REACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.73[2] | -1.29[3] | -0.95[4] | -1.34[5] | -0.83[6] | -0.32[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.29[16] | -0.54[17] | -0.59[18] | -0.48[19] | -0.45[20] | 0.14[21] |
4 | HSP90AA1 | Heat shock protein HSP 90-alpha | [22] | 0.82[23] | 1.43[24] | 0.85[25] | 1.53[26] | 1.27[27] | 0.31[28] |
5 | CDC37 | Hsp90 co-chaperone Cdc37 | [29] | 0.71[30] | -0.30[31] | 0.26[32] | -0.36[33] | 0.26[34] | -0.42[35] |
6 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [36] | 2.15[37] | 1.70[38] | 2.92[39] | 0.91[40] | 1.78[41] | 0.91[42] |
7 | AKT1 | RAC-alpha serine/threonine-protein kinase | [43] | 1.55[44] | 0.96[45] | 0.06[46] | 1.39[47] | 1.46[48] | 1.32[49] |
8 | STUB1 | E3 ubiquitin-protein ligase CHIP | [50] | -0.52[51] | -0.85[52] | -1.32[53] | -1.22[54] | -0.85[55] | -0.69[56] |
9 | AKT2 | RAC-beta serine/threonine-protein kinase | [57] | 2.42[58] | 2.34[59] | 2.66[60] | 2.30[61] | 2.14[62] | 2.69[63] |
10 | PTPN12 | Tyrosine-protein phosphatase non-receptor type 12 | [64] | 2.25[65] | 2.27[66] | 1.42[67] | 3.20[68] | 2.32[69] | 1.11[70] |
11 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | [71] | 3.47[72] | 4.49[73] | 3.72[74] | -4.43[75] | -4.13[76] | 3.87[77] |
12 | USP8 | Ubiquitin carboxyl-terminal hydrolase 8 | [78] | 1.29[79] | 2.05[80] | 2.23[81] | 2.58[82] | 2.37[83] | 3.00[84] |
13 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | [85] | 3.84[86] | 2.30[87] | 3.66[88] | 2.70[89] | 2.35[90] | 1.72[91] |
14 | EGFR | Epidermal growth factor receptor | [92] | 0.77[93] | 0.04[94] | 3.11[95] | 1.88[96] | 2.54[97] | 4.21[98] |
15 | PTPN18 | Tyrosine-protein phosphatase non-receptor type 18 | [99] | 1.44[100] | 1.60[101] | 0.41[102] | -0.64[103] | 1.70[104] | 2.04[105] |
16 | CUL5 | Cullin-5 | [106] | 2.04[107] | 3.17[108] | 2.84[109] | 3.97[110] | 3.16[111] | 3.89[112] |
17 | RNF41 | E3 ubiquitin-protein ligase NRDP1 | [113] | 3.12[114] | 3.06[115] | 3.61[116] | 3.02[117] | 3.47[118] | 2.94[119] |
18 | HBEGF | Proheparin-binding EGF-like growth factor | [120] | 0.48[121] | -0.69[122] | -1.57[123] | 1.75[124] | 1.48[125] | -0.87[126] |
19 | NRG1 | Pro-neuregulin-1, membrane-bound isoform | [127] | 1.80[128] | -4.69[129] | -1.62[130] | 3.50[131] | -3.93[132] | 2.33[133] |
20 | BTC | Probetacellulin | [134] | -6.68[135] | -7.42[136] | -3.01[137] | -1.43[138] | -1.41[139] | -1.36[140] |
21 | NRG4 | Pro-neuregulin-4, membrane-bound isoform | [141] | -2.63[142] | -0.11[143] | 0.03[144] | 1.73[145] | -0.42[146] | 0.63[147] |
22 | AKT3 | RAC-gamma serine/threonine-protein kinase | [148] | -0.38[149] | -3.29[150] | -2.42[151] | 7.29[152] | 6.29[153] | 5.17[154] |
23 | EREG | Proepiregulin | [155] | 3.22[156] | 2.79[157] | -1.44[158] | -0.12[159] | 5.17[160] | 0.09[161] |
24 | MATK | Megakaryocyte-associated tyrosine-protein kinase | [162] | 1.69[163] | [164] | [165] | -2.77[166] | -0.20[167] | 2.85[168] |
25 | EGF | Pro-epidermal growth factor | [169] | 3.43[170] | 4.86[171] | 8.66[172] | 10.47[173] | 7.94[174] | 3.14[175] |
26 | ERBB4 | Receptor tyrosine-protein kinase erbB-4 | [176] | [177] | [178] | [179] | [180] | [181] | [182] |
27 | ERBIN | Erbin | [183] | [184] | [185] | [186] | [187] | [188] | [189] |
28 | NRG3 | Pro-neuregulin-3, membrane-bound isoform | [190] | [191] | [192] | [193] | [194] | [195] | [196] |
29 | NRG2 | Pro-neuregulin-2, membrane-bound isoform | [197] | [198] | [199] | [200] | [201] | [202] | [203] |