REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.23[2] | -1.32[3] | -1.19[4] | -1.58[5] | -1.18[6] | -0.65[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.79[16] | -0.57[17] | -0.83[18] | -0.72[19] | -0.80[20] | -0.19[21] |
4 | PPIA | Peptidyl-prolyl cis-trans isomerase A | [22] | 0.86[23] | 1.11[24] | 1.42[25] | 0.97[26] | 1.03[27] | 0.85[28] |
5 | PSME1 | Proteasome activator complex subunit 1 | [29] | -0.56[30] | -2.16[31] | -1.80[32] | -1.44[33] | -2.02[34] | -1.15[35] |
6 | PSME2 | Proteasome activator complex subunit 2 | [36] | -0.38[37] | -1.78[38] | -1.89[39] | -1.23[40] | -1.56[41] | -0.77[42] |
7 | PSMA7 | Proteasome subunit alpha type-7 | [43] | 0.58[44] | 0.68[45] | -0.64[46] | 0.40[47] | -0.09[48] | 0.25[49] |
8 | PSMB1 | Proteasome subunit beta type-1 | [50] | 0.13[51] | 0.24[52] | -0.84[53] | -0.85[54] | -0.13[55] | 0.09[56] |
9 | PSMB3 | Proteasome subunit beta type-3 | [57] | -0.36[58] | -1.15[59] | -0.11[60] | -0.87[61] | -1.03[62] | -0.21[63] |
10 | PSMB4 | Proteasome subunit beta type-4 | [64] | -0.11[65] | 0.05[66] | 0.19[67] | 0.56[68] | 0.51[69] | -0.53[70] |
11 | PSMB7 | Proteasome subunit beta type-7 | [71] | -1.06[72] | -1.05[73] | -0.91[74] | -1.21[75] | -0.81[76] | -0.97[77] |
12 | PSMB5 | Proteasome subunit beta type-5 | [78] | 1.34[79] | -0.09[80] | -0.15[81] | -0.49[82] | -0.25[83] | -0.50[84] |
13 | PSMA6 | Proteasome subunit alpha type-6 | [85] | 1.47[86] | 0.19[87] | 0.13[88] | 0.04[89] | 0.01[90] | -0.42[91] |
14 | NFKBIA | NF-kappa-B inhibitor alpha | [92] | -0.09[93] | -1.77[94] | -2.17[95] | -2.32[96] | -0.50[97] | 0.09[98] |
15 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | [99] | 0.85[100] | 0.56[101] | -1.02[102] | 0.94[103] | 0.47[104] | -0.14[105] |
16 | PSMA4 | Proteasome subunit alpha type-4 | [106] | -0.46[107] | 0.21[108] | 0.01[109] | 0.34[110] | 0.13[111] | -0.49[112] |
17 | SKP1 | S-phase kinase-associated protein 1 | [113] | -0.01[114] | 0.49[115] | -0.40[116] | 0.70[117] | 0.86[118] | 0.54[119] |
18 | PSMC3 | 26S proteasome regulatory subunit 6A | [120] | -0.49[121] | -0.55[122] | 0.07[123] | -0.86[124] | -0.70[125] | -0.02[126] |
19 | PSMA3 | Proteasome subunit alpha type-3 | [127] | -1.08[128] | -0.07[129] | -0.74[130] | -0.11[131] | -0.60[132] | -0.25[133] |
20 | PSMB6 | Proteasome subunit beta type-6 | [134] | -0.53[135] | -0.38[136] | -0.23[137] | -0.66[138] | -0.96[139] | -0.09[140] |
21 | PSMA2 | Proteasome subunit alpha type-2 | [141] | -0.61[142] | 0.35[143] | 0.69[144] | -0.16[145] | 0.17[146] | 0.13[147] |
22 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [148] | -0.10[149] | -0.08[150] | 0.13[151] | 0.54[152] | -0.03[153] | -0.19[154] |
23 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [155] | -0.18[156] | 0.20[157] | 0.06[158] | -0.55[159] | -0.11[160] | -0.36[161] |
24 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [162] | -0.01[163] | 0.23[164] | 0.38[165] | -0.27[166] | 0.45[167] | -0.34[168] |
25 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [169] | 1.52[170] | 0.70[171] | 0.78[172] | 0.84[173] | 2.10[174] | 0.70[175] |
26 | PSMC1 | 26S proteasome regulatory subunit 4 | [176] | -0.16[177] | -0.09[178] | -0.73[179] | 1.02[180] | 0.51[181] | -0.14[182] |
27 | PSMA1 | Proteasome subunit alpha type-1 | [183] | 0.02[184] | 0.42[185] | 0.49[186] | 0.60[187] | 0.06[188] | 0.35[189] |
28 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [190] | 1.65[191] | 1.66[192] | 2.69[193] | 0.67[194] | 1.43[195] | 0.58[196] |
29 | PSMC5 | 26S proteasome regulatory subunit 8 | [197] | 0.34[198] | 0.24[199] | 0.33[200] | 0.01[201] | 0.38[202] | 0.11[203] |
30 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [204] | 0.74[205] | 0.24[206] | 0.84[207] | 0.54[208] | 0.72[209] | -0.17[210] |
31 | PSMB8 | Proteasome subunit beta type-8 | [211] | -1.66[212] | -2.24[213] | -9.45[214] | 0.51[215] | -0.83[216] | -0.86[217] |
32 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [218] | -0.08[219] | 0.53[220] | 0.79[221] | 0.40[222] | 0.40[223] | -0.32[224] |
33 | PSMC4 | 26S proteasome regulatory subunit 6B | [225] | 0.34[226] | 0.38[227] | 0.32[228] | 0.03[229] | 0.11[230] | 0.16[231] |
34 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [232] | -0.81[233] | -0.32[234] | -1.41[235] | -0.60[236] | 0.18[237] | -0.43[238] |
35 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [239] | 0.39[240] | 0.51[241] | 1.01[242] | 0.46[243] | -0.06[244] | -0.24[245] |
36 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [246] | -0.43[247] | -0.35[248] | -0.65[249] | 0.08[250] | 0.11[251] | -0.32[252] |
37 | PSMC6 | 26S proteasome regulatory subunit 10B | [253] | -0.14[254] | 1.45[255] | 0.27[256] | 0.44[257] | 0.34[258] | 0.33[259] |
38 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [260] | 0.75[261] | 0.37[262] | 0.96[263] | 0.85[264] | 0.97[265] | 1.16[266] |
39 | PSMC2 | 26S proteasome regulatory subunit 7 | [267] | 0.50[268] | 0.91[269] | 0.69[270] | 1.24[271] | 1.04[272] | 1.21[273] |
40 | CALM1 | Calmodulin-1 | [274] | 1.04[275] | 1.19[276] | 1.63[277] | 2.79[278] | 2.00[279] | 2.85[280] |
41 | PSME3 | Proteasome activator complex subunit 3 | [281] | 1.73[282] | 1.45[283] | 1.14[284] | 1.27[285] | 1.50[286] | 0.78[287] |
42 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [288] | 1.49[289] | 1.81[290] | 1.70[291] | 2.07[292] | 2.05[293] | 1.97[294] |
43 | IKBKG | NF-kappa-B essential modulator | [295] | 0.08[296] | 0.33[297] | -1.93[298] | 0.35[299] | -0.92[300] | 0.63[301] |
44 | PSMB10 | Proteasome subunit beta type-10 | [302] | -1.24[303] | -0.63[304] | -2.52[305] | -0.14[306] | -1.34[307] | -0.18[308] |
45 | PSMA5 | Proteasome subunit alpha type-5 | [309] | 1.82[310] | 2.25[311] | 1.82[312] | 2.13[313] | 1.65[314] | 1.80[315] |
46 | PSMF1 | Proteasome inhibitor PI31 subunit | [316] | 2.20[317] | 2.25[318] | 1.06[319] | 1.13[320] | 0.86[321] | 1.75[322] |
47 | PSMB2 | Proteasome subunit beta type-2 | [323] | 1.98[324] | 1.72[325] | 2.11[326] | 2.43[327] | 2.38[328] | 2.29[329] |
48 | RELA | Transcription factor p65 | [330] | 1.10[331] | 0.70[332] | 0.82[333] | 1.15[334] | 0.99[335] | 0.35[336] |
49 | PSMB9 | Proteasome subunit beta type-9 | [337] | -2.03[338] | -4.64[339] | -6.95[340] | 1.68[341] | -0.62[342] | -0.60[343] |
50 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [344] | 0.35[345] | 0.85[346] | -0.13[347] | 0.31[348] | 0.71[349] | 0.62[350] |
51 | NRAS | GTPase NRas | [351] | 1.60[352] | 2.14[353] | 2.53[354] | 2.20[355] | 1.71[356] | 0.98[357] |
52 | CUL1 | Cullin-1 | [358] | 0.58[359] | 1.37[360] | 0.90[361] | 1.78[362] | 1.38[363] | 1.98[364] |
53 | NFKBIB | NF-kappa-B inhibitor beta | [365] | -0.19[366] | -0.26[367] | 0.05[368] | -0.61[369] | -0.33[370] | -0.50[371] |
54 | PPP3R1 | Calcineurin subunit B type 1 | [372] | 1.15[373] | 1.44[374] | 1.34[375] | 1.91[376] | 1.61[377] | 0.08[378] |
55 | HRAS | GTPase HRas | [379] | -0.04[380] | -0.64[381] | -1.45[382] | 0.25[383] | -0.02[384] | -1.43[385] |
56 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [386] | 0.91[387] | 1.24[388] | 1.26[389] | 1.98[390] | 1.26[391] | 0.61[392] |
57 | KRAS | GTPase KRas | [393] | 0.45[394] | 0.54[395] | 2.12[396] | 2.00[397] | 1.60[398] | 1.91[399] |
58 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [400] | 0.87[401] | 2.05[402] | 1.90[403] | 1.69[404] | 1.81[405] | 1.48[406] |
59 | PSME4 | Proteasome activator complex subunit 4 | [407] | 2.44[408] | 3.35[409] | 3.36[410] | 2.54[411] | 2.46[412] | 2.87[413] |
60 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [414] | 1.64[415] | 1.42[416] | 1.19[417] | 0.96[418] | 1.80[419] | 1.68[420] |
61 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [421] | 1.33[422] | 0.89[423] | 2.45[424] | 2.36[425] | 2.41[426] | 2.05[427] |
62 | FBXW11 | F-box/WD repeat-containing protein 11 | [428] | 2.34[429] | 2.36[430] | 3.10[431] | 2.73[432] | 2.58[433] | 2.18[434] |
63 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 1.45[435] | 2.35[436] | 1.84[437] | 1.96[438] | 1.65[439] | 1.08[440] | |
64 | NFATC3 | Nuclear factor of activated T-cells, cytoplasmic 3 | [441] | 2.43[442] | 3.32[443] | 3.20[444] | 2.07[445] | 2.38[446] | 3.63[447] |
65 | NFKBIE | NF-kappa-B inhibitor epsilon | [448] | 1.01[449] | 2.04[450] | 0.15[451] | 0.42[452] | 0.82[453] | -0.04[454] |
66 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [455] | 1.87[456] | 3.20[457] | 3.14[458] | 1.85[459] | 2.60[460] | 2.75[461] |
67 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [462] | 1.49[463] | 1.65[464] | 1.74[465] | 1.46[466] | 1.49[467] | 2.41[468] |
68 | PPP3CA | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 1.69[469] | 1.56[470] | 1.35[471] | 3.15[472] | 2.83[473] | 3.04[474] | |
69 | BCL10 | B-cell lymphoma/leukemia 10 | [475] | 1.06[476] | 0.67[477] | 1.64[478] | 1.74[479] | 1.72[480] | 1.76[481] |
70 | BTRC | F-box/WD repeat-containing protein 1A | [482] | 2.38[483] | 3.28[484] | 2.88[485] | 1.96[486] | 2.44[487] | 2.58[488] |
71 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 3.82[489] | 3.77[490] | 3.18[491] | 3.24[492] | 2.47[493] | 3.49[494] | |
72 | RASGRP3 | Ras guanyl-releasing protein 3 | [495] | -2.22[496] | -5.24[497] | 3.26[498] | 2.12[499] | -3.01[500] | 2.75[501] |
73 | REL | Proto-oncogene c-Rel | [502] | 0.45[503] | 2.32[504] | 2.24[505] | 1.35[506] | 1.44[507] | 3.58[508] |
74 | NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 | [509] | -0.98[510] | -3.39[511] | 3.19[512] | -4.77[513] | 3.57[514] | 1.96[515] |
75 | NFATC2 | Nuclear factor of activated T-cells, cytoplasmic 2 | [516] | 3.55[517] | 4.92[518] | 4.31[519] | 1.38[520] | 2.28[521] | 4.52[522] |
76 | PRKCB | Protein kinase C beta type | [523] | -5.85[524] | -4.54[525] | [526] | 3.68[527] | -1.68[528] | 4.77[529] |
77 | CARD11 | Caspase recruitment domain-containing protein 11 | [530] | 2.10[531] | -4.30[532] | -5.09[533] | 2.45[534] | 6.90[535] | 3.51[536] |
78 | RASGRP1 | RAS guanyl-releasing protein 1 | [537] | 2.20[538] | 3.00[539] | 3.63[540] | 5.35[541] | 6.37[542] | 8.04[543] |
79 | PSMB11 | Proteasome subunit beta type-11 | [544] | [545] | [546] | [547] | [548] | [549] | [550] |
80 | PSMA8 | Proteasome subunit alpha type-7-like | [551] | [552] | [553] | [554] | [555] | [556] | [557] |
81 | SEM1 | Putative protein SEM1, isoform 2 | [558] | [559] | [560] | [561] | [562] | [563] | [564] |