REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0.14[1] -0.37[2] -0.31[3] 0.21[4] -0.64[5] -0.53[6]
2 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform -0.39[7] -0.63[8] -1.12[9] -0.25[10] -0.32[11] -0.78[12]
3 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform -1.05[13] -1.73[14] -1.51[15] -1.45[16] -1.74[17] -1.66[18]
4 TFDP1 Transcription factor Dp-1 [19] 0.00[20] -1.00[21] -0.80[22] -0.39[23] 0.01[24] -1.82[25]
5 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform -0.21[26] -1.07[27] -0.52[28] -0.72[29] -1.12[30] 2.26[31]
6 CCNB1 G2/mitotic-specific cyclin-B1 [32] 1.19[33] 1.08[34] 1.40[35] 0.61[36] 1.41[37] -3.02[38]
7 ORC4 Origin recognition complex subunit 4 [39] -0.60[40] 0.24[41] 0.10[42] 0.38[43] -0.55[44] 2.30[45]
8 ORC5 Origin recognition complex subunit 5 [46] -1.64[47] -1.63[48] -0.91[49] -1.14[50] -1.56[51] -0.85[52]
9 CDK1 Cyclin-dependent kinase 1 [53] 0.59[54] 2.32[55] 1.19[56] 1.27[57] 1.91[58] -3.14[59]
10 ORC2 Origin recognition complex subunit 2 [60] -0.20[61] 0.42[62] 0.29[63] -0.69[64] -0.58[65] -1.11[66]
11 ORC6 Origin recognition complex subunit 6 [67] 0.10[68] 0.32[69] -0.31[70] -0.21[71] -0.14[72] -4.37[73]
12 ORC3 Origin recognition complex subunit 3 [74] -0.58[75] 0.29[76] 0.57[77] -0.45[78] 0.34[79] -0.42[80]
13 RB1 Retinoblastoma-associated protein [81] 0.56[82] 0.72[83] 1.42[84] 1.28[85] 1.42[86] 0.80[87]
14 E2F1 Transcription factor E2F1 [88] 1.29[89] 0.81[90] 1.07[91] 0.87[92] 1.13[93] -4.29[94]
15 POLA2 DNA polymerase alpha subunit B [95] -0.02[96] -0.72[97] -0.02[98] 0.52[99] 0.64[100] -1.51[101]
16 PRIM1 DNA primase small subunit [102] 0.01[103] 1.00[104] 1.47[105] 0.17[106] 0.57[107] -1.58[108]
17 PRIM2 DNA primase large subunit [109] 0.62[110] 0.09[111] -0.16[112] 0.19[113] 0.25[114] -2.26[115]
18 TFDP2 Transcription factor Dp-2 [116] 1.25[117] 1.60[118] 1.76[119] 1.39[120] 1.44[121] 1.68[122]
19 MCM8 DNA helicase MCM8 [123] 1.53[124] 1.91[125] 1.33[126] 1.61[127] 0.98[128] -1.04[129]
20 ORC1 Origin recognition complex subunit 1 [130] 0.89[131] 0.58[132] 2.23[133] 0.28[134] 0.67[135] -2.78[136]
21 PPP2R3B Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [137] [138] [139] [140] [141] [142]
22 POLA1 DNA polymerase alpha catalytic subunit [143] 1.35[144] 1.12[145] 1.82[146] 1.99[147] 1.78[148] 0.99[149]
[1]
ref_hepatocyte PPP2R1A
Mean 27.9
Standard deviation 5.4
Values 23 30 23 36 28
[2]
HepG2 PPP2R1A
Mean 107
Standard deviation 6.5
Values 1.1e+02 1e+02
[3]
HepG2.C3A PPP2R1A
Mean 84.7
Standard deviation 12
Values 93 76
[4]
HuH.7 PPP2R1A
Mean 77.2
Standard deviation 6.8
Values 84 70 78
[5]
SNU475 PPP2R1A
Mean 118
Standard deviation 14
Values 1.3e+02 1.1e+02
[6]
THLE PPP2R1A
Mean 83.3
Standard deviation 16
Values 72 94
[7]
liver PPP2R1A
Mean 43.9
Standard deviation 17
Values 51 30 65 30
[8]
ref_hepatocyte PPP2CA
Mean 27.3
Standard deviation 6.4
Values 27 38 22 24 25
[9]
HepG2 PPP2CA
Mean 72.8
Standard deviation 15
Values 62 83
[10]
HepG2.C3A PPP2CA
Mean 69.2
Standard deviation 19
Values 55 83
[11]
HuH.7 PPP2CA
Mean 42.8
Standard deviation 4.9
Values 43 38 48
[12]
SNU475 PPP2CA
Mean 83.9
Standard deviation 4.1
Values 81 87
[13]
THLE PPP2CA
Mean 102
Standard deviation 13
Values 92 1.1e+02
[14]
liver PPP2CA
Mean 36.1
Standard deviation 13
Values 49 27 46 23
[15]
ref_hepatocyte PPP2CB
Mean 25.5
Standard deviation 11
Values 15 43 27 17 26
[16]
HepG2 PPP2CB
Mean 43
Standard deviation 1.5
Values 44 42
[17]
HepG2.C3A PPP2CB
Mean 30.2
Standard deviation 0.78
Values 31 30
[18]
HuH.7 PPP2CB
Mean 30.6
Standard deviation 2.8
Values 28 34 30
[19]
SNU475 PPP2CB
Mean 34.2
Standard deviation 0.1
Values 34 34
[20]
THLE PPP2CB
Mean 35.7
Standard deviation 2.6
Values 37 34
[21]
liver PPP2CB
Mean 18.3
Standard deviation 7.2
Values 28 14 19 12
[22]
ref_hepatocyte TFDP1
Mean 14.3
Standard deviation 8.3
Values 23 24 5.8 10 9.4
[23]
HepG2 TFDP1
Mean 50.2
Standard deviation 7.6
Values 45 56
[24]
HepG2.C3A TFDP1
Mean 28.1
Standard deviation 13
Values 19 38
[25]
HuH.7 TFDP1
Mean 28.3
Standard deviation 13
Values 35 13 37
[26]
SNU475 TFDP1
Mean 40
Standard deviation 3.2
Values 42 38
[27]
THLE TFDP1
Mean 67
Standard deviation 13
Values 58 76
[28]
liver TFDP1
Mean 9.23
Standard deviation 0.4
Values 9.3 9.6 8.7 9.3
[29]
ref_hepatocyte PPP2R1B
Mean 12
Standard deviation 3.3
Values 7 14 11 15 13
[30]
HepG2 PPP2R1B
Mean 36.3
Standard deviation 12
Values 27 45
[31]
HepG2.C3A PPP2R1B
Mean 22.5
Standard deviation 5.6
Values 19 26
[32]
HuH.7 PPP2R1B
Mean 28.7
Standard deviation 4.1
Values 32 30 24
[33]
SNU475 PPP2R1B
Mean 26.6
Standard deviation 1.2
Values 26 27
[34]
THLE PPP2R1B
Mean 25.6
Standard deviation 5.7
Values 22 30
[35]
liver PPP2R1B
Mean 130
Standard deviation 78
Values 52 1.6e+02 82 2.2e+02
[36]
ref_hepatocyte CCNB1
Mean 8.2
Standard deviation 8.6
Values 15 20 1.8 3.1 1.3
[37]
HepG2 CCNB1
Mean 65.1
Standard deviation 21
Values 50 80
[38]
HepG2.C3A CCNB1
Mean 68.3
Standard deviation 39
Values 41 96
[39]
HuH.7 CCNB1
Mean 74.2
Standard deviation 37
Values 87 33 1e+02
[40]
SNU475 CCNB1
Mean 45.8
Standard deviation 3.3
Values 48 44
[41]
THLE CCNB1
Mean 101
Standard deviation 30
Values 80 1.2e+02
[42]
liver CCNB1
Mean 2.29
Standard deviation 1.6
Values 2.3 2.4 4.2 0.28
[43]
ref_hepatocyte ORC4
Mean 7.34
Standard deviation 1.8
Values 9.4 4.6 8.6 6.9 7.2
[44]
HepG2 ORC4
Mean 16.9
Standard deviation 4.9
Values 13 20
[45]
HepG2.C3A ORC4
Mean 34.1
Standard deviation 8.3
Values 28 40
[46]
HuH.7 ORC4
Mean 27
Standard deviation 4
Values 28 31 23
[47]
SNU475 ORC4
Mean 34.9
Standard deviation 3.4
Values 32 37
[48]
THLE ORC4
Mean 23.3
Standard deviation 2.6
Values 25 21
[49]
liver ORC4
Mean 81.8
Standard deviation 55
Values 38 1.4e+02 33 1.2e+02
[50]
ref_hepatocyte ORC5
Mean 6.5
Standard deviation 1.9
Values 3.5 7.8 7.3 8.2 5.7
[51]
HepG2 ORC5
Mean 7.28
Standard deviation 2.2
Values 5.8 8.8
[52]
HepG2.C3A ORC5
Mean 8.23
Standard deviation 4.9
Values 4.8 12
[53]
HuH.7 ORC5
Mean 11.8
Standard deviation 2.5
Values 13 9 14
[54]
SNU475 ORC5
Mean 10.8
Standard deviation 1.4
Values 9.8 12
[55]
THLE ORC5
Mean 10.3
Standard deviation 0.9
Values 9.6 11
[56]
liver ORC5
Mean 8.17
Standard deviation 1.7
Values 7.3 8.1 11 6.7
[57]
ref_hepatocyte CDK1
Mean 5.78
Standard deviation 6.9
Values 13 14 0.06 1.6 0.72
[58]
HepG2 CDK1
Mean 30.4
Standard deviation 14
Values 21 40
[59]
HepG2.C3A CDK1
Mean 113
Standard deviation 85
Values 53 1.7e+02
[60]
HuH.7 CDK1
Mean 45.1
Standard deviation 21
Values 55 21 60
[61]
SNU475 CDK1
Mean 51.1
Standard deviation 5
Values 48 55
[62]
THLE CDK1
Mean 101
Standard deviation 11
Values 93 1.1e+02
[63]
liver CDK1
Mean 1.48
Standard deviation 1.4
Values 1 1.4 3.4 0.013
[64]
ref_hepatocyte ORC2
Mean 5.18
Standard deviation 5.6
Values 14 7.4 2.6 0.85 0.94
[65]
HepG2 ORC2
Mean 15.7
Standard deviation 4.5
Values 13 19
[66]
HepG2.C3A ORC2
Mean 27.2
Standard deviation 6.2
Values 23 32
[67]
HuH.7 ORC2
Mean 21.7
Standard deviation 4
Values 24 17 24
[68]
SNU475 ORC2
Mean 11.7
Standard deviation 1.6
Values 13 11
[69]
THLE ORC2
Mean 16.1
Standard deviation 1.1
Values 15 17
[70]
liver ORC2
Mean 5.45
Standard deviation 2.1
Values 6.1 5.5 2.6 7.7
[71]
ref_hepatocyte ORC6
Mean 4.29
Standard deviation 5.9
Values 14 6.1 0.59 0.53 0.4
[72]
HepG2 ORC6
Mean 16
Standard deviation 4.8
Values 13 19
[73]
HepG2.C3A ORC6
Mean 21.1
Standard deviation 15
Values 11 32
[74]
HuH.7 ORC6
Mean 11.8
Standard deviation 5.5
Values 12 6.2 17
[75]
SNU475 ORC6
Mean 13.6
Standard deviation 0.87
Values 13 14
[76]
THLE ORC6
Mean 18.1
Standard deviation 2.6
Values 16 20
[77]
liver ORC6
Mean 0.47
Standard deviation 0.32
Values 0.26 0.46 0.92 0.24
[78]
ref_hepatocyte ORC3
Mean 3.83
Standard deviation 0.95
Values 4.8 3 4.9 3.1 3.3
[79]
HepG2 ORC3
Mean 8.96
Standard deviation 5.2
Values 5.3 13
[80]
HepG2.C3A ORC3
Mean 18.4
Standard deviation 9
Values 12 25
[81]
HuH.7 ORC3
Mean 19.5
Standard deviation 5.8
Values 24 13 21
[82]
SNU475 ORC3
Mean 10.2
Standard deviation 0.75
Values 9.7 11
[83]
THLE ORC3
Mean 22.5
Standard deviation 0.42
Values 23 22
[84]
liver ORC3
Mean 6.5
Standard deviation 1.7
Values 6.9 6.4 8.4 4.3
[85]
ref_hepatocyte RB1
Mean 3.07
Standard deviation 1.4
Values 5 3.8 3 1.4 2.2
[86]
HepG2 RB1
Mean 15.8
Standard deviation 7.9
Values 10 21
[87]
HepG2.C3A RB1
Mean 19.9
Standard deviation 6.1
Values 16 24
[88]
HuH.7 RB1
Mean 28.2
Standard deviation 3.3
Values 32 25 28
[89]
SNU475 RB1
Mean 27.3
Standard deviation 0.91
Values 28 27
[90]
THLE RB1
Mean 38.3
Standard deviation 1.7
Values 37 40
[91]
liver RB1
Mean 12.1
Standard deviation 2.2
Values 12 14 13 9
[92]
ref_hepatocyte E2F1
Mean 2.5
Standard deviation 3.1
Values 7.9 2.2 0.64 1.2 0.54
[93]
HepG2 E2F1
Mean 21.3
Standard deviation 1.8
Values 20 23
[94]
HepG2.C3A E2F1
Mean 17.2
Standard deviation 4.9
Values 14 21
[95]
HuH.7 E2F1
Mean 18
Standard deviation 12
Values 21 5.1 28
[96]
SNU475 E2F1
Mean 16.7
Standard deviation 4.8
Values 13 20
[97]
THLE E2F1
Mean 25.4
Standard deviation 2.4
Values 24 27
[98]
liver E2F1
Mean 0.29
Standard deviation 0.19
Values 0.12 0.49 0.41 0.15
[99]
ref_hepatocyte POLA2
Mean 2.46
Standard deviation 0.96
Values 1.8 2.8 3.9 2.3 1.5
[100]
HepG2 POLA2
Mean 8.49
Standard deviation 2.2
Values 6.9 10
[101]
HepG2.C3A POLA2
Mean 5.87
Standard deviation 3.6
Values 3.3 8.4
[102]
HuH.7 POLA2
Mean 8.32
Standard deviation 5.1
Values 11 2.5 11
[103]
SNU475 POLA2
Mean 12.9
Standard deviation 3.1
Values 11 15
[104]
THLE POLA2
Mean 17.9
Standard deviation 4
Values 15 21
[105]
liver POLA2
Mean 1.96
Standard deviation 0.6
Values 1.2 1.9 2.6 2.2
[106]
ref_hepatocyte PRIM1
Mean 2.43
Standard deviation 1.4
Values 4.4 2.6 0.57 2.6 1.9
[107]
HepG2 PRIM1
Mean 8.54
Standard deviation 0.87
Values 7.9 9.2
[108]
HepG2.C3A PRIM1
Mean 19.1
Standard deviation 8.1
Values 13 25
[109]
HuH.7 PRIM1
Mean 23.1
Standard deviation 6.2
Values 27 16 26
[110]
SNU475 PRIM1
Mean 9.98
Standard deviation 3.1
Values 7.8 12
[111]
THLE PRIM1
Mean 16.8
Standard deviation 2.1
Values 15 18
[112]
liver PRIM1
Mean 1.84
Standard deviation 0.34
Values 2.1 1.6 2.1 1.5
[113]
ref_hepatocyte PRIM2
Mean 2.32
Standard deviation 2.3
Values 6.1 2.9 0.46 1.4 0.78
[114]
HepG2 PRIM2
Mean 12.4
Standard deviation 3.6
Values 9.9 15
[115]
HepG2.C3A PRIM2
Mean 9.66
Standard deviation 4.4
Values 6.5 13
[116]
HuH.7 PRIM2
Mean 7.1
Standard deviation 1.5
Values 7.8 5.4 8.1
[117]
SNU475 PRIM2
Mean 9.65
Standard deviation 1.6
Values 8.5 11
[118]
THLE PRIM2
Mean 12.8
Standard deviation 1.5
Values 12 14
[119]
liver PRIM2
Mean 1.1
Standard deviation 0.41
Values 0.68 1.5 0.82 1.4
[120]
ref_hepatocyte TFDP2
Mean 1.97
Standard deviation 0.83
Values 3.4 2.1 1.3 1.4 1.7
[121]
HepG2 TFDP2
Mean 16.3
Standard deviation 2.5
Values 15 18
[122]
HepG2.C3A TFDP2
Mean 23.5
Standard deviation 2.1
Values 22 25
[123]
HuH.7 TFDP2
Mean 22.8
Standard deviation 3.1
Values 26 20 22
[124]
SNU475 TFDP2
Mean 18.9
Standard deviation 4.1
Values 22 16
[125]
THLE TFDP2
Mean 24.9
Standard deviation 1.2
Values 24 26
[126]
liver TFDP2
Mean 14.3
Standard deviation 3.4
Values 17 14 9.6 16
[127]
ref_hepatocyte MCM8
Mean 1.68
Standard deviation 1.7
Values 3.8 3.2 0.45 0.49 0.46
[128]
HepG2 MCM8
Mean 16.9
Standard deviation 9.8
Values 10 24
[129]
HepG2.C3A MCM8
Mean 24.7
Standard deviation 16
Values 14 36
[130]
HuH.7 MCM8
Mean 14.5
Standard deviation 7.7
Values 22 6.3 15
[131]
SNU475 MCM8
Mean 18.7
Standard deviation 3.3
Values 16 21
[132]
THLE MCM8
Mean 15.3
Standard deviation 1.1
Values 15 16
[133]
liver MCM8
Mean 1.84
Standard deviation 1.3
Values 0.8 3.4 0.82 2.3
[134]
ref_hepatocyte ORC1
Mean 1.51
Standard deviation 1.9
Values 4.6 1.8 0.38 0.4 0.31
[135]
HepG2 ORC1
Mean 9.76
Standard deviation 4.5
Values 6.6 13
[136]
HepG2.C3A ORC1
Mean 8.91
Standard deviation 3.7
Values 6.3 11
[137]
HuH.7 ORC1
Mean 24.2
Standard deviation 9.6
Values 31 13 29
[138]
SNU475 ORC1
Mean 6.72
Standard deviation 3.5
Values 4.2 9.2
[139]
THLE ORC1
Mean 11.2
Standard deviation 2.9
Values 9.2 13
[140]
liver ORC1
Mean 0.5
Standard deviation 0.15
Values 0.47 0.56 0.67 0.3
[141]
ref_hepatocyte PPP2R3B
Mean 1.4
Standard deviation 0.74
Values 2.3 0.82 2.1 0.99 0.8
[142]
HepG2 PPP2R3B
Missing
[143]
HepG2.C3A PPP2R3B
Missing
[144]
HuH.7 PPP2R3B
Missing
[145]
SNU475 PPP2R3B
Missing
[146]
THLE PPP2R3B
Missing
[147]
liver PPP2R3B
Missing
[148]
ref_hepatocyte POLA1
Mean 0.985
Standard deviation 0.81
Values 1.8 2 0.27 0.52 0.41
[149]
HepG2 POLA1
Mean 8.75
Standard deviation 4.7
Values 5.4 12
[150]
HepG2.C3A POLA1
Mean 8.42
Standard deviation 3.5
Values 5.9 11
[151]
HuH.7 POLA1
Mean 11.9
Standard deviation 5.3
Values 17 6.3 13
[152]
SNU475 POLA1
Mean 14.3
Standard deviation 5.6
Values 10 18
[153]
THLE POLA1
Mean 15.7
Standard deviation 1.1
Values 15 17
[154]
liver POLA1
Mean 4.45
Standard deviation 2.4
Values 1.9 7.6 3.5 4.8