REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR3 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [1] | -0.56[2] | -0.26[3] | -0.46[4] | -0.43[5] | 0.34[6] | 0.31[7] |
2 | GRB2 | Growth factor receptor-bound protein 2 | [8] | 0.19[9] | -0.11[10] | -0.14[11] | -0.76[12] | -0.71[13] | -0.65[14] |
3 | SHC1 | SHC-transforming protein 1 | [15] | 0.16[16] | 0.24[17] | 0.17[18] | 1.34[19] | 0.96[20] | -0.17[21] |
4 | NRAS | GTPase NRas | [22] | -0.37[23] | -0.08[24] | 0.18[25] | -0.32[26] | -0.61[27] | -1.20[28] |
5 | HRAS | GTPase HRas | [29] | -2.01[30] | -2.85[31] | -3.79[32] | -2.26[33] | -2.34[34] | -3.61[35] |
6 | KRAS | GTPase KRas | [36] | -1.52[37] | -1.68[38] | -0.23[39] | -0.51[40] | -0.72[41] | -0.27[42] |
7 | FGFR3 | Fibroblast growth factor receptor 3 | [43] | 1.73[44] | 1.50[45] | 1.68[46] | -4.61[47] | -3.13[48] | -0.50[49] |
8 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [50] | -1.47[51] | -1.50[52] | -0.55[53] | 0.75[54] | 0.39[55] | 2.05[56] |
9 | SOS1 | Son of sevenless homolog 1 | [57] | -1.10[58] | 0.29[59] | -0.35[60] | -0.47[61] | -1.10[62] | -0.41[63] |
10 | FGF2 | Fibroblast growth factor 2 | [64] | -7.69[65] | -7.57[66] | -3.57[67] | -0.38[68] | 1.33[69] | -2.61[70] |
11 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 2.49[71] | 1.97[72] | 1.15[73] | 1.51[74] | 1.13[75] | -0.61[76] | |
12 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.38[77] | 0.12[78] | 0.16[79] | -0.19[80] | 0.15[81] | 0.97[82] | |
13 | FRS2 | Fibroblast growth factor receptor substrate 2 | [83] | 0.29[84] | 1.24[85] | 1.59[86] | 1.59[87] | 1.35[88] | 2.39[89] |
14 | FRS3 | Fibroblast growth factor receptor substrate 3 | [90] | -0.38[91] | -0.68[92] | -1.85[93] | -1.02[94] | -1.23[95] | -1.86[96] |
15 | GAB1 | GRB2-associated-binding protein 1 | [97] | 0.30[98] | 1.25[99] | 1.22[100] | 0.62[101] | 0.61[102] | 1.93[103] |
16 | FGF5 | Fibroblast growth factor 5 | [104] | -1.99[105] | -0.81[106] | -1.03[107] | 0.17[108] | -0.01[109] | 2.19[110] |
17 | FGF1 | Fibroblast growth factor 1 | [111] | -3.77[112] | -3.12[113] | -7.73[114] | -0.73[115] | 0.99[116] | -0.91[117] |
18 | FGF8 | Fibroblast growth factor 8 | [118] | -4.33[119] | -4.12[120] | 0.22[121] | -3.23[122] | [123] | 1.75[124] |
19 | FGF18 | Fibroblast growth factor 18 | [125] | 0.78[126] | -3.48[127] | -1.46[128] | -0.70[129] | 0.03[130] | -0.36[131] |
20 | FGF9 | Fibroblast growth factor 9 | [132] | 1.26[133] | -2.54[134] | [135] | 1.47[136] | -3.51[137] | -0.84[138] |
21 | FGF17 | Fibroblast growth factor 17 | [139] | [140] | [141] | [142] | [143] | [144] | [145] |
22 | FGF23 | Fibroblast growth factor 23 | [146] | [147] | [148] | [149] | [150] | [151] | [152] |
23 | FGF20 | Fibroblast growth factor 20 | [153] | [154] | [155] | [156] | [157] | [158] | [159] |
24 | FGF16 | Fibroblast growth factor 16 | [160] | [161] | [162] | [163] | [164] | [165] | [166] |
25 | FGF4 | Fibroblast growth factor 4 | [167] | [168] | [169] | [170] | [171] | [172] | [173] |