REACTOME_ERYTHROPOIETIN_ACTIVATES_RAS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] 0.43[2] 0.07[3] 0.01[4] -0.64[5] -0.49[6] -0.26[7]
2 SHC1 SHC-transforming protein 1 [8] 0.40[9] 0.42[10] 0.31[11] 1.46[12] 1.18[13] 0.23[14]
3 NRAS GTPase NRas [15] -0.13[16] 0.10[17] 0.32[18] -0.20[19] -0.39[20] -0.81[21]
4 HRAS GTPase HRas [22] -1.77[23] -2.67[24] -3.65[25] -2.14[26] -2.12[27] -3.22[28]
5 KRAS GTPase KRas [29] -1.28[30] -1.49[31] -0.08[32] -0.39[33] -0.50[34] 0.12[35]
6 CRKL Crk-like protein [36] 0.94[37] 0.84[38] 1.26[39] -0.07[40] 0.37[41] 0.90[42]
7 SOS1 Son of sevenless homolog 1 [43] -0.86[44] 0.47[45] -0.21[46] -0.35[47] -0.88[48] -0.02[49]
8 LYN Tyrosine-protein kinase Lyn [50] -1.62[51] -2.00[52] -1.66[53] -0.14[54] -1.14[55] -0.54[56]
9 RAPGEF1 Rap guanine nucleotide exchange factor 1 [57] 1.32[58] 0.96[59] 0.49[60] 0.06[61] -0.03[62] 0.62[63]
10 EPO Erythropoietin [64] -1.90[65] 0.07[66] -3.97[67] -10.86[68] -12.50[69] -0.57[70]
11 IRS2 Insulin receptor substrate 2 [71] -6.41[72] [73] -3.94[74] -1.86[75] 2.20[76] 1.83[77]
12 JAK2 Tyrosine-protein kinase JAK2 [78] -0.54[79] -0.74[80] -1.37[81] -0.43[82] 0.40[83] 2.15[84]
13 EPOR Erythropoietin receptor [85] 0.50[86] 1.43[87] 2.26[88] -0.03[89] 1.05[90] 2.03[91]
14 VAV1 Proto-oncogene vav [92] -9.26[93] -4.63[94] -6.53[95] -7.28[96] -8.31[97] 0.63[98]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[9]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[10]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[11]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[12]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[13]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[14]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[15]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[16]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[17]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[18]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[19]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[20]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[21]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[22]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[23]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[24]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[25]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[26]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[27]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[28]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[29]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[30]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[31]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[32]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[33]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[34]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[35]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[36]
ref_hepatocyte CRKL
Mean 7.86
Standard deviation 3.2
Values 13 7.5 7.1 6.1 5.2
[37]
HepG2 CRKL
Mean 56.6
Standard deviation 7.1
Values 52 62
[38]
HepG2.C3A CRKL
Mean 53.9
Standard deviation 8
Values 60 48
[39]
HuH.7 CRKL
Mean 78.7
Standard deviation 6.8
Values 86 76 74
[40]
SNU475 CRKL
Mean 31.5
Standard deviation 0.52
Values 32 31
[41]
THLE CRKL
Mean 40.6
Standard deviation 0.46
Values 41 40
[42]
liver CRKL
Mean 30.6
Standard deviation 3.9
Values 25 32 32 33
[43]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[44]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[45]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[46]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[47]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[48]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[49]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[50]
ref_hepatocyte LYN
Mean 5.33
Standard deviation 4.4
Values 0.29 6.8 12 3.7 3.8
[51]
HepG2 LYN
Mean 6.48
Standard deviation 1
Values 5.8 7.2
[52]
HepG2.C3A LYN
Mean 5.11
Standard deviation 2.1
Values 3.6 6.6
[53]
HuH.7 LYN
Mean 7.08
Standard deviation 0.67
Values 7.4 7.5 6.3
[54]
SNU475 LYN
Mean 20.4
Standard deviation 4.4
Values 17 23
[55]
THLE LYN
Mean 9.65
Standard deviation 1.4
Values 8.7 11
[56]
liver LYN
Mean 7.66
Standard deviation 1.7
Values 7.2 9.4 5.5 8.6
[57]
ref_hepatocyte RAPGEF1
Mean 4.9
Standard deviation 2.3
Values 6.6 5.4 7.5 2.5 2.6
[58]
HepG2 RAPGEF1
Mean 46
Standard deviation 2.9
Values 48 44
[59]
HepG2.C3A RAPGEF1
Mean 36.5
Standard deviation 6.8
Values 41 32
[60]
HuH.7 RAPGEF1
Mean 28.7
Standard deviation 4.9
Values 30 33 23
[61]
SNU475 RAPGEF1
Mean 21.5
Standard deviation 2.8
Values 23 20
[62]
THLE RAPGEF1
Mean 19.2
Standard deviation 5.1
Values 16 23
[63]
liver RAPGEF1
Mean 15.7
Standard deviation 4.8
Values 16 19 8.9 19
[64]
ref_hepatocyte EPO
Mean 4.3
Standard deviation 5.9
Values 1.1 0 0.32 14 6.2
[65]
HepG2 EPO
Mean 4.34
Standard deviation 2.9
Values 2.3 6.4
[66]
HepG2.C3A EPO
Mean 17.3
Standard deviation 2.6
Values 15 19
[67]
HuH.7 EPO
Mean 1.15
Standard deviation 0.76
Values 0.71 2 0.72
[68]
SNU475 EPO
Mean 0.00971
Standard deviation 0.00061
Values 0.0093 0.01
[69]
THLE EPO
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[70]
liver EPO
Mean 6.05
Standard deviation 8
Values 3.1 2.9 18 0.3
[71]
ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 0.019 0.61 1.4 5.7 2.9
[72]
HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.14 0.043
[73]
HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.2 1.4 0.17
[75]
SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.1 2.8
[76]
THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43
[77]
liver IRS2
Mean 15.7
Standard deviation 9.9
Values 29 11 6.3 17
[78]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[79]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[80]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[81]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[82]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[83]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[84]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8
[85]
ref_hepatocyte EPOR
Mean 0.552
Standard deviation 0.22
Values 0.24 0.48 0.53 0.69 0.82
[86]
HepG2 EPOR
Mean 2.93
Standard deviation 0.93
Values 3.6 2.3
[87]
HepG2.C3A EPOR
Mean 5.68
Standard deviation 2.7
Values 7.6 3.8
[88]
HuH.7 EPOR
Mean 11.1
Standard deviation 0.46
Values 11 11 11
[89]
SNU475 EPOR
Mean 2.28
Standard deviation 0.26
Values 2.1 2.5
[90]
THLE EPOR
Mean 4.55
Standard deviation 0.058
Values 4.5 4.6
[91]
liver EPOR
Mean 4.7
Standard deviation 1.7
Values 6.5 3.4 5.7 3.1
[92]
ref_hepatocyte VAV1
Mean 0.469
Standard deviation 0.4
Values 0 0.2 0.63 0.48 1
[93]
HepG2 VAV1
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[94]
HepG2.C3A VAV1
Mean 0.0726
Standard deviation 0.034
Values 0.049 0.097
[95]
HuH.7 VAV1
Mean 0.0213
Standard deviation 0.0061
Values 0.016 0.019 0.028
[96]
SNU475 VAV1
Mean 0.0127
Standard deviation 0.018
Values 0 0.025
[97]
THLE VAV1
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[98]
liver VAV1
Mean 1.51
Standard deviation 0.9
Values 0.75 1.8 0.82 2.6