REACTOME_FLT3_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.67[2] | -0.85[3] | -0.94[4] | -1.15[5] | -0.83[6] | -0.57[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.23[16] | -0.09[17] | -0.57[18] | -0.30[19] | -0.45[20] | -0.12[21] |
4 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [22] | 2.21[23] | 2.14[24] | 2.94[25] | 1.10[26] | 1.78[27] | 0.65[28] |
5 | AKT1 | RAC-alpha serine/threonine-protein kinase | [29] | 1.61[30] | 1.40[31] | 0.08[32] | 1.58[33] | 1.47[34] | 1.06[35] |
6 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [36] | 1.97[37] | 2.43[38] | 2.14[39] | 2.52[40] | 3.02[41] | 2.57[42] |
7 | GRB2 | Growth factor receptor-bound protein 2 | [43] | 2.72[44] | 2.59[45] | 2.46[46] | 2.18[47] | 1.96[48] | 1.61[49] |
8 | NRAS | GTPase NRas | [50] | 2.15[51] | 2.62[52] | 2.78[53] | 2.62[54] | 2.06[55] | 1.06[56] |
9 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [57] | 1.44[58] | 1.91[59] | 1.86[60] | 0.52[61] | 0.85[62] | 0.40[63] |
10 | HRAS | GTPase HRas | [64] | 0.52[65] | -0.16[66] | -1.20[67] | 0.68[68] | 0.33[69] | -1.35[70] |
11 | AKT2 | RAC-beta serine/threonine-protein kinase | [71] | 2.48[72] | 2.79[73] | 2.67[74] | 2.49[75] | 2.14[76] | 2.44[77] |
12 | CSK | Tyrosine-protein kinase CSK | [78] | 1.90[79] | 1.43[80] | 1.56[81] | 1.62[82] | 1.08[83] | 0.44[84] |
13 | KRAS | GTPase KRas | [85] | 1.01[86] | 1.02[87] | 2.37[88] | 2.43[89] | 1.95[90] | 1.98[91] |
14 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [92] | 1.05[93] | 1.20[94] | 2.05[95] | 3.69[96] | 3.06[97] | 4.31[98] |
15 | SOS1 | Son of sevenless homolog 1 | [99] | 1.43[100] | 2.98[101] | 2.25[102] | 2.47[103] | 1.57[104] | 1.85[105] |
16 | STAT5B | Signal transducer and activator of transcription 5B | [106] | 2.88[107] | 2.54[108] | 3.00[109] | 3.18[110] | 2.18[111] | 2.93[112] |
17 | SOCS6 | Suppressor of cytokine signaling 6 | [113] | 1.89[114] | 2.76[115] | 1.56[116] | 2.96[117] | 2.44[118] | 3.14[119] |
18 | GRB10 | Growth factor receptor-bound protein 10 | [120] | 4.03[121] | 0.98[122] | 3.11[123] | 2.31[124] | 3.05[125] | 3.25[126] |
19 | PTPRJ | Receptor-type tyrosine-protein phosphatase eta | [127] | 0.45[128] | 2.10[129] | 3.18[130] | 3.09[131] | 2.99[132] | 3.27[133] |
20 | SOCS2 | Suppressor of cytokine signaling 2 | [134] | 0.72[135] | -1.79[136] | -3.79[137] | 2.28[138] | -3.58[139] | 2.96[140] |
21 | SH2B3 | SH2B adapter protein 3 | [141] | 2.64[142] | 2.26[143] | 2.24[144] | 3.18[145] | 3.88[146] | 2.71[147] |
22 | FOXO3 | Forkhead box protein O3 | [148] | 1.98[149] | 2.10[150] | 2.49[151] | 2.03[152] | 3.13[153] | 3.64[154] |
23 | STAT5A | Signal transducer and activator of transcription 5A | [155] | -0.42[156] | 0.78[157] | -0.39[158] | 0.78[159] | 1.41[160] | 1.55[161] |
24 | FYN | Tyrosine-protein kinase Fyn | [162] | 2.47[163] | -6.10[164] | 2.22[165] | 3.10[166] | 4.49[167] | 2.28[168] |
25 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1.15[169] | 2.81[170] | 2.76[171] | 2.76[172] | 2.83[173] | 3.22[174] | |
26 | FLT3LG | Fms-related tyrosine kinase 3 ligand | [175] | -0.73[176] | -0.61[177] | -0.39[178] | -0.71[179] | 0.25[180] | -0.85[181] |
27 | GAB2 | GRB2-associated-binding protein 2 | [182] | 3.09[183] | 2.91[184] | 2.91[185] | 2.55[186] | 2.50[187] | 1.85[188] |
28 | BCL2L11 | Bcl-2-like protein 11 | [189] | 3.03[190] | 3.07[191] | 3.15[192] | 3.49[193] | 2.34[194] | 3.29[195] |
29 | HCK | Tyrosine-protein kinase HCK | [196] | -4.32[197] | -4.47[198] | [199] | -3.64[200] | -4.71[201] | 2.01[202] |
30 | ABL2 | Abelson tyrosine-protein kinase 2 | [203] | 3.60[204] | 3.65[205] | 4.35[206] | 5.51[207] | 5.58[208] | 4.23[209] |
31 | SLA | Src-like-adapter | [210] | -6.65[211] | [212] | -1.93[213] | -1.38[214] | -1.04[215] | 3.57[216] |
32 | CBL | E3 ubiquitin-protein ligase CBL | [217] | 5.97[218] | 4.95[219] | 4.92[220] | 6.76[221] | 6.11[222] | 5.07[223] |
33 | AKT3 | RAC-gamma serine/threonine-protein kinase | [224] | -0.32[225] | -2.85[226] | -2.40[227] | 7.47[228] | 6.29[229] | 4.92[230] |
34 | SLA2 | Src-like-adapter 2 | [231] | 3.20[232] | 5.32[233] | -1.58[234] | -2.62[235] | -3.00[236] | 1.23[237] |
35 | LCK | Tyrosine-protein kinase Lck | [238] | 4.30[239] | 4.41[240] | -5.83[241] | -3.46[242] | -3.79[243] | 2.54[244] |
36 | SYK | Tyrosine-protein kinase SYK | [245] | -6.64[246] | -0.74[247] | -4.00[248] | 1.73[249] | -1.92[250] | 4.67[251] |
37 | GRAP2 | GRB2-related adapter protein 2 | [252] | -4.32[253] | [254] | -0.92[255] | -0.35[256] | 0.55[257] | 2.15[258] |
38 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | [259] | [260] | [261] | -2.19[262] | -1.16[263] | [264] | 4.23[265] |