REACTOME_ERKS_ARE_INACTIVATED Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0.21[1] -0.01[2] -0.02[3] 0.69[4] 0.16[5] -0.69[6]
2 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform -0.32[7] -0.27[8] -0.84[9] 0.22[10] 0.48[11] -0.94[12]
3 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform -0.98[13] -1.37[14] -1.23[15] -0.97[16] -0.94[17] -1.82[18]
4 DUSP3 Dual specificity protein phosphatase 3 [19] 0.18[20] -0.46[21] 0.14[22] -1.20[23] -1.05[24] 0.57[25]
5 DUSP6 Dual specificity protein phosphatase 6 [26] -1.08[27] 0.96[28] 0.30[29] -4.43[30] -0.50[31] -0.58[32]
6 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform -0.14[33] -0.71[34] -0.23[35] -0.25[36] -0.32[37] 2.10[38]
7 MAPK1 Mitogen-activated protein kinase 1 [39] 1.12[40] 1.21[41] 1.10[42] 1.33[43] 1.12[44] 0.94[45]
8 VRK3 Inactive serine/threonine-protein kinase VRK3 [46] -1.35[47] -1.23[48] -0.89[49] -1.66[50] -1.91[51] -1.32[52]
9 PPP2R5D Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform 0.66[53] 0.38[54] -0.01[55] 0.77[56] 0.80[57] -1.10[58]
10 MAPK3 Mitogen-activated protein kinase 3 [59] 1.26[60] 1.26[61] 1.36[62] -0.09[63] 0.07[64] -1.88[65]
11 DUSP7 Dual specificity protein phosphatase 7 [66] 0.96[67] 0.00[68] 1.31[69] -0.94[70] 1.59[71] -0.81[72]
12 MAPK7 Mitogen-activated protein kinase 7 [73] 0.84[74] 0.10[75] 0.16[76] 1.29[77] 1.52[78] -0.50[79]
13 DUSP4 Dual specificity protein phosphatase 4 [80] 4.91[81] 1.86[82] 7.82[83] 7.21[84] 5.29[85] 3.00[86]
[1]
ref_hepatocyte PPP2R1A
Mean 27.9
Standard deviation 5.4
Values 23 30 23 36 28
[2]
HepG2 PPP2R1A
Mean 107
Standard deviation 6.5
Values 1.1e+02 1e+02
[3]
HepG2.C3A PPP2R1A
Mean 84.7
Standard deviation 12
Values 93 76
[4]
HuH.7 PPP2R1A
Mean 77.2
Standard deviation 6.8
Values 84 70 78
[5]
SNU475 PPP2R1A
Mean 118
Standard deviation 14
Values 1.3e+02 1.1e+02
[6]
THLE PPP2R1A
Mean 83.3
Standard deviation 16
Values 72 94
[7]
liver PPP2R1A
Mean 43.9
Standard deviation 17
Values 51 30 65 30
[8]
ref_hepatocyte PPP2CA
Mean 27.3
Standard deviation 6.4
Values 27 38 22 24 25
[9]
HepG2 PPP2CA
Mean 72.8
Standard deviation 15
Values 62 83
[10]
HepG2.C3A PPP2CA
Mean 69.2
Standard deviation 19
Values 55 83
[11]
HuH.7 PPP2CA
Mean 42.8
Standard deviation 4.9
Values 43 38 48
[12]
SNU475 PPP2CA
Mean 83.9
Standard deviation 4.1
Values 81 87
[13]
THLE PPP2CA
Mean 102
Standard deviation 13
Values 92 1.1e+02
[14]
liver PPP2CA
Mean 36.1
Standard deviation 13
Values 49 27 46 23
[15]
ref_hepatocyte PPP2CB
Mean 25.5
Standard deviation 11
Values 15 43 27 17 26
[16]
HepG2 PPP2CB
Mean 43
Standard deviation 1.5
Values 44 42
[17]
HepG2.C3A PPP2CB
Mean 30.2
Standard deviation 0.78
Values 31 30
[18]
HuH.7 PPP2CB
Mean 30.6
Standard deviation 2.8
Values 28 34 30
[19]
SNU475 PPP2CB
Mean 34.2
Standard deviation 0.1
Values 34 34
[20]
THLE PPP2CB
Mean 35.7
Standard deviation 2.6
Values 37 34
[21]
liver PPP2CB
Mean 18.3
Standard deviation 7.2
Values 28 14 19 12
[22]
ref_hepatocyte DUSP3
Mean 23.2
Standard deviation 6.4
Values 30 24 15 29 18
[23]
HepG2 DUSP3
Mean 87.3
Standard deviation 15
Values 76 98
[24]
HepG2.C3A DUSP3
Mean 51.6
Standard deviation 6.9
Values 56 47
[25]
HuH.7 DUSP3
Mean 71.8
Standard deviation 1.7
Values 70 74 72
[26]
SNU475 DUSP3
Mean 26.6
Standard deviation 2
Values 28 25
[27]
THLE DUSP3
Mean 30.1
Standard deviation 0.95
Values 29 31
[28]
liver DUSP3
Mean 87.3
Standard deviation 14
Values 92 73 1e+02 80
[29]
ref_hepatocyte DUSP6
Mean 15.3
Standard deviation 12
Values 1.5 4.5 29 26 15
[30]
HepG2 DUSP6
Mean 24.2
Standard deviation 10
Values 31 17
[31]
HepG2.C3A DUSP6
Mean 91
Standard deviation 18
Values 1e+02 78
[32]
HuH.7 DUSP6
Mean 52.9
Standard deviation 18
Values 62 32 65
[33]
SNU475 DUSP6
Mean 1.87
Standard deviation 2.3
Values 0.26 3.5
[34]
THLE DUSP6
Mean 28.9
Standard deviation 3.7
Values 26 32
[35]
liver DUSP6
Mean 25.9
Standard deviation 9.5
Values 38 19 28 18
[36]
ref_hepatocyte PPP2R1B
Mean 12
Standard deviation 3.3
Values 7 14 11 15 13
[37]
HepG2 PPP2R1B
Mean 36.3
Standard deviation 12
Values 27 45
[38]
HepG2.C3A PPP2R1B
Mean 22.5
Standard deviation 5.6
Values 19 26
[39]
HuH.7 PPP2R1B
Mean 28.7
Standard deviation 4.1
Values 32 30 24
[40]
SNU475 PPP2R1B
Mean 26.6
Standard deviation 1.2
Values 26 27
[41]
THLE PPP2R1B
Mean 25.6
Standard deviation 5.7
Values 22 30
[42]
liver PPP2R1B
Mean 130
Standard deviation 78
Values 52 1.6e+02 82 2.2e+02
[43]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[44]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[45]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[46]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[47]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[48]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[49]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[50]
ref_hepatocyte VRK3
Mean 9.48
Standard deviation 2.5
Values 6.5 7.8 12 12 8.9
[51]
HepG2 VRK3
Mean 12.4
Standard deviation 0.32
Values 13 12
[52]
HepG2.C3A VRK3
Mean 12.4
Standard deviation 1.1
Values 12 13
[53]
HuH.7 VRK3
Mean 14.4
Standard deviation 3.9
Values 16 9.9 17
[54]
SNU475 VRK3
Mean 7.86
Standard deviation 1.4
Values 8.8 6.9
[55]
THLE VRK3
Mean 6.73
Standard deviation 0.17
Values 6.9 6.6
[56]
liver VRK3
Mean 9.61
Standard deviation 5.9
Values 12 5.3 17 4.4
[57]
ref_hepatocyte PPP2R5D
Mean 7.67
Standard deviation 1.8
Values 11 7.4 6.7 6.6 6.7
[58]
HepG2 PPP2R5D
Mean 40.3
Standard deviation 5.9
Values 36 44
[59]
HepG2.C3A PPP2R5D
Mean 30.4
Standard deviation 4.1
Values 27 33
[60]
HuH.7 PPP2R5D
Mean 21.5
Standard deviation 4.4
Values 26 17 22
[61]
SNU475 PPP2R5D
Mean 34.4
Standard deviation 4.8
Values 38 31
[62]
THLE PPP2R5D
Mean 35.6
Standard deviation 5.6
Values 32 40
[63]
liver PPP2R5D
Mean 9.05
Standard deviation 4.1
Values 11 5.8 14 5.4
[64]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[65]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[66]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[67]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[68]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[69]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[70]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[71]
ref_hepatocyte DUSP7
Mean 1.21
Standard deviation 1.1
Values 1.2 0.72 3.1 0.56 0.45
[72]
HepG2 DUSP7
Mean 7.84
Standard deviation 0.41
Values 8.1 7.6
[73]
HepG2.C3A DUSP7
Mean 3.71
Standard deviation 0.37
Values 3.5 4
[74]
HuH.7 DUSP7
Mean 8.47
Standard deviation 1.7
Values 9.6 6.5 9.2
[75]
SNU475 DUSP7
Mean 1.66
Standard deviation 0.53
Values 1.3 2
[76]
THLE DUSP7
Mean 9.74
Standard deviation 1.7
Values 8.5 11
[77]
liver DUSP7
Mean 1.76
Standard deviation 0.63
Values 2.3 1.3 1.2 2.3
[78]
ref_hepatocyte MAPK7
Mean 1.09
Standard deviation 0.71
Values 1.1 0.26 2.2 1 0.89
[79]
HepG2 MAPK7
Mean 6.54
Standard deviation 1.5
Values 5.4 7.6
[80]
HepG2.C3A MAPK7
Mean 3.58
Standard deviation 0.65
Values 4 3.1
[81]
HuH.7 MAPK7
Mean 3.43
Standard deviation 0.61
Values 4 2.8 3.6
[82]
SNU475 MAPK7
Mean 7.01
Standard deviation 0.043
Values 7 7
[83]
THLE MAPK7
Mean 8.39
Standard deviation 0.71
Values 7.9 8.9
[84]
liver MAPK7
Mean 1.96
Standard deviation 0.9
Values 2.9 0.9 2.4 1.6
[85]
ref_hepatocyte DUSP4
Mean 0.0303
Standard deviation 0.044
Values 0 0 0 0.095 0.057
[86]
HepG2 DUSP4
Mean 3.05
Standard deviation 2.7
Values 4.9 1.2
[87]
HepG2.C3A DUSP4
Mean 0.336
Standard deviation 0.0055
Values 0.34 0.33
[88]
HuH.7 DUSP4
Mean 19.3
Standard deviation 5.6
Values 23 13 22
[89]
SNU475 DUSP4
Mean 11.8
Standard deviation 7.2
Values 6.8 17
[90]
THLE DUSP4
Mean 3.18
Standard deviation 0.19
Values 3 3.3
[91]
liver DUSP4
Mean 0.614
Standard deviation 0.19
Values 0.45 0.73 0.46 0.82