REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOINOSITIDE_3_KINASE_PI3K Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [1] -0.55[2] -1.29[3] 0.05[4] 0.95[5] 0.31[6] 1.01[7]
2 LYN Tyrosine-protein kinase Lyn [8] -0.94[9] -1.97[10] -1.19[11] -0.06[12] -1.44[13] -1.97[14]
3 EPO Erythropoietin [15] -1.21[16] 0.10[17] -3.50[18] -10.79[19] -12.81[20] -2.00[21]
4 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1.14[22] 0.79[23] 1.20[24] -0.07[25] -0.05[26] -0.83[27]
5 IRS2 Insulin receptor substrate 2 [28] -5.73[29] [30] -3.48[31] -1.79[32] 1.90[33] 0.40[34]
6 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -0.45[35] 0.33[36] 0.76[37] 0.01[38] 0.07[39] -0.08[40]
7 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1.81[41] 2.04[42] -1.52[43] -0.84[44] -0.21[45] -1.69[46]
8 GAB1 GRB2-associated-binding protein 1 [47] 1.23[48] 1.46[49] 1.83[50] 0.81[51] 0.54[52] 0.88[53]
9 JAK2 Tyrosine-protein kinase JAK2 [54] 0.15[55] -0.71[56] -0.90[57] -0.36[58] 0.10[59] 0.72[60]
10 EPOR Erythropoietin receptor [61] 1.19[62] 1.45[63] 2.73[64] 0.05[65] 0.74[66] 0.59[67]
11 PIK3R5 Phosphoinositide 3-kinase regulatory subunit 5 [68] -7.24[69] [70] -3.22[71] -5.04[72] -4.84[73] 0.35[74]
12 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [75] [76] [77] 0.22[78] -4.80[79] 2.11[80]
[1]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[2]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[3]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[4]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[5]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[6]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[7]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[8]
ref_hepatocyte LYN
Mean 5.33
Standard deviation 4.4
Values 0.29 6.8 12 3.7 3.8
[9]
HepG2 LYN
Mean 6.48
Standard deviation 1
Values 5.8 7.2
[10]
HepG2.C3A LYN
Mean 5.11
Standard deviation 2.1
Values 3.6 6.6
[11]
HuH.7 LYN
Mean 7.08
Standard deviation 0.67
Values 7.4 7.5 6.3
[12]
SNU475 LYN
Mean 20.4
Standard deviation 4.4
Values 17 23
[13]
THLE LYN
Mean 9.65
Standard deviation 1.4
Values 8.7 11
[14]
liver LYN
Mean 7.66
Standard deviation 1.7
Values 7.2 9.4 5.5 8.6
[15]
ref_hepatocyte EPO
Mean 4.3
Standard deviation 5.9
Values 1.1 0 0.32 14 6.2
[16]
HepG2 EPO
Mean 4.34
Standard deviation 2.9
Values 2.3 6.4
[17]
HepG2.C3A EPO
Mean 17.3
Standard deviation 2.6
Values 15 19
[18]
HuH.7 EPO
Mean 1.15
Standard deviation 0.76
Values 0.71 2 0.72
[19]
SNU475 EPO
Mean 0.00971
Standard deviation 0.00061
Values 0.0093 0.01
[20]
THLE EPO
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[21]
liver EPO
Mean 6.05
Standard deviation 8
Values 3.1 2.9 18 0.3
[22]
ref_hepatocyte PIK3CB
Mean 3.18
Standard deviation 1.5
Values 5.2 4.2 2.6 1.8 2.1
[23]
HepG2 PIK3CB
Mean 16.3
Standard deviation 2.1
Values 15 18
[24]
HepG2.C3A PIK3CB
Mean 20.6
Standard deviation 2.7
Values 23 19
[25]
HuH.7 PIK3CB
Mean 22.1
Standard deviation 2.1
Values 24 23 20
[26]
SNU475 PIK3CB
Mean 12.1
Standard deviation 2.7
Values 14 10
[27]
THLE PIK3CB
Mean 15.1
Standard deviation 0.94
Values 14 16
[28]
liver PIK3CB
Mean 10.1
Standard deviation 3.7
Values 6.4 15 7.9 11
[29]
ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 0.019 0.61 1.4 5.7 2.9
[30]
HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.14 0.043
[31]
HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0
[32]
HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.2 1.4 0.17
[33]
SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.1 2.8
[34]
THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43
[35]
liver IRS2
Mean 15.7
Standard deviation 9.9
Values 29 11 6.3 17
[36]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[37]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[38]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[39]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[40]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[41]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[42]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[43]
ref_hepatocyte PIK3CD
Mean 1.86
Standard deviation 1.7
Values 4.1 0.94 3.3 0.38 0.66
[44]
HepG2 PIK3CD
Mean 15.2
Standard deviation 3.8
Values 18 13
[45]
HepG2.C3A PIK3CD
Mean 28.8
Standard deviation 2.6
Values 31 27
[46]
HuH.7 PIK3CD
Mean 1.97
Standard deviation 0.32
Values 2 2.3 1.6
[47]
SNU475 PIK3CD
Mean 4.15
Standard deviation 0.57
Values 4.6 3.7
[48]
THLE PIK3CD
Mean 7.91
Standard deviation 1.1
Values 7.1 8.7
[49]
liver PIK3CD
Mean 3.25
Standard deviation 1.3
Values 2.4 3 2.6 5.1
[50]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[51]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[52]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[53]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[54]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[55]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[56]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[57]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 1.3 1.3 0.62 0.18 0.5
[58]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 1 2.9
[59]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 1.3 2.2
[60]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 1.2 1.6 0.9
[61]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.3 2.4
[62]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[63]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 4.7 11 2.9 9.8
[64]
ref_hepatocyte EPOR
Mean 0.552
Standard deviation 0.22
Values 0.24 0.48 0.53 0.69 0.82
[65]
HepG2 EPOR
Mean 2.93
Standard deviation 0.93
Values 3.6 2.3
[66]
HepG2.C3A EPOR
Mean 5.68
Standard deviation 2.7
Values 7.6 3.8
[67]
HuH.7 EPOR
Mean 11.1
Standard deviation 0.46
Values 11 11 11
[68]
SNU475 EPOR
Mean 2.28
Standard deviation 0.26
Values 2.1 2.5
[69]
THLE EPOR
Mean 4.55
Standard deviation 0.058
Values 4.5 4.6
[70]
liver EPOR
Mean 4.7
Standard deviation 1.7
Values 6.5 3.4 5.7 3.1
[71]
ref_hepatocyte PIK3R5
Mean 0.373
Standard deviation 0.52
Values 0 0 1.3 0.29 0.3
[72]
HepG2 PIK3R5
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[73]
HepG2.C3A PIK3R5
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 PIK3R5
Mean 0.122
Standard deviation 0.035
Values 0.09 0.12 0.16
[75]
SNU475 PIK3R5
Mean 0.0452
Standard deviation 0.051
Values 0.0093 0.081
[76]
THLE PIK3R5
Mean 0.0642
Standard deviation 0.068
Values 0.11 0.016
[77]
liver PIK3R5
Mean 2.68
Standard deviation 0.95
Values 1.9 2.9 2 3.9
[78]
ref_hepatocyte PIK3CG
Mean 0.0637
Standard deviation 0.13
Values 0 0 0 0.026 0.29
[79]
HepG2 PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[80]
HepG2.C3A PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 PIK3CG
Mean 0
Standard deviation 0
Values 0 0 0
[82]
SNU475 PIK3CG
Mean 0.296
Standard deviation 0.1
Values 0.22 0.37
[83]
THLE PIK3CG
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[84]
liver PIK3CG
Mean 1.55
Standard deviation 0.43
Values 0.94 1.9 1.7 1.6