REACTOME_FERTILIZATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CD9 CD9 antigen [1] -1.99[2] -3.12[3] -8.74[4] -1.84[5] -1.73[6] -1.90[7]
2 B4GALT1 Beta-1,4-galactosyltransferase 1 [8] 1.96[9] 2.04[10] 2.29[11] 1.92[12] 1.96[13] 1.87[14]
3 ZP3 Zona pellucida sperm-binding protein 3 [15] -4.10[16] -6.86[17] -5.50[18] 0.15[19] -3.18[20] -3.15[21]
4 IZUMO4 Izumo sperm-egg fusion protein 4 [22] -2.96[23] 0.75[24] -2.56[25] -3.11[26] -4.48[27] -2.23[28]
5 OVGP1 Oviduct-specific glycoprotein [29] 0.69[30] 2.17[31] 1.55[32] -1.95[33] -3.24[34] 1.83[35]
6 CATSPER2 Cation channel sperm-associated protein 2 [36] -1.14[37] 0.36[38] -2.30[39] 1.28[40] -1.46[41] 0.29[42]
7 ADAM21 Disintegrin and metalloproteinase domain-containing protein 21 [43] -2.06[44] -2.74[45] -4.85[46] -0.68[47] -1.13[48] -0.68[49]
8 HVCN1 Voltage-gated hydrogen channel 1 [50] 0.36[51] 0.25[52] -3.82[53] -1.57[54] -1.61[55] 2.22[56]
9 CATSPER3 Cation channel sperm-associated protein 3 [57] -0.43[58] 1.01[59] -1.31[60] -0.05[61] -2.26[62] 0.55[63]
10 ACR Acrosin [64] -0.26[65] -2.48[66] 0.45[67] -3.17[68] [69] -0.88[70]
11 CATSPERG Cation channel sperm-associated protein subunit gamma [71] 3.69[72] 3.60[73] 0.95[74] 0.99[75] -2.80[76] 2.31[77]
12 ADAM20 Disintegrin and metalloproteinase domain-containing protein 20 [78] -1.17[79] 0.45[80] -0.55[81] 1.19[82] -0.13[83] 5.92[84]
13 CATSPERB Cation channel sperm-associated protein subunit beta [85] -1.91[86] -0.23[87] 4.16[88] [89] [90] 3.31[91]
14 CATSPER1 Cation channel sperm-associated protein 1 [92] 6.51[93] 3.52[94] -0.94[95] 7.84[96] 4.83[97] 1.41[98]
15 ZP1 Zona pellucida sperm-binding protein 1 [99] [100] [101] [102] [103] [104] [105]
16 ZP4 Zona pellucida sperm-binding protein 4 [106] [107] [108] [109] [110] [111] [112]
17 ZP2 Zona pellucida sperm-binding protein 2 [113] [114] [115] [116] [117] [118] [119]
18 CATSPERD Cation channel sperm-associated protein subunit delta [120] [121] [122] [123] [124] [125] [126]
19 KCNU1 Potassium channel subfamily U member 1 [127] [128] [129] [130] [131] [132] [133]
20 IZUMO3 Izumo sperm-egg fusion protein 3 [134] [135] [136] [137] [138] [139] [140]
21 IZUMO2 Izumo sperm-egg fusion protein 2 [141] [142] [143] [144] [145] [146] [147]
22 IZUMO1 Izumo sperm-egg fusion protein 1 [148] [149] [150] [151] [152] [153] [154]
23 CATSPER4 Cation channel sperm-associated protein 4 [155] [156] [157] [158] [159] [160] [161]
24 SPAM1 Hyaluronidase PH-20 [162] [163] [164] [165] [166] [167] [168]
25 ADAM2 Disintegrin and metalloproteinase domain-containing protein 2 [169] [170] [171] [172] [173] [174] [175]
26 ADAM30 Disintegrin and metalloproteinase domain-containing protein 30 [176] [177] [178] [179] [180] [181] [182]
[1]
ref_hepatocyte CD9
Mean 95.7
Standard deviation 1.3e+02
Values 54 3.2e+02 70 14 19
[2]
HepG2 CD9
Mean 12.5
Standard deviation 1.9
Values 14 11
[3]
HepG2.C3A CD9
Mean 4.46
Standard deviation 0.55
Values 4.9 4.1
[4]
HuH.7 CD9
Mean 0.141
Standard deviation 0.074
Values 0.11 0.22 0.084
[5]
SNU475 CD9
Mean 12.5
Standard deviation 4.3
Values 16 9.5
[6]
THLE CD9
Mean 51.2
Standard deviation 17
Values 39 63
[7]
liver CD9
Mean 15.5
Standard deviation 14
Values 35 6.2 17 3.5
[8]
ref_hepatocyte B4GALT1
Mean 24.8
Standard deviation 5.2
Values 17 26 28 31 23
[9]
HepG2 B4GALT1
Mean 50.3
Standard deviation 11
Values 58 42
[10]
HepG2.C3A B4GALT1
Mean 41.3
Standard deviation 12
Values 50 32
[11]
HuH.7 B4GALT1
Mean 76.8
Standard deviation 16
Values 83 90 58
[12]
SNU475 B4GALT1
Mean 44.1
Standard deviation 8.5
Values 50 38
[13]
THLE B4GALT1
Mean 172
Standard deviation 9.4
Values 1.7e+02 1.8e+02
[14]
liver B4GALT1
Mean 55
Standard deviation 12
Values 52 46 73 49
[15]
ref_hepatocyte ZP3
Mean 1.54
Standard deviation 3
Values 0.08 0 6.8 0.29 0.48
[16]
HepG2 ZP3
Mean 0.0465
Standard deviation 0.00095
Values 0.046 0.047
[17]
HepG2.C3A ZP3
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[18]
HuH.7 ZP3
Mean 0.0215
Standard deviation 0.01
Values 0.033 0.013 0.019
[19]
SNU475 ZP3
Mean 0.801
Standard deviation 0.035
Values 0.83 0.78
[20]
THLE ZP3
Mean 0.303
Standard deviation 0.082
Values 0.36 0.24
[21]
liver ZP3
Mean 0.105
Standard deviation 0.096
Values 0.21 0 0.15 0.053
[22]
ref_hepatocyte IZUMO4
Mean 1.5
Standard deviation 2.2
Values 0.25 0 0 2.1 5.1
[23]
HepG2 IZUMO4
Mean 0.1
Standard deviation 0.077
Values 0.046 0.15
[24]
HepG2.C3A IZUMO4
Mean 1.02
Standard deviation 0.66
Values 1.5 0.55
[25]
HuH.7 IZUMO4
Mean 0.16
Standard deviation 0.1
Values 0.082 0.28 0.12
[26]
SNU475 IZUMO4
Mean 0.0816
Standard deviation 0.022
Values 0.097 0.066
[27]
THLE IZUMO4
Mean 0.119
Standard deviation 0.12
Values 0.2 0.037
[28]
liver IZUMO4
Mean 0.193
Standard deviation 0.077
Values 0.31 0.14 0.18 0.15
[29]
ref_hepatocyte OVGP1
Mean 1.35
Standard deviation 0.58
Values 0.79 1.2 1.8 2.1 0.87
[30]
HepG2 OVGP1
Mean 1.13
Standard deviation 0.19
Values 1 1.3
[31]
HepG2.C3A OVGP1
Mean 2.47
Standard deviation 1.3
Values 3.4 1.6
[32]
HuH.7 OVGP1
Mean 2.51
Standard deviation 0.31
Values 2.2 2.5 2.8
[33]
SNU475 OVGP1
Mean 0.164
Standard deviation 0.13
Values 0.07 0.26
[34]
THLE OVGP1
Mean 0.255
Standard deviation 0.015
Values 0.27 0.24
[35]
liver OVGP1
Mean 2.91
Standard deviation 4.2
Values 9.3 0.66 0.69 1
[36]
ref_hepatocyte CATSPER2
Mean 0.61
Standard deviation 0.3
Values 0.6 0.22 0.43 0.98 0.81
[37]
HepG2 CATSPER2
Mean 0.144
Standard deviation 0.015
Values 0.15 0.13
[38]
HepG2.C3A CATSPER2
Mean 0.318
Standard deviation 0.051
Values 0.28 0.35
[39]
HuH.7 CATSPER2
Mean 0.0782
Standard deviation 0.019
Values 0.057 0.083 0.094
[40]
SNU475 CATSPER2
Mean 0.697
Standard deviation 0.018
Values 0.71 0.68
[41]
THLE CATSPER2
Mean 0.394
Standard deviation 0.2
Values 0.53 0.26
[42]
liver CATSPER2
Mean 0.451
Standard deviation 0.19
Values 0.16 0.54 0.51 0.58
[43]
ref_hepatocyte ADAM21
Mean 0.506
Standard deviation 0.84
Values 0.089 2 0.43 0 0.033
[44]
HepG2 ADAM21
Mean 0.063
Standard deviation 0.041
Values 0.092 0.034
[45]
HepG2.C3A ADAM21
Mean 0.0307
Standard deviation 0.0021
Values 0.029 0.032
[46]
HuH.7 ADAM21
Mean 0.0111
Standard deviation 0.0067
Values 0.0082 0.0064 0.019
[47]
SNU475 ADAM21
Mean 0.148
Standard deviation 0.013
Values 0.14 0.16
[48]
THLE ADAM21
Mean 0.411
Standard deviation 0.096
Values 0.34 0.48
[49]
liver ADAM21
Mean 0.191
Standard deviation 0.14
Values 0.19 0.29 0 0.29
[50]
ref_hepatocyte HVCN1
Mean 0.392
Standard deviation 0.23
Values 0 0.41 0.48 0.53 0.54
[51]
HepG2 HVCN1
Mean 0.261
Standard deviation 0.084
Values 0.32 0.2
[52]
HepG2.C3A HVCN1
Mean 0.189
Standard deviation 0.02
Values 0.17 0.2
[53]
HuH.7 HVCN1
Mean 0.0175
Standard deviation 0.0088
Values 0.0082 0.026 0.019
[54]
SNU475 HVCN1
Mean 0.0621
Standard deviation 0.048
Values 0.028 0.096
[55]
THLE HVCN1
Mean 0.228
Standard deviation 0.038
Values 0.2 0.26
[56]
liver HVCN1
Mean 1.1
Standard deviation 0.44
Values 1.4 0.68 1.6 0.78
[57]
ref_hepatocyte CATSPER3
Mean 0.317
Standard deviation 0.22
Values 0.26 0.34 0 0.62 0.36
[58]
HepG2 CATSPER3
Mean 0.122
Standard deviation 0.0029
Values 0.12 0.12
[59]
HepG2.C3A CATSPER3
Mean 0.258
Standard deviation 0.09
Values 0.19 0.32
[60]
HuH.7 CATSPER3
Mean 0.0811
Standard deviation 0.019
Values 0.066 0.1 0.075
[61]
SNU475 CATSPER3
Mean 0.144
Standard deviation 0.026
Values 0.13 0.16
[62]
THLE CATSPER3
Mean 0.118
Standard deviation 0.00092
Values 0.12 0.12
[63]
liver CATSPER3
Mean 0.28
Standard deviation 0.046
Values 0.31 0.23 0.26 0.33
[64]
ref_hepatocyte ACR
Mean 0.133
Standard deviation 0.15
Values 0.35 0 0.11 0.21 0
[65]
HepG2 ACR
Mean 0.058
Standard deviation 0.064
Values 0.1 0.013
[66]
HepG2.C3A ACR
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[67]
HuH.7 ACR
Mean 0.116
Standard deviation 0.023
Values 0.09 0.13 0.12
[68]
SNU475 ACR
Mean 0.00696
Standard deviation 0.0098
Values 0.014 0
[69]
THLE ACR
Mean 0
Standard deviation 0
Values 0 0
[70]
liver ACR
Mean 0.0439
Standard deviation 0.04
Values 0.094 0.029 0 0.053
[71]
ref_hepatocyte CATSPERG
Mean 0.11
Standard deviation 0.08
Values 0.19 0.065 0 0.18 0.11
[72]
HepG2 CATSPERG
Mean 0.739
Standard deviation 0.24
Values 0.91 0.57
[73]
HepG2.C3A CATSPERG
Mean 0.542
Standard deviation 0.24
Values 0.71 0.38
[74]
HuH.7 CATSPERG
Mean 0.134
Standard deviation 0.038
Values 0.098 0.17 0.13
[75]
SNU475 CATSPERG
Mean 0.102
Standard deviation 0.02
Values 0.088 0.12
[76]
THLE CATSPERG
Mean 0.0281
Standard deviation 0.0021
Values 0.03 0.027
[77]
liver CATSPERG
Mean 0.331
Standard deviation 0.11
Values 0.19 0.3 0.41 0.42
[78]
ref_hepatocyte ADAM20
Mean 0.0185
Standard deviation 0.041
Values 0 0 0.092 0 0
[79]
HepG2 ADAM20
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[80]
HepG2.C3A ADAM20
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[81]
HuH.7 ADAM20
Mean 0.008
Standard deviation 0.0015
Values 0.0082 0.0064 0.0094
[82]
SNU475 ADAM20
Mean 0.0198
Standard deviation 0.015
Values 0.0093 0.03
[83]
THLE ADAM20
Mean 0.0302
Standard deviation 0.018
Values 0.018 0.043
[84]
liver ADAM20
Mean 0.678
Standard deviation 0.7
Values 0.071 1.3 0.077 1.3
[85]
ref_hepatocyte CATSPERB
Mean 0.0155
Standard deviation 0.035
Values 0 0 0 0.078 0
[86]
HepG2 CATSPERB
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[87]
HepG2.C3A CATSPERB
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[88]
HuH.7 CATSPERB
Mean 0.176
Standard deviation 0.048
Values 0.16 0.23 0.14
[89]
SNU475 CATSPERB
Mean 0
Standard deviation 0
Values 0 0
[90]
THLE CATSPERB
Mean 0
Standard deviation 0
Values 0 0
[91]
liver CATSPERB
Mean 0.093
Standard deviation 0.073
Values 0.071 0.14 0 0.16
[92]
ref_hepatocyte CATSPER1
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[93]
HepG2 CATSPER1
Mean 0.308
Standard deviation 0.25
Values 0.49 0.13
[94]
HepG2.C3A CATSPER1
Mean 0.0302
Standard deviation 0.012
Values 0.039 0.021
[95]
HuH.7 CATSPER1
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[96]
SNU475 CATSPER1
Mean 0.702
Standard deviation 0.45
Values 0.38 1
[97]
THLE CATSPER1
Mean 0.328
Standard deviation 0.13
Values 0.24 0.42
[98]
liver CATSPER1
Mean 0.0104
Standard deviation 0.014
Values 0 0.029 0 0.013
[99]
ref_hepatocyte ZP1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 ZP1
Mean 0.178
Standard deviation 0.14
Values 0.28 0.082
[101]
HepG2.C3A ZP1
Mean 0.58
Standard deviation 0.26
Values 0.4 0.76
[102]
HuH.7 ZP1
Mean 0.00487
Standard deviation 0.0043
Values 0.0082 0.0064 0
[103]
SNU475 ZP1
Mean 0.0686
Standard deviation 0.025
Values 0.051 0.086
[104]
THLE ZP1
Mean 0.252
Standard deviation 0.078
Values 0.31 0.2
[105]
liver ZP1
Mean 0.0158
Standard deviation 0.019
Values 0.024 0 0 0.04
[106]
ref_hepatocyte ZP4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 ZP4
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A ZP4
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 ZP4
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 ZP4
Mean 0
Standard deviation 0
Values 0 0
[111]
THLE ZP4
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[112]
liver ZP4
Mean 0
Standard deviation 0
Values 0 0 0 0
[113]
ref_hepatocyte ZP2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 ZP2
Mean 0.00501
Standard deviation 0.001
Values 0.0057 0.0043
[115]
HepG2.C3A ZP2
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 ZP2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[117]
SNU475 ZP2
Mean 0
Standard deviation 0
Values 0 0
[118]
THLE ZP2
Mean 0
Standard deviation 0
Values 0 0
[119]
liver ZP2
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte CATSPERD
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 CATSPERD
Mean 0.0516
Standard deviation 0.073
Values 0.1 0
[122]
HepG2.C3A CATSPERD
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[123]
HuH.7 CATSPERD
Mean 0.0113
Standard deviation 0.012
Values 0.025 0 0.0094
[124]
SNU475 CATSPERD
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[125]
THLE CATSPERD
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[126]
liver CATSPERD
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0
[127]
ref_hepatocyte KCNU1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 KCNU1
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[129]
HepG2.C3A KCNU1
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 KCNU1
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 KCNU1
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[132]
THLE KCNU1
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[133]
liver KCNU1
Mean 0.00331
Standard deviation 0.0066
Values 0 0 0 0.013
[134]
ref_hepatocyte IZUMO3
Missing
[135]
HepG2 IZUMO3
Missing
[136]
HepG2.C3A IZUMO3
Missing
[137]
HuH.7 IZUMO3
Missing
[138]
SNU475 IZUMO3
Missing
[139]
THLE IZUMO3
Missing
[140]
liver IZUMO3
Missing
[141]
ref_hepatocyte IZUMO2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 IZUMO2
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A IZUMO2
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 IZUMO2
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 IZUMO2
Mean 0
Standard deviation 0
Values 0 0
[146]
THLE IZUMO2
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[147]
liver IZUMO2
Mean 0
Standard deviation 0
Values 0 0 0 0
[148]
ref_hepatocyte IZUMO1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 IZUMO1
Mean 0.0415
Standard deviation 0.047
Values 0.074 0.0086
[150]
HepG2.C3A IZUMO1
Mean 0.247
Standard deviation 0.075
Values 0.19 0.3
[151]
HuH.7 IZUMO1
Mean 0.032
Standard deviation 0.018
Values 0.016 0.051 0.028
[152]
SNU475 IZUMO1
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[153]
THLE IZUMO1
Mean 0.0435
Standard deviation 0.039
Values 0.071 0.016
[154]
liver IZUMO1
Mean 0.0288
Standard deviation 0.027
Values 0.024 0 0.026 0.066
[155]
ref_hepatocyte CATSPER4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 CATSPER4
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A CATSPER4
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[158]
HuH.7 CATSPER4
Mean 0
Standard deviation 0
Values 0 0 0
[159]
SNU475 CATSPER4
Mean 0
Standard deviation 0
Values 0 0
[160]
THLE CATSPER4
Mean 0
Standard deviation 0
Values 0 0
[161]
liver CATSPER4
Mean 0
Standard deviation 0
Values 0 0 0 0
[162]
ref_hepatocyte SPAM1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 SPAM1
Missing
[164]
HepG2.C3A SPAM1
Missing
[165]
HuH.7 SPAM1
Missing
[166]
SNU475 SPAM1
Missing
[167]
THLE SPAM1
Missing
[168]
liver SPAM1
Missing
[169]
ref_hepatocyte ADAM2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 ADAM2
Mean 0
Standard deviation 0
Values 0 0
[171]
HepG2.C3A ADAM2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[172]
HuH.7 ADAM2
Mean 0
Standard deviation 0
Values 0 0 0
[173]
SNU475 ADAM2
Mean 0
Standard deviation 0
Values 0 0
[174]
THLE ADAM2
Mean 0
Standard deviation 0
Values 0 0
[175]
liver ADAM2
Mean 0
Standard deviation 0
Values 0 0 0 0
[176]
ref_hepatocyte ADAM30
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[177]
HepG2 ADAM30
Missing
[178]
HepG2.C3A ADAM30
Missing
[179]
HuH.7 ADAM30
Missing
[180]
SNU475 ADAM30
Missing
[181]
THLE ADAM30
Missing
[182]
liver ADAM30
Missing