REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.41[2] -0.68[3] -0.64[4] -0.55[5] -0.26[6] -0.13[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] 0.03[16] 0.08[17] -0.28[18] 0.31[19] 0.12[20] 0.32[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.46[23] 2.31[24] 3.23[25] 1.70[26] 2.35[27] 1.09[28]
5 AKT1 RAC-alpha serine/threonine-protein kinase [29] 1.87[30] 1.57[31] 0.37[32] 2.18[33] 2.03[34] 1.50[35]
6 AKT2 RAC-beta serine/threonine-protein kinase [36] 2.74[37] 2.96[38] 2.97[39] 3.09[40] 2.71[41] 2.88[42]
7 ERBB3 Receptor tyrosine-protein kinase erbB-3 [43] 3.79[44] 5.11[45] 4.03[46] -3.64[47] -3.56[48] 4.05[49]
8 USP8 Ubiquitin carboxyl-terminal hydrolase 8 [50] 1.61[51] 2.67[52] 2.54[53] 3.36[54] 2.94[55] 3.18[56]
9 ERBB2 Receptor tyrosine-protein kinase erbB-2 [57] 4.16[58] 2.92[59] 3.97[60] 3.49[61] 2.92[62] 1.90[63]
10 RNF41 E3 ubiquitin-protein ligase NRDP1 [64] 3.44[65] 3.67[66] 3.91[67] 3.80[68] 4.05[69] 3.12[70]
11 NRG1 Pro-neuregulin-1, membrane-bound isoform [71] 2.12[72] -4.08[73] -1.31[74] 4.28[75] -3.36[76] 2.52[77]
12 AKT3 RAC-gamma serine/threonine-protein kinase [78] -0.06[79] -2.68[80] -2.11[81] 8.07[82] 6.86[83] 5.36[84]
13 NRG2 Pro-neuregulin-2, membrane-bound isoform [85] [86] [87] [88] [89] [90] [91]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 55 50 19 31 32
[30]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 89 86
[31]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 65 68
[32]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 33 23 35
[33]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 76 57
[34]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[35]
liver AKT1
Mean 45.1
Standard deviation 25
Values 34 48 20 79
[36]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 7.2 8.4 11 13 14
[37]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 48 43
[38]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 55 43
[39]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 59 41 55
[40]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 39 31
[41]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[42]
liver AKT2
Mean 33
Standard deviation 9.4
Values 24 36 27 45
[43]
ref_hepatocyte ERBB3
Mean 8.22
Standard deviation 4
Values 12 3.8 4.1 11 10
[44]
HepG2 ERBB3
Mean 72.9
Standard deviation 2.6
Values 75 71
[45]
HepG2.C3A ERBB3
Mean 169
Standard deviation 42
Values 2e+02 1.4e+02
[46]
HuH.7 ERBB3
Mean 83.4
Standard deviation 7.8
Values 92 80 78
[47]
SNU475 ERBB3
Mean 0.258
Standard deviation 0.12
Values 0.18 0.34
[48]
THLE ERBB3
Mean 0.344
Standard deviation 0.05
Values 0.38 0.31
[49]
liver ERBB3
Mean 57.8
Standard deviation 20
Values 44 71 39 79
[50]
ref_hepatocyte USP8
Mean 6.73
Standard deviation 4.3
Values 12 10 3.2 3.5 4.3
[51]
HepG2 USP8
Mean 13.2
Standard deviation 5.6
Values 9.2 17
[52]
HepG2.C3A USP8
Mean 25.5
Standard deviation 2.2
Values 24 27
[53]
HuH.7 USP8
Mean 24.3
Standard deviation 2.7
Values 26 26 21
[54]
SNU475 USP8
Mean 27.1
Standard deviation 1.4
Values 26 28
[55]
THLE USP8
Mean 25.4
Standard deviation 6.5
Values 30 21
[56]
liver USP8
Mean 25.8
Standard deviation 2.7
Values 29 26 25 23
[57]
ref_hepatocyte ERBB2
Mean 6.44
Standard deviation 3.8
Values 13 3.9 4.7 3.7 7.1
[58]
HepG2 ERBB2
Mean 73.6
Standard deviation 10
Values 66 81
[59]
HepG2.C3A ERBB2
Mean 29
Standard deviation 6.9
Values 34 24
[60]
HuH.7 ERBB2
Mean 62.5
Standard deviation 7.1
Values 69 55 63
[61]
SNU475 ERBB2
Mean 28.2
Standard deviation 8.4
Values 34 22
[62]
THLE ERBB2
Mean 24.1
Standard deviation 2.7
Values 22 26
[63]
liver ERBB2
Mean 10.2
Standard deviation 3.4
Values 7.9 8.1 9.6 15
[64]
ref_hepatocyte RNF41
Mean 3.02
Standard deviation 0.95
Values 2.6 3.1 4.3 3.4 1.7
[65]
HepG2 RNF41
Mean 20.9
Standard deviation 2.4
Values 23 19
[66]
HepG2.C3A RNF41
Mean 22.9
Standard deviation 1.4
Values 24 22
[67]
HuH.7 RNF41
Mean 28.2
Standard deviation 1.9
Values 30 26 28
[68]
SNU475 RNF41
Mean 16.5
Standard deviation 2.7
Values 18 15
[69]
THLE RNF41
Mean 24.5
Standard deviation 1
Values 25 24
[70]
liver RNF41
Mean 11.1
Standard deviation 1.6
Values 11 13 9.1 12
[71]
ref_hepatocyte NRG1
Mean 1.2
Standard deviation 1
Values 0 1 2.8 1.5 0.74
[72]
HepG2 NRG1
Mean 3.35
Standard deviation 2.7
Values 1.4 5.3
[73]
HepG2.C3A NRG1
Mean 0.0424
Standard deviation 0.046
Values 0.0097 0.075
[74]
HuH.7 NRG1
Mean 0.302
Standard deviation 0.17
Values 0.16 0.49 0.25
[75]
SNU475 NRG1
Mean 9.16
Standard deviation 3.3
Values 12 6.8
[76]
THLE NRG1
Mean 0.0576
Standard deviation 0.031
Values 0.035 0.08
[77]
liver NRG1
Mean 2.92
Standard deviation 2.1
Values 1.2 5.5 3.6 1.2
[78]
ref_hepatocyte AKT3
Mean 0.387
Standard deviation 0.32
Values 0 0.53 0.83 0.16 0.41
[79]
HepG2 AKT3
Mean 0.238
Standard deviation 0.15
Values 0.34 0.13
[80]
HepG2.C3A AKT3
Mean 0.036
Standard deviation 0.0097
Values 0.029 0.043
[81]
HuH.7 AKT3
Mean 0.0557
Standard deviation 0.031
Values 0.049 0.09 0.028
[82]
SNU475 AKT3
Mean 40.8
Standard deviation 10
Values 48 34
[83]
THLE AKT3
Mean 22.1
Standard deviation 4.4
Values 25 19
[84]
liver AKT3
Mean 6.71
Standard deviation 4.9
Values 2.8 12 2.3 9.4
[85]
ref_hepatocyte NRG2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[86]
HepG2 NRG2
Mean 0.0236
Standard deviation 0.015
Values 0.034 0.013
[87]
HepG2.C3A NRG2
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 NRG2
Mean 0
Standard deviation 0
Values 0 0 0
[89]
SNU475 NRG2
Mean 0.181
Standard deviation 0.12
Values 0.093 0.27
[90]
THLE NRG2
Mean 0.79
Standard deviation 0.23
Values 0.63 0.95
[91]
liver NRG2
Mean 0.0321
Standard deviation 0.024
Values 0.047 0.029 0 0.053