REACTOME_ERK_MAPK_TARGETS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0.31[1] 0.10[2] 0.06[3] 0.69[4] 0.18[5] -0.63[6]
2 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform -0.22[7] -0.16[8] -0.76[9] 0.23[10] 0.50[11] -0.88[12]
3 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform -0.88[13] -1.26[14] -1.15[15] -0.97[16] -0.92[17] -1.76[18]
4 DUSP3 Dual specificity protein phosphatase 3 [19] 0.28[20] -0.35[21] 0.22[22] -1.19[23] -1.02[24] 0.63[25]
5 DUSP6 Dual specificity protein phosphatase 6 [26] -0.97[27] 1.07[28] 0.38[29] -4.43[30] -0.48[31] -0.52[32]
6 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform -0.04[33] -0.60[34] -0.15[35] -0.24[36] -0.30[37] 2.16[38]
7 MAPK1 Mitogen-activated protein kinase 1 [39] 1.22[40] 1.32[41] 1.18[42] 1.33[43] 1.14[44] 1.00[45]
8 RPS6KA3 Ribosomal protein S6 kinase alpha-3 [46] [47] [48] [49] [50] [51] [52]
9 VRK3 Inactive serine/threonine-protein kinase VRK3 [53] -1.25[54] -1.12[55] -0.81[56] -1.66[57] -1.89[58] -1.26[59]
10 MAPK14 Mitogen-activated protein kinase 14 [60] 0.98[61] 1.02[62] 0.63[63] 1.17[64] 0.80[65] 0.51[66]
11 PPP2R5D Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform 0.76[67] 0.48[68] 0.08[69] 0.78[70] 0.82[71] -1.04[72]
12 ELK1 ETS domain-containing protein Elk-1 [73] -0.80[74] -2.98[75] -0.52[76] -0.24[77] 0.50[78] -0.94[79]
13 RPS6KA1 Ribosomal protein S6 kinase alpha-1 [80] [81] [82] [83] [84] [85] [86]
14 MAPK3 Mitogen-activated protein kinase 3 [87] 1.36[88] 1.37[89] 1.44[90] -0.09[91] 0.09[92] -1.81[93]
15 MEF2A Myocyte-specific enhancer factor 2A [94] -0.52[95] 0.23[96] 0.94[97] 0.66[98] 0.90[99] 1.38[100]
16 RPS6KA2 Ribosomal protein S6 kinase alpha-2 [101] [102] [103] [104] [105] [106] [107]
17 DUSP7 Dual specificity protein phosphatase 7 [108] 1.06[109] 0.11[110] 1.40[111] -0.94[112] 1.61[113] -0.74[114]
18 MAPK7 Mitogen-activated protein kinase 7 [115] 0.95[116] 0.21[117] 0.24[118] 1.29[119] 1.54[120] -0.44[121]
19 RPS6KA5 Ribosomal protein S6 kinase alpha-5 [122] [123] [124] [125] [126] [127] [128]
20 MAPK11 Mitogen-activated protein kinase 11 [129] -0.66[130] -0.80[131] -1.66[132] -0.16[133] 1.99[134] -0.61[135]
21 MEF2C Myocyte-specific enhancer factor 2C [136] -3.60[137] -2.51[138] 2.49[139] 5.10[140] 1.24[141] 4.52[142]
22 DUSP4 Dual specificity protein phosphatase 4 [143] 5.02[144] 1.97[145] 7.90[146] 7.22[147] 5.32[148] 3.06[149]
[1]
ref_hepatocyte PPP2R1A
Mean 27.9
Standard deviation 5.4
Values 23 30 23 36 28
[2]
HepG2 PPP2R1A
Mean 107
Standard deviation 6.5
Values 1.1e+02 1e+02
[3]
HepG2.C3A PPP2R1A
Mean 84.7
Standard deviation 12
Values 93 76
[4]
HuH.7 PPP2R1A
Mean 77.2
Standard deviation 6.8
Values 84 70 78
[5]
SNU475 PPP2R1A
Mean 118
Standard deviation 14
Values 1.3e+02 1.1e+02
[6]
THLE PPP2R1A
Mean 83.3
Standard deviation 16
Values 72 94
[7]
liver PPP2R1A
Mean 43.9
Standard deviation 17
Values 51 30 65 30
[8]
ref_hepatocyte PPP2CA
Mean 27.3
Standard deviation 6.4
Values 27 38 22 24 25
[9]
HepG2 PPP2CA
Mean 72.8
Standard deviation 15
Values 62 83
[10]
HepG2.C3A PPP2CA
Mean 69.2
Standard deviation 19
Values 55 83
[11]
HuH.7 PPP2CA
Mean 42.8
Standard deviation 4.9
Values 43 38 48
[12]
SNU475 PPP2CA
Mean 83.9
Standard deviation 4.1
Values 81 87
[13]
THLE PPP2CA
Mean 102
Standard deviation 13
Values 92 1.1e+02
[14]
liver PPP2CA
Mean 36.1
Standard deviation 13
Values 49 27 46 23
[15]
ref_hepatocyte PPP2CB
Mean 25.5
Standard deviation 11
Values 15 43 27 17 26
[16]
HepG2 PPP2CB
Mean 43
Standard deviation 1.5
Values 44 42
[17]
HepG2.C3A PPP2CB
Mean 30.2
Standard deviation 0.78
Values 31 30
[18]
HuH.7 PPP2CB
Mean 30.6
Standard deviation 2.8
Values 28 34 30
[19]
SNU475 PPP2CB
Mean 34.2
Standard deviation 0.1
Values 34 34
[20]
THLE PPP2CB
Mean 35.7
Standard deviation 2.6
Values 37 34
[21]
liver PPP2CB
Mean 18.3
Standard deviation 7.2
Values 28 14 19 12
[22]
ref_hepatocyte DUSP3
Mean 23.2
Standard deviation 6.4
Values 30 24 15 29 18
[23]
HepG2 DUSP3
Mean 87.3
Standard deviation 15
Values 76 98
[24]
HepG2.C3A DUSP3
Mean 51.6
Standard deviation 6.9
Values 56 47
[25]
HuH.7 DUSP3
Mean 71.8
Standard deviation 1.7
Values 70 74 72
[26]
SNU475 DUSP3
Mean 26.6
Standard deviation 2
Values 28 25
[27]
THLE DUSP3
Mean 30.1
Standard deviation 0.95
Values 29 31
[28]
liver DUSP3
Mean 87.3
Standard deviation 14
Values 92 73 1e+02 80
[29]
ref_hepatocyte DUSP6
Mean 15.3
Standard deviation 12
Values 1.5 4.5 29 26 15
[30]
HepG2 DUSP6
Mean 24.2
Standard deviation 10
Values 31 17
[31]
HepG2.C3A DUSP6
Mean 91
Standard deviation 18
Values 1e+02 78
[32]
HuH.7 DUSP6
Mean 52.9
Standard deviation 18
Values 62 32 65
[33]
SNU475 DUSP6
Mean 1.87
Standard deviation 2.3
Values 0.26 3.5
[34]
THLE DUSP6
Mean 28.9
Standard deviation 3.7
Values 26 32
[35]
liver DUSP6
Mean 25.9
Standard deviation 9.5
Values 38 19 28 18
[36]
ref_hepatocyte PPP2R1B
Mean 12
Standard deviation 3.3
Values 7 14 11 15 13
[37]
HepG2 PPP2R1B
Mean 36.3
Standard deviation 12
Values 27 45
[38]
HepG2.C3A PPP2R1B
Mean 22.5
Standard deviation 5.6
Values 19 26
[39]
HuH.7 PPP2R1B
Mean 28.7
Standard deviation 4.1
Values 32 30 24
[40]
SNU475 PPP2R1B
Mean 26.6
Standard deviation 1.2
Values 26 27
[41]
THLE PPP2R1B
Mean 25.6
Standard deviation 5.7
Values 22 30
[42]
liver PPP2R1B
Mean 130
Standard deviation 78
Values 52 1.6e+02 82 2.2e+02
[43]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[44]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[45]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[46]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[47]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[48]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[49]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[50]
ref_hepatocyte RPS6KA3
Mean 9.94
Standard deviation 10
Values 28 6.9 4.8 4.1 6.3
[51]
HepG2 RPS6KA3
Missing
[52]
HepG2.C3A RPS6KA3
Missing
[53]
HuH.7 RPS6KA3
Missing
[54]
SNU475 RPS6KA3
Missing
[55]
THLE RPS6KA3
Missing
[56]
liver RPS6KA3
Missing
[57]
ref_hepatocyte VRK3
Mean 9.48
Standard deviation 2.5
Values 6.5 7.8 12 12 8.9
[58]
HepG2 VRK3
Mean 12.4
Standard deviation 0.32
Values 13 12
[59]
HepG2.C3A VRK3
Mean 12.4
Standard deviation 1.1
Values 12 13
[60]
HuH.7 VRK3
Mean 14.4
Standard deviation 3.9
Values 16 9.9 17
[61]
SNU475 VRK3
Mean 7.86
Standard deviation 1.4
Values 8.8 6.9
[62]
THLE VRK3
Mean 6.73
Standard deviation 0.17
Values 6.9 6.6
[63]
liver VRK3
Mean 9.61
Standard deviation 5.9
Values 12 5.3 17 4.4
[64]
ref_hepatocyte MAPK14
Mean 8.71
Standard deviation 2
Values 12 8.5 7.2 7.5 8.3
[65]
HepG2 MAPK14
Mean 53.4
Standard deviation 8.7
Values 47 60
[66]
HepG2.C3A MAPK14
Mean 49.9
Standard deviation 0.11
Values 50 50
[67]
HuH.7 MAPK14
Mean 35.7
Standard deviation 1.3
Values 37 36 34
[68]
SNU475 MAPK14
Mean 51.3
Standard deviation 0.4
Values 52 51
[69]
THLE MAPK14
Mean 40
Standard deviation 3.6
Values 37 43
[70]
liver MAPK14
Mean 30.1
Standard deviation 8.3
Values 24 38 22 37
[71]
ref_hepatocyte PPP2R5D
Mean 7.67
Standard deviation 1.8
Values 11 7.4 6.7 6.6 6.7
[72]
HepG2 PPP2R5D
Mean 40.3
Standard deviation 5.9
Values 36 44
[73]
HepG2.C3A PPP2R5D
Mean 30.4
Standard deviation 4.1
Values 27 33
[74]
HuH.7 PPP2R5D
Mean 21.5
Standard deviation 4.4
Values 26 17 22
[75]
SNU475 PPP2R5D
Mean 34.4
Standard deviation 4.8
Values 38 31
[76]
THLE PPP2R5D
Mean 35.6
Standard deviation 5.6
Values 32 40
[77]
liver PPP2R5D
Mean 9.05
Standard deviation 4.1
Values 11 5.8 14 5.4
[78]
ref_hepatocyte ELK1
Mean 6.81
Standard deviation 3.9
Values 1.7 12 7.5 8.5 4.4
[79]
HepG2 ELK1
Mean 12.1
Standard deviation 1.5
Values 13 11
[80]
HepG2.C3A ELK1
Mean 2.45
Standard deviation 0.82
Values 3 1.9
[81]
HuH.7 ELK1
Mean 12.6
Standard deviation 1.8
Values 14 11 13
[82]
SNU475 ELK1
Mean 15.1
Standard deviation 0.2
Values 15 15
[83]
THLE ELK1
Mean 25.4
Standard deviation 3.5
Values 23 28
[84]
liver ELK1
Mean 8.61
Standard deviation 2.4
Values 10 6 11 7.1
[85]
ref_hepatocyte RPS6KA1
Mean 4.78
Standard deviation 3.4
Values 10 5.6 3.5 2.9 1.5
[86]
HepG2 RPS6KA1
Missing
[87]
HepG2.C3A RPS6KA1
Missing
[88]
HuH.7 RPS6KA1
Missing
[89]
SNU475 RPS6KA1
Missing
[90]
THLE RPS6KA1
Missing
[91]
liver RPS6KA1
Missing
[92]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[93]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[94]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[95]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[96]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[97]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[98]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[99]
ref_hepatocyte MEF2A
Mean 3.86
Standard deviation 1.1
Values 2.4 5.2 4.5 3.3 3.9
[100]
HepG2 MEF2A
Mean 8.35
Standard deviation 1.4
Values 7.3 9.4
[101]
HepG2.C3A MEF2A
Mean 12.8
Standard deviation 1.9
Values 14 11
[102]
HuH.7 MEF2A
Mean 19.6
Standard deviation 3.2
Values 18 23 17
[103]
SNU475 MEF2A
Mean 16
Standard deviation 1.3
Values 17 15
[104]
THLE MEF2A
Mean 19
Standard deviation 0.15
Values 19 19
[105]
liver MEF2A
Mean 24.5
Standard deviation 4.2
Values 30 23 20 25
[106]
ref_hepatocyte RPS6KA2
Mean 1.31
Standard deviation 0.89
Values 0 1.8 2.4 1.1 1.3
[107]
HepG2 RPS6KA2
Missing
[108]
HepG2.C3A RPS6KA2
Missing
[109]
HuH.7 RPS6KA2
Missing
[110]
SNU475 RPS6KA2
Missing
[111]
THLE RPS6KA2
Missing
[112]
liver RPS6KA2
Missing
[113]
ref_hepatocyte DUSP7
Mean 1.21
Standard deviation 1.1
Values 1.2 0.72 3.1 0.56 0.45
[114]
HepG2 DUSP7
Mean 7.84
Standard deviation 0.41
Values 8.1 7.6
[115]
HepG2.C3A DUSP7
Mean 3.71
Standard deviation 0.37
Values 3.5 4
[116]
HuH.7 DUSP7
Mean 8.47
Standard deviation 1.7
Values 9.6 6.5 9.2
[117]
SNU475 DUSP7
Mean 1.66
Standard deviation 0.53
Values 1.3 2
[118]
THLE DUSP7
Mean 9.74
Standard deviation 1.7
Values 8.5 11
[119]
liver DUSP7
Mean 1.76
Standard deviation 0.63
Values 2.3 1.3 1.2 2.3
[120]
ref_hepatocyte MAPK7
Mean 1.09
Standard deviation 0.71
Values 1.1 0.26 2.2 1 0.89
[121]
HepG2 MAPK7
Mean 6.54
Standard deviation 1.5
Values 5.4 7.6
[122]
HepG2.C3A MAPK7
Mean 3.58
Standard deviation 0.65
Values 4 3.1
[123]
HuH.7 MAPK7
Mean 3.43
Standard deviation 0.61
Values 4 2.8 3.6
[124]
SNU475 MAPK7
Mean 7.01
Standard deviation 0.043
Values 7 7
[125]
THLE MAPK7
Mean 8.39
Standard deviation 0.71
Values 7.9 8.9
[126]
liver MAPK7
Mean 1.96
Standard deviation 0.9
Values 2.9 0.9 2.4 1.6
[127]
ref_hepatocyte RPS6KA5
Mean 0.385
Standard deviation 0.19
Values 0.21 0.42 0.65 0.18 0.46
[128]
HepG2 RPS6KA5
Missing
[129]
HepG2.C3A RPS6KA5
Missing
[130]
HuH.7 RPS6KA5
Missing
[131]
SNU475 RPS6KA5
Missing
[132]
THLE RPS6KA5
Missing
[133]
liver RPS6KA5
Missing
[134]
ref_hepatocyte MAPK11
Mean 0.382
Standard deviation 0.29
Values 0 0.34 0.22 0.71 0.64
[135]
HepG2 MAPK11
Mean 0.749
Standard deviation 0.18
Values 0.62 0.88
[136]
HepG2.C3A MAPK11
Mean 0.621
Standard deviation 0.12
Values 0.53 0.71
[137]
HuH.7 MAPK11
Mean 0.322
Standard deviation 0.15
Values 0.28 0.2 0.49
[138]
SNU475 MAPK11
Mean 0.898
Standard deviation 0.33
Values 1.1 0.66
[139]
THLE MAPK11
Mean 4.01
Standard deviation 0.7
Values 4.5 3.5
[140]
liver MAPK11
Mean 0.609
Standard deviation 0.32
Values 0.96 0.49 0.23 0.75
[141]
ref_hepatocyte MEF2C
Mean 0.12
Standard deviation 0.15
Values 0 0 0.19 0.069 0.34
[142]
HepG2 MEF2C
Mean 0.0308
Standard deviation 0.011
Values 0.023 0.039
[143]
HepG2.C3A MEF2C
Mean 0.0598
Standard deviation 0.039
Values 0.087 0.032
[144]
HuH.7 MEF2C
Mean 1.79
Standard deviation 0.19
Values 2 1.8 1.6
[145]
SNU475 MEF2C
Mean 10.8
Standard deviation 1
Values 10 12
[146]
THLE MEF2C
Mean 0.747
Standard deviation 0.16
Values 0.63 0.86
[147]
liver MEF2C
Mean 6.67
Standard deviation 1.2
Values 7.3 8 6 5.4
[148]
ref_hepatocyte DUSP4
Mean 0.0303
Standard deviation 0.044
Values 0 0 0 0.095 0.057
[149]
HepG2 DUSP4
Mean 3.05
Standard deviation 2.7
Values 4.9 1.2
[150]
HepG2.C3A DUSP4
Mean 0.336
Standard deviation 0.0055
Values 0.34 0.33
[151]
HuH.7 DUSP4
Mean 19.3
Standard deviation 5.6
Values 23 13 22
[152]
SNU475 DUSP4
Mean 11.8
Standard deviation 7.2
Values 6.8 17
[153]
THLE DUSP4
Mean 3.18
Standard deviation 0.19
Values 3 3.3
[154]
liver DUSP4
Mean 0.614
Standard deviation 0.19
Values 0.45 0.73 0.46 0.82