REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.86[2] -1.05[3] -1.11[4] -1.29[5] -0.96[6] -0.32[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.41[16] -0.29[17] -0.75[18] -0.44[19] -0.58[20] 0.13[21]
4 STRAP Serine-threonine kinase receptor-associated protein [22] 0.13[23] 0.10[24] 0.50[25] 0.14[26] 0.85[27] -0.22[28]
5 UBA52 Ubiquitin-60S ribosomal protein L40 [29] 2.02[30] 1.94[31] 2.77[32] 0.96[33] 1.64[34] 0.90[35]
6 PPP1R15A Protein phosphatase 1 regulatory subunit 15A [36] -0.41[37] -1.35[38] -1.05[39] -0.73[40] 0.10[41] -2.06[42]
7 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [43] 1.32[44] 1.05[45] 2.05[46] 3.02[47] 0.50[48] 0.60[49]
8 STUB1 E3 ubiquitin-protein ligase CHIP [50] -0.64[51] -0.61[52] -1.48[53] -1.18[54] -0.98[55] -0.70[56]
9 PPP1CB Serine/threonine-protein phosphatase PP1-beta catalytic subunit [57] 1.10[58] 1.68[59] 1.55[60] 2.25[61] 1.94[62] 2.05[63]
10 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit 2.02[64] 2.82[65] 2.82[66] 1.73[67] 1.70[68] 0.48[69]
11 XPO1 Exportin-1 [70] 2.70[71] 3.43[72] 3.24[73] 3.62[74] 3.58[75] 2.41[76]
12 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5 [77] 0.32[78] 1.19[79] 0.60[80] 1.99[81] 1.43[82] 1.34[83]
13 TGFBR2 TGF-beta receptor type-2 [84] 4.16[85] 3.64[86] 3.08[87] 2.55[88] 4.14[89] 3.06[90]
14 MTMR4 Myotubularin-related protein 4 [91] 1.98[92] 2.84[93] 2.98[94] 0.91[95] 1.41[96] 3.90[97]
15 BAMBI BMP and activin membrane-bound inhibitor homolog [98] 2.56[99] 1.53[100] 1.99[101] 2.49[102] 1.65[103] -0.10[104]
16 SMAD3 Mothers against decapentaplegic homolog 3 [105] 3.27[106] 2.68[107] 2.69[108] 3.28[109] 4.04[110] 1.77[111]
17 NEDD4L E3 ubiquitin-protein ligase NEDD4-like [112] 3.87[113] 3.80[114] 3.40[115] 1.56[116] 2.35[117] 2.29[118]
18 TGFBR1 TGF-beta receptor type-1 [119] 1.67[120] 1.91[121] 1.19[122] 1.83[123] 2.81[124] 2.89[125]
19 SMAD7 Mothers against decapentaplegic homolog 7 [126] 3.20[127] 1.33[128] 0.10[129] 2.07[130] 1.65[131] 1.56[132]
20 SMURF1 E3 ubiquitin-protein ligase SMURF1 [133] 2.78[134] 2.24[135] 2.94[136] 2.70[137] 2.46[138] 2.94[139]
21 USP15 Ubiquitin carboxyl-terminal hydrolase 15 [140] 1.46[141] 3.34[142] 2.54[143] 3.48[144] 3.26[145] 4.20[146]
22 SMAD2 Mothers against decapentaplegic homolog 2 [147] 3.36[148] 3.63[149] 2.92[150] 3.87[151] 3.93[152] 4.13[153]
23 TGFB1 Transforming growth factor beta-1 [154] 4.81[155] 3.79[156] 0.82[157] 5.32[158] 4.43[159] 0.33[160]
24 SMURF2 E3 ubiquitin-protein ligase SMURF2 [161] 3.06[162] 3.10[163] 1.39[164] 2.68[165] 2.99[166] 1.69[167]
25 ZFYVE9 Zinc finger FYVE domain-containing protein 9 [168] 2.99[169] 3.23[170] 2.97[171] 3.09[172] 3.41[173] 3.76[174]
26 PMEPA1 Protein TMEPAI [175] 4.77[176] [177] -4.02[178] 5.19[179] 5.56[180] 3.52[181]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte STRAP
Mean 72.7
Standard deviation 45
Values 59 1.1e+02 1.3e+02 34 33
[23]
HepG2 STRAP
Mean 69.3
Standard deviation 6
Values 65 74
[24]
HepG2.C3A STRAP
Mean 60
Standard deviation 6.9
Values 55 65
[25]
HuH.7 STRAP
Mean 88.3
Standard deviation 13
Values 94 74 98
[26]
SNU475 STRAP
Mean 52.5
Standard deviation 2
Values 51 54
[27]
THLE STRAP
Mean 105
Standard deviation 8
Values 99 1.1e+02
[28]
liver STRAP
Mean 30.3
Standard deviation 20
Values 40 15 54 12
[29]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[30]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[31]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[32]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[33]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[34]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[35]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[36]
ref_hepatocyte PPP1R15A
Mean 46.5
Standard deviation 53
Values 18 55 1.4e+02 19 5.3
[37]
HepG2 PPP1R15A
Mean 30.6
Standard deviation 24
Values 47 14
[38]
HepG2.C3A PPP1R15A
Mean 14
Standard deviation 6.7
Values 19 9.2
[39]
HuH.7 PPP1R15A
Mean 19.2
Standard deviation 5.6
Values 14 25 18
[40]
SNU475 PPP1R15A
Mean 18.4
Standard deviation 6.4
Values 14 23
[41]
THLE PPP1R15A
Mean 40
Standard deviation 0.53
Values 40 40
[42]
liver PPP1R15A
Mean 5.39
Standard deviation 1.5
Values 5.7 3.3 6.8 5.8
[43]
ref_hepatocyte PPP1CA
Mean 42.2
Standard deviation 7
Values 36 44 39 54 39
[44]
HepG2 PPP1CA
Mean 92
Standard deviation 5.7
Values 96 88
[45]
HepG2.C3A PPP1CA
Mean 67.5
Standard deviation 3.3
Values 65 70
[46]
HuH.7 PPP1CA
Mean 150
Standard deviation 50
Values 1.7e+02 93 1.9e+02
[47]
SNU475 PPP1CA
Mean 224
Standard deviation 25
Values 2.4e+02 2.1e+02
[48]
THLE PPP1CA
Mean 47.8
Standard deviation 8.9
Values 41 54
[49]
liver PPP1CA
Mean 31
Standard deviation 18
Values 42 17 51 15
[50]
ref_hepatocyte STUB1
Mean 35.4
Standard deviation 14
Values 24 59 27 30 37
[51]
HepG2 STUB1
Mean 19.8
Standard deviation 3.3
Values 22 17
[52]
HepG2.C3A STUB1
Mean 17.9
Standard deviation 1.3
Values 19 17
[53]
HuH.7 STUB1
Mean 10.9
Standard deviation 1.8
Values 11 9 13
[54]
SNU475 STUB1
Mean 10.3
Standard deviation 1.7
Values 12 9
[55]
THLE STUB1
Mean 14.4
Standard deviation 1.6
Values 13 16
[56]
liver STUB1
Mean 10.6
Standard deviation 7.6
Values 18 4.2 16 3.9
[57]
ref_hepatocyte PPP1CB
Mean 31.9
Standard deviation 30
Values 65 64 8.8 6.2 16
[58]
HepG2 PPP1CB
Mean 59.8
Standard deviation 14
Values 50 70
[59]
HepG2.C3A PPP1CB
Mean 78.8
Standard deviation 12
Values 71 87
[60]
HuH.7 PPP1CB
Mean 80.4
Standard deviation 9.9
Values 92 76 74
[61]
SNU475 PPP1CB
Mean 99.4
Standard deviation 25
Values 1.2e+02 82
[62]
THLE PPP1CB
Mean 98.3
Standard deviation 1.6
Values 99 97
[63]
liver PPP1CB
Mean 64.1
Standard deviation 7.2
Values 67 68 67 53
[64]
ref_hepatocyte PPP1CC
Mean 27
Standard deviation 18
Values 56 31 20 14 14
[65]
HepG2 PPP1CC
Mean 95.3
Standard deviation 20
Values 81 1.1e+02
[66]
HepG2.C3A PPP1CC
Mean 146
Standard deviation 2.8
Values 1.5e+02 1.4e+02
[67]
HuH.7 PPP1CC
Mean 164
Standard deviation 10
Values 1.8e+02 1.6e+02 1.6e+02
[68]
SNU475 PPP1CC
Mean 58.5
Standard deviation 7.8
Values 53 64
[69]
THLE PPP1CC
Mean 70.4
Standard deviation 7.7
Values 65 76
[70]
liver PPP1CC
Mean 18.1
Standard deviation 3.3
Values 23 17 15 18
[71]
ref_hepatocyte XPO1
Mean 13.2
Standard deviation 5.7
Values 20 19 8.6 8.1 11
[72]
HepG2 XPO1
Mean 74.7
Standard deviation 37
Values 48 1e+02
[73]
HepG2.C3A XPO1
Mean 109
Standard deviation 54
Values 71 1.5e+02
[74]
HuH.7 XPO1
Mean 107
Standard deviation 26
Values 1.3e+02 77 1.2e+02
[75]
SNU475 XPO1
Mean 106
Standard deviation 0.46
Values 1.1e+02 1.1e+02
[76]
THLE XPO1
Mean 127
Standard deviation 5.2
Values 1.2e+02 1.3e+02
[77]
liver XPO1
Mean 34
Standard deviation 14
Values 22 53 24 37
[78]
ref_hepatocyte UCHL5
Mean 12.5
Standard deviation 8.3
Values 13 25 14 4.5 5.6
[79]
HepG2 UCHL5
Mean 13.6
Standard deviation 3.9
Values 11 16
[80]
HepG2.C3A UCHL5
Mean 22
Standard deviation 8.8
Values 16 28
[81]
HuH.7 UCHL5
Mean 16.3
Standard deviation 5.1
Values 20 11 18
[82]
SNU475 UCHL5
Mean 32.6
Standard deviation 1
Values 32 33
[83]
THLE UCHL5
Mean 26.9
Standard deviation 0.76
Values 27 26
[84]
liver UCHL5
Mean 15.3
Standard deviation 3.4
Values 18 12 18 13
[85]
ref_hepatocyte TGFBR2
Mean 11.1
Standard deviation 9.7
Values 26 15 6.4 4.2 3.5
[86]
HepG2 TGFBR2
Mean 172
Standard deviation 10
Values 1.7e+02 1.8e+02
[87]
HepG2.C3A TGFBR2
Mean 106
Standard deviation 5.8
Values 1.1e+02 1e+02
[88]
HuH.7 TGFBR2
Mean 80.1
Standard deviation 11
Values 92 71 77
[89]
SNU475 TGFBR2
Mean 42.5
Standard deviation 18
Values 29 55
[90]
THLE TGFBR2
Mean 157
Standard deviation 23
Values 1.4e+02 1.7e+02
[91]
liver TGFBR2
Mean 44.6
Standard deviation 11
Values 31 51 40 57
[92]
ref_hepatocyte MTMR4
Mean 6.86
Standard deviation 3.5
Values 11 5.3 2 6.5 9.8
[93]
HepG2 MTMR4
Mean 23.6
Standard deviation 2.3
Values 22 25
[94]
HepG2.C3A MTMR4
Mean 37.9
Standard deviation 2.1
Values 39 36
[95]
HuH.7 MTMR4
Mean 46.4
Standard deviation 18
Values 38 67 34
[96]
SNU475 MTMR4
Mean 8.44
Standard deviation 2.5
Values 10 6.7
[97]
THLE MTMR4
Mean 14.7
Standard deviation 0.29
Values 14 15
[98]
liver MTMR4
Mean 49.4
Standard deviation 19
Values 29 70 37 61
[99]
ref_hepatocyte BAMBI
Mean 6.64
Standard deviation 3.4
Values 5.3 4.8 12 7.6 3.5
[100]
HepG2 BAMBI
Mean 34.2
Standard deviation 4.3
Values 37 31
[101]
HepG2.C3A BAMBI
Mean 14.7
Standard deviation 0.51
Values 15 14
[102]
HuH.7 BAMBI
Mean 22.6
Standard deviation 1.8
Values 20 23 24
[103]
SNU475 BAMBI
Mean 24.5
Standard deviation 5.2
Values 28 21
[104]
THLE BAMBI
Mean 16.7
Standard deviation 0.53
Values 17 16
[105]
liver BAMBI
Mean 3
Standard deviation 1.7
Values 5.2 1.7 3.5 1.6
[106]
ref_hepatocyte SMAD3
Mean 5.99
Standard deviation 4.6
Values 4.8 8.4 13 1.9 2.2
[107]
HepG2 SMAD3
Mean 50.4
Standard deviation 14
Values 60 40
[108]
HepG2.C3A SMAD3
Mean 29.5
Standard deviation 11
Values 37 22
[109]
HuH.7 SMAD3
Mean 33.2
Standard deviation 6.9
Values 31 41 28
[110]
SNU475 SMAD3
Mean 38.2
Standard deviation 2.7
Values 40 36
[111]
THLE SMAD3
Mean 78.9
Standard deviation 8.4
Values 73 85
[112]
liver SMAD3
Mean 9.85
Standard deviation 3
Values 12 7.4 7.1 13
[113]
ref_hepatocyte NEDD4L
Mean 4.96
Standard deviation 4.4
Values 12 5.6 4.9 1.7 0.72
[114]
HepG2 NEDD4L
Mean 63.2
Standard deviation 5
Values 60 67
[115]
HepG2.C3A NEDD4L
Mean 53.1
Standard deviation 11
Values 61 45
[116]
HuH.7 NEDD4L
Mean 44.8
Standard deviation 8.9
Values 44 54 36
[117]
SNU475 NEDD4L
Mean 9.57
Standard deviation 0.3
Values 9.4 9.8
[118]
THLE NEDD4L
Mean 20.2
Standard deviation 2.2
Values 19 22
[119]
liver NEDD4L
Mean 11.8
Standard deviation 9.5
Values 26 8.9 7.8 4.7
[120]
ref_hepatocyte TGFBR1
Mean 4.72
Standard deviation 3.6
Values 4.2 11 3.6 1.8 3.1
[121]
HepG2 TGFBR1
Mean 13.1
Standard deviation 3.3
Values 11 15
[122]
HepG2.C3A TGFBR1
Mean 13.6
Standard deviation 0.22
Values 13 14
[123]
HuH.7 TGFBR1
Mean 9.25
Standard deviation 2.6
Values 8.3 12 7.2
[124]
SNU475 TGFBR1
Mean 11
Standard deviation 1.8
Values 9.7 12
[125]
THLE TGFBR1
Mean 26.5
Standard deviation 5.3
Values 30 23
[126]
liver TGFBR1
Mean 16.9
Standard deviation 7.4
Values 8.6 25 13 20
[127]
ref_hepatocyte SMAD7
Mean 3.77
Standard deviation 2.9
Values 5.6 7.9 2.4 1.7 1.3
[128]
HepG2 SMAD7
Mean 30.1
Standard deviation 6.8
Values 35 25
[129]
HepG2.C3A SMAD7
Mean 7.28
Standard deviation 2.6
Values 5.5 9.1
[130]
HuH.7 SMAD7
Mean 3.45
Standard deviation 0.58
Values 3.1 4.1 3.1
[131]
SNU475 SMAD7
Mean 10.4
Standard deviation 2.4
Values 12 8.7
[132]
THLE SMAD7
Mean 9.45
Standard deviation 1.3
Values 8.6 10
[133]
liver SMAD7
Mean 5.35
Standard deviation 1.1
Values 4.2 6.5 6 4.8
[134]
ref_hepatocyte SMURF1
Mean 3.55
Standard deviation 2.6
Values 3 5.1 7.2 1.5 0.92
[135]
HepG2 SMURF1
Mean 21.3
Standard deviation 3.9
Values 24 19
[136]
HepG2.C3A SMURF1
Mean 12.9
Standard deviation 1.5
Values 14 12
[137]
HuH.7 SMURF1
Mean 23.3
Standard deviation 5.2
Values 23 29 18
[138]
SNU475 SMURF1
Mean 15.1
Standard deviation 1.3
Values 14 16
[139]
THLE SMURF1
Mean 15.7
Standard deviation 2.1
Values 14 17
[140]
liver SMURF1
Mean 13.2
Standard deviation 6
Values 7.3 18 8.8 19
[141]
ref_hepatocyte USP15
Mean 3.51
Standard deviation 1.8
Values 1.7 6.4 3.1 2.8 3.5
[142]
HepG2 USP15
Mean 8.45
Standard deviation 3.7
Values 5.9 11
[143]
HepG2.C3A USP15
Mean 27.4
Standard deviation 6.1
Values 23 32
[144]
HuH.7 USP15
Mean 17.5
Standard deviation 1.1
Values 16 18 18
[145]
SNU475 USP15
Mean 25.6
Standard deviation 3.4
Values 23 28
[146]
THLE USP15
Mean 27.1
Standard deviation 5.4
Values 31 23
[147]
liver USP15
Mean 31.3
Standard deviation 2.5
Values 31 34 28 32
[148]
ref_hepatocyte SMAD2
Mean 2.54
Standard deviation 1.2
Values 4.5 2.8 1.9 1.9 1.6
[149]
HepG2 SMAD2
Mean 22.7
Standard deviation 2.3
Values 21 24
[150]
HepG2.C3A SMAD2
Mean 24.2
Standard deviation 1.1
Values 25 23
[151]
HuH.7 SMAD2
Mean 16.4
Standard deviation 1.6
Values 17 18 15
[152]
SNU475 SMAD2
Mean 24.3
Standard deviation 3.3
Values 27 22
[153]
THLE SMAD2
Mean 31
Standard deviation 0.65
Values 31 32
[154]
liver SMAD2
Mean 21.4
Standard deviation 6.7
Values 17 29 15 25
[155]
ref_hepatocyte TGFB1
Mean 2.22
Standard deviation 1.8
Values 5.3 1.3 0.92 1.3 2.3
[156]
HepG2 TGFB1
Mean 54.4
Standard deviation 32
Values 77 32
[157]
HepG2.C3A TGFB1
Mean 23.6
Standard deviation 8.3
Values 29 18
[158]
HuH.7 TGFB1
Mean 3.37
Standard deviation 1.4
Values 4.5 1.8 3.7
[159]
SNU475 TGFB1
Mean 58.3
Standard deviation 7.8
Values 64 53
[160]
THLE TGFB1
Mean 38.3
Standard deviation 9.8
Values 31 45
[161]
liver TGFB1
Mean 1.34
Standard deviation 0.71
Values 1.1 1.4 0.62 2.3
[162]
ref_hepatocyte SMURF2
Mean 2.04
Standard deviation 1.5
Values 4 2.4 2.7 0.61 0.48
[163]
HepG2 SMURF2
Mean 14.8
Standard deviation 1.9
Values 13 16
[164]
HepG2.C3A SMURF2
Mean 13.4
Standard deviation 0.28
Values 13 14
[165]
HuH.7 SMURF2
Mean 4.58
Standard deviation 0.75
Values 4.3 5.4 4
[166]
SNU475 SMURF2
Mean 8.55
Standard deviation 1
Values 7.8 9.3
[167]
THLE SMURF2
Mean 13
Standard deviation 1.5
Values 12 14
[168]
liver SMURF2
Mean 3.18
Standard deviation 1.7
Values 1.8 5.1 1.8 4
[169]
ref_hepatocyte ZFYVE9
Mean 1.96
Standard deviation 0.58
Values 3 1.6 1.8 1.5 1.9
[170]
HepG2 ZFYVE9
Mean 13.5
Standard deviation 4
Values 11 16
[171]
HepG2.C3A ZFYVE9
Mean 14.2
Standard deviation 1.5
Values 13 15
[172]
HuH.7 ZFYVE9
Mean 13.2
Standard deviation 2.5
Values 16 13 11
[173]
SNU475 ZFYVE9
Mean 10.9
Standard deviation 1.4
Values 12 10
[174]
THLE ZFYVE9
Mean 16.8
Standard deviation 0.22
Values 17 17
[175]
liver ZFYVE9
Mean 12.8
Standard deviation 11
Values 4.9 25 1.8 20
[176]
ref_hepatocyte PMEPA1
Mean 0.232
Standard deviation 0.22
Values 0 0.18 0.48 0.43 0.065
[177]
HepG2 PMEPA1
Mean 5.51
Standard deviation 3.5
Values 8 3.1
[178]
HepG2.C3A PMEPA1
Mean 0
Standard deviation 0
Values 0 0
[179]
HuH.7 PMEPA1
Mean 0.0123
Standard deviation 0.0061
Values 0.0082 0.019 0.0094
[180]
SNU475 PMEPA1
Mean 5.56
Standard deviation 1
Values 4.9 6.3
[181]
THLE PMEPA1
Mean 8.75
Standard deviation 3.2
Values 6.5 11
[182]
liver PMEPA1
Mean 1.28
Standard deviation 0.33
Values 1.2 0.9 1.3 1.7