REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
KRT8 |
Keratin, type II cytoskeletal 8 |
[1] |
-0.20[2] |
-0.18[3] |
-0.50[4] |
0.54[5] |
-0.86[6] |
-1.50[7] |
2 |
KRT18 |
Keratin, type I cytoskeletal 18 |
[8] |
-0.84[9] |
-0.53[10] |
-0.92[11] |
-0.38[12] |
-1.17[13] |
-0.77[14] |
3 |
KRT7 |
Keratin, type II cytoskeletal 7 |
[15] |
-5.53[16] |
-13.22[17] |
-10.08[18] |
-6.46[19] |
0.51[20] |
-4.98[21] |
4 |
CAPNS1 |
Calpain small subunit 1 |
[22] |
-0.95[23] |
-0.58[24] |
0.24[25] |
-0.43[26] |
0.60[27] |
-1.73[28] |
5 |
PERP |
p53 apoptosis effector related to PMP-22 |
[29] |
0.17[30] |
0.79[31] |
1.17[32] |
-0.07[33] |
1.00[34] |
0.93[35] |
6 |
FURIN |
Furin |
[36] |
1.23[37] |
-1.90[38] |
1.23[39] |
-0.90[40] |
0.56[41] |
2.37[42] |
7 |
KRT19 |
Keratin, type I cytoskeletal 19 |
[43] |
2.73[44] |
0.57[45] |
-5.81[46] |
-1.99[47] |
0.52[48] |
-3.85[49] |
8 |
CAPN1 |
Calpain-1 catalytic subunit |
[50] |
0.13[51] |
-0.43[52] |
1.13[53] |
0.74[54] |
1.40[55] |
0.37[56] |
9 |
PCSK6 |
Proprotein convertase subtilisin/kexin type 6 |
[57] |
-0.12[58] |
0.34[59] |
0.60[60] |
-6.42[61] |
-5.75[62] |
3.18[63] |
10 |
JUP |
Junction plakoglobin |
[64] |
0.59[65] |
0.01[66] |
1.24[67] |
-0.19[68] |
0.13[69] |
1.13[70] |
11 |
DSP |
Desmoplakin |
[71] |
2.66[72] |
3.60[73] |
3.10[74] |
0.95[75] |
-0.90[76] |
3.55[77] |
12 |
PKP4 |
Plakophilin-4 |
[78] |
-0.14[79] |
1.15[80] |
2.77[81] |
-0.22[82] |
0.86[83] |
0.44[84] |
13 |
PRSS8 |
Prostasin |
[85] |
-1.65[86] |
0.53[87] |
-8.02[88] |
-4.47[89] |
-8.12[90] |
0.39[91] |
14 |
DSG2 |
Desmoglein-2 |
[92] |
1.25[93] |
2.35[94] |
2.51[95] |
2.92[96] |
3.45[97] |
1.26[98] |
15 |
KRT81 |
Keratin, type II cuticular Hb1 |
[99] |
-3.06[100] |
[101] |
-10.89[102] |
-0.53[103] |
-2.72[104] |
-10.04[105] |
16 |
PKP2 |
Plakophilin-2 |
[106] |
-0.04[107] |
0.58[108] |
2.58[109] |
0.81[110] |
0.87[111] |
2.08[112] |
17 |
DSC2 |
Desmocollin-2 |
[113] |
-0.02[114] |
0.77[115] |
1.43[116] |
-2.47[117] |
-0.08[118] |
1.32[119] |
18 |
CSTA |
Cystatin-A |
[120] |
-2.11[121] |
-0.23[122] |
2.20[123] |
-7.55[124] |
-1.30[125] |
-2.31[126] |
19 |
KRT10 |
Keratin, type I cytoskeletal 10 |
[127] |
-0.21[128] |
-0.45[129] |
0.97[130] |
0.61[131] |
1.49[132] |
1.14[133] |
20 |
PPL |
Periplakin |
[134] |
0.75[135] |
0.12[136] |
-0.28[137] |
1.41[138] |
-1.34[139] |
2.44[140] |
21 |
ST14 |
Suppressor of tumorigenicity 14 protein |
[141] |
-2.36[142] |
-2.16[143] |
-5.42[144] |
-3.40[145] |
-4.68[146] |
0.99[147] |
22 |
KRT80 |
Keratin, type II cytoskeletal 80 |
[148] |
2.08[149] |
-1.88[150] |
-5.47[151] |
3.29[152] |
4.96[153] |
-4.13[154] |
23 |
KRT16 |
Keratin, type I cytoskeletal 16 |
[155] |
-8.49[156] |
[157] |
[158] |
-4.01[159] |
-5.07[160] |
[161] |
24 |
KRT34 |
Keratin, type I cuticular Ha4 |
[162] |
-7.82[163] |
[164] |
[165] |
-2.70[166] |
-3.79[167] |
[168] |
25 |
KRT17 |
Keratin, type I cytoskeletal 17 |
[169] |
0.09[170] |
-3.79[171] |
-8.83[172] |
-2.77[173] |
-2.65[174] |
[175] |
26 |
PKP3 |
Plakophilin-3 |
[176] |
3.68[177] |
4.53[178] |
-5.19[179] |
0.55[180] |
-1.49[181] |
-4.34[182] |
27 |
KAZN |
Kazrin |
[183] |
3.52[184] |
5.25[185] |
-3.80[186] |
3.17[187] |
1.07[188] |
2.20[189] |
28 |
EVPL |
Envoplakin |
[190] |
3.13[191] |
3.29[192] |
-4.72[193] |
1.34[194] |
1.22[195] |
-4.04[196] |
29 |
KLK14 |
Kallikrein-14 |
[197] |
-5.26[198] |
-1.87[199] |
-1.13[200] |
-2.44[201] |
-3.38[202] |
-4.55[203] |
30 |
PI3 |
Elafin |
[204] |
-2.36[205] |
-4.45[206] |
0.41[207] |
-0.74[208] |
2.57[209] |
[210] |
31 |
KRT15 |
Keratin, type I cytoskeletal 15 |
[211] |
2.72[212] |
0.00[213] |
1.23[214] |
-1.52[215] |
-0.70[216] |
[217] |
32 |
KRT23 |
Keratin, type I cytoskeletal 23 |
[218] |
7.41[219] |
7.47[220] |
5.03[221] |
-1.87[222] |
-1.79[223] |
-0.46[224] |
33 |
DSG1 |
Desmoglein-1 |
[225] |
-5.27[226] |
-1.65[227] |
0.85[228] |
-5.19[229] |
[230] |
3.18[231] |
34 |
KRT26 |
Keratin, type I cytoskeletal 26 |
[232] |
[233] |
[234] |
[235] |
[236] |
[237] |
[238] |
35 |
CASP14 |
Caspase-14 |
[239] |
-3.57[240] |
-2.17[241] |
-2.80[242] |
-3.57[243] |
-2.73[244] |
-3.38[245] |
36 |
KRT14 |
Keratin, type I cytoskeletal 14 |
[246] |
-4.31[247] |
[248] |
[249] |
-3.25[250] |
[251] |
[252] |
37 |
TGM1 |
Protein-glutamine gamma-glutamyltransferase K |
[253] |
1.43[254] |
2.04[255] |
1.76[256] |
0.69[257] |
1.62[258] |
1.79[259] |
38 |
SPRR2A |
Small proline-rich protein 2A |
[260] |
[261] |
[262] |
[263] |
[264] |
[265] |
[266] |
39 |
DSG3 |
Desmoglein-3 |
[267] |
0.62[268] |
2.20[269] |
5.99[270] |
1.71[271] |
2.28[272] |
3.70[273] |
40 |
KRT86 |
Keratin, type II cuticular Hb6 |
[274] |
-1.18[275] |
[276] |
[277] |
3.00[278] |
4.11[279] |
-2.51[280] |
41 |
SPINK9 |
Serine protease inhibitor Kazal-type 9 |
[281] |
[282] |
[283] |
[284] |
[285] |
[286] |
-1.62[287] |
42 |
LCE3D |
Late cornified envelope protein 3D |
[288] |
[289] |
[290] |
[291] |
[292] |
-1.18[293] |
[294] |
43 |
KLK13 |
Kallikrein-13 |
[295] |
-2.32[296] |
[297] |
[298] |
-3.33[299] |
[300] |
[301] |
44 |
KRT33B |
Keratin, type I cuticular Ha3-II |
[302] |
[303] |
[304] |
[305] |
-2.97[306] |
-0.77[307] |
[308] |
45 |
DSC1 |
Desmocollin-1 |
[309] |
-0.88[310] |
1.13[311] |
1.21[312] |
0.14[313] |
0.93[314] |
0.78[315] |
46 |
TCHH |
Trichohyalin |
[316] |
[317] |
[318] |
[319] |
2.46[320] |
1.50[321] |
2.90[322] |
47 |
SPINK5 |
Serine protease inhibitor Kazal-type 5 |
[323] |
-3.69[324] |
[325] |
6.88[326] |
-2.11[327] |
-0.66[328] |
1.47[329] |
48 |
KRT71 |
Keratin, type II cytoskeletal 71 |
[330] |
[331] |
-2.70[332] |
[333] |
0.01[334] |
[335] |
[336] |
49 |
KRT32 |
Keratin, type I cuticular Ha2 |
[337] |
-0.51[338] |
[339] |
[340] |
1.53[341] |
-0.66[342] |
[343] |
50 |
KRT85 |
Keratin, type II cuticular Hb5 |
[344] |
-0.97[345] |
-2.17[346] |
[347] |
0.92[348] |
-0.27[349] |
[350] |
51 |
LIPJ |
Lipase member J |
[351] |
[352] |
[353] |
-1.79[354] |
-2.81[355] |
[356] |
2.46[357] |
52 |
DSC3 |
Desmocollin-3 |
[358] |
5.52[359] |
4.99[360] |
7.00[361] |
6.63[362] |
12.40[363] |
6.19[364] |
53 |
FLG |
Filaggrin |
[365] |
6.97[366] |
-0.08[367] |
[368] |
5.50[369] |
5.47[370] |
7.53[371] |
54 |
KRT76 |
Keratin, type II cytoskeletal 2 oral |
[372] |
[373] |
[374] |
[375] |
[376] |
[377] |
[378] |
55 |
LIPN |
Lipase member N |
[379] |
[380] |
[381] |
[382] |
[383] |
[384] |
[385] |
56 |
LCE1F |
Late cornified envelope protein 1F |
[386] |
[387] |
[388] |
[389] |
[390] |
[391] |
[392] |
57 |
LCE1B |
Late cornified envelope protein 1B |
[393] |
[394] |
[395] |
[396] |
[397] |
[398] |
[399] |
58 |
LCE2C |
Late cornified envelope protein 2C |
[400] |
[401] |
[402] |
[403] |
[404] |
[405] |
[406] |
59 |
SPRR1A |
Cornifin-A |
[407] |
[408] |
[409] |
[410] |
[411] |
[412] |
[413] |
60 |
SPRR2F |
Small proline-rich protein 2F |
[414] |
[415] |
[416] |
[417] |
[418] |
[419] |
[420] |
61 |
LCE4A |
Late cornified envelope protein 4A |
[421] |
[422] |
[423] |
[424] |
[425] |
[426] |
[427] |
62 |
LCE2B |
Late cornified envelope protein 2B |
[428] |
[429] |
[430] |
[431] |
[432] |
[433] |
[434] |
63 |
KRT4 |
Keratin, type II cytoskeletal 4 |
[435] |
[436] |
[437] |
[438] |
[439] |
[440] |
[441] |
64 |
LCE1C |
Late cornified envelope protein 1C |
[442] |
[443] |
[444] |
[445] |
[446] |
[447] |
[448] |
65 |
LCE5A |
Late cornified envelope protein 5A |
[449] |
[450] |
[451] |
[452] |
[453] |
[454] |
[455] |
66 |
KRT33A |
Keratin, type I cuticular Ha3-I |
[456] |
[457] |
[458] |
[459] |
[460] |
[461] |
[462] |
67 |
KLK8 |
Kallikrein-8 |
[463] |
[464] |
[465] |
[466] |
[467] |
[468] |
[469] |
68 |
KLK5 |
Kallikrein-5 |
[470] |
[471] |
[472] |
[473] |
[474] |
[475] |
[476] |
69 |
KRT5 |
Keratin, type II cytoskeletal 5 |
[477] |
[478] |
[479] |
[480] |
[481] |
[482] |
[483] |
70 |
KRT73 |
Keratin, type II cytoskeletal 73 |
[484] |
[485] |
[486] |
[487] |
[488] |
[489] |
[490] |
71 |
LCE1D |
Late cornified envelope protein 1D |
[491] |
[492] |
[493] |
[494] |
[495] |
[496] |
[497] |
72 |
CELA2A |
Chymotrypsin-like elastase family member 2A |
[498] |
[499] |
[500] |
[501] |
[502] |
[503] |
[504] |
73 |
KRT79 |
Keratin, type II cytoskeletal 79 |
[505] |
[506] |
[507] |
[508] |
[509] |
[510] |
[511] |
74 |
KRT13 |
Keratin, type I cytoskeletal 13 |
[512] |
[513] |
[514] |
[515] |
[516] |
[517] |
[518] |
75 |
KRT84 |
Keratin, type II cuticular Hb4 |
[519] |
[520] |
[521] |
[522] |
[523] |
[524] |
[525] |
76 |
KRT77 |
Keratin, type II cytoskeletal 1b |
[526] |
[527] |
[528] |
[529] |
[530] |
[531] |
[532] |
77 |
SPRR2D |
Small proline-rich protein 2D |
[533] |
[534] |
[535] |
[536] |
[537] |
[538] |
[539] |
78 |
KRT6A |
Keratin, type II cytoskeletal 6A |
[540] |
[541] |
[542] |
[543] |
[544] |
[545] |
[546] |
79 |
KLK12 |
Kallikrein-12 |
[547] |
[548] |
[549] |
[550] |
[551] |
[552] |
[553] |
80 |
KRT12 |
Keratin, type I cytoskeletal 12 |
[554] |
[555] |
[556] |
[557] |
[558] |
[559] |
[560] |
81 |
LCE3E |
Late cornified envelope protein 3E |
[561] |
[562] |
[563] |
[564] |
[565] |
[566] |
[567] |
82 |
KRT20 |
Keratin, type I cytoskeletal 20 |
[568] |
[569] |
[570] |
[571] |
[572] |
[573] |
[574] |
83 |
KRT9 |
Keratin, type I cytoskeletal 9 |
[575] |
[576] |
[577] |
[578] |
[579] |
[580] |
[581] |
84 |
KRT38 |
Keratin, type I cuticular Ha8 |
[582] |
[583] |
[584] |
[585] |
[586] |
[587] |
[588] |
85 |
LCE3A |
Late cornified envelope protein 3A |
[589] |
[590] |
[591] |
[592] |
[593] |
[594] |
[595] |
86 |
KRT72 |
Keratin, type II cytoskeletal 72 |
[596] |
[597] |
[598] |
[599] |
[600] |
[601] |
[602] |
87 |
KRT3 |
Keratin, type II cytoskeletal 3 |
[603] |
[604] |
[605] |
[606] |
[607] |
[608] |
[609] |
88 |
KRT27 |
Keratin, type I cytoskeletal 27 |
[610] |
[611] |
[612] |
[613] |
[614] |
[615] |
[616] |
89 |
KRT35 |
Keratin, type I cuticular Ha5 |
[617] |
[618] |
[619] |
[620] |
[621] |
[622] |
[623] |
90 |
LCE2D |
Late cornified envelope protein 2D |
[624] |
[625] |
[626] |
[627] |
[628] |
[629] |
[630] |
91 |
LCE2A |
Late cornified envelope protein 2A |
[631] |
[632] |
[633] |
[634] |
[635] |
[636] |
[637] |
92 |
CDSN |
Corneodesmosin |
[638] |
[639] |
[640] |
[641] |
[642] |
[643] |
[644] |
93 |
KRT2 |
Keratin, type II cytoskeletal 2 epidermal |
[645] |
[646] |
[647] |
[648] |
[649] |
[650] |
[651] |
94 |
KRT39 |
Keratin, type I cytoskeletal 39 |
[652] |
[653] |
[654] |
[655] |
[656] |
[657] |
[658] |
95 |
KRT37 |
Keratin, type I cuticular Ha7 |
[659] |
[660] |
[661] |
[662] |
[663] |
[664] |
[665] |
96 |
KRT25 |
Keratin, type I cytoskeletal 25 |
[666] |
[667] |
[668] |
[669] |
[670] |
[671] |
[672] |
97 |
LIPK |
Lipase member K |
[673] |
[674] |
[675] |
[676] |
[677] |
[678] |
[679] |
98 |
PKP1 |
Plakophilin-1 |
[680] |
[681] |
[682] |
[683] |
[684] |
[685] |
[686] |
99 |
TGM5 |
Protein-glutamine gamma-glutamyltransferase 5 |
[687] |
[688] |
[689] |
[690] |
[691] |
[692] |
[693] |
100 |
KRT28 |
Keratin, type I cytoskeletal 28 |
[694] |
[695] |
[696] |
[697] |
[698] |
[699] |
[700] |
101 |
SPRR2G |
Small proline-rich protein 2G |
[701] |
[702] |
[703] |
[704] |
[705] |
[706] |
[707] |
102 |
LORICRIN |
|
[708] |
[709] |
[710] |
[711] |
[712] |
[713] |
[714] |
103 |
KRT75 |
Keratin, type II cytoskeletal 75 |
[715] |
[716] |
[717] |
[718] |
[719] |
[720] |
[721] |
104 |
LCE1E |
Late cornified envelope protein 1E |
[722] |
[723] |
[724] |
[725] |
[726] |
[727] |
[728] |
105 |
SPRR2B |
Small proline-rich protein 2B |
[729] |
[730] |
[731] |
[732] |
[733] |
[734] |
[735] |
106 |
KRT78 |
Keratin, type II cytoskeletal 78 |
[736] |
[737] |
[738] |
[739] |
[740] |
[741] |
[742] |
107 |
KRT1 |
Keratin, type II cytoskeletal 1 |
[743] |
[744] |
[745] |
[746] |
[747] |
[748] |
[749] |
108 |
LCE1A |
Late cornified envelope protein 1A |
[750] |
[751] |
[752] |
[753] |
[754] |
[755] |
[756] |
109 |
DSG4 |
Desmoglein-4 |
[757] |
[758] |
[759] |
[760] |
[761] |
[762] |
[763] |
110 |
KRT40 |
Keratin, type I cytoskeletal 40 |
[764] |
[765] |
[766] |
[767] |
[768] |
[769] |
[770] |
111 |
KRT74 |
Keratin, type II cytoskeletal 74 |
[771] |
[772] |
[773] |
[774] |
[775] |
[776] |
[777] |
112 |
SPRR3 |
Small proline-rich protein 3 |
[778] |
[779] |
[780] |
[781] |
[782] |
[783] |
[784] |
113 |
SPINK6 |
Serine protease inhibitor Kazal-type 6 |
[785] |
[786] |
[787] |
[788] |
[789] |
[790] |
[791] |
114 |
KRT6C |
Keratin, type II cytoskeletal 6C |
[792] |
[793] |
[794] |
[795] |
[796] |
[797] |
[798] |
115 |
KRT83 |
Keratin, type II cuticular Hb3 |
[799] |
[800] |
[801] |
[802] |
[803] |
[804] |
[805] |
116 |
SPRR2E |
Small proline-rich protein 2E |
[806] |
[807] |
[808] |
[809] |
[810] |
[811] |
[812] |
117 |
LCE3B |
Late cornified envelope protein 3B |
[813] |
[814] |
[815] |
[816] |
[817] |
[818] |
[819] |
118 |
RPTN |
Repetin |
[820] |
[821] |
[822] |
[823] |
[824] |
[825] |
[826] |
119 |
KRT36 |
Keratin, type I cuticular Ha6 |
[827] |
[828] |
[829] |
[830] |
[831] |
[832] |
[833] |
120 |
LELP1 |
Late cornified envelope-like proline-rich protein 1 |
[834] |
[835] |
[836] |
[837] |
[838] |
[839] |
[840] |
121 |
LCE6A |
Late cornified envelope protein 6A |
[841] |
[842] |
[843] |
[844] |
[845] |
[846] |
[847] |
122 |
KRT82 |
Keratin, type II cuticular Hb2 |
[848] |
[849] |
[850] |
[851] |
[852] |
[853] |
[854] |
123 |
LIPM |
Lipase member M |
[855] |
[856] |
[857] |
[858] |
[859] |
[860] |
[861] |
124 |
KRT31 |
Keratin, type I cuticular Ha1 |
[862] |
[863] |
[864] |
[865] |
[866] |
[867] |
[868] |
125 |
SPRR1B |
Cornifin-B |
[869] |
[870] |
[871] |
[872] |
[873] |
[874] |
[875] |
126 |
LCE3C |
Late cornified envelope protein 3C |
[876] |
[877] |
[878] |
[879] |
[880] |
[881] |
[882] |
127 |
KRT24 |
Keratin, type I cytoskeletal 24 |
[883] |
[884] |
[885] |
[886] |
[887] |
[888] |
[889] |
128 |
IVL |
Involucrin |
[890] |
[891] |
[892] |
[893] |
[894] |
[895] |
[896] |
129 |
KRT6B |
Keratin, type II cytoskeletal 6B |
[897] |
[898] |
[899] |
[900] |
[901] |
[902] |
[903] |
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