REACTOME_FLT3_SIGNALING_IN_DISEASE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.12[2] | -1.17[3] | -1.34[4] | -1.14[5] | -0.91[6] | -0.88[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.68[16] | -0.42[17] | -0.98[18] | -0.29[19] | -0.53[20] | -0.43[21] |
4 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [22] | 1.76[23] | 1.81[24] | 2.53[25] | 1.11[26] | 1.70[27] | 0.34[28] |
5 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [29] | 1.92[30] | 0.68[31] | -2.34[32] | -0.35[33] | 1.98[34] | -0.84[35] |
6 | BCL2L1 | Bcl-2-like protein 1 | [36] | 3.22[37] | 2.75[38] | 3.39[39] | 1.02[40] | 1.18[41] | 0.18[42] |
7 | SPTBN1 | Spectrin beta chain, non-erythrocytic 1 | [43] | 3.83[44] | 3.51[45] | 3.59[46] | 3.05[47] | 3.17[48] | 3.95[49] |
8 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [50] | 1.52[51] | 2.10[52] | 1.74[53] | 2.53[54] | 2.93[55] | 2.25[56] |
9 | GRB2 | Growth factor receptor-bound protein 2 | [57] | 2.27[58] | 2.26[59] | 2.06[60] | 2.19[61] | 1.88[62] | 1.29[63] |
10 | NRAS | GTPase NRas | [64] | 1.71[65] | 2.29[66] | 2.38[67] | 2.63[68] | 1.98[69] | 0.74[70] |
11 | HRAS | GTPase HRas | [71] | 0.07[72] | -0.49[73] | -1.60[74] | 0.69[75] | 0.25[76] | -1.67[77] |
12 | PIM1 | Serine/threonine-protein kinase pim-1 | [78] | 1.27[79] | 1.19[80] | 0.23[81] | 2.02[82] | 0.78[83] | -0.13[84] |
13 | KRAS | GTPase KRas | [85] | 0.56[86] | 0.69[87] | 1.97[88] | 2.44[89] | 1.87[90] | 1.67[91] |
14 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [92] | 0.61[93] | 0.87[94] | 1.64[95] | 3.70[96] | 2.98[97] | 4.00[98] |
15 | MYO18A | Unconventional myosin-XVIIIa | [99] | 2.16[100] | 2.59[101] | 3.17[102] | 2.67[103] | 1.46[104] | 3.61[105] |
16 | SOS1 | Son of sevenless homolog 1 | [106] | 0.98[107] | 2.66[108] | 1.84[109] | 2.48[110] | 1.49[111] | 1.53[112] |
17 | STAT5B | Signal transducer and activator of transcription 5B | [113] | 2.44[114] | 2.21[115] | 2.59[116] | 3.19[117] | 2.10[118] | 2.62[119] |
18 | GOLGB1 | Golgin subfamily B member 1 | [120] | 1.66[121] | 4.01[122] | 3.94[123] | 3.62[124] | 3.53[125] | 5.00[126] |
19 | TRIP11 | Thyroid receptor-interacting protein 11 | [127] | 0.55[128] | 3.00[129] | 2.46[130] | 3.54[131] | 2.84[132] | 4.09[133] |
20 | STAT5A | Signal transducer and activator of transcription 5A | [134] | -0.87[135] | 0.45[136] | -0.80[137] | 0.79[138] | 1.33[139] | 1.23[140] |
21 | ZMYM2 | Zinc finger MYM-type protein 2 | [141] | 2.71[142] | 3.99[143] | 3.18[144] | 4.61[145] | 3.91[146] | 4.27[147] |
22 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 0.70[148] | 2.48[149] | 2.35[150] | 2.77[151] | 2.74[152] | 2.91[153] | |
23 | FLT3LG | Fms-related tyrosine kinase 3 ligand | [154] | -1.18[155] | -0.94[156] | -0.80[157] | -0.70[158] | 0.16[159] | -1.17[160] |
24 | GAB2 | GRB2-associated-binding protein 2 | [161] | 2.64[162] | 2.58[163] | 2.50[164] | 2.56[165] | 2.42[166] | 1.54[167] |
25 | ETV6 | Transcription factor ETV6 | [168] | 1.41[169] | 1.61[170] | 1.42[171] | 3.30[172] | 2.67[173] | 2.58[174] |
26 | CBL | E3 ubiquitin-protein ligase CBL | [175] | 5.53[176] | 4.62[177] | 4.52[178] | 6.77[179] | 6.03[180] | 4.75[181] |
27 | NOX4 | NADPH oxidase 4 | [182] | -2.16[183] | 0.77[184] | 0.64[185] | -0.95[186] | 0.05[187] | 3.09[188] |
28 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | [189] | [190] | [191] | -2.59[192] | -1.15[193] | [194] | 3.91[195] |