REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | STAT3 | Signal transducer and activator of transcription 3 | [1] | -0.26[2] | -1.72[3] | -1.03[4] | -0.83[5] | -1.21[6] | 1.22[7] |
2 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [8] | -0.37[9] | 0.11[10] | 0.01[11] | -0.19[12] | 0.79[13] | 0.07[14] |
3 | GRB2 | Growth factor receptor-bound protein 2 | [15] | 0.38[16] | 0.26[17] | 0.33[18] | -0.52[19] | -0.26[20] | -0.89[21] |
4 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [22] | -0.88[23] | -1.76[24] | -0.70[25] | 1.46[26] | -0.46[27] | -0.24[28] |
5 | CRK | Adapter molecule crk | [29] | -1.02[30] | -1.04[31] | -1.02[32] | -1.32[33] | -0.57[34] | -0.34[35] |
6 | STAT6 | Signal transducer and activator of transcription 6 | [36] | -0.46[37] | -0.18[38] | -1.32[39] | -0.23[40] | 0.02[41] | -0.49[42] |
7 | NRAS | GTPase NRas | [43] | -0.18[44] | 0.29[45] | 0.65[46] | -0.08[47] | -0.16[48] | -1.44[49] |
8 | HRAS | GTPase HRas | [50] | -1.82[51] | -2.49[52] | -3.33[53] | -2.02[54] | -1.89[55] | -3.85[56] |
9 | NCK1 | Cytoplasmic protein NCK1 | [57] | -2.41[58] | -2.26[59] | -2.20[60] | -1.64[61] | -1.18[62] | -1.66[63] |
10 | BCAR1 | Breast cancer anti-estrogen resistance protein 1 | [64] | 0.32[65] | 0.24[66] | -0.94[67] | 0.30[68] | 0.37[69] | -1.12[70] |
11 | KRAS | GTPase KRas | [71] | -1.33[72] | -1.31[73] | 0.24[74] | -0.27[75] | -0.27[76] | -0.51[77] |
12 | CRKL | Crk-like protein | [78] | 0.89[79] | 1.03[80] | 1.59[81] | 0.05[82] | 0.60[83] | 0.27[84] |
13 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [85] | -1.28[86] | -1.13[87] | -0.08[88] | 0.99[89] | 0.84[90] | 1.82[91] |
14 | SOS1 | Son of sevenless homolog 1 | [92] | -0.91[93] | 0.66[94] | 0.12[95] | -0.23[96] | -0.65[97] | -0.65[98] |
15 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [99] | 1.06[100] | 1.33[101] | 1.89[102] | -0.37[103] | 0.54[104] | -1.48[105] |
16 | RAPGEF1 | Rap guanine nucleotide exchange factor 1 | [106] | 1.28[107] | 1.15[108] | 0.82[109] | 0.18[110] | 0.20[111] | -0.01[112] |
17 | NCK2 | Cytoplasmic protein NCK2 | [113] | -0.02[114] | -0.39[115] | -2.02[116] | -1.40[117] | -0.31[118] | -2.01[119] |
18 | STAT5B | Signal transducer and activator of transcription 5B | [120] | 0.55[121] | 0.21[122] | 0.87[123] | 0.48[124] | -0.04[125] | 0.44[126] |
19 | SRC | Proto-oncogene tyrosine-protein kinase Src | [127] | 2.21[128] | 2.24[129] | 1.19[130] | 1.32[131] | 0.85[132] | -2.04[133] |
20 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 2.68[134] | 2.34[135] | 1.62[136] | 1.75[137] | 1.59[138] | -0.85[139] | |
21 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.40[140] | 0.95[141] | 1.06[142] | -0.02[143] | 0.48[144] | -0.03[145] | |
22 | RASA1 | Ras GTPase-activating protein 1 | [146] | -0.43[147] | 0.52[148] | 0.57[149] | 0.84[150] | 0.24[151] | 0.03[152] |
23 | STAT5A | Signal transducer and activator of transcription 5A | [153] | -2.76[154] | -1.55[155] | -2.52[156] | -1.92[157] | -0.81[158] | -0.95[159] |
24 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.19[160] | 0.49[161] | 0.63[162] | 0.05[163] | 0.61[164] | 0.73[165] | |
25 | GRB7 | Growth factor receptor-bound protein 7 | [166] | 1.59[167] | 1.95[168] | -0.92[169] | -3.72[170] | -2.65[171] | -1.51[172] |
26 | PDGFA | Platelet-derived growth factor subunit A | [173] | -1.82[174] | -1.56[175] | 0.47[176] | -1.42[177] | -1.98[178] | -1.94[179] |
27 | PDGFB | Platelet-derived growth factor subunit B | [180] | 2.24[181] | 2.15[182] | -0.71[183] | -1.01[184] | -1.09[185] | -0.81[186] |
28 | PDGFRA | Platelet-derived growth factor receptor alpha | [187] | -4.43[188] | -5.37[189] | 2.22[190] | -0.55[191] | 4.47[192] | 4.13[193] |
29 | PDGFRB | Platelet-derived growth factor receptor beta | [194] | 0.49[195] | 0.92[196] | -1.58[197] | 0.78[198] | 1.69[199] | 2.23[200] |