REACTOME_EPH_EPHRIN_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | ACTB | Actin, cytoplasmic 1 | [1] | -0.61[2] | -0.93[3] | -0.35[4] | -0.34[5] | -0.50[6] | 0.04[7] |
2 | MYL6 | Myosin light polypeptide 6 | [8] | -2.49[9] | -1.95[10] | -3.15[11] | -1.79[12] | -1.91[13] | -2.39[14] |
3 | ACTG1 | Actin, cytoplasmic 2 | [15] | 0.67[16] | -0.29[17] | -0.24[18] | -0.53[19] | 0.09[20] | -0.70[21] |
4 | MYL12B | Myosin regulatory light chain 12B | [22] | -1.23[23] | -0.75[24] | -0.83[25] | -0.86[26] | -1.34[27] | -1.17[28] |
5 | CFL1 | Cofilin-1 | [29] | 0.52[30] | -0.14[31] | -0.21[32] | 0.19[33] | 0.48[34] | 0.28[35] |
6 | MYL12A | Myosin regulatory light chain 12A | [36] | -1.00[37] | -0.62[38] | -0.46[39] | -0.83[40] | -1.22[41] | -0.60[42] |
7 | RHOA | Transforming protein RhoA | [43] | -0.16[44] | -0.30[45] | -0.12[46] | -0.57[47] | 0.11[48] | -0.10[49] |
8 | CLTA | Clathrin light chain A | [50] | -1.10[51] | -0.92[52] | -0.85[53] | -1.81[54] | -1.21[55] | -2.04[56] |
9 | ARPC3 | Actin-related protein 2/3 complex subunit 3 | [57] | -0.74[58] | 0.12[59] | -0.41[60] | -0.77[61] | -0.85[62] | -1.27[63] |
10 | CDC42 | Cell division control protein 42 homolog | [64] | -0.05[65] | 1.03[66] | -0.02[67] | 0.12[68] | -0.37[69] | -0.86[70] |
11 | MYH9 | Myosin-9 | [71] | 2.20[72] | 1.00[73] | 0.93[74] | 1.87[75] | 1.99[76] | 1.62[77] |
12 | ARPC2 | Actin-related protein 2/3 complex subunit 2 | [78] | 0.40[79] | 0.54[80] | 0.00[81] | 0.28[82] | 0.43[83] | -0.55[84] |
13 | ACTR2 | Actin-related protein 2 | [85] | 0.72[86] | 1.27[87] | 1.13[88] | 1.50[89] | 1.14[90] | -0.08[91] |
14 | EFNA1 | Ephrin-A1 | [92] | -0.45[93] | 1.39[94] | 0.62[95] | -3.91[96] | -3.77[97] | 1.35[98] |
15 | ACTR3 | Actin-related protein 3 | [99] | 0.49[100] | 1.03[101] | 0.43[102] | 1.51[103] | 0.79[104] | 0.30[105] |
16 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [106] | 0.39[107] | 0.42[108] | 1.08[109] | 0.67[110] | 0.88[111] | 0.26[112] |
17 | CLTB | Clathrin light chain B | [113] | 0.22[114] | -1.43[115] | -1.67[116] | -1.99[117] | -1.40[118] | -1.07[119] |
18 | ARPC5 | Actin-related protein 2/3 complex subunit 5 | [120] | 0.36[121] | 0.07[122] | -0.59[123] | 1.54[124] | 0.94[125] | 0.28[126] |
19 | SDC2 | Syndecan-2 | [127] | 1.19[128] | 2.49[129] | 2.09[130] | 0.47[131] | -2.52[132] | 1.85[133] |
20 | AP2M1 | AP-2 complex subunit mu | [134] | 1.00[135] | 1.16[136] | 0.62[137] | 1.63[138] | 2.37[139] | 1.06[140] |
21 | ARPC1A | Actin-related protein 2/3 complex subunit 1A | [141] | 0.20[142] | 0.06[143] | 0.74[144] | 0.34[145] | 0.25[146] | 0.33[147] |
22 | AP2S1 | AP-2 complex subunit sigma | [148] | -0.84[149] | -0.50[150] | 0.16[151] | -0.09[152] | 0.57[153] | 0.20[154] |
23 | ARPC4 | Actin-related protein 2/3 complex subunit 4 | [155] | -0.62[156] | -0.78[157] | 0.76[158] | -0.82[159] | -0.30[160] | -0.68[161] |
24 | ARPC1B | Actin-related protein 2/3 complex subunit 1B | [162] | 0.77[163] | 0.83[164] | -0.20[165] | 1.60[166] | 0.86[167] | 0.24[168] |
25 | APH1A | Gamma-secretase subunit APH-1A | [169] | 0.71[170] | 1.35[171] | 1.53[172] | 0.39[173] | 0.51[174] | 0.21[175] |
26 | SDCBP | Syntenin-1 | [176] | -0.23[177] | -0.19[178] | -0.87[179] | 1.69[180] | 1.53[181] | 1.21[182] |
27 | CLTC | Clathrin heavy chain 1 | [183] | 2.40[184] | 2.85[185] | 2.99[186] | 2.33[187] | 2.70[188] | 3.68[189] |
28 | PSENEN | Gamma-secretase subunit PEN-2 | [190] | -1.29[191] | -0.91[192] | -0.49[193] | -1.23[194] | -1.42[195] | -0.84[196] |
29 | YES1 | Tyrosine-protein kinase Yes | [197] | -0.08[198] | 1.77[199] | 1.95[200] | 1.10[201] | 0.79[202] | 1.35[203] |
30 | NCSTN | Nicastrin | [204] | 2.13[205] | 1.65[206] | 1.76[207] | 1.74[208] | 1.85[209] | 1.62[210] |
31 | HRAS | GTPase HRas | [211] | -0.23[212] | -0.57[213] | -1.41[214] | -0.29[215] | -0.28[216] | -1.43[217] |
32 | PAK2 | Serine/threonine-protein kinase PAK 2 | [218] | 2.23[219] | 2.33[220] | 2.59[221] | 1.41[222] | 2.18[223] | 2.59[224] |
33 | AP2A1 | AP-2 complex subunit alpha-1 | [225] | 1.99[226] | 2.01[227] | 2.80[228] | 2.05[229] | 2.36[230] | 2.18[231] |
34 | AP2B1 | AP-2 complex subunit beta | [232] | 3.02[233] | 3.11[234] | 4.79[235] | 3.21[236] | 3.29[237] | 2.16[238] |
35 | PTK2 | Focal adhesion kinase 1 | [239] | 1.52[240] | 2.36[241] | 2.70[242] | 2.60[243] | 2.03[244] | 1.99[245] |
36 | ITSN1 | Intersectin-1 | [246] | 0.67[247] | 1.14[248] | 1.86[249] | 1.66[250] | 2.15[251] | 2.95[252] |
37 | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 | [253] | 1.76[254] | 2.61[255] | 2.59[256] | 1.93[257] | 2.57[258] | 2.02[259] |
38 | WASL | Neural Wiskott-Aldrich syndrome protein | [260] | 0.30[261] | 1.73[262] | 2.09[263] | 1.76[264] | 1.14[265] | 2.36[266] |
39 | VAV2 | Guanine nucleotide exchange factor VAV2 | [267] | 2.08[268] | 2.69[269] | 2.14[270] | 0.12[271] | 0.77[272] | 1.74[273] |
40 | AP2A2 | AP-2 complex subunit alpha-2 | [274] | 2.04[275] | 2.24[276] | 2.33[277] | 1.50[278] | 1.38[279] | 1.90[280] |
41 | EPHA2 | Ephrin type-A receptor 2 | [281] | 3.04[282] | 3.60[283] | 1.38[284] | 1.60[285] | 2.38[286] | 0.45[287] |
42 | EPHB4 | Ephrin type-B receptor 4 | [288] | 2.70[289] | 2.43[290] | 2.65[291] | 0.09[292] | 1.10[293] | 2.91[294] |
43 | ROCK1 | Rho-associated protein kinase 1 | [295] | -0.17[296] | 1.71[297] | 2.44[298] | 2.02[299] | 1.59[300] | 2.81[301] |
44 | PSEN1 | Presenilin-1 | [302] | 1.84[303] | 2.42[304] | 1.94[305] | 1.91[306] | 2.01[307] | 2.22[308] |
45 | MYH14 | Myosin-14 | [309] | 1.66[310] | 2.13[311] | 2.07[312] | 1.15[313] | -2.06[314] | 2.48[315] |
46 | MYH10 | Myosin-10 | [316] | 3.11[317] | 3.49[318] | 4.01[319] | 3.12[320] | 3.24[321] | 3.28[322] |
47 | LYN | Tyrosine-protein kinase Lyn | [323] | -0.08[324] | 0.10[325] | 0.59[326] | 1.71[327] | 0.70[328] | 1.24[329] |
48 | ROCK2 | Rho-associated protein kinase 2 | [330] | 2.26[331] | 3.86[332] | 2.28[333] | 3.29[334] | 1.29[335] | 3.15[336] |
49 | MYL9 | Myosin regulatory light polypeptide 9 | [337] | 1.84[338] | 2.01[339] | -0.72[340] | 5.24[341] | 2.92[342] | 1.15[343] |
50 | NCK2 | Cytoplasmic protein NCK2 | [344] | 1.58[345] | 1.52[346] | -0.10[347] | 0.32[348] | 1.30[349] | 0.40[350] |
51 | PSEN2 | Presenilin-2 | [351] | 0.09[352] | -0.41[353] | -4.26[354] | 0.73[355] | -0.41[356] | 1.13[357] |
52 | NGEF | Ephexin-1 | [358] | 1.13[359] | 2.39[360] | 2.52[361] | -4.36[362] | -1.53[363] | 2.03[364] |
53 | SRC | Proto-oncogene tyrosine-protein kinase Src | [365] | 3.80[366] | 4.15[367] | 3.11[368] | 3.05[369] | 2.46[370] | 0.38[371] |
54 | LIMK2 | LIM domain kinase 2 | [372] | 2.28[373] | 3.02[374] | 3.12[375] | 1.02[376] | 1.89[377] | 2.51[378] |
55 | GIT1 | ARF GTPase-activating protein GIT1 | [379] | 2.75[380] | 2.99[381] | 2.35[382] | 2.61[383] | 2.55[384] | 0.75[385] |
56 | EFNA4 | Ephrin-A4 | [386] | 1.03[387] | 0.94[388] | 2.06[389] | -0.06[390] | -0.51[391] | -0.68[392] |
57 | ARHGEF7 | Rho guanine nucleotide exchange factor 7 | [393] | 2.40[394] | 2.75[395] | 2.56[396] | 2.47[397] | 2.45[398] | 3.58[399] |
58 | RASA1 | Ras GTPase-activating protein 1 | [400] | 1.16[401] | 2.43[402] | 2.49[403] | 2.57[404] | 1.85[405] | 2.44[406] |
59 | LIMK1 | LIM domain kinase 1 | [407] | 3.08[408] | 2.34[409] | 1.87[410] | 4.16[411] | 2.63[412] | -0.26[413] |
60 | PAK1 | Serine/threonine-protein kinase PAK 1 | [414] | 0.77[415] | 0.37[416] | 2.73[417] | -1.20[418] | 2.81[419] | 1.49[420] |
61 | EPHA1 | Ephrin type-A receptor 1 | [421] | 0.96[422] | 2.62[423] | -1.77[424] | -6.30[425] | -6.46[426] | 2.88[427] |
62 | FYN | Tyrosine-protein kinase Fyn | [428] | 1.72[429] | -6.52[430] | 2.01[431] | 2.13[432] | 3.88[433] | 2.20[434] |
63 | EFNA2 | Ephrin-A2 | [435] | 2.02[436] | 2.51[437] | 1.88[438] | -3.11[439] | -4.66[440] | 1.74[441] |
64 | EFNB1 | Ephrin-B1 | [442] | 2.12[443] | 0.47[444] | -6.65[445] | 2.27[446] | 2.57[447] | 2.14[448] |
65 | KALRN | Kalirin | [449] | 2.13[450] | 4.03[451] | 3.49[452] | 2.56[453] | -1.88[454] | 4.79[455] |
66 | MMP9 | Matrix metalloproteinase-9 | [456] | -1.94[457] | -2.63[458] | -5.07[459] | -0.78[460] | -3.11[461] | 1.09[462] |
67 | EPHB2 | Ephrin type-B receptor 2 | [463] | -0.05[464] | -4.76[465] | 1.63[466] | 3.02[467] | 4.00[468] | -0.35[469] |
68 | CLTCL1 | Clathrin heavy chain 2 | [470] | 2.86[471] | 2.77[472] | 2.58[473] | 2.56[474] | 2.23[475] | 2.97[476] |
69 | APH1B | Gamma-secretase subunit APH-1B | [477] | 0.54[478] | 1.71[479] | 4.80[480] | 3.75[481] | 3.02[482] | 2.45[483] |
70 | EPHB6 | Ephrin type-B receptor 6 | [484] | -4.32[485] | [486] | -6.94[487] | -2.04[488] | 1.18[489] | 2.03[490] |
71 | TIAM1 | T-lymphoma invasion and metastasis-inducing protein 1 | [491] | -3.92[492] | -0.89[493] | -6.12[494] | -0.71[495] | 1.57[496] | 4.57[497] |
72 | VAV3 | Guanine nucleotide exchange factor VAV3 | [498] | 2.59[499] | 1.24[500] | 3.37[501] | 4.34[502] | -1.41[503] | 2.58[504] |
73 | EFNA3 | Ephrin-A3 | [505] | 2.32[506] | 2.41[507] | 4.48[508] | 1.09[509] | 1.27[510] | 1.73[511] |
74 | EPHB1 | Ephrin type-B receptor 1 | [512] | 1.57[513] | -3.77[514] | -4.67[515] | [516] | -4.73[517] | 2.99[518] |
75 | EPHA10 | Ephrin type-A receptor 10 | [519] | 1.65[520] | 1.36[521] | 0.18[522] | -0.26[523] | -1.03[524] | 0.31[525] |
76 | EFNB2 | Ephrin-B2 | [526] | 0.20[527] | -1.61[528] | 1.27[529] | -0.25[530] | 5.98[531] | 5.05[532] |
77 | DNM1 | Dynamin-1 | [533] | 3.02[534] | 1.55[535] | 3.21[536] | 6.25[537] | 5.97[538] | 3.16[539] |
78 | MMP2 | 72 kDa type IV collagenase | [540] | 4.22[541] | -2.41[542] | -1.18[543] | 8.09[544] | 7.87[545] | 5.16[546] |
79 | PAK3 | Serine/threonine-protein kinase PAK 3 | [547] | -5.63[548] | [549] | [550] | -0.95[551] | 1.00[552] | 2.01[553] |
80 | EPHB3 | Ephrin type-B receptor 3 | [554] | 1.38[555] | -2.78[556] | 4.46[557] | 4.02[558] | 4.12[559] | 4.23[560] |
81 | EPHA4 | Ephrin type-A receptor 4 | [561] | -4.02[562] | -2.73[563] | -2.10[564] | 2.96[565] | 7.34[566] | 5.98[567] |
82 | GRIN2B | Glutamate receptor ionotropic, NMDA 2B | [568] | -1.68[569] | [570] | [571] | 1.74[572] | -0.84[573] | 3.09[574] |
83 | EPHA7 | Ephrin type-A receptor 7 | [575] | [576] | [577] | [578] | [579] | 1.84[580] | 1.44[581] |
84 | EFNB3 | Ephrin-B3 | [582] | 3.81[583] | 0.63[584] | 2.20[585] | 4.38[586] | 6.91[587] | 4.89[588] |
85 | MYH11 | Myosin-11 | [589] | 4.15[590] | 4.14[591] | 4.37[592] | 4.33[593] | 3.69[594] | 11.18[595] |
86 | EPHA8 | Ephrin type-A receptor 8 | [596] | -0.28[597] | [598] | [599] | -0.32[600] | [601] | [602] |
87 | EFNA5 | Ephrin-A5 | [603] | 1.98[604] | 0.75[605] | 6.83[606] | 8.82[607] | 10.33[608] | 8.68[609] |
88 | EPHA3 | Ephrin type-A receptor 3 | [610] | 2.34[611] | 1.38[612] | 4.52[613] | 0.98[614] | 9.56[615] | 9.14[616] |
89 | EPHA5 | Ephrin type-A receptor 5 | [617] | [618] | [619] | [620] | [621] | [622] | [623] |
90 | ARHGEF28 | Rho guanine nucleotide exchange factor 28 | [624] | [625] | [626] | [627] | [628] | [629] | [630] |
91 | EPHA6 | Ephrin type-A receptor 6 | [631] | [632] | [633] | [634] | [635] | [636] | [637] |
92 | GRIN1 | Glutamate receptor ionotropic, NMDA 1 | [638] | [639] | [640] | [641] | [642] | [643] | [644] |