REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR2 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [1] | -0.31[2] | -0.07[3] | -0.27[4] | -0.50[5] | 0.28[6] | 0.22[7] |
2 | GRB2 | Growth factor receptor-bound protein 2 | [8] | 0.44[9] | 0.08[10] | 0.05[11] | -0.84[12] | -0.77[13] | -0.74[14] |
3 | SHC1 | SHC-transforming protein 1 | [15] | 0.40[16] | 0.43[17] | 0.36[18] | 1.26[19] | 0.90[20] | -0.26[21] |
4 | NRAS | GTPase NRas | [22] | -0.13[23] | 0.11[24] | 0.37[25] | -0.39[26] | -0.67[27] | -1.29[28] |
5 | HRAS | GTPase HRas | [29] | -1.77[30] | -2.66[31] | -3.61[32] | -2.34[33] | -2.40[34] | -3.70[35] |
6 | KRAS | GTPase KRas | [36] | -1.27[37] | -1.48[38] | -0.04[39] | -0.59[40] | -0.78[41] | -0.36[42] |
7 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [43] | -1.23[44] | -1.30[45] | -0.37[46] | 0.68[47] | 0.33[48] | 1.96[49] |
8 | SOS1 | Son of sevenless homolog 1 | [50] | -0.86[51] | 0.48[52] | -0.17[53] | -0.55[54] | -1.16[55] | -0.50[56] |
9 | FGF2 | Fibroblast growth factor 2 | [57] | -7.45[58] | -7.38[59] | -3.38[60] | -0.46[61] | 1.28[62] | -2.70[63] |
10 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 2.73[64] | 2.16[65] | 1.34[66] | 1.43[67] | 1.08[68] | -0.70[69] | |
11 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.14[70] | 0.31[71] | 0.34[72] | -0.26[73] | 0.10[74] | 0.88[75] | |
12 | FGFR2 | Fibroblast growth factor receptor 2 | [76] | -3.27[77] | -2.25[78] | 1.54[79] | 0.07[80] | -4.62[81] | 2.39[82] |
13 | FRS2 | Fibroblast growth factor receptor substrate 2 | [83] | 0.53[84] | 1.43[85] | 1.78[86] | 1.51[87] | 1.29[88] | 2.30[89] |
14 | FRS3 | Fibroblast growth factor receptor substrate 3 | [90] | -0.13[91] | -0.49[92] | -1.66[93] | -1.10[94] | -1.29[95] | -1.94[96] |
15 | GAB1 | GRB2-associated-binding protein 1 | [97] | 0.54[98] | 1.44[99] | 1.41[100] | 0.54[101] | 0.56[102] | 1.84[103] |
16 | FGF7 | Fibroblast growth factor 7 | [104] | -10.05[105] | -6.55[106] | [107] | -6.76[108] | -2.34[109] | -2.49[110] |
17 | FGF5 | Fibroblast growth factor 5 | [111] | -1.75[112] | -0.62[113] | -0.85[114] | 0.09[115] | -0.07[116] | 2.10[117] |
18 | FGF1 | Fibroblast growth factor 1 | [118] | -3.52[119] | -2.92[120] | -7.54[121] | -0.81[122] | 0.93[123] | -1.00[124] |
19 | FGF8 | Fibroblast growth factor 8 | [125] | -4.09[126] | -3.93[127] | 0.41[128] | -3.31[129] | [130] | 1.66[131] |
20 | FGF18 | Fibroblast growth factor 18 | [132] | 1.02[133] | -3.29[134] | -1.27[135] | -0.78[136] | -0.03[137] | -0.45[138] |
21 | FGF9 | Fibroblast growth factor 9 | [139] | 1.50[140] | -2.35[141] | [142] | 1.39[143] | -3.57[144] | -0.93[145] |
22 | FGF4 | Fibroblast growth factor 4 | [146] | [147] | [148] | [149] | [150] | [151] | [152] |
23 | FGF16 | Fibroblast growth factor 16 | [153] | [154] | [155] | [156] | [157] | [158] | [159] |
24 | FGF3 | Fibroblast growth factor 3 | [160] | [161] | [162] | [163] | [164] | [165] | [166] |
25 | FGF20 | Fibroblast growth factor 20 | [167] | [168] | [169] | [170] | [171] | [172] | [173] |
26 | FGF23 | Fibroblast growth factor 23 | [174] | [175] | [176] | [177] | [178] | [179] | [180] |
27 | FGF22 | Fibroblast growth factor 22 | [181] | [182] | [183] | [184] | [185] | [186] | [187] |
28 | FGF10 | Fibroblast growth factor 10 | [188] | [189] | [190] | [191] | [192] | [193] | [194] |
29 | FGF17 | Fibroblast growth factor 17 | [195] | [196] | [197] | [198] | [199] | [200] | [201] |
30 | FGF6 | Fibroblast growth factor 6 | [202] | [203] | [204] | [205] | [206] | [207] | [208] |