REACTOME_ESTROGEN_DEPENDENT_NUCLEAR_EVENTS_DOWNSTREAM_OF_ESR_MEMBRANE_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 FOS Proto-oncogene c-Fos [1] -7.08[2] -5.36[3] -6.17[4] -7.20[5] -5.82[6] -2.05[7]
2 AKT1 RAC-alpha serine/threonine-protein kinase [8] -0.99[9] -0.76[10] -1.99[11] -1.08[12] -0.75[13] -1.00[14]
3 CCND1 G1/S-specific cyclin-D1 [15] 1.98[16] -0.06[17] 0.62[18] 0.85[19] -0.31[20] 0.30[21]
4 CDKN1B Cyclin-dependent kinase inhibitor 1B [22] -1.15[23] -0.26[24] -0.20[25] -2.14[26] -1.36[27] -1.66[28]
5 XPO1 Exportin-1 [29] 0.29[30] 1.46[31] 1.35[32] 1.10[33] 1.50[34] 0.11[35]
6 MAPK1 Mitogen-activated protein kinase 1 [36] 0.64[37] 1.24[38] 0.92[39] 0.82[40] 0.78[41] 1.03[42]
7 AKT2 RAC-beta serine/threonine-protein kinase [43] -0.11[44] 0.62[45] 0.61[46] -0.18[47] -0.07[48] 0.38[49]
8 PTK2 Focal adhesion kinase 1 [50] -0.33[51] 0.61[52] 0.85[53] 0.91[54] 0.43[55] 0.01[56]
9 UHMK1 Serine/threonine-protein kinase Kist [57] 0.13[58] 0.70[59] 1.02[60] 1.92[61] 1.88[62] 2.38[63]
10 ELK1 ETS domain-containing protein Elk-1 [64] -1.38[65] -3.06[66] -0.78[67] -0.76[68] 0.14[69] -0.92[70]
11 SRF Serum response factor [71] 0.39[72] 0.41[73] -0.46[74] 0.51[75] -0.09[76] -1.53[77]
12 EGFR Epidermal growth factor receptor [78] -1.76[79] -1.68[80] 1.06[81] -0.60[82] 0.34[83] 1.90[84]
13 AREG Amphiregulin [85] -3.93[86] -6.71[87] -8.62[88] -10.73[89] -0.11[90] -11.06[91]
14 MAPK3 Mitogen-activated protein kinase 3 [92] 0.78[93] 1.28[94] 1.18[95] -0.61[96] -0.27[97] -1.79[98]
15 FOXO3 Forkhead box protein O3 [99] -0.61[100] -0.07[101] 0.43[102] -0.63[103] 0.92[104] 1.58[105]
16 TGFA Protransforming growth factor alpha [106] 0.72[107] 2.24[108] -8.95[109] -1.99[110] -2.90[111] -1.14[112]
17 HBEGF Proheparin-binding EGF-like growth factor [113] -2.05[114] -2.41[115] -3.62[116] -0.73[117] -0.72[118] -3.18[119]
18 CREB1 Cyclic AMP-responsive element-binding protein 1 [120] 0.66[121] 2.27[122] 2.61[123] 1.51[124] 1.77[125] 1.59[126]
19 BTC Probetacellulin [127] -9.21[128] -9.14[129] -5.06[130] -3.91[131] -3.62[132] -3.67[133]
20 AKT3 RAC-gamma serine/threonine-protein kinase [134] -2.91[135] -5.01[136] -4.47[137] 4.81[138] 4.08[139] 2.86[140]
21 EREG Proepiregulin [141] 0.69[142] 1.07[143] -3.49[144] -2.60[145] 2.97[146] -2.22[147]
22 BCL2 Apoptosis regulator Bcl-2 [148] -3.92[149] 1.94[150] -5.61[151] 0.74[152] 0.77[153] 2.48[154]
23 EGF Pro-epidermal growth factor [155] 0.90[156] 3.14[157] 6.62[158] 7.99[159] 5.73[160] 0.83[161]
24 EPGN Epigen [162] [163] [164] [165] [166] [167] [168]
[1]
ref_hepatocyte FOS
Mean 40
Standard deviation 67
Values 4 0.65 9 1.6e+02 27
[2]
HepG2 FOS
Mean 1.37
Standard deviation 1
Values 2.1 0.66
[3]
HepG2.C3A FOS
Mean 2.92
Standard deviation 1.9
Values 4.3 1.6
[4]
HuH.7 FOS
Mean 1.77
Standard deviation 0.38
Values 1.5 1.6 2.2
[5]
SNU475 FOS
Mean 1.02
Standard deviation 0.13
Values 0.93 1.1
[6]
THLE FOS
Mean 2.4
Standard deviation 0.3
Values 2.2 2.6
[7]
liver FOS
Mean 23
Standard deviation 32
Values 71 4.8 10 5.7
[8]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 55 50 19 31 32
[9]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 89 86
[10]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 65 68
[11]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 33 23 35
[12]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 76 57
[13]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[14]
liver AKT1
Mean 45.1
Standard deviation 25
Values 34 48 20 79
[15]
ref_hepatocyte CCND1
Mean 23
Standard deviation 14
Values 44 28 19 11 12
[16]
HepG2 CCND1
Mean 421
Standard deviation 48
Values 4.5e+02 3.9e+02
[17]
HepG2.C3A CCND1
Mean 66.1
Standard deviation 12
Values 58 74
[18]
HuH.7 CCND1
Mean 113
Standard deviation 31
Values 1.4e+02 79 1.2e+02
[19]
SNU475 CCND1
Mean 155
Standard deviation 66
Values 1.1e+02 2e+02
[20]
THLE CCND1
Mean 62.5
Standard deviation 6.4
Values 67 58
[21]
liver CCND1
Mean 67.8
Standard deviation 49
Values 26 1.1e+02 1.1e+02 25
[22]
ref_hepatocyte CDKN1B
Mean 13.8
Standard deviation 6
Values 23 13 7.5 10 15
[23]
HepG2 CDKN1B
Mean 28.7
Standard deviation 3.4
Values 31 26
[24]
HepG2.C3A CDKN1B
Mean 34.7
Standard deviation 1.4
Values 34 36
[25]
HuH.7 CDKN1B
Mean 38.2
Standard deviation 3.7
Values 35 42 37
[26]
SNU475 CDKN1B
Mean 11.8
Standard deviation 2.9
Values 14 9.7
[27]
THLE CDKN1B
Mean 18.2
Standard deviation 3.4
Values 16 21
[28]
liver CDKN1B
Mean 10.5
Standard deviation 3.5
Values 9.9 14 5.8 12
[29]
ref_hepatocyte XPO1
Mean 13.2
Standard deviation 5.7
Values 20 19 8.6 8.1 11
[30]
HepG2 XPO1
Mean 74.7
Standard deviation 37
Values 48 1e+02
[31]
HepG2.C3A XPO1
Mean 109
Standard deviation 54
Values 71 1.5e+02
[32]
HuH.7 XPO1
Mean 107
Standard deviation 26
Values 1.3e+02 77 1.2e+02
[33]
SNU475 XPO1
Mean 106
Standard deviation 0.46
Values 1.1e+02 1.1e+02
[34]
THLE XPO1
Mean 127
Standard deviation 5.2
Values 1.2e+02 1.3e+02
[35]
liver XPO1
Mean 34
Standard deviation 14
Values 22 53 24 37
[36]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[37]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[38]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[39]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[40]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[41]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[42]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[43]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 7.2 8.4 11 13 14
[44]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 48 43
[45]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 55 43
[46]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 59 41 55
[47]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 39 31
[48]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[49]
liver AKT2
Mean 33
Standard deviation 9.4
Values 24 36 27 45
[50]
ref_hepatocyte PTK2
Mean 8.92
Standard deviation 4.8
Values 15 11 11 4.1 3.9
[51]
HepG2 PTK2
Mean 32.8
Standard deviation 5.2
Values 29 36
[52]
HepG2.C3A PTK2
Mean 40.9
Standard deviation 2.3
Values 43 39
[53]
HuH.7 PTK2
Mean 51.1
Standard deviation 2.8
Values 53 52 48
[54]
SNU475 PTK2
Mean 63.1
Standard deviation 3.5
Values 66 61
[55]
THLE PTK2
Mean 40.6
Standard deviation 3.7
Values 38 43
[56]
liver PTK2
Mean 21.5
Standard deviation 4.9
Values 19 27 16 24
[57]
ref_hepatocyte UHMK1
Mean 7.11
Standard deviation 3.8
Values 6.2 13 5.1 3.1 7.9
[58]
HepG2 UHMK1
Mean 36.1
Standard deviation 19
Values 23 49
[59]
HepG2.C3A UHMK1
Mean 34.8
Standard deviation 11
Values 27 43
[60]
HuH.7 UHMK1
Mean 45.9
Standard deviation 9
Values 52 50 36
[61]
SNU475 UHMK1
Mean 101
Standard deviation 11
Values 1.1e+02 93
[62]
THLE UHMK1
Mean 88.6
Standard deviation 4.2
Values 86 92
[63]
liver UHMK1
Mean 88.3
Standard deviation 28
Values 67 1.2e+02 62 1.1e+02
[64]
ref_hepatocyte ELK1
Mean 6.81
Standard deviation 3.9
Values 1.7 12 7.5 8.5 4.4
[65]
HepG2 ELK1
Mean 12.1
Standard deviation 1.5
Values 13 11
[66]
HepG2.C3A ELK1
Mean 2.45
Standard deviation 0.82
Values 3 1.9
[67]
HuH.7 ELK1
Mean 12.6
Standard deviation 1.8
Values 14 11 13
[68]
SNU475 ELK1
Mean 15.1
Standard deviation 0.2
Values 15 15
[69]
THLE ELK1
Mean 25.4
Standard deviation 3.5
Values 23 28
[70]
liver ELK1
Mean 8.61
Standard deviation 2.4
Values 10 6 11 7.1
[71]
ref_hepatocyte SRF
Mean 6.43
Standard deviation 4.1
Values 9.2 3.7 12 6.2 1.5
[72]
HepG2 SRF
Mean 39.1
Standard deviation 3.7
Values 42 36
[73]
HepG2.C3A SRF
Mean 25.8
Standard deviation 4.2
Values 29 23
[74]
HuH.7 SRF
Mean 14.9
Standard deviation 1.6
Values 16 13 16
[75]
SNU475 SRF
Mean 34.4
Standard deviation 3.7
Values 37 32
[76]
THLE SRF
Mean 20.4
Standard deviation 3.8
Values 18 23
[77]
liver SRF
Mean 5.31
Standard deviation 3.4
Values 3.8 5.8 1.8 9.8
[78]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[79]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[80]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[81]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[82]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[83]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[84]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[85]
ref_hepatocyte AREG
Mean 5.24
Standard deviation 9.3
Values 1.7 22 1.7 0.57 0.4
[86]
HepG2 AREG
Mean 1.59
Standard deviation 1.3
Values 2.5 0.67
[87]
HepG2.C3A AREG
Mean 0.15
Standard deviation 0.061
Values 0.11 0.19
[88]
HuH.7 AREG
Mean 0.0425
Standard deviation 0.021
Values 0.057 0.051 0.019
[89]
SNU475 AREG
Mean 0.0116
Standard deviation 0.016
Values 0.023 0
[90]
THLE AREG
Mean 16.4
Standard deviation 1.7
Values 15 18
[91]
liver AREG
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[92]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[93]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[94]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[95]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[96]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[97]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[98]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[99]
ref_hepatocyte FOXO3
Mean 2.79
Standard deviation 0.38
Values 3.3 2.7 2.3 2.8 2.9
[100]
HepG2 FOXO3
Mean 8.44
Standard deviation 1
Values 7.7 9.2
[101]
HepG2.C3A FOXO3
Mean 8
Standard deviation 2.4
Values 9.7 6.3
[102]
HuH.7 FOXO3
Mean 11.9
Standard deviation 3.6
Values 13 15 7.9
[103]
SNU475 FOXO3
Mean 6.76
Standard deviation 0.76
Values 7.3 6.2
[104]
THLE FOXO3
Mean 17.9
Standard deviation 3.1
Values 16 20
[105]
liver FOXO3
Mean 20
Standard deviation 5.5
Values 24 21 12 23
[106]
ref_hepatocyte TGFA
Mean 2
Standard deviation 1.3
Values 3.8 2.7 2.1 0.72 0.76
[107]
HepG2 TGFA
Mean 15.3
Standard deviation 2.1
Values 17 14
[108]
HepG2.C3A TGFA
Mean 28.4
Standard deviation 4.2
Values 25 31
[109]
HuH.7 TGFA
Mean 0.0129
Standard deviation 0.0035
Values 0.016 0.013 0.0094
[110]
SNU475 TGFA
Mean 1.88
Standard deviation 0.53
Values 1.5 2.3
[111]
THLE TGFA
Mean 0.903
Standard deviation 0.47
Values 1.2 0.57
[112]
liver TGFA
Mean 2.16
Standard deviation 0.15
Values 2.1 2.3 2.2 2
[113]
ref_hepatocyte HBEGF
Mean 1.81
Standard deviation 1.5
Values 1 3.1 3.8 0.78 0.34
[114]
HepG2 HBEGF
Mean 2.02
Standard deviation 0.16
Values 2.1 1.9
[115]
HepG2.C3A HBEGF
Mean 1.02
Standard deviation 0.3
Values 1.2 0.82
[116]
HuH.7 HBEGF
Mean 0.469
Standard deviation 0.044
Values 0.52 0.43 0.46
[117]
SNU475 HBEGF
Mean 4.11
Standard deviation 0.34
Values 3.9 4.4
[118]
THLE HBEGF
Mean 3.71
Standard deviation 0.17
Values 3.8 3.6
[119]
liver HBEGF
Mean 0.478
Standard deviation 0.29
Values 0.89 0.27 0.28 0.46
[120]
ref_hepatocyte CREB1
Mean 1.8
Standard deviation 1.2
Values 3.7 2.1 1.5 0.96 0.81
[121]
HepG2 CREB1
Mean 13.1
Standard deviation 2.8
Values 11 15
[122]
HepG2.C3A CREB1
Mean 26.1
Standard deviation 3.2
Values 24 28
[123]
HuH.7 CREB1
Mean 35.1
Standard deviation 4
Values 38 36 31
[124]
SNU475 CREB1
Mean 19.3
Standard deviation 0.081
Values 19 19
[125]
THLE CREB1
Mean 20.8
Standard deviation 2.1
Values 22 19
[126]
liver CREB1
Mean 13
Standard deviation 3.1
Values 12 16 9.3 15
[127]
ref_hepatocyte BTC
Mean 0.915
Standard deviation 1.9
Values 0 4.4 0.079 0 0.12
[128]
HepG2 BTC
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[129]
HepG2.C3A BTC
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[130]
HuH.7 BTC
Mean 0.087
Standard deviation 0.09
Values 0.066 0.19 0.0094
[131]
SNU475 BTC
Mean 0.229
Standard deviation 0.03
Values 0.25 0.21
[132]
THLE BTC
Mean 0.251
Standard deviation 0.13
Values 0.34 0.16
[133]
liver BTC
Mean 0.172
Standard deviation 0.058
Values 0.21 0.23 0.1 0.15
[134]
ref_hepatocyte AKT3
Mean 0.387
Standard deviation 0.32
Values 0 0.53 0.83 0.16 0.41
[135]
HepG2 AKT3
Mean 0.238
Standard deviation 0.15
Values 0.34 0.13
[136]
HepG2.C3A AKT3
Mean 0.036
Standard deviation 0.0097
Values 0.029 0.043
[137]
HuH.7 AKT3
Mean 0.0557
Standard deviation 0.031
Values 0.049 0.09 0.028
[138]
SNU475 AKT3
Mean 40.8
Standard deviation 10
Values 48 34
[139]
THLE AKT3
Mean 22.1
Standard deviation 4.4
Values 25 19
[140]
liver AKT3
Mean 6.71
Standard deviation 4.9
Values 2.8 12 2.3 9.4
[141]
ref_hepatocyte EREG
Mean 0.24
Standard deviation 0.13
Values 0.3 0.18 0.15 0.13 0.45
[142]
HepG2 EREG
Mean 1.79
Standard deviation 1.2
Values 2.6 0.95
[143]
HepG2.C3A EREG
Mean 1.51
Standard deviation 1
Values 0.81 2.2
[144]
HuH.7 EREG
Mean 0.068
Standard deviation 0.032
Values 0.033 0.096 0.075
[145]
SNU475 EREG
Mean 0.149
Standard deviation 0.12
Values 0.065 0.23
[146]
THLE EREG
Mean 6.34
Standard deviation 2.2
Values 7.9 4.8
[147]
liver EREG
Mean 0.123
Standard deviation 0.11
Values 0 0.13 0.26 0.11
[148]
ref_hepatocyte BCL2
Mean 0.0984
Standard deviation 0.087
Values 0.019 0 0.15 0.12 0.2
[149]
HepG2 BCL2
Mean 0.0301
Standard deviation 0.0061
Values 0.034 0.026
[150]
HepG2.C3A BCL2
Mean 1.13
Standard deviation 0.21
Values 1.3 0.99
[151]
HuH.7 BCL2
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[152]
SNU475 BCL2
Mean 0.618
Standard deviation 0.094
Values 0.55 0.68
[153]
THLE BCL2
Mean 0.568
Standard deviation 0.0088
Values 0.56 0.57
[154]
liver BCL2
Mean 1.31
Standard deviation 1
Values 0.49 1.8 0.49 2.5
[155]
ref_hepatocyte EGF
Mean 0.00415
Standard deviation 0.0093
Values 0 0.021 0 0 0
[156]
HepG2 EGF
Mean 0.0358
Standard deviation 0.014
Values 0.046 0.026
[157]
HepG2.C3A EGF
Mean 0.11
Standard deviation 0.087
Values 0.049 0.17
[158]
HuH.7 EGF
Mean 1.29
Standard deviation 0.44
Values 0.97 1.8 1.1
[159]
SNU475 EGF
Mean 3.97
Standard deviation 0.5
Values 4.3 3.6
[160]
THLE EGF
Mean 0.743
Standard deviation 0.02
Values 0.76 0.73
[161]
liver EGF
Mean 0.0176
Standard deviation 0.027
Values 0 0.057 0 0.013
[162]
ref_hepatocyte EPGN
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 EPGN
Mean 0.0544
Standard deviation 0.028
Values 0.074 0.034
[164]
HepG2.C3A EPGN
Mean 0.0501
Standard deviation 0.025
Values 0.068 0.032
[165]
HuH.7 EPGN
Mean 0.127
Standard deviation 0.084
Values 0.082 0.22 0.075
[166]
SNU475 EPGN
Mean 0.503
Standard deviation 0.27
Values 0.31 0.69
[167]
THLE EPGN
Mean 4.76
Standard deviation 1.2
Values 5.6 3.9
[168]
liver EPGN
Mean 0.161
Standard deviation 0.11
Values 0.12 0.17 0.051 0.3