REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SCD | Acyl-CoA desaturase | [1] | -0.42[2] | 0.50[3] | 0.81[4] | -1.83[5] | -2.93[6] | -0.62[7] |
2 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | [8] | -1.82[9] | -5.20[10] | -5.03[11] | -3.80[12] | -0.82[13] | 1.15[14] |
3 | ELOVL5 | Elongation of very long chain fatty acids protein 5 | [15] | -1.13[16] | -1.92[17] | -1.56[18] | 0.87[19] | 0.13[20] | -2.10[21] |
4 | SLC25A1 | Tricarboxylate transport protein, mitochondrial | [22] | -0.23[23] | -0.90[24] | -1.40[25] | 0.07[26] | -0.89[27] | -1.51[28] |
5 | TECR | Very-long-chain enoyl-CoA reductase | [29] | -0.63[30] | -1.93[31] | -0.64[32] | -0.63[33] | -0.08[34] | -1.53[35] |
6 | ACLY | ATP-citrate synthase | [36] | 1.39[37] | 0.14[38] | 0.60[39] | 2.21[40] | 1.79[41] | -1.47[42] |
7 | ACSL5 | Long-chain-fatty-acid--CoA ligase 5 | [43] | 0.45[44] | -0.55[45] | -4.43[46] | -2.25[47] | -4.98[48] | -0.02[49] |
8 | ELOVL1 | Elongation of very long chain fatty acids protein 1 | [50] | 0.01[51] | -1.45[52] | -2.21[53] | 0.68[54] | -0.12[55] | -2.90[56] |
9 | HSD17B8 | Estradiol 17-beta-dehydrogenase 8 | [57] | -3.01[58] | -3.16[59] | -3.43[60] | -5.00[61] | -4.14[62] | -2.41[63] |
10 | HSD17B12 | Very-long-chain 3-oxoacyl-CoA reductase | [64] | -0.99[65] | -0.66[66] | -0.54[67] | -1.00[68] | -0.10[69] | -0.12[70] |
11 | ACSL3 | Long-chain-fatty-acid--CoA ligase 3 | [71] | 0.31[72] | 1.54[73] | 0.26[74] | 1.36[75] | 0.67[76] | -0.40[77] |
12 | FASN | Fatty acid synthase | [78] | 2.61[79] | 2.33[80] | 2.44[81] | 1.88[82] | 1.73[83] | 1.39[84] |
13 | PPT1 | Palmitoyl-protein thioesterase 1 | [85] | 1.79[86] | 0.55[87] | -0.87[88] | 1.46[89] | 2.44[90] | -1.37[91] |
14 | ELOVL6 | Elongation of very long chain fatty acids protein 6 | [92] | -2.55[93] | -0.41[94] | -0.78[95] | 0.04[96] | 0.58[97] | -0.76[98] |
15 | ELOVL2 | Elongation of very long chain fatty acids protein 2 | [99] | 0.20[100] | 1.10[101] | -0.66[102] | -0.72[103] | -2.94[104] | -0.94[105] |
16 | ACSL4 | Long-chain-fatty-acid--CoA ligase 4 | [106] | 2.93[107] | 3.74[108] | 3.58[109] | 2.70[110] | 3.35[111] | -0.15[112] |
17 | CBR4 | Carbonyl reductase family member 4 | [113] | -1.04[114] | -0.85[115] | -0.10[116] | -0.28[117] | -0.25[118] | -0.31[119] |
18 | SLC27A3 | Long-chain fatty acid transport protein 3 | [120] | -2.68[121] | -1.67[122] | -3.34[123] | -2.37[124] | -1.41[125] | -0.56[126] |
19 | MORC2 | MORC family CW-type zinc finger protein 2 | [127] | 1.48[128] | 0.31[129] | 0.33[130] | 1.69[131] | 1.16[132] | -1.19[133] |
20 | ACSF3 | Acyl-CoA synthetase family member 3, mitochondrial | [134] | 0.58[135] | -0.31[136] | -1.81[137] | 0.51[138] | 0.95[139] | 0.15[140] |
21 | PPT2 | Lysosomal thioesterase PPT2 | [141] | 0.05[142] | -0.37[143] | -1.29[144] | -1.08[145] | 0.09[146] | -2.16[147] |
22 | ACACA | Acetyl-CoA carboxylase 1 | [148] | 2.66[149] | 2.09[150] | 2.55[151] | 3.73[152] | 2.74[153] | 2.24[154] |
23 | SCD5 | Stearoyl-CoA desaturase 5 | [155] | -3.41[156] | -2.93[157] | -0.25[158] | 2.28[159] | 3.64[160] | -1.72[161] |
24 | ELOVL7 | Elongation of very long chain fatty acids protein 7 | [162] | 1.06[163] | 1.71[164] | 1.54[165] | 1.59[166] | 1.03[167] | -1.48[168] |
25 | HSD17B3 | Testosterone 17-beta-dehydrogenase 3 | [169] | -2.99[170] | -3.95[171] | 0.19[172] | 1.08[173] | -5.01[174] | -0.24[175] |
26 | ACSL6 | Long-chain-fatty-acid--CoA ligase 6 | [176] | 0.14[177] | 1.60[178] | -1.47[179] | -0.12[180] | -0.87[181] | 1.90[182] |
27 | OLAH | S-acyl fatty acid synthase thioesterase, medium chain | [183] | 0.99[184] | -1.79[185] | -2.97[186] | 2.46[187] | 4.37[188] | -1.00[189] |
28 | ELOVL4 | Elongation of very long chain fatty acids protein 4 | [190] | -1.02[191] | [192] | -3.51[193] | 2.34[194] | 5.10[195] | -1.96[196] |
29 | ELOVL3 | Elongation of very long chain fatty acids protein 3 | [197] | 3.35[198] | 1.84[199] | 1.58[200] | 1.22[201] | 5.01[202] | [203] |
30 | ACSBG1 | Long-chain-fatty-acid--CoA ligase ACSBG1 | [204] | 1.47[205] | 3.34[206] | -1.68[207] | 1.34[208] | 0.77[209] | -0.03[210] |
31 | TECRL | Trans-2,3-enoyl-CoA reductase-like | [211] | [212] | -2.98[213] | [214] | -1.61[215] | [216] | -3.50[217] |
32 | ACSBG2 | Long-chain-fatty-acid--CoA ligase ACSBG2 | [218] | 0.66[219] | 0.66[220] | 1.11[221] | 2.31[222] | 2.68[223] | 0.97[224] |
33 | HACD1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 | [225] | [226] | [227] | [228] | [229] | [230] | [231] |
34 | HACD2 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 | [232] | [233] | [234] | [235] | [236] | [237] | [238] |
35 | HACD3 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 | [239] | [240] | [241] | [242] | [243] | [244] | [245] |
36 | HTD2 | Hydroxyacyl-thioester dehydratase type 2, mitochondrial | [246] | [247] | [248] | [249] | [250] | [251] | [252] |
37 | HACD4 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 | [253] | [254] | [255] | [256] | [257] | [258] | [259] |