REACTOME_EICOSANOIDS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP4A11 Cytochrome P450 4A11 [1] -9.41[2] -7.91[3] -10.06[4] -7.84[5] -10.48[6] -0.50[7]
2 CYP8B1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [8] -2.96[9] -1.55[10] -5.76[11] -5.48[12] -8.94[13] 1.07[14]
3 CYP4F2 Phylloquinone omega-hydroxylase CYP4F2 [15] -1.37[16] 1.13[17] -10.86[18] -9.05[19] -8.79[20] -0.56[21]
4 CYP4F11 Phylloquinone omega-hydroxylase CYP4F11 [22] 2.73[23] 1.18[24] -6.41[25] 3.38[26] -8.29[27] -0.63[28]
5 CYP4F3 Docosahexaenoic acid omega-hydroxylase CYP4F3 [29] 1.80[30] 1.58[31] 2.56[32] -0.02[33] -7.79[34] 0.81[35]
6 CYP4F12 Cytochrome P450 4F12 [36] 2.56[37] 2.76[38] 3.65[39] -0.45[40] -6.12[41] -1.18[42]
7 CYP4A22 Cytochrome P450 4A22 [43] [44] [45] [46] [47] [48] 0.89[49]
8 CYP4F22 Cytochrome P450 4F22 [50] -0.62[51] [52] -7.05[53] -5.47[54] -5.28[55] -2.35[56]
9 TBXAS1 Thromboxane-A synthase [57] 2.29[58] 3.22[59] -0.26[60] 5.14[61] 2.06[62] 0.27[63]
10 PTGIS Prostacyclin synthase [64] 3.70[65] 3.69[66] 7.38[67] 5.61[68] 9.93[69] 3.46[70]
11 CYP4B1 Cytochrome P450 4B1 [71] [72] [73] [74] [75] [76] [77]
12 CYP4F8 Cytochrome P450 4F8 [78] [79] [80] [81] [82] [83] [84]
[1]
ref_hepatocyte CYP4A11
Mean 109
Standard deviation 1.6e+02
Values 0 0 4 2e+02 3.4e+02
[2]
HepG2 CYP4A11
Mean 0.0093
Standard deviation 0.005
Values 0.0057 0.013
[3]
HepG2.C3A CYP4A11
Mean 0.0511
Standard deviation 0.0036
Values 0.049 0.054
[4]
HuH.7 CYP4A11
Mean 0.0135
Standard deviation 0.0098
Values 0.025 0.0064 0.0094
[5]
SNU475 CYP4A11
Mean 0.039
Standard deviation 0.0093
Values 0.032 0.046
[6]
THLE CYP4A11
Mean 0.0216
Standard deviation 0.022
Values 0.0059 0.037
[7]
liver CYP4A11
Mean 286
Standard deviation 2.2e+02
Values 5.7e+02 87 3.6e+02 1.3e+02
[8]
ref_hepatocyte CYP8B1
Mean 34.6
Standard deviation 44
Values 1.2 0.33 6.4 79 86
[9]
HepG2 CYP8B1
Mean 0.257
Standard deviation 0.2
Values 0.11 0.4
[10]
HepG2.C3A CYP8B1
Mean 1.33
Standard deviation 0.5
Values 1.7 0.98
[11]
HuH.7 CYP8B1
Mean 0.084
Standard deviation 0.016
Values 0.09 0.096 0.066
[12]
SNU475 CYP8B1
Mean 0.0631
Standard deviation 0.004
Values 0.06 0.066
[13]
THLE CYP8B1
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[14]
liver CYP8B1
Mean 269
Standard deviation 1.3e+02
Values 4.2e+02 1.3e+02 3e+02 2.2e+02
[15]
ref_hepatocyte CYP4F2
Mean 30.2
Standard deviation 38
Values 1.2 0.054 11 51 87
[16]
HepG2 CYP4F2
Mean 0.677
Standard deviation 0.5
Values 1 0.32
[17]
HepG2.C3A CYP4F2
Mean 7.41
Standard deviation 4.8
Values 11 4
[18]
HuH.7 CYP4F2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[19]
SNU475 CYP4F2
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[20]
THLE CYP4F2
Mean 0.0192
Standard deviation 0.01
Values 0.012 0.027
[21]
liver CYP4F2
Mean 75.6
Standard deviation 42
Values 86 50 1.3e+02 36
[22]
ref_hepatocyte CYP4F11
Mean 14.8
Standard deviation 11
Values 1.7 6.9 14 28 23
[23]
HepG2 CYP4F11
Mean 5.67
Standard deviation 2.2
Values 7.3 4.1
[24]
HepG2.C3A CYP4F11
Mean 3.76
Standard deviation 0.42
Values 4.1 3.5
[25]
HuH.7 CYP4F11
Mean 0.023
Standard deviation 0.029
Values 0 0.013 0.056
[26]
SNU475 CYP4F11
Mean 12.6
Standard deviation 0.65
Values 12 13
[27]
THLE CYP4F11
Mean 0.0133
Standard deviation 0.019
Values 0 0.027
[28]
liver CYP4F11
Mean 35.3
Standard deviation 12
Values 20 46 34 42
[29]
ref_hepatocyte CYP4F3
Mean 13.8
Standard deviation 15
Values 3.1 2 2.4 29 33
[30]
HepG2 CYP4F3
Mean 2.77
Standard deviation 0.38
Values 3 2.5
[31]
HepG2.C3A CYP4F3
Mean 4.62
Standard deviation 0.54
Values 5 4.2
[32]
HuH.7 CYP4F3
Mean 10.7
Standard deviation 7.3
Values 7.3 19 5.8
[33]
SNU475 CYP4F3
Mean 1.11
Standard deviation 0.19
Values 1.2 0.97
[34]
THLE CYP4F3
Mean 0.0175
Standard deviation 0.017
Values 0.03 0.0053
[35]
liver CYP4F3
Mean 88.9
Standard deviation 26
Values 68 1.2e+02 95 70
[36]
ref_hepatocyte CYP4F12
Mean 7.85
Standard deviation 7.8
Values 11 0.13 0.73 8.4 19
[37]
HepG2 CYP4F12
Mean 2.67
Standard deviation 0.39
Values 2.9 2.4
[38]
HepG2.C3A CYP4F12
Mean 5.98
Standard deviation 2.1
Values 7.5 4.5
[39]
HuH.7 CYP4F12
Mean 13
Standard deviation 3.4
Values 9.3 16 14
[40]
SNU475 CYP4F12
Mean 0.47
Standard deviation 0.47
Values 0.8 0.14
[41]
THLE CYP4F12
Mean 0.0316
Standard deviation 0.022
Values 0.047 0.016
[42]
liver CYP4F12
Mean 12.8
Standard deviation 14
Values 34 5.3 8.3 3.9
[43]
ref_hepatocyte CYP4A22
Mean 3.13
Standard deviation 4
Values 0 0.14 0.49 7.2 7.8
[44]
HepG2 CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[45]
HepG2.C3A CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[46]
HuH.7 CYP4A22
Mean 0
Standard deviation 0
Values 0 0 0
[47]
SNU475 CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[48]
THLE CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[49]
liver CYP4A22
Mean 21.4
Standard deviation 17
Values 46 6.3 15 18
[50]
ref_hepatocyte CYP4F22
Mean 2.74
Standard deviation 3.4
Values 0 0.23 8.2 3.5 1.8
[51]
HepG2 CYP4F22
Mean 0.103
Standard deviation 0.15
Values 0.21 0
[52]
HepG2.C3A CYP4F22
Mean 0
Standard deviation 0
Values 0 0
[53]
HuH.7 CYP4F22
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[54]
SNU475 CYP4F22
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[55]
THLE CYP4F22
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[56]
liver CYP4F22
Mean 1.99
Standard deviation 1.8
Values 4.7 0.59 1.6 1.1
[57]
ref_hepatocyte TBXAS1
Mean 0.896
Standard deviation 0.62
Values 0.56 0.49 0.32 1.7 1.4
[58]
HepG2 TBXAS1
Mean 0.253
Standard deviation 0.096
Values 0.32 0.18
[59]
HepG2.C3A TBXAS1
Mean 0.938
Standard deviation 0.16
Values 1 0.83
[60]
HuH.7 TBXAS1
Mean 0.0986
Standard deviation 0.058
Values 0.12 0.032 0.14
[61]
SNU475 TBXAS1
Mean 2.57
Standard deviation 0.093
Values 2.5 2.6
[62]
THLE TBXAS1
Mean 1.05
Standard deviation 0.095
Values 1.1 0.98
[63]
liver TBXAS1
Mean 4
Standard deviation 1.4
Values 2.1 4.8 4.1 5.1
[64]
ref_hepatocyte PTGIS
Mean 0.218
Standard deviation 0.14
Values 0.14 0.08 0.32 0.4 0.15
[65]
HepG2 PTGIS
Mean 0.163
Standard deviation 0.012
Values 0.17 0.15
[66]
HepG2.C3A PTGIS
Mean 0.316
Standard deviation 0.0069
Values 0.32 0.31
[67]
HuH.7 PTGIS
Mean 4.77
Standard deviation 0.64
Values 5.5 4.3 4.5
[68]
SNU475 PTGIS
Mean 0.868
Standard deviation 0.11
Values 0.79 0.94
[69]
THLE PTGIS
Mean 59.9
Standard deviation 32
Values 37 82
[70]
liver PTGIS
Mean 8.86
Standard deviation 2.8
Values 5.9 11 12 7.1
[71]
ref_hepatocyte CYP4B1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[72]
HepG2 CYP4B1
Mean 0.00501
Standard deviation 0.001
Values 0.0057 0.0043
[73]
HepG2.C3A CYP4B1
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 CYP4B1
Mean 0
Standard deviation 0
Values 0 0 0
[75]
SNU475 CYP4B1
Mean 0.0177
Standard deviation 0.025
Values 0 0.035
[76]
THLE CYP4B1
Mean 0.129
Standard deviation 0.077
Values 0.18 0.074
[77]
liver CYP4B1
Mean 0.0575
Standard deviation 0.045
Values 0.047 0 0.077 0.11
[78]
ref_hepatocyte CYP4F8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[79]
HepG2 CYP4F8
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[80]
HepG2.C3A CYP4F8
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 CYP4F8
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[82]
SNU475 CYP4F8
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[83]
THLE CYP4F8
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[84]
liver CYP4F8
Mean 0
Standard deviation 0
Values 0 0 0 0