REACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ERBB3 Receptor tyrosine-protein kinase erbB-3 [1] 0.48[2] 1.33[3] 0.48[4] -6.27[5] -5.83[6] 0.55[7]
2 ERBB2 Receptor tyrosine-protein kinase erbB-2 [8] 0.85[9] -0.86[10] 0.41[11] 0.86[12] 0.66[13] -1.60[14]
3 EGFR Epidermal growth factor receptor [15] -2.22[16] -3.12[17] -0.14[18] 0.04[19] 0.85[20] 0.89[21]
4 HBEGF Proheparin-binding EGF-like growth factor [22] -2.51[23] -3.85[24] -4.82[25] -0.09[26] -0.21[27] -4.19[28]
5 NRG1 Pro-neuregulin-1, membrane-bound isoform [29] -1.19[30] -7.86[31] -4.86[32] 1.65[33] -5.63[34] -0.99[35]
6 BTC Probetacellulin [36] -9.66[37] -10.59[38] -6.26[39] -3.27[40] -3.11[41] -4.67[42]
7 NRG4 Pro-neuregulin-4, membrane-bound isoform [43] -5.61[44] -3.27[45] -3.22[46] -0.11[47] -2.12[48] -2.69[49]
8 PTK6 Protein-tyrosine kinase 6 [50] -2.64[51] -0.96[52] -2.62[53] -2.05[54] -2.28[55] -2.33[56]
9 EREG Proepiregulin [57] 0.23[58] -0.37[59] -4.69[60] -1.96[61] 3.48[62] -3.23[63]
10 EGF Pro-epidermal growth factor [64] 0.45[65] 1.70[66] 5.42[67] 8.63[68] 6.24[69] -0.18[70]
11 NRG3 Pro-neuregulin-3, membrane-bound isoform [71] [72] [73] [74] [75] [76] [77]
12 ERBB4 Receptor tyrosine-protein kinase erbB-4 [78] [79] [80] [81] [82] [83] [84]
13 NRG2 Pro-neuregulin-2, membrane-bound isoform [85] [86] [87] [88] [89] [90] [91]
[1]
ref_hepatocyte ERBB3
Mean 8.22
Standard deviation 4
Values 12 3.8 4.1 11 10
[2]
HepG2 ERBB3
Mean 72.9
Standard deviation 2.6
Values 75 71
[3]
HepG2.C3A ERBB3
Mean 169
Standard deviation 42
Values 2e+02 1.4e+02
[4]
HuH.7 ERBB3
Mean 83.4
Standard deviation 7.8
Values 92 80 78
[5]
SNU475 ERBB3
Mean 0.258
Standard deviation 0.12
Values 0.18 0.34
[6]
THLE ERBB3
Mean 0.344
Standard deviation 0.05
Values 0.38 0.31
[7]
liver ERBB3
Mean 57.8
Standard deviation 20
Values 44 71 39 79
[8]
ref_hepatocyte ERBB2
Mean 6.44
Standard deviation 3.8
Values 13 3.9 4.7 3.7 7.1
[9]
HepG2 ERBB2
Mean 73.6
Standard deviation 10
Values 66 81
[10]
HepG2.C3A ERBB2
Mean 29
Standard deviation 6.9
Values 34 24
[11]
HuH.7 ERBB2
Mean 62.5
Standard deviation 7.1
Values 69 55 63
[12]
SNU475 ERBB2
Mean 28.2
Standard deviation 8.4
Values 34 22
[13]
THLE ERBB2
Mean 24.1
Standard deviation 2.7
Values 22 26
[14]
liver ERBB2
Mean 10.2
Standard deviation 3.4
Values 7.9 8.1 9.6 15
[15]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[16]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[17]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[18]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[19]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[20]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[21]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[22]
ref_hepatocyte HBEGF
Mean 1.81
Standard deviation 1.5
Values 1 3.1 3.8 0.78 0.34
[23]
HepG2 HBEGF
Mean 2.02
Standard deviation 0.16
Values 2.1 1.9
[24]
HepG2.C3A HBEGF
Mean 1.02
Standard deviation 0.3
Values 1.2 0.82
[25]
HuH.7 HBEGF
Mean 0.469
Standard deviation 0.044
Values 0.52 0.43 0.46
[26]
SNU475 HBEGF
Mean 4.11
Standard deviation 0.34
Values 3.9 4.4
[27]
THLE HBEGF
Mean 3.71
Standard deviation 0.17
Values 3.8 3.6
[28]
liver HBEGF
Mean 0.478
Standard deviation 0.29
Values 0.89 0.27 0.28 0.46
[29]
ref_hepatocyte NRG1
Mean 1.2
Standard deviation 1
Values 0 1 2.8 1.5 0.74
[30]
HepG2 NRG1
Mean 3.35
Standard deviation 2.7
Values 1.4 5.3
[31]
HepG2.C3A NRG1
Mean 0.0424
Standard deviation 0.046
Values 0.0097 0.075
[32]
HuH.7 NRG1
Mean 0.302
Standard deviation 0.17
Values 0.16 0.49 0.25
[33]
SNU475 NRG1
Mean 9.16
Standard deviation 3.3
Values 12 6.8
[34]
THLE NRG1
Mean 0.0576
Standard deviation 0.031
Values 0.035 0.08
[35]
liver NRG1
Mean 2.92
Standard deviation 2.1
Values 1.2 5.5 3.6 1.2
[36]
ref_hepatocyte BTC
Mean 0.915
Standard deviation 1.9
Values 0 4.4 0.079 0 0.12
[37]
HepG2 BTC
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[38]
HepG2.C3A BTC
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[39]
HuH.7 BTC
Mean 0.087
Standard deviation 0.09
Values 0.066 0.19 0.0094
[40]
SNU475 BTC
Mean 0.229
Standard deviation 0.03
Values 0.25 0.21
[41]
THLE BTC
Mean 0.251
Standard deviation 0.13
Values 0.34 0.16
[42]
liver BTC
Mean 0.172
Standard deviation 0.058
Values 0.21 0.23 0.1 0.15
[43]
ref_hepatocyte NRG4
Mean 0.631
Standard deviation 0.35
Values 0 0.75 0.81 0.78 0.81
[44]
HepG2 NRG4
Mean 0.0816
Standard deviation 0.03
Values 0.1 0.06
[45]
HepG2.C3A NRG4
Mean 0.534
Standard deviation 0.042
Values 0.56 0.5
[46]
HuH.7 NRG4
Mean 0.494
Standard deviation 0.053
Values 0.43 0.51 0.53
[47]
SNU475 NRG4
Mean 1.41
Standard deviation 0.46
Values 1.7 1.1
[48]
THLE NRG4
Mean 0.345
Standard deviation 0.16
Values 0.46 0.23
[49]
liver NRG4
Mean 0.468
Standard deviation 0.12
Values 0.45 0.41 0.64 0.37
[50]
ref_hepatocyte PTK6
Mean 0.543
Standard deviation 0.59
Values 0 0.55 1.5 0.39 0.24
[51]
HepG2 PTK6
Mean 0.551
Standard deviation 0.28
Values 0.75 0.35
[52]
HepG2.C3A PTK6
Mean 2.27
Standard deviation 0.8
Values 2.8 1.7
[53]
HuH.7 PTK6
Mean 0.643
Standard deviation 0.082
Values 0.66 0.55 0.71
[54]
SNU475 PTK6
Mean 0.316
Standard deviation 0.047
Values 0.28 0.35
[55]
THLE PTK6
Mean 0.264
Standard deviation 0.02
Values 0.28 0.25
[56]
liver PTK6
Mean 0.517
Standard deviation 0.32
Values 0.12 0.64 0.44 0.87
[57]
ref_hepatocyte EREG
Mean 0.24
Standard deviation 0.13
Values 0.3 0.18 0.15 0.13 0.45
[58]
HepG2 EREG
Mean 1.79
Standard deviation 1.2
Values 2.6 0.95
[59]
HepG2.C3A EREG
Mean 1.51
Standard deviation 1
Values 0.81 2.2
[60]
HuH.7 EREG
Mean 0.068
Standard deviation 0.032
Values 0.033 0.096 0.075
[61]
SNU475 EREG
Mean 0.149
Standard deviation 0.12
Values 0.065 0.23
[62]
THLE EREG
Mean 6.34
Standard deviation 2.2
Values 7.9 4.8
[63]
liver EREG
Mean 0.123
Standard deviation 0.11
Values 0 0.13 0.26 0.11
[64]
ref_hepatocyte EGF
Mean 0.00415
Standard deviation 0.0093
Values 0 0.021 0 0 0
[65]
HepG2 EGF
Mean 0.0358
Standard deviation 0.014
Values 0.046 0.026
[66]
HepG2.C3A EGF
Mean 0.11
Standard deviation 0.087
Values 0.049 0.17
[67]
HuH.7 EGF
Mean 1.29
Standard deviation 0.44
Values 0.97 1.8 1.1
[68]
SNU475 EGF
Mean 3.97
Standard deviation 0.5
Values 4.3 3.6
[69]
THLE EGF
Mean 0.743
Standard deviation 0.02
Values 0.76 0.73
[70]
liver EGF
Mean 0.0176
Standard deviation 0.027
Values 0 0.057 0 0.013
[71]
ref_hepatocyte NRG3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[72]
HepG2 NRG3
Mean 0
Standard deviation 0
Values 0 0
[73]
HepG2.C3A NRG3
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 NRG3
Mean 0.376
Standard deviation 0.32
Values 0.18 0.75 0.2
[75]
SNU475 NRG3
Mean 0
Standard deviation 0
Values 0 0
[76]
THLE NRG3
Mean 0
Standard deviation 0
Values 0 0
[77]
liver NRG3
Mean 0.222
Standard deviation 0.073
Values 0.28 0.2 0.13 0.28
[78]
ref_hepatocyte ERBB4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[79]
HepG2 ERBB4
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[80]
HepG2.C3A ERBB4
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[81]
HuH.7 ERBB4
Mean 0.136
Standard deviation 0.15
Values 0.098 0.3 0.0094
[82]
SNU475 ERBB4
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[83]
THLE ERBB4
Mean 0.0662
Standard deviation 0.027
Values 0.047 0.085
[84]
liver ERBB4
Mean 0.308
Standard deviation 0.33
Values 0.14 0.29 0.026 0.78
[85]
ref_hepatocyte NRG2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[86]
HepG2 NRG2
Mean 0.0236
Standard deviation 0.015
Values 0.034 0.013
[87]
HepG2.C3A NRG2
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 NRG2
Mean 0
Standard deviation 0
Values 0 0 0
[89]
SNU475 NRG2
Mean 0.181
Standard deviation 0.12
Values 0.093 0.27
[90]
THLE NRG2
Mean 0.79
Standard deviation 0.23
Values 0.63 0.95
[91]
liver NRG2
Mean 0.0321
Standard deviation 0.024
Values 0.047 0.029 0 0.053