REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GADD45A Growth arrest and DNA damage-inducible protein GADD45 alpha [1] -2.47[2] -3.17[3] -2.93[4] -3.78[5] -2.52[6] -2.80[7]
2 CDKN1A Cyclin-dependent kinase inhibitor 1 [8] 0.84[9] -0.17[10] -2.81[11] -1.78[12] 0.30[13] -1.62[14]
3 CAV1 Caveolin-1 [15] -6.84[16] -9.28[17] -2.96[18] 1.58[19] -0.24[20] -1.79[21]
4 BTG1 Protein BTG1 [22] -1.21[23] -0.38[24] 0.69[25] -1.25[26] -1.25[27] 1.21[28]
5 CDKN1B Cyclin-dependent kinase inhibitor 1B [29] -0.09[30] 0.73[31] 0.98[32] -0.90[33] -0.91[34] -0.70[35]
6 RBL2 Retinoblastoma-like protein 2 [36] 0.84[37] 2.06[38] 2.17[39] 1.44[40] 0.67[41] 2.35[42]
7 SMAD3 Mothers against decapentaplegic homolog 3 [43] 1.93[44] 1.70[45] 1.98[46] 2.00[47] 2.41[48] 0.42[49]
8 KLF4 Krueppel-like factor 4 [50] -2.20[51] -5.57[52] -2.83[53] -3.95[54] -0.05[55] -1.72[56]
9 PCBP4 Poly(rC)-binding protein 4 [57] 2.80[58] 2.42[59] 1.61[60] 0.53[61] 0.61[62] -1.09[63]
10 SMAD4 Mothers against decapentaplegic homolog 4 [64] 1.39[65] 2.40[66] 2.42[67] 2.12[68] 2.01[69] 3.00[70]
11 FOXO3 Forkhead box protein O3 [71] 0.45[72] 0.92[73] 1.61[74] 0.61[75] 1.37[76] 2.54[77]
12 SMAD2 Mothers against decapentaplegic homolog 2 [78] 2.02[79] 2.66[80] 2.21[81] 2.59[82] 2.31[83] 2.78[84]
13 FOXO1 Forkhead box protein O1 [85] 1.69[86] 1.74[87] 1.93[88] 1.38[89] 2.93[90] 3.30[91]
14 CCNG2 Cyclin-G2 [92] 0.88[93] 1.93[94] 2.90[95] 0.53[96] 1.53[97] 0.33[98]
15 FOXO4 Forkhead box protein O4 [99] 0.73[100] 1.51[101] 1.39[102] 0.37[103] 0.11[104] -0.48[105]
16 FOXG1 Forkhead box protein G1 [106] [107] [108] [109] [110] [111] [112]
17 MSTN Growth/differentiation factor 8 [113] [114] [115] [116] [117] [118] [119]
[1]
ref_hepatocyte GADD45A
Mean 72.7
Standard deviation 61
Values 28 1.5e+02 1.2e+02 23 36
[2]
HepG2 GADD45A
Mean 29
Standard deviation 18
Values 42 16
[3]
HepG2.C3A GADD45A
Mean 12.2
Standard deviation 0.97
Values 13 12
[4]
HuH.7 GADD45A
Mean 13.4
Standard deviation 4.4
Values 9.2 18 13
[5]
SNU475 GADD45A
Mean 8.43
Standard deviation 3
Values 6.3 11
[6]
THLE GADD45A
Mean 31.4
Standard deviation 0.034
Values 31 31
[7]
liver GADD45A
Mean 12.8
Standard deviation 5.7
Values 15 5.8 19 11
[8]
ref_hepatocyte CDKN1A
Mean 40.1
Standard deviation 28
Values 19 48 76 52 5.7
[9]
HepG2 CDKN1A
Mean 158
Standard deviation 49
Values 1.9e+02 1.2e+02
[10]
HepG2.C3A CDKN1A
Mean 53.9
Standard deviation 3.9
Values 51 57
[11]
HuH.7 CDKN1A
Mean 8
Standard deviation 1.9
Values 6.5 10 7.3
[12]
SNU475 CDKN1A
Mean 18.6
Standard deviation 7.8
Values 13 24
[13]
THLE CDKN1A
Mean 122
Standard deviation 11
Values 1.3e+02 1.1e+02
[14]
liver CDKN1A
Mean 16
Standard deviation 8.1
Values 16 6.2 26 16
[15]
ref_hepatocyte CAV1
Mean 22.6
Standard deviation 36
Values 0 84 28 0.35 0.99
[16]
HepG2 CAV1
Mean 0.438
Standard deviation 0.44
Values 0.75 0.12
[17]
HepG2.C3A CAV1
Mean 0.055
Standard deviation 0.032
Values 0.078 0.032
[18]
HuH.7 CAV1
Mean 4.08
Standard deviation 1.9
Values 3.5 6.2 2.5
[19]
SNU475 CAV1
Mean 108
Standard deviation 15
Values 1.2e+02 98
[20]
THLE CAV1
Mean 47.4
Standard deviation 15
Values 37 58
[21]
liver CAV1
Mean 8.05
Standard deviation 2.9
Values 7.6 8.2 12 4.7
[22]
ref_hepatocyte BTG1
Mean 16.7
Standard deviation 11
Values 2.9 9.9 17 30 23
[23]
HepG2 BTG1
Mean 15.9
Standard deviation 11
Values 23 8.5
[24]
HepG2.C3A BTG1
Mean 19.4
Standard deviation 10
Values 27 12
[25]
HuH.7 BTG1
Mean 37.6
Standard deviation 14
Values 27 53 33
[26]
SNU475 BTG1
Mean 11.1
Standard deviation 0.094
Values 11 11
[27]
THLE BTG1
Mean 17.4
Standard deviation 0.028
Values 17 17
[28]
liver BTG1
Mean 47.3
Standard deviation 44
Values 1.1e+02 14 52 15
[29]
ref_hepatocyte CDKN1B
Mean 13.8
Standard deviation 6
Values 23 13 7.5 10 15
[30]
HepG2 CDKN1B
Mean 28.7
Standard deviation 3.4
Values 31 26
[31]
HepG2.C3A CDKN1B
Mean 34.7
Standard deviation 1.4
Values 34 36
[32]
HuH.7 CDKN1B
Mean 38.2
Standard deviation 3.7
Values 35 42 37
[33]
SNU475 CDKN1B
Mean 11.8
Standard deviation 2.9
Values 14 9.7
[34]
THLE CDKN1B
Mean 18.2
Standard deviation 3.4
Values 16 21
[35]
liver CDKN1B
Mean 10.5
Standard deviation 3.5
Values 9.9 14 5.8 12
[36]
ref_hepatocyte RBL2
Mean 6.31
Standard deviation 3.1
Values 6.8 4 4.2 5 12
[37]
HepG2 RBL2
Mean 24.9
Standard deviation 4.6
Values 22 28
[38]
HepG2.C3A RBL2
Mean 39.8
Standard deviation 0.53
Values 39 40
[39]
HuH.7 RBL2
Mean 39.7
Standard deviation 1.6
Values 42 39 39
[40]
SNU475 RBL2
Mean 27.1
Standard deviation 11
Values 35 19
[41]
THLE RBL2
Mean 24.9
Standard deviation 0.58
Values 25 24
[42]
liver RBL2
Mean 39.5
Standard deviation 5.1
Values 37 41 34 46
[43]
ref_hepatocyte SMAD3
Mean 5.99
Standard deviation 4.6
Values 4.8 8.4 13 1.9 2.2
[44]
HepG2 SMAD3
Mean 50.4
Standard deviation 14
Values 60 40
[45]
HepG2.C3A SMAD3
Mean 29.5
Standard deviation 11
Values 37 22
[46]
HuH.7 SMAD3
Mean 33.2
Standard deviation 6.9
Values 31 41 28
[47]
SNU475 SMAD3
Mean 38.2
Standard deviation 2.7
Values 40 36
[48]
THLE SMAD3
Mean 78.9
Standard deviation 8.4
Values 73 85
[49]
liver SMAD3
Mean 9.85
Standard deviation 3
Values 12 7.4 7.1 13
[50]
ref_hepatocyte KLF4
Mean 4.48
Standard deviation 4.2
Values 0 4.3 11 5.9 1.4
[51]
HepG2 KLF4
Mean 2.15
Standard deviation 2.2
Values 3.7 0.62
[52]
HepG2.C3A KLF4
Mean 0.143
Standard deviation 0.14
Values 0.24 0.043
[53]
HuH.7 KLF4
Mean 0.885
Standard deviation 0.91
Values 0.38 1.9 0.35
[54]
SNU475 KLF4
Mean 0.46
Standard deviation 0.23
Values 0.3 0.62
[55]
THLE KLF4
Mean 10.7
Standard deviation 1.6
Values 9.6 12
[56]
liver KLF4
Mean 1.67
Standard deviation 1.4
Values 1.1 1.1 0.77 3.7
[57]
ref_hepatocyte PCBP4
Mean 3.72
Standard deviation 1.5
Values 5.9 3.3 4 3.5 1.9
[58]
HepG2 PCBP4
Mean 57.4
Standard deviation 6.4
Values 62 53
[59]
HepG2.C3A PCBP4
Mean 30.2
Standard deviation 1.3
Values 31 29
[60]
HuH.7 PCBP4
Mean 16
Standard deviation 0.35
Values 16 16 16
[61]
SNU475 PCBP4
Mean 8.57
Standard deviation 2.4
Values 10 6.9
[62]
THLE PCBP4
Mean 14.1
Standard deviation 2.1
Values 16 13
[63]
liver PCBP4
Mean 2.15
Standard deviation 0.53
Values 2.3 1.8 2.8 1.6
[64]
ref_hepatocyte SMAD4
Mean 3.16
Standard deviation 0.71
Values 2.9 2.8 4.2 2.4 3.4
[65]
HepG2 SMAD4
Mean 18.3
Standard deviation 3.2
Values 16 21
[66]
HepG2.C3A SMAD4
Mean 25.2
Standard deviation 3
Values 27 23
[67]
HuH.7 SMAD4
Mean 23.6
Standard deviation 3.4
Values 24 27 20
[68]
SNU475 SMAD4
Mean 21.8
Standard deviation 2.7
Values 24 20
[69]
THLE SMAD4
Mean 31.4
Standard deviation 1.4
Values 30 32
[70]
liver SMAD4
Mean 31
Standard deviation 13
Values 23 40 16 44
[71]
ref_hepatocyte FOXO3
Mean 2.79
Standard deviation 0.38
Values 3.3 2.7 2.3 2.8 2.9
[72]
HepG2 FOXO3
Mean 8.44
Standard deviation 1
Values 7.7 9.2
[73]
HepG2.C3A FOXO3
Mean 8
Standard deviation 2.4
Values 9.7 6.3
[74]
HuH.7 FOXO3
Mean 11.9
Standard deviation 3.6
Values 13 15 7.9
[75]
SNU475 FOXO3
Mean 6.76
Standard deviation 0.76
Values 7.3 6.2
[76]
THLE FOXO3
Mean 17.9
Standard deviation 3.1
Values 16 20
[77]
liver FOXO3
Mean 20
Standard deviation 5.5
Values 24 21 12 23
[78]
ref_hepatocyte SMAD2
Mean 2.54
Standard deviation 1.2
Values 4.5 2.8 1.9 1.9 1.6
[79]
HepG2 SMAD2
Mean 22.7
Standard deviation 2.3
Values 21 24
[80]
HepG2.C3A SMAD2
Mean 24.2
Standard deviation 1.1
Values 25 23
[81]
HuH.7 SMAD2
Mean 16.4
Standard deviation 1.6
Values 17 18 15
[82]
SNU475 SMAD2
Mean 24.3
Standard deviation 3.3
Values 27 22
[83]
THLE SMAD2
Mean 31
Standard deviation 0.65
Values 31 32
[84]
liver SMAD2
Mean 21.4
Standard deviation 6.7
Values 17 29 15 25
[85]
ref_hepatocyte FOXO1
Mean 1.77
Standard deviation 0.68
Values 0.71 1.7 2 1.9 2.6
[86]
HepG2 FOXO1
Mean 12.6
Standard deviation 1.8
Values 11 14
[87]
HepG2.C3A FOXO1
Mean 8.92
Standard deviation 1.5
Values 10 7.9
[88]
HuH.7 FOXO1
Mean 9.41
Standard deviation 1.6
Values 10 10 7.6
[89]
SNU475 FOXO1
Mean 7.33
Standard deviation 1.8
Values 8.6 6
[90]
THLE FOXO1
Mean 33.2
Standard deviation 1.9
Values 32 35
[91]
liver FOXO1
Mean 21.4
Standard deviation 7
Values 25 19 13 29
[92]
ref_hepatocyte CCNG2
Mean 1.61
Standard deviation 1.5
Values 4.1 1.4 0.51 0.59 1.5
[93]
HepG2 CCNG2
Mean 6.56
Standard deviation 1.1
Values 5.7 7.4
[94]
HepG2.C3A CCNG2
Mean 9.28
Standard deviation 0.28
Values 9.5 9.1
[95]
HuH.7 CCNG2
Mean 16.9
Standard deviation 5.8
Values 13 24 14
[96]
SNU475 CCNG2
Mean 3.7
Standard deviation 1.2
Values 4.5 2.9
[97]
THLE CCNG2
Mean 11.5
Standard deviation 1.9
Values 10 13
[98]
liver CCNG2
Mean 2.49
Standard deviation 0.33
Values 2.5 2.7 2.7 2
[99]
ref_hepatocyte FOXO4
Mean 1.56
Standard deviation 0.85
Values 2.8 1.6 0.42 1.7 1.3
[100]
HepG2 FOXO4
Mean 5.71
Standard deviation 1.3
Values 6.6 4.8
[101]
HepG2.C3A FOXO4
Mean 6.69
Standard deviation 3.6
Values 9.2 4.2
[102]
HuH.7 FOXO4
Mean 5.72
Standard deviation 1.5
Values 5.1 7.5 4.6
[103]
SNU475 FOXO4
Mean 3.21
Standard deviation 1.1
Values 4 2.4
[104]
THLE FOXO4
Mean 4.17
Standard deviation 0.02
Values 4.2 4.2
[105]
liver FOXO4
Mean 1.37
Standard deviation 1.1
Values 0.54 2 0.33 2.6
[106]
ref_hepatocyte FOXG1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 FOXG1
Mean 0.0122
Standard deviation 0.001
Values 0.011 0.013
[108]
HepG2.C3A FOXG1
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[109]
HuH.7 FOXG1
Mean 5.07
Standard deviation 0.98
Values 4.4 4.7 6.2
[110]
SNU475 FOXG1
Mean 18.8
Standard deviation 1.9
Values 20 17
[111]
THLE FOXG1
Mean 0.0228
Standard deviation 0.0096
Values 0.03 0.016
[112]
liver FOXG1
Mean 0
Standard deviation 0
Values 0 0 0 0
[113]
ref_hepatocyte MSTN
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 MSTN
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[115]
HepG2.C3A MSTN
Mean 0.0292
Standard deviation 0.041
Values 0.058 0
[116]
HuH.7 MSTN
Mean 0.00625
Standard deviation 0.011
Values 0 0 0.019
[117]
SNU475 MSTN
Mean 0.0125
Standard deviation 0.011
Values 0.0046 0.02
[118]
THLE MSTN
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[119]
liver MSTN
Mean 0.0804
Standard deviation 0.14
Values 0.28 0 0 0.04