REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHEB | GTP-binding protein Rheb | [1] | -1.64[2] | -1.34[3] | -1.55[4] | -0.82[5] | -0.73[6] | -1.14[7] |
2 | LAMTOR2 | Ragulator complex protein LAMTOR2 | [8] | -3.11[9] | -3.35[10] | -3.71[11] | -3.25[12] | -3.08[13] | -2.23[14] |
3 | LAMTOR1 | Ragulator complex protein LAMTOR1 | [15] | -0.31[16] | -1.33[17] | -1.57[18] | -0.79[19] | -0.86[20] | -1.36[21] |
4 | RRAGA | Ras-related GTP-binding protein A | [22] | 0.62[23] | -0.41[24] | -1.83[25] | -0.75[26] | -0.17[27] | -0.89[28] |
5 | PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 | [29] | -1.11[30] | -0.85[31] | -0.87[32] | -0.06[33] | -0.37[34] | -1.70[35] |
6 | STRADB | STE20-related kinase adapter protein beta | [36] | -0.43[37] | -0.23[38] | -0.50[39] | -0.71[40] | -1.23[41] | 0.44[42] |
7 | CAB39 | Calcium-binding protein 39 | [43] | -0.18[44] | -0.08[45] | 0.17[46] | 0.50[47] | 0.69[48] | 0.01[49] |
8 | PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 | [50] | -3.75[51] | -9.12[52] | -2.83[53] | -1.46[54] | -1.34[55] | -0.53[56] |
9 | STK11 | Serine/threonine-protein kinase STK11 | [57] | 0.22[58] | -0.11[59] | 0.00[60] | -0.42[61] | -0.10[62] | -0.92[63] |
10 | MLST8 | Target of rapamycin complex subunit LST8 | [64] | 0.14[65] | 0.19[66] | 0.42[67] | -0.69[68] | -0.37[69] | -0.62[70] |
11 | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | [71] | 0.23[72] | 1.23[73] | 2.61[74] | 1.75[75] | 1.99[76] | 2.01[77] |
12 | PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | [78] | 1.20[79] | 2.11[80] | 2.08[81] | 1.31[82] | 0.26[83] | 1.36[84] |
13 | RRAGC | Ras-related GTP-binding protein C | [85] | -0.24[86] | -1.36[87] | -1.10[88] | 0.66[89] | 0.32[90] | -1.01[91] |
14 | SLC38A9 | Sodium-coupled neutral amino acid transporter 9 | [92] | -0.37[93] | -0.40[94] | -1.42[95] | -0.63[96] | -0.75[97] | -0.28[98] |
15 | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | [99] | 1.02[100] | 1.28[101] | 0.29[102] | 0.22[103] | 0.30[104] | -0.05[105] |
16 | PPM1A | Protein phosphatase 1A | [106] | 0.63[107] | 1.31[108] | 1.14[109] | 1.51[110] | 1.55[111] | 2.15[112] |
17 | LAMTOR3 | Ragulator complex protein LAMTOR3 | [113] | 1.29[114] | 1.60[115] | 0.57[116] | 0.76[117] | 1.25[118] | 0.84[119] |
18 | MTOR | Serine/threonine-protein kinase mTOR | [120] | 2.84[121] | 3.58[122] | 3.01[123] | 2.97[124] | 3.02[125] | 3.40[126] |
19 | TSC2 | Tuberin | [127] | 2.12[128] | 1.38[129] | 1.92[130] | 1.49[131] | 1.98[132] | 2.03[133] |
20 | STRADA | STE20-related kinase adapter protein alpha | [134] | 1.26[135] | 1.09[136] | 0.74[137] | 1.36[138] | 1.13[139] | 0.21[140] |
21 | RPTOR | Regulatory-associated protein of mTOR | [141] | 3.39[142] | 2.36[143] | 2.31[144] | 2.13[145] | 2.34[146] | 2.28[147] |
22 | RRAGD | Ras-related GTP-binding protein D | [148] | -0.70[149] | -4.68[150] | 3.07[151] | 1.40[152] | -0.34[153] | 1.13[154] |
23 | TSC1 | Hamartin | [155] | 2.20[156] | 2.59[157] | 2.59[158] | 2.35[159] | 2.53[160] | 2.70[161] |
24 | RRAGB | Ras-related GTP-binding protein B | [162] | 0.03[163] | 0.32[164] | -9.29[165] | 0.73[166] | 0.53[167] | 0.54[168] |
25 | CAB39L | Calcium-binding protein 39-like | [169] | -0.19[170] | 0.04[171] | 0.57[172] | -0.55[173] | 0.55[174] | 0.49[175] |
26 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | [176] | 3.34[177] | 3.52[178] | 3.40[179] | 3.33[180] | 1.34[181] | 1.80[182] |
27 | PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 | [183] | -1.43[184] | [185] | -2.17[186] | -0.73[187] | [188] | 3.07[189] |
28 | LAMTOR5 | Ragulator complex protein LAMTOR5 | [190] | [191] | [192] | [193] | [194] | [195] | [196] |
29 | LAMTOR4 | Ragulator complex protein LAMTOR4 | [197] | [198] | [199] | [200] | [201] | [202] | [203] |