REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.12[2] | -1.35[3] | -0.99[4] | -1.20[5] | -1.93[6] | -0.49[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.68[16] | -0.60[17] | -0.63[18] | -0.35[19] | -1.55[20] | -0.04[21] |
4 | SERPINE1 | Plasminogen activator inhibitor 1 | [22] | 2.21[23] | 2.40[24] | -4.12[25] | -2.23[26] | 3.26[27] | -2.49[28] |
5 | UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 | [29] | 0.25[30] | 0.54[31] | 0.99[32] | 0.84[33] | 0.13[34] | 1.24[35] |
6 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [36] | 1.76[37] | 1.63[38] | 2.88[39] | 1.05[40] | 0.68[41] | 0.73[42] |
7 | PARP1 | Poly [ADP-ribose] polymerase 1 | [43] | 1.20[44] | 0.93[45] | 1.88[46] | 2.10[47] | 0.44[48] | 0.98[49] |
8 | SNW1 | SNW domain-containing protein 1 | [50] | 0.08[51] | 0.22[52] | 0.45[53] | 1.44[54] | 0.01[55] | -0.24[56] |
9 | HDAC1 | Histone deacetylase 1 | [57] | 1.58[58] | 1.57[59] | 2.46[60] | 2.22[61] | 0.82[62] | 0.92[63] |
10 | TGIF1 | Homeobox protein TGIF1 | [64] | 0.77[65] | 0.10[66] | 1.14[67] | 1.19[68] | -0.35[69] | -0.46[70] |
11 | NCOR1 | Nuclear receptor corepressor 1 | [71] | 2.16[72] | 2.63[73] | 3.49[74] | 3.14[75] | 2.01[76] | 4.19[77] |
12 | SMAD3 | Mothers against decapentaplegic homolog 3 | [78] | 3.01[79] | 2.37[80] | 2.81[81] | 3.37[82] | 3.07[83] | 1.60[84] |
13 | TGIF2 | Homeobox protein TGIF2 | [85] | 2.32[86] | 2.72[87] | 2.31[88] | -0.70[89] | -0.45[90] | 0.50[91] |
14 | WWTR1 | WW domain-containing transcription regulator protein 1 | [92] | 2.97[93] | 2.53[94] | 1.75[95] | 3.89[96] | 2.02[97] | 2.12[98] |
15 | NEDD4L | E3 ubiquitin-protein ligase NEDD4-like | [99] | 3.60[100] | 3.49[101] | 3.52[102] | 1.65[103] | 1.38[104] | 2.13[105] |
16 | PPM1A | Protein phosphatase 1A | [106] | 1.40[107] | 2.32[108] | 2.50[109] | 2.80[110] | 1.68[111] | 3.59[112] |
17 | USP9X | Probable ubiquitin carboxyl-terminal hydrolase FAF-X | [113] | 2.92[114] | 3.60[115] | 4.65[116] | 5.30[117] | 4.03[118] | 5.58[119] |
18 | SMAD7 | Mothers against decapentaplegic homolog 7 | [120] | 2.93[121] | 1.02[122] | 0.22[123] | 2.16[124] | 0.68[125] | 1.39[126] |
19 | SKI | Ski oncogene | [127] | 3.55[128] | 3.22[129] | 2.90[130] | 3.74[131] | 2.91[132] | 2.42[133] |
20 | SMAD4 | Mothers against decapentaplegic homolog 4 | [134] | 2.47[135] | 3.07[136] | 3.25[137] | 3.49[138] | 2.67[139] | 4.18[140] |
21 | TRIM33 | E3 ubiquitin-protein ligase TRIM33 | [141] | 2.94[142] | 3.37[143] | 3.43[144] | 3.62[145] | 2.36[146] | 3.74[147] |
22 | NCOR2 | Nuclear receptor corepressor 2 | [148] | 4.42[149] | 2.79[150] | 3.10[151] | 5.73[152] | 4.04[153] | 3.28[154] |
23 | SMAD2 | Mothers against decapentaplegic homolog 2 | [155] | 3.10[156] | 3.33[157] | 3.03[158] | 3.96[159] | 2.97[160] | 3.96[161] |
24 | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 | [162] | 1.87[163] | 2.71[164] | 3.26[165] | 3.10[166] | 1.68[167] | 1.89[168] |
25 | SKIL | Ski-like protein | [169] | 2.74[170] | 2.75[171] | 4.41[172] | 4.21[173] | 3.06[174] | 4.54[175] |
26 | SMURF2 | E3 ubiquitin-protein ligase SMURF2 | [176] | 2.79[177] | 2.79[178] | 1.51[179] | 2.77[180] | 2.03[181] | 1.52[182] |
27 | RNF111 | E3 ubiquitin-protein ligase Arkadia | [183] | 2.69[184] | 2.48[185] | 3.24[186] | 4.00[187] | 2.51[188] | 3.68[189] |
28 | ATP1B4 | Protein ATP1B4 | [190] | 0.82[191] | 2.11[192] | 1.68[193] | 1.73[194] | 0.92[195] | 0.15[196] |