REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR1 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [1] | -0.42[2] | -0.07[3] | -0.40[4] | -0.60[5] | 0.18[6] | 0.29[7] |
2 | GRB2 | Growth factor receptor-bound protein 2 | [8] | 0.33[9] | 0.09[10] | -0.07[11] | -0.93[12] | -0.87[13] | -0.67[14] |
3 | SHC1 | SHC-transforming protein 1 | [15] | 0.30[16] | 0.44[17] | 0.23[18] | 1.17[19] | 0.80[20] | -0.19[21] |
4 | NRAS | GTPase NRas | [22] | -0.24[23] | 0.12[24] | 0.25[25] | -0.49[26] | -0.77[27] | -1.22[28] |
5 | HRAS | GTPase HRas | [29] | -1.87[30] | -2.66[31] | -3.73[32] | -2.43[33] | -2.50[34] | -3.63[35] |
6 | KRAS | GTPase KRas | [36] | -1.38[37] | -1.48[38] | -0.16[39] | -0.68[40] | -0.88[41] | -0.29[42] |
7 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [43] | -1.34[44] | -1.30[45] | -0.49[46] | 0.58[47] | 0.23[48] | 2.03[49] |
8 | SOS1 | Son of sevenless homolog 1 | [50] | -0.97[51] | 0.48[52] | -0.29[53] | -0.64[54] | -1.26[55] | -0.43[56] |
9 | FLRT3 | Leucine-rich repeat transmembrane protein FLRT3 | [57] | -2.49[58] | -8.47[59] | 1.00[60] | -1.26[61] | -3.26[62] | -0.80[63] |
10 | FGF2 | Fibroblast growth factor 2 | [64] | -7.55[65] | -7.38[66] | -3.51[67] | -0.55[68] | 1.17[69] | -2.63[70] |
11 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 2.62[71] | 2.16[72] | 1.21[73] | 1.34[74] | 0.97[75] | -0.63[76] | |
12 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.25[77] | 0.31[78] | 0.22[79] | -0.36[80] | -0.01[81] | 0.94[82] | |
13 | FRS2 | Fibroblast growth factor receptor substrate 2 | [83] | 0.42[84] | 1.44[85] | 1.65[86] | 1.42[87] | 1.19[88] | 2.37[89] |
14 | FRS3 | Fibroblast growth factor receptor substrate 3 | [90] | -0.24[91] | -0.49[92] | -1.79[93] | -1.19[94] | -1.39[95] | -1.88[96] |
15 | FGFR1 | Fibroblast growth factor receptor 1 | [97] | 3.71[98] | 1.95[99] | 3.32[100] | 3.57[101] | 2.98[102] | 0.69[103] |
16 | GAB1 | GRB2-associated-binding protein 1 | [104] | 0.43[105] | 1.45[106] | 1.29[107] | 0.45[108] | 0.45[109] | 1.90[110] |
17 | KL | Klotho | [111] | -6.92[112] | [113] | [114] | -2.88[115] | -7.98[116] | -0.72[117] |
18 | FGF5 | Fibroblast growth factor 5 | [118] | -1.86[119] | -0.61[120] | -0.97[121] | 0.00[122] | -0.17[123] | 2.17[124] |
19 | FGF1 | Fibroblast growth factor 1 | [125] | -3.63[126] | -2.92[127] | -7.67[128] | -0.90[129] | 0.83[130] | -0.93[131] |
20 | FLRT1 | Leucine-rich repeat transmembrane protein FLRT1 | [132] | 1.16[133] | 2.34[134] | 1.11[135] | -0.17[136] | 1.27[137] | 4.02[138] |
21 | FGF8 | Fibroblast growth factor 8 | [139] | -4.20[140] | -3.93[141] | 0.28[142] | -3.40[143] | [144] | 1.73[145] |
22 | FGF9 | Fibroblast growth factor 9 | [146] | 1.39[147] | -2.34[148] | [149] | 1.30[150] | -3.67[151] | -0.87[152] |
23 | FLRT2 | Leucine-rich repeat transmembrane protein FLRT2 | [153] | 8.47[154] | [155] | 7.70[156] | 8.45[157] | 10.90[158] | 7.73[159] |
24 | FGF3 | Fibroblast growth factor 3 | [160] | [161] | [162] | [163] | [164] | [165] | [166] |
25 | FGF20 | Fibroblast growth factor 20 | [167] | [168] | [169] | [170] | [171] | [172] | [173] |
26 | FGF23 | Fibroblast growth factor 23 | [174] | [175] | [176] | [177] | [178] | [179] | [180] |
27 | FGF22 | Fibroblast growth factor 22 | [181] | [182] | [183] | [184] | [185] | [186] | [187] |
28 | FGF10 | Fibroblast growth factor 10 | [188] | [189] | [190] | [191] | [192] | [193] | [194] |
29 | FGF17 | Fibroblast growth factor 17 | [195] | [196] | [197] | [198] | [199] | [200] | [201] |
30 | FGF4 | Fibroblast growth factor 4 | [202] | [203] | [204] | [205] | [206] | [207] | [208] |
31 | FGF6 | Fibroblast growth factor 6 | [209] | [210] | [211] | [212] | [213] | [214] | [215] |