growth factor 4 [113] [114] [115] [116] [117] [118] [119]
18 FGF17 Fibroblast growth factor 17 [120] [121] [122] [123] [124] [125] [126]
19 FGF10 Fibroblast growth factor 10 [127] [128] [129] [130] [131] [132] [133]
20 FGF22 Fibroblast growth factor 22 [134] [135] [136] [137] [138] [139] [140]
21 FGF20 Fibroblast growth factor 20 [141] [142] [143] [144] [145] [146] [147]
22 FGF23 Fibroblast growth factor 23 [148] [149] [150] [151] [152] [153] [154]
23 FGF3 Fibroblast growth factor 3 [155] [156] [157] [158] [159] [160] [161]
[1]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[2]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[3]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[4]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[5]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[6]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[7]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[16]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[17]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[18]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[19]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[20]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[21]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[22]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[23]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[24]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[25]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[26]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[27]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[28]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[29]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[30]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[31]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[32]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[33]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[34]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[35]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[36]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[37]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[38]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[39]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[40]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[41]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[42]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[43]
ref_hepatocyte FGF2
Mean 4.04
Standard deviation 6.5
Values 0.052 15 3.7 0.37 0.73
[44]
HepG2 FGF2
Mean 0.0866
Standard deviation 0.08
Values 0.14 0.03
[45]
HepG2.C3A FGF2
Mean 0.092
Standard deviation 0.0064
Values 0.087 0.097
[46]
HuH.7 FGF2
Mean 1.57
Standard deviation 0.89
Values 0.98 2.6 1.1
[47]
SNU475 FGF2
Mean 14.2
Standard deviation 1.3
Values 13 15
[48]
THLE FGF2
Mean 47.5
Standard deviation 0.66
Values 48 47
[49]
liver FGF2
Mean 1.81
Standard deviation 0.66
Values 1.9 2.5 0.9 2
[50]
ref_hepatocyte FRS2
Mean 1.15
Standard deviation 0.48
Values 1.3 1.9 0.69 0.74 1.2
[51]
HepG2 FRS2
Mean 6.18
Standard deviation 3
Values 4 8.3
[52]
HepG2.C3A FRS2
Mean 11.7
Standard deviation 4
Values 8.9 15
[53]
HuH.7 FRS2
Mean 15.9
Standard deviation 4.9
Values 16 21 11
[54]
SNU475 FRS2
Mean 15.7
Standard deviation 0.35
Values 16 15
[55]
THLE FRS2
Mean 13.6
Standard deviation 0.96
Values 14 13
[56]
liver FRS2
Mean 16.5
Standard deviation 3.3
Values 18 20 13 15
[57]
ref_hepatocyte FRS3
Mean 0.88
Standard deviation 0.75
Values 2 0.11 0.65 0.39 1.3
[58]
HepG2 FRS3
Mean 3
Standard deviation 0.84
Values 3.6 2.4
[59]
HepG2.C3A FRS3
Mean 2.38
Standard deviation 0.57
Values 2.8 2
[60]
HuH.7 FRS3
Mean 1.13
Standard deviation 0.22
Values 1.1 0.94 1.4
[61]
SNU475 FRS3
Mean 1.98
Standard deviation 0.18
Values 2.1 1.9
[62]
THLE FRS3
Mean 1.75
Standard deviation 0.21
Values 1.9 1.6
[63]
liver FRS3
Mean 0.666
Standard deviation 0.45
Values 1.1 0.26 0.98 0.3
[64]
ref_hepatocyte FGFR1
Mean 0.81
Standard deviation 0.63
Values 1.2 0.49 1.6 0.06 0.62
[65]
HepG2 FGFR1
Mean 42.7
Standard deviation 4
Values 40 46
[66]
HepG2.C3A FGFR1
Mean 11.8
Standard deviation 3.5
Values 9.3 14
[67]
HuH.7 FGFR1
Mean 35.6
Standard deviation 13
Values 43 20 43
[68]
SNU475 FGFR1
Mean 49.5
Standard deviation 1.4
Values 50 49
[69]
THLE FGFR1
Mean 33.4
Standard deviation 3.3
Values 36 31
[70]
liver FGFR1
Mean 3.64
Standard deviation 0.67
Values 3 4.2 3.2 4.3
[71]
ref_hepatocyte KL
Mean 0.258
Standard deviation 0.29
Values 0 0 0.4 0.2 0.69
[72]
HepG2 KL
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[73]
HepG2.C3A KL
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 KL
Mean 0
Standard deviation 0
Values 0 0 0
[75]
SNU475 KL
Mean 0.181
Standard deviation 0.026
Values 0.2 0.16
[76]
THLE KL
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[77]
liver KL
Mean 0.436
Standard deviation 0.32
Values 0.38 0.31 0.15 0.9
[78]
ref_hepatocyte FGF5
Mean 0.241
Standard deviation 0.27
Values 0.042 0.036 0.09 0.64 0.4
[79]
HepG2 FGF5
Mean 0.268
Standard deviation 0.022
Values 0.25 0.28
[80]
HepG2.C3A FGF5
Mean 0.596
Standard deviation 0.024
Values 0.61 0.58
[81]
HuH.7 FGF5
Mean 0.543
Standard deviation 0.15
Values 0.62 0.65 0.37
[82]
SNU475 FGF5
Mean 1.24
Standard deviation 0.35
Values 0.99 1.5
[83]
THLE FGF5
Mean 1.11
Standard deviation 0.17
Values 0.99 1.2
[84]
liver FGF5
Mean 3.01
Standard deviation 1.5
Values 2.3 4.5 1.2 4.1
[85]
ref_hepatocyte FGF1
Mean 0.126
Standard deviation 0.27
Values 0 0.6 0 0 0.024
[86]
HepG2 FGF1
Mean 0.0408
Standard deviation 0.04
Values 0.069 0.013
[87]
HepG2.C3A FGF1
Mean 0.0628
Standard deviation 0.048
Values 0.029 0.097
[88]
HuH.7 FGF1
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[89]
SNU475 FGF1
Mean 0.346
Standard deviation 0.077
Values 0.29 0.4
[90]
THLE FGF1
Mean 1.16
Standard deviation 0.44
Values 0.85 1.5
[91]
liver FGF1
Mean 0.184
Standard deviation 0.042
Values 0.14 0.21 0.15 0.23
[92]
ref_hepatocyte FGF8
Mean 0.0195
Standard deviation 0.044
Values 0 0 0 0 0.098
[93]
HepG2 FGF8
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[94]
HepG2.C3A FGF8
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[95]
HuH.7 FGF8
Mean 0.105
Standard deviation 0.073
Values 0.19 0.051 0.075
[96]
SNU475 FGF8
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[97]
THLE FGF8
Mean 0
Standard deviation 0
Values 0 0
[98]
liver FGF8
Mean 0.18
Standard deviation 0.14
Values 0.047 0.34 0.077 0.25
[99]
ref_hepatocyte FGF9
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[100]
HepG2 FGF9
Mean 0.0687
Standard deviation 9.1e-05
Values 0.069 0.069
[101]
HepG2.C3A FGF9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[102]
HuH.7 FGF9
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 FGF9
Mean 0.0822
Standard deviation 0.08
Values 0.14 0.025
[104]
THLE FGF9
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[105]
liver FGF9
Mean 0.00993
Standard deviation 0.02
Values 0 0 0 0.04
[106]
ref_hepatocyte FGF6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 FGF6
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[108]
HepG2.C3A FGF6
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 FGF6
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 FGF6
Mean 0
Standard deviation 0
Values 0 0
[111]
THLE FGF6
Mean 0
Standard deviation 0
Values 0 0
[112]
liver FGF6
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0
[113]
ref_hepatocyte FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 FGF4
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A FGF4
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 FGF4
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 FGF4
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[118]
THLE FGF4
Mean 0
Standard deviation 0
Values 0 0
[119]
liver FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte FGF17
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 FGF17
Mean 0.398
Standard deviation 0.15
Values 0.5 0.29
[122]
HepG2.C3A FGF17
Mean 1.23
Standard deviation 1.1
Values 2 0.46
[123]
HuH.7 FGF17
Mean 0.183
Standard deviation 0.2
Values 0.074 0.41 0.066
[124]
SNU475 FGF17
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[125]
THLE FGF17
Mean 0.0228
Standard deviation 0.0096
Values 0.03 0.016
[126]
liver FGF17
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[127]
ref_hepatocyte FGF10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 FGF10
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A FGF10
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 FGF10
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 FGF10
Mean 0
Standard deviation 0
Values 0 0
[132]
THLE FGF10
Mean 0
Standard deviation 0
Values 0 0
[133]
liver FGF10
Mean 0.0234
Standard deviation 0.038
Values 0 0.014 0 0.079
[134]
ref_hepatocyte FGF22
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 FGF22
Mean 0.01
Standard deviation 0.002
Values 0.011 0.0086
[136]
HepG2.C3A FGF22
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 FGF22
Mean 0.00625
Standard deviation 0.011
Values 0 0 0.019
[138]
SNU475 FGF22
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[139]
THLE FGF22
Mean 0
Standard deviation 0
Values 0 0
[140]
liver FGF22
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte FGF20
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 FGF20
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[143]
HepG2.C3A FGF20
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 FGF20
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 FGF20
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[146]
THLE FGF20
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[147]
liver FGF20
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[148]
ref_hepatocyte FGF23
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 FGF23
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A FGF23
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 FGF23
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[152]
SNU475 FGF23
Mean 0
Standard deviation 0
Values 0 0
[153]
THLE FGF23
Mean 0
Standard deviation 0
Values 0 0
[154]
liver FGF23
Mean 0.68
Standard deviation 0.31
Values 0.59 0.67 1.1 0.36
[155]
ref_hepatocyte FGF3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 FGF3
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[157]
HepG2.C3A FGF3
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 FGF3
Mean 0.00487
Standard deviation 0.0043
Values 0.0082 0.0064 0
[159]
SNU475 FGF3
Mean 0.00717
Standard deviation 0.003
Values 0.0093 0.0051
[160]
THLE FGF3
Mean 0
Standard deviation 0
Values 0 0
[161]
liver FGF3
Mean 0
Standard deviation 0
Values 0 0 0 0