REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR4 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [1] -0.50[2] -0.27[3] -0.66[4] -0.24[5] 0.53[6] 0.29[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.25[9] -0.12[10] -0.34[11] -0.58[12] -0.52[13] -0.67[14]
3 SHC1 SHC-transforming protein 1 [15] 0.22[16] 0.23[17] -0.03[18] 1.52[19] 1.15[20] -0.19[21]
4 FGFR4 Fibroblast growth factor receptor 4 [22] 1.01[23] 1.14[24] 1.39[25] -5.36[26] -5.35[27] -0.47[28]
5 NRAS GTPase NRas [29] -0.32[30] -0.09[31] -0.02[32] -0.13[33] -0.42[34] -1.22[35]
6 HRAS GTPase HRas [36] -1.95[37] -2.86[38] -3.99[39] -2.08[40] -2.15[41] -3.63[42]
7 KLB Beta-klotho [43] -0.35[44] -0.72[45] 0.39[46] -7.10[47] -7.59[48] 0.58[49]
8 KRAS GTPase KRas [50] -1.46[51] -1.69[52] -0.43[53] -0.33[54] -0.53[55] -0.30[56]
9 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [57] -1.42[58] -1.51[59] -0.75[60] 0.94[61] 0.58[62] 2.03[63]
10 SOS1 Son of sevenless homolog 1 [64] -1.05[65] 0.28[66] -0.55[67] -0.29[68] -0.91[69] -0.43[70]
11 FGF2 Fibroblast growth factor 2 [71] -7.63[72] -7.58[73] -3.77[74] -0.20[75] 1.52[76] -2.63[77]
12 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 2.54[78] 1.96[79] 0.95[80] 1.69[81] 1.33[82] -0.63[83]
13 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.33[84] 0.11[85] -0.04[86] 0.00[87] 0.34[88] 0.94[89]
14 FRS2 Fibroblast growth factor receptor substrate 2 [90] 0.34[91] 1.23[92] 1.39[93] 1.77[94] 1.54[95] 2.37[96]
15 FRS3 Fibroblast growth factor receptor substrate 3 [97] -0.32[98] -0.69[99] -2.05[100] -0.84[101] -1.04[102] -1.88[103]
16 GAB1 GRB2-associated-binding protein 1 [104] 0.35[105] 1.24[106] 1.02[107] 0.80[108] 0.80[109] 1.90[110]
17 FGF1 Fibroblast growth factor 1 [111] -3.71[112] -3.13[113] -7.93[114] -0.54[115] 1.18[116] -0.93[117]
18 FGF19 Fibroblast growth factor 19 [118] -3.01[119] -2.06[120] 4.34[121] -0.30[122] -3.63[123] [124]
19 FGF8 Fibroblast growth factor 8 [125] -4.28[126] -4.13[127] 0.02[128] -3.05[129] [130] 1.72[131]
20 FGF18 Fibroblast growth factor 18 [132] 0.83[133] -3.49[134] -1.66[135] -0.51[136] 0.22[137] -0.39[138]
21 FGF9 Fibroblast growth factor 9 [139] 1.31[140] -2.55[141] [142] 1.65[143] -3.32[144] -0.87[145]
22 FGF4 Fibroblast growth factor 4 [146] [147] [148] [149] [150] [151] [152]
23 FGF16 Fibroblast growth factor 16 [153] [154] [155] [156] [157] [158] [159]
24 FGF20 Fibroblast growth factor 20 [160] [161] [162] [163] [164] [165] [166]
25 FGF23 Fibroblast growth factor 23 [167] [168] [169] [170] [171] [172] [173]
26 FGF17 Fibroblast growth factor 17 [174] [175] [176] [177] [178] [179] [180]
27 FGF6 Fibroblast growth factor 6 [181] [182] [183] [184] [185] [186] [187]
[1]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[2]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[3]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[4]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[5]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[6]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[7]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[16]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[17]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[18]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[19]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[20]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[21]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[22]
ref_hepatocyte FGFR4
Mean 15.1
Standard deviation 12
Values 30 2.5 2.2 18 23
[23]
HepG2 FGFR4
Mean 129
Standard deviation 13
Values 1.2e+02 1.4e+02
[24]
HepG2.C3A FGFR4
Mean 146
Standard deviation 22
Values 1.6e+02 1.3e+02
[25]
HuH.7 FGFR4
Mean 209
Standard deviation 68
Values 2.4e+02 1.3e+02 2.5e+02
[26]
SNU475 FGFR4
Mean 1.47
Standard deviation 0.43
Values 1.2 1.8
[27]
THLE FGFR4
Mean 1.51
Standard deviation 0.45
Values 1.8 1.2
[28]
liver FGFR4
Mean 30.3
Standard deviation 10
Values 43 18 31 29
[29]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[30]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[31]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[32]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[33]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[34]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[35]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[36]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[37]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[38]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[39]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[40]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[41]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[42]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[43]
ref_hepatocyte KLB
Mean 9.92
Standard deviation 12
Values 30 1.9 0.71 6.7 9.9
[44]
HepG2 KLB
Mean 33.1
Standard deviation 23
Values 17 49
[45]
HepG2.C3A KLB
Mean 26.3
Standard deviation 0.12
Values 26 26
[46]
HuH.7 KLB
Mean 68.9
Standard deviation 30
Values 57 1e+02 46
[47]
SNU475 KLB
Mean 0.292
Standard deviation 0.04
Values 0.32 0.26
[48]
THLE KLB
Mean 0.21
Standard deviation 0.004
Values 0.21 0.21
[49]
liver KLB
Mean 41.2
Standard deviation 7.6
Values 52 37 40 36
[50]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[51]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[52]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[53]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[54]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[55]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[56]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[57]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[58]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[59]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[60]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[61]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[62]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[63]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[64]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[65]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[66]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[67]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[68]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[69]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[70]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[71]
ref_hepatocyte FGF2
Mean 4.04
Standard deviation 6.5
Values 0.052 15 3.7 0.37 0.73
[72]
HepG2 FGF2
Mean 0.0866
Standard deviation 0.08
Values 0.14 0.03
[73]
HepG2.C3A FGF2
Mean 0.092
Standard deviation 0.0064
Values 0.087 0.097
[74]
HuH.7 FGF2
Mean 1.57
Standard deviation 0.89
Values 0.98 2.6 1.1
[75]
SNU475 FGF2
Mean 14.2
Standard deviation 1.3
Values 13 15
[76]
THLE FGF2
Mean 47.5
Standard deviation 0.66
Values 48 47
[77]
liver FGF2
Mean 1.81
Standard deviation 0.66
Values 1.9 2.5 0.9 2
[78]
ref_hepatocyte PLCG1
Mean 3.54
Standard deviation 4.5
Values 11 2.4 1.7 0.91 1.2
[79]
HepG2 PLCG1
Mean 87.8
Standard deviation 4.3
Values 91 85
[80]
HepG2.C3A PLCG1
Mean 60.1
Standard deviation 10
Values 67 53
[81]
HuH.7 PLCG1
Mean 36.2
Standard deviation 5.9
Values 40 30 39
[82]
SNU475 PLCG1
Mean 45.9
Standard deviation 1.9
Values 47 45
[83]
THLE PLCG1
Mean 36.2
Standard deviation 0.92
Values 36 37
[84]
liver PLCG1
Mean 6.36
Standard deviation 4.9
Values 2.3 8.9 2.2 12
[85]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[86]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[87]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[88]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[89]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[90]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[91]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[92]
ref_hepatocyte FRS2
Mean 1.15
Standard deviation 0.48
Values 1.3 1.9 0.69 0.74 1.2
[93]
HepG2 FRS2
Mean 6.18
Standard deviation 3
Values 4 8.3
[94]
HepG2.C3A FRS2
Mean 11.7
Standard deviation 4
Values 8.9 15
[95]
HuH.7 FRS2
Mean 15.9
Standard deviation 4.9
Values 16 21 11
[96]
SNU475 FRS2
Mean 15.7
Standard deviation 0.35
Values 16 15
[97]
THLE FRS2
Mean 13.6
Standard deviation 0.96
Values 14 13
[98]
liver FRS2
Mean 16.5
Standard deviation 3.3
Values 18 20 13 15
[99]
ref_hepatocyte FRS3
Mean 0.88
Standard deviation 0.75
Values 2 0.11 0.65 0.39 1.3
[100]
HepG2 FRS3
Mean 3
Standard deviation 0.84
Values 3.6 2.4
[101]
HepG2.C3A FRS3
Mean 2.38
Standard deviation 0.57
Values 2.8 2
[102]
HuH.7 FRS3
Mean 1.13
Standard deviation 0.22
Values 1.1 0.94 1.4
[103]
SNU475 FRS3
Mean 1.98
Standard deviation 0.18
Values 2.1 1.9
[104]
THLE FRS3
Mean 1.75
Standard deviation 0.21
Values 1.9 1.6
[105]
liver FRS3
Mean 0.666
Standard deviation 0.45
Values 1.1 0.26 0.98 0.3
[106]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[107]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[108]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[109]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[110]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[111]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[112]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[113]
ref_hepatocyte FGF1
Mean 0.126
Standard deviation 0.27
Values 0 0.6 0 0 0.024
[114]
HepG2 FGF1
Mean 0.0408
Standard deviation 0.04
Values 0.069 0.013
[115]
HepG2.C3A FGF1
Mean 0.0628
Standard deviation 0.048
Values 0.029 0.097
[116]
HuH.7 FGF1
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[117]
SNU475 FGF1
Mean 0.346
Standard deviation 0.077
Values 0.29 0.4
[118]
THLE FGF1
Mean 1.16
Standard deviation 0.44
Values 0.85 1.5
[119]
liver FGF1
Mean 0.184
Standard deviation 0.042
Values 0.14 0.21 0.15 0.23
[120]
ref_hepatocyte FGF19
Mean 0.122
Standard deviation 0.27
Values 0 0 0.61 0 0
[121]
HepG2 FGF19
Mean 0.0644
Standard deviation 0.0062
Values 0.069 0.06
[122]
HepG2.C3A FGF19
Mean 0.128
Standard deviation 0.0016
Values 0.13 0.13
[123]
HuH.7 FGF19
Mean 13.1
Standard deviation 3.4
Values 11 17 12
[124]
SNU475 FGF19
Mean 0.397
Standard deviation 0.15
Values 0.51 0.29
[125]
THLE FGF19
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[126]
liver FGF19
Mean 0
Standard deviation 0
Values 0 0 0 0
[127]
ref_hepatocyte FGF8
Mean 0.0195
Standard deviation 0.044
Values 0 0 0 0 0.098
[128]
HepG2 FGF8
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[129]
HepG2.C3A FGF8
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[130]
HuH.7 FGF8
Mean 0.105
Standard deviation 0.073
Values 0.19 0.051 0.075
[131]
SNU475 FGF8
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[132]
THLE FGF8
Mean 0
Standard deviation 0
Values 0 0
[133]
liver FGF8
Mean 0.18
Standard deviation 0.14
Values 0.047 0.34 0.077 0.25
[134]
ref_hepatocyte FGF18
Mean 0.0138
Standard deviation 0.031
Values 0 0 0 0.069 0
[135]
HepG2 FGF18
Mean 0.105
Standard deviation 0.039
Values 0.13 0.077
[136]
HepG2.C3A FGF18
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[137]
HuH.7 FGF18
Mean 0.0232
Standard deviation 0.02
Values 0 0.032 0.037
[138]
SNU475 FGF18
Mean 0.0388
Standard deviation 0.0024
Values 0.037 0.041
[139]
THLE FGF18
Mean 0.0657
Standard deviation 0.033
Values 0.089 0.043
[140]
liver FGF18
Mean 0.0294
Standard deviation 0.0072
Values 0.024 0.029 0.026 0.04
[141]
ref_hepatocyte FGF9
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[142]
HepG2 FGF9
Mean 0.0687
Standard deviation 9.1e-05
Values 0.069 0.069
[143]
HepG2.C3A FGF9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[144]
HuH.7 FGF9
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 FGF9
Mean 0.0822
Standard deviation 0.08
Values 0.14 0.025
[146]
THLE FGF9
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[147]
liver FGF9
Mean 0.00993
Standard deviation 0.02
Values 0 0 0 0.04
[148]
ref_hepatocyte FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 FGF4
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A FGF4
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 FGF4
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 FGF4
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[153]
THLE FGF4
Mean 0
Standard deviation 0
Values 0 0
[154]
liver FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0
[155]
ref_hepatocyte FGF16
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 FGF16
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A FGF16
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 FGF16
Mean 0
Standard deviation 0
Values 0 0 0
[159]
SNU475 FGF16
Mean 0
Standard deviation 0
Values 0 0
[160]
THLE FGF16
Mean 0
Standard deviation 0
Values 0 0
[161]
liver FGF16
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[162]
ref_hepatocyte FGF20
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 FGF20
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[164]
HepG2.C3A FGF20
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 FGF20
Mean 0
Standard deviation 0
Values 0 0 0
[166]
SNU475 FGF20
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[167]
THLE FGF20
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[168]
liver FGF20
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[169]
ref_hepatocyte FGF23
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 FGF23
Mean 0
Standard deviation 0
Values 0 0
[171]
HepG2.C3A FGF23
Mean 0
Standard deviation 0
Values 0 0
[172]
HuH.7 FGF23
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[173]
SNU475 FGF23
Mean 0
Standard deviation 0
Values 0 0
[174]
THLE FGF23
Mean 0
Standard deviation 0
Values 0 0
[175]
liver FGF23
Mean 0.68
Standard deviation 0.31
Values 0.59 0.67 1.1 0.36
[176]
ref_hepatocyte FGF17
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[177]
HepG2 FGF17
Mean 0.398
Standard deviation 0.15
Values 0.5 0.29
[178]
HepG2.C3A FGF17
Mean 1.23
Standard deviation 1.1
Values 2 0.46
[179]
HuH.7 FGF17
Mean 0.183
Standard deviation 0.2
Values 0.074 0.41 0.066
[180]
SNU475 FGF17
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[181]
THLE FGF17
Mean 0.0228
Standard deviation 0.0096
Values 0.03 0.016
[182]
liver FGF17
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[183]
ref_hepatocyte FGF6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[184]
HepG2 FGF6
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[185]
HepG2.C3A FGF6
Mean 0
Standard deviation 0
Values 0 0
[186]
HuH.7 FGF6
Mean 0
Standard deviation 0
Values 0 0 0
[187]
SNU475 FGF6
Mean 0
Standard deviation 0
Values 0 0
[188]
THLE FGF6
Mean 0
Standard deviation 0
Values 0 0
[189]
liver FGF6
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0