REACTOME_ENDOGENOUS_STEROLS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CYP27A1 | Sterol 26-hydroxylase, mitochondrial | [1] | -0.88[2] | -0.59[3] | -3.57[4] | -2.78[5] | -4.98[6] | -1.01[7] |
2 | CYP51A1 | Lanosterol 14-alpha demethylase | [8] | -1.51[9] | 0.40[10] | 0.44[11] | -0.65[12] | -1.64[13] | -0.30[14] |
3 | CYP8B1 | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase | [15] | -7.02[16] | -4.97[17] | -8.79[18] | -8.20[19] | -10.68[20] | 1.35[21] |
4 | NR1H4 | Bile acid receptor | [22] | -0.39[23] | -0.31[24] | 1.59[25] | -6.27[26] | -6.95[27] | -0.58[28] |
5 | RXRA | Retinoic acid receptor RXR-alpha | [29] | 1.15[30] | 0.45[31] | 1.40[32] | 1.79[33] | 0.81[34] | 1.05[35] |
6 | FDX1 | Adrenodoxin, mitochondrial | [36] | 0.50[37] | -0.43[38] | -1.85[39] | 1.49[40] | 0.75[41] | -0.29[42] |
7 | CYP4V2 | Cytochrome P450 4V2 | [43] | -2.04[44] | -0.79[45] | -2.62[46] | -2.09[47] | -2.20[48] | 0.66[49] |
8 | FDXR | NADPH:adrenodoxin oxidoreductase, mitochondrial | [50] | 3.81[51] | 2.64[52] | -0.40[53] | -0.12[54] | 0.32[55] | -3.02[56] |
9 | CYP39A1 | 24-hydroxycholesterol 7-alpha-hydroxylase | [57] | -3.86[58] | -4.54[59] | 0.21[60] | -3.15[61] | -1.85[62] | -0.63[63] |
10 | ARNT | Aryl hydrocarbon receptor nuclear translocator | [64] | 1.62[65] | 0.91[66] | 1.89[67] | 3.15[68] | 2.27[69] | 0.43[70] |
11 | CYP21A2 | Steroid 21-hydroxylase | [71] | -4.66[72] | -3.23[73] | -7.49[74] | -2.45[75] | -8.41[76] | -1.37[77] |
12 | AHR | Aryl hydrocarbon receptor | [78] | 2.32[79] | 2.13[80] | 3.25[81] | 2.33[82] | 2.59[83] | 1.49[84] |
13 | CYP7A1 | Cholesterol 7-alpha-monooxygenase | [85] | -3.14[86] | -5.97[87] | -9.40[88] | -8.19[89] | [90] | -4.06[91] |
14 | CYP1B1 | Cytochrome P450 1B1 | [92] | -5.85[93] | -5.78[94] | -1.56[95] | 3.29[96] | 5.24[97] | -0.09[98] |
15 | NCOA1 | Nuclear receptor coactivator 1 | [99] | 1.67[100] | 1.74[101] | 2.04[102] | 3.57[103] | 2.38[104] | 1.55[105] |
16 | CYP7B1 | 25-hydroxycholesterol 7-alpha-hydroxylase | [106] | -6.83[107] | -6.04[108] | [109] | -7.25[110] | -4.17[111] | 1.17[112] |
17 | NCOA2 | Nuclear receptor coactivator 2 | [113] | 2.78[114] | 3.10[115] | 5.04[116] | 4.98[117] | 2.63[118] | 3.50[119] |
18 | CYP19A1 | Aromatase | [120] | 3.13[121] | 3.66[122] | -2.69[123] | 0.13[124] | -2.97[125] | -7.44[126] |
19 | POMC | Pro-opiomelanocortin | [127] | [128] | -7.66[129] | [130] | [131] | -5.99[132] | -3.29[133] |
20 | CYP11A1 | Cholesterol side-chain cleavage enzyme, mitochondrial | [134] | 0.54[135] | -2.47[136] | [137] | -1.48[138] | 1.92[139] | -0.63[140] |
21 | PTGIS | Prostacyclin synthase | [141] | -0.36[142] | 0.27[143] | 4.35[144] | 2.90[145] | 8.20[146] | 3.74[147] |
22 | AHRR | Aryl hydrocarbon receptor repressor | [148] | 2.59[149] | 1.21[150] | 1.62[151] | 6.57[152] | 4.31[153] | -0.37[154] |
23 | CYP46A1 | Cholesterol 24-hydroxylase | [155] | -2.58[156] | -1.74[157] | -2.66[158] | -0.78[159] | -0.23[160] | 1.15[161] |
24 | ARNT2 | Aryl hydrocarbon receptor nuclear translocator 2 | [162] | 6.58[163] | -1.91[164] | -0.48[165] | 8.21[166] | 9.32[167] | 3.85[168] |
25 | PDCD6-AHRR | [169] | [170] | [171] | [172] | [173] | [174] | [175] | |
26 | FDX2 | Ferredoxin-2, mitochondrial | [176] | [177] | [178] | [179] | [180] | [181] | [182] |
27 | CYP11B2 | Cytochrome P450 11B2, mitochondrial | [183] | [184] | [185] | [186] | [187] | [188] | [189] |
28 | CYP11B1 | Cytochrome P450 11B1, mitochondrial | [190] | [191] | [192] | [193] | [194] | [195] | [196] |