REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CCNB1 G2/mitotic-specific cyclin-B1 [1] 0.91[2] 0.19[3] 0.68[4] 0.28[5] 0.78[6] -3.13[7]
2 ORC4 Origin recognition complex subunit 4 [8] -0.88[9] -0.65[10] -0.62[11] 0.05[12] -1.18[13] 2.19[14]
3 ORC5 Origin recognition complex subunit 5 [15] -1.91[16] -2.53[17] -1.64[18] -1.47[19] -2.19[20] -0.96[21]
4 CDK1 Cyclin-dependent kinase 1 [22] 0.32[23] 1.42[24] 0.47[25] 0.94[26] 1.28[27] -3.26[28]
5 ORC2 Origin recognition complex subunit 2 [29] -0.47[30] -0.48[31] -0.43[32] -1.02[33] -1.21[34] -1.22[35]
6 ORC6 Origin recognition complex subunit 6 [36] -0.18[37] -0.58[38] -1.03[39] -0.53[40] -0.77[41] -4.49[42]
7 ORC3 Origin recognition complex subunit 3 [43] -0.85[44] -0.61[45] -0.15[46] -0.78[47] -0.29[48] -0.53[49]
8 MCM8 DNA helicase MCM8 [50] 1.26[51] 1.01[52] 0.61[53] 1.28[54] 0.35[55] -1.15[56]
9 ORC1 Origin recognition complex subunit 1 [57] 0.61[58] -0.31[59] 1.51[60] -0.05[61] 0.04[62] -2.89[63]
[1]
ref_hepatocyte CCNB1
Mean 8.2
Standard deviation 8.6
Values 15 20 1.8 3.1 1.3
[2]
HepG2 CCNB1
Mean 65.1
Standard deviation 21
Values 50 80
[3]
HepG2.C3A CCNB1
Mean 68.3
Standard deviation 39
Values 41 96
[4]
HuH.7 CCNB1
Mean 74.2
Standard deviation 37
Values 87 33 1e+02
[5]
SNU475 CCNB1
Mean 45.8
Standard deviation 3.3
Values 48 44
[6]
THLE CCNB1
Mean 101
Standard deviation 30
Values 80 1.2e+02
[7]
liver CCNB1
Mean 2.29
Standard deviation 1.6
Values 2.3 2.4 4.2 0.28
[8]
ref_hepatocyte ORC4
Mean 7.34
Standard deviation 1.8
Values 9.4 4.6 8.6 6.9 7.2
[9]
HepG2 ORC4
Mean 16.9
Standard deviation 4.9
Values 13 20
[10]
HepG2.C3A ORC4
Mean 34.1
Standard deviation 8.3
Values 28 40
[11]
HuH.7 ORC4
Mean 27
Standard deviation 4
Values 28 31 23
[12]
SNU475 ORC4
Mean 34.9
Standard deviation 3.4
Values 32 37
[13]
THLE ORC4
Mean 23.3
Standard deviation 2.6
Values 25 21
[14]
liver ORC4
Mean 81.8
Standard deviation 55
Values 38 1.4e+02 33 1.2e+02
[15]
ref_hepatocyte ORC5
Mean 6.5
Standard deviation 1.9
Values 3.5 7.8 7.3 8.2 5.7
[16]
HepG2 ORC5
Mean 7.28
Standard deviation 2.2
Values 5.8 8.8
[17]
HepG2.C3A ORC5
Mean 8.23
Standard deviation 4.9
Values 4.8 12
[18]
HuH.7 ORC5
Mean 11.8
Standard deviation 2.5
Values 13 9 14
[19]
SNU475 ORC5
Mean 10.8
Standard deviation 1.4
Values 9.8 12
[20]
THLE ORC5
Mean 10.3
Standard deviation 0.9
Values 9.6 11
[21]
liver ORC5
Mean 8.17
Standard deviation 1.7
Values 7.3 8.1 11 6.7
[22]
ref_hepatocyte CDK1
Mean 5.78
Standard deviation 6.9
Values 13 14 0.06 1.6 0.72
[23]
HepG2 CDK1
Mean 30.4
Standard deviation 14
Values 21 40
[24]
HepG2.C3A CDK1
Mean 113
Standard deviation 85
Values 53 1.7e+02
[25]
HuH.7 CDK1
Mean 45.1
Standard deviation 21
Values 55 21 60
[26]
SNU475 CDK1
Mean 51.1
Standard deviation 5
Values 48 55
[27]
THLE CDK1
Mean 101
Standard deviation 11
Values 93 1.1e+02
[28]
liver CDK1
Mean 1.48
Standard deviation 1.4
Values 1 1.4 3.4 0.013
[29]
ref_hepatocyte ORC2
Mean 5.18
Standard deviation 5.6
Values 14 7.4 2.6 0.85 0.94
[30]
HepG2 ORC2
Mean 15.7
Standard deviation 4.5
Values 13 19
[31]
HepG2.C3A ORC2
Mean 27.2
Standard deviation 6.2
Values 23 32
[32]
HuH.7 ORC2
Mean 21.7
Standard deviation 4
Values 24 17 24
[33]
SNU475 ORC2
Mean 11.7
Standard deviation 1.6
Values 13 11
[34]
THLE ORC2
Mean 16.1
Standard deviation 1.1
Values 15 17
[35]
liver ORC2
Mean 5.45
Standard deviation 2.1
Values 6.1 5.5 2.6 7.7
[36]
ref_hepatocyte ORC6
Mean 4.29
Standard deviation 5.9
Values 14 6.1 0.59 0.53 0.4
[37]
HepG2 ORC6
Mean 16
Standard deviation 4.8
Values 13 19
[38]
HepG2.C3A ORC6
Mean 21.1
Standard deviation 15
Values 11 32
[39]
HuH.7 ORC6
Mean 11.8
Standard deviation 5.5
Values 12 6.2 17
[40]
SNU475 ORC6
Mean 13.6
Standard deviation 0.87
Values 13 14
[41]
THLE ORC6
Mean 18.1
Standard deviation 2.6
Values 16 20
[42]
liver ORC6
Mean 0.47
Standard deviation 0.32
Values 0.26 0.46 0.92 0.24
[43]
ref_hepatocyte ORC3
Mean 3.83
Standard deviation 0.95
Values 4.8 3 4.9 3.1 3.3
[44]
HepG2 ORC3
Mean 8.96
Standard deviation 5.2
Values 5.3 13
[45]
HepG2.C3A ORC3
Mean 18.4
Standard deviation 9
Values 12 25
[46]
HuH.7 ORC3
Mean 19.5
Standard deviation 5.8
Values 24 13 21
[47]
SNU475 ORC3
Mean 10.2
Standard deviation 0.75
Values 9.7 11
[48]
THLE ORC3
Mean 22.5
Standard deviation 0.42
Values 23 22
[49]
liver ORC3
Mean 6.5
Standard deviation 1.7
Values 6.9 6.4 8.4 4.3
[50]
ref_hepatocyte MCM8
Mean 1.68
Standard deviation 1.7
Values 3.8 3.2 0.45 0.49 0.46
[51]
HepG2 MCM8
Mean 16.9
Standard deviation 9.8
Values 10 24
[52]
HepG2.C3A MCM8
Mean 24.7
Standard deviation 16
Values 14 36
[53]
HuH.7 MCM8
Mean 14.5
Standard deviation 7.7
Values 22 6.3 15
[54]
SNU475 MCM8
Mean 18.7
Standard deviation 3.3
Values 16 21
[55]
THLE MCM8
Mean 15.3
Standard deviation 1.1
Values 15 16
[56]
liver MCM8
Mean 1.84
Standard deviation 1.3
Values 0.8 3.4 0.82 2.3
[57]
ref_hepatocyte ORC1
Mean 1.51
Standard deviation 1.9
Values 4.6 1.8 0.38 0.4 0.31
[58]
HepG2 ORC1
Mean 9.76
Standard deviation 4.5
Values 6.6 13
[59]
HepG2.C3A ORC1
Mean 8.91
Standard deviation 3.7
Values 6.3 11
[60]
HuH.7 ORC1
Mean 24.2
Standard deviation 9.6
Values 31 13 29
[61]
SNU475 ORC1
Mean 6.72
Standard deviation 3.5
Values 4.2 9.2
[62]
THLE ORC1
Mean 11.2
Standard deviation 2.9
Values 9.2 13
[63]
liver ORC1
Mean 0.5
Standard deviation 0.15
Values 0.47 0.56 0.67 0.3