REACTOME_FBXW7_MUTANTS_AND_NOTCH1_IN_CANCER Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SKP1 S-phase kinase-associated protein 1 [1] 0.16[2] 0.13[3] -0.21[4] 0.23[5] 0.29[6] -0.22[7]
2 RBX1 E3 ubiquitin-protein ligase RBX1 [8] -0.91[9] -0.91[10] -0.49[11] -1.97[12] -1.70[13] -1.62[14]
3 CUL1 Cullin-1 [15] 0.76[16] 1.01[17] 1.10[18] 1.31[19] 0.81[20] 1.22[21]
4 FBXW7 F-box/WD repeat-containing protein 7 [22] 0.41[23] 0.66[24] 1.17[25] -0.17[26] 0.69[27] 1.63[28]
5 NOTCH1 Neurogenic locus notch homolog protein 1 [29] 3.05[30] 1.46[31] 3.33[32] 3.32[33] 3.51[34] 5.11[35]
[1]
ref_hepatocyte SKP1
Mean 80.8
Standard deviation 44
Values 1.5e+02 92 24 71 71
[2]
HepG2 SKP1
Mean 90.4
Standard deviation 11
Values 83 98
[3]
HepG2.C3A SKP1
Mean 106
Standard deviation 20
Values 91 1.2e+02
[4]
HuH.7 SKP1
Mean 55.5
Standard deviation 13
Values 57 42 67
[5]
SNU475 SKP1
Mean 105
Standard deviation 22
Values 1.2e+02 89
[6]
THLE SKP1
Mean 137
Standard deviation 18
Values 1.2e+02 1.5e+02
[7]
liver SKP1
Mean 71
Standard deviation 55
Values 1.1e+02 27 1.3e+02 20
[8]
ref_hepatocyte RBX1
Mean 54.3
Standard deviation 41
Values 88 1.1e+02 7.4 33 36
[9]
HepG2 RBX1
Mean 28.8
Standard deviation 5.7
Values 25 33
[10]
HepG2.C3A RBX1
Mean 34.6
Standard deviation 13
Values 26 44
[11]
HuH.7 RBX1
Mean 30.6
Standard deviation 15
Values 29 17 46
[12]
SNU475 RBX1
Mean 15.3
Standard deviation 1.3
Values 16 14
[13]
THLE RBX1
Mean 23
Standard deviation 3.5
Values 21 25
[14]
liver RBX1
Mean 18
Standard deviation 18
Values 36 2.5 32 1.8
[15]
ref_hepatocyte CUL1
Mean 14.3
Standard deviation 4.3
Values 13 22 12 14 11
[16]
HepG2 CUL1
Mean 24.2
Standard deviation 10
Values 17 31
[17]
HepG2.C3A CUL1
Mean 34.5
Standard deviation 8.6
Values 28 41
[18]
HuH.7 CUL1
Mean 24.2
Standard deviation 1.9
Values 26 22 25
[19]
SNU475 CUL1
Mean 39.3
Standard deviation 2.3
Values 41 38
[20]
THLE CUL1
Mean 34.6
Standard deviation 5.4
Values 31 38
[21]
liver CUL1
Mean 34
Standard deviation 1.6
Values 32 35 34 36
[22]
ref_hepatocyte FBXW7
Mean 3.48
Standard deviation 1.5
Values 4.4 5.4 3.8 2 1.9
[23]
HepG2 FBXW7
Mean 4.61
Standard deviation 0.31
Values 4.4 4.8
[24]
HepG2.C3A FBXW7
Mean 6.56
Standard deviation 0.24
Values 6.4 6.7
[25]
HuH.7 FBXW7
Mean 6.19
Standard deviation 0.32
Values 6.5 6.1 5.9
[26]
SNU475 FBXW7
Mean 3.42
Standard deviation 0.12
Values 3.5 3.3
[27]
THLE FBXW7
Mean 7.75
Standard deviation 2.2
Values 9.3 6.2
[28]
liver FBXW7
Mean 11
Standard deviation 3.8
Values 10 15 6.1 13
[29]
ref_hepatocyte NOTCH1
Mean 0.644
Standard deviation 0.25
Values 0.33 0.55 0.55 0.91 0.89
[30]
HepG2 NOTCH1
Mean 5.33
Standard deviation 3.7
Values 8 2.7
[31]
HepG2.C3A NOTCH1
Mean 2.12
Standard deviation 0.1
Values 2.1 2.2
[32]
HuH.7 NOTCH1
Mean 5.14
Standard deviation 1.4
Values 5.4 6.4 3.6
[33]
SNU475 NOTCH1
Mean 7.09
Standard deviation 0.64
Values 6.6 7.5
[34]
THLE NOTCH1
Mean 10.2
Standard deviation 2.2
Values 8.6 12
[35]
liver NOTCH1
Mean 22.8
Standard deviation 16
Values 10 31 8.8 41