REACTOME_EGFR_DOWNREGULATION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.67[2] | -0.97[3] | -0.83[4] | -0.99[5] | -0.62[6] | -0.31[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.23[16] | -0.22[17] | -0.47[18] | -0.14[19] | -0.25[20] | 0.15[21] |
4 | CDC42 | Cell division control protein 42 homolog | [22] | 0.70[23] | 1.32[24] | 0.30[25] | 1.25[26] | 0.44[27] | -0.51[28] |
5 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [29] | 2.21[30] | 2.02[31] | 3.04[32] | 1.26[33] | 1.98[34] | 0.92[35] |
6 | EPN1 | Epsin-1 | [36] | 1.55[37] | 1.09[38] | 1.17[39] | 1.21[40] | 1.54[41] | 0.81[42] |
7 | GRB2 | Growth factor receptor-bound protein 2 | [43] | 2.72[44] | 2.46[45] | 2.57[46] | 2.34[47] | 2.16[48] | 1.87[49] |
8 | HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate | [50] | 2.43[51] | 1.83[52] | 1.29[53] | 2.28[54] | 2.11[55] | 0.80[56] |
9 | SH3GL1 | Endophilin-A2 | [57] | 2.60[58] | 2.89[59] | 2.04[60] | 2.32[61] | 2.57[62] | 1.14[63] |
10 | PTPN12 | Tyrosine-protein phosphatase non-receptor type 12 | [64] | 2.31[65] | 2.59[66] | 1.54[67] | 3.54[68] | 2.53[69] | 1.12[70] |
11 | PTPRK | Receptor-type tyrosine-protein phosphatase kappa | [71] | 2.72[72] | 3.58[73] | 3.09[74] | 2.39[75] | 2.01[76] | 3.70[77] |
12 | PTPN3 | Tyrosine-protein phosphatase non-receptor type 3 | [78] | 1.93[79] | 2.10[80] | 2.33[81] | 1.50[82] | 2.32[83] | 4.13[84] |
13 | EGFR | Epidermal growth factor receptor | [85] | 0.83[86] | 0.36[87] | 3.23[88] | 2.22[89] | 2.75[90] | 4.22[91] |
14 | AREG | Amphiregulin | [92] | -1.33[93] | -4.67[94] | -6.45[95] | -7.91[96] | 2.30[97] | -8.74[98] |
15 | EPS15 | Epidermal growth factor receptor substrate 15 | [99] | 1.67[100] | 2.45[101] | 2.72[102] | 3.38[103] | 2.81[104] | 3.82[105] |
16 | STAM | Signal transducing adapter molecule 1 | [106] | 2.58[107] | 2.93[108] | 1.96[109] | 3.48[110] | 2.69[111] | 1.33[112] |
17 | STAM2 | Signal transducing adapter molecule 2 | [113] | 1.79[114] | 2.48[115] | 1.58[116] | 3.35[117] | 2.54[118] | 2.77[119] |
18 | SH3KBP1 | SH3 domain-containing kinase-binding protein 1 | [120] | 3.12[121] | 2.89[122] | 3.61[123] | 3.58[124] | 3.97[125] | 2.05[126] |
19 | EPS15L1 | Epidermal growth factor receptor substrate 15-like 1 | [127] | 2.46[128] | 2.21[129] | 2.98[130] | 2.21[131] | 2.84[132] | 1.87[133] |
20 | SPRY2 | Protein sprouty homolog 2 | [134] | 0.93[135] | 0.99[136] | 3.39[137] | -0.48[138] | 1.45[139] | 1.74[140] |
21 | ARHGEF7 | Rho guanine nucleotide exchange factor 7 | [141] | 3.15[142] | 3.04[143] | 2.88[144] | 3.60[145] | 3.26[146] | 3.92[147] |
22 | TGFA | Protransforming growth factor alpha | [148] | 3.32[149] | 4.29[150] | -6.78[151] | 0.83[152] | -0.49[153] | 1.18[154] |
23 | HBEGF | Proheparin-binding EGF-like growth factor | [155] | 0.54[156] | -0.37[157] | -1.45[158] | 2.09[159] | 1.69[160] | -0.86[161] |
24 | BTC | Probetacellulin | [162] | -6.61[163] | -7.10[164] | -2.89[165] | -1.09[166] | -1.21[167] | -1.35[168] |
25 | SPRY1 | Protein sprouty homolog 1 | [169] | 3.77[170] | 4.53[171] | 4.20[172] | 2.13[173] | 3.76[174] | 3.64[175] |
26 | CBL | E3 ubiquitin-protein ligase CBL | [176] | 5.98[177] | 4.82[178] | 5.03[179] | 6.92[180] | 6.31[181] | 5.33[182] |
27 | EREG | Proepiregulin | [183] | 3.28[184] | 3.11[185] | -1.32[186] | 0.22[187] | 5.38[188] | 0.10[189] |
28 | SH3GL2 | Endophilin-A1 | [190] | -0.73[191] | [192] | -3.63[193] | 2.80[194] | 1.48[195] | 1.76[196] |
29 | EGF | Pro-epidermal growth factor | [197] | 3.50[198] | 5.19[199] | 8.79[200] | 10.81[201] | 8.14[202] | 3.15[203] |
30 | SH3GL3 | Endophilin-A3 | [204] | [205] | [206] | [207] | [208] | [209] | [210] |
31 | EPGN | Epigen | [211] | [212] | [213] | [214] | [215] | [216] | [217] |