REACTOME_DNA_DOUBLE_STRAND_BREAK_RESPONSE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.76[2] | -1.04[3] | -1.13[4] | -1.21[5] | -0.97[6] | -0.35[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.31[16] | -0.29[17] | -0.76[18] | -0.36[19] | -0.59[20] | 0.10[21] |
4 | SUMO1 | Small ubiquitin-related modifier 1 | [22] | -0.15[23] | -0.09[24] | -0.69[25] | 0.10[26] | -0.17[27] | -0.02[28] |
5 | UBXN1 | UBX domain-containing protein 1 | [29] | -0.66[30] | -0.81[31] | -0.19[32] | -0.88[33] | -0.92[34] | -1.88[35] |
6 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [36] | 2.12[37] | 1.94[38] | 2.75[39] | 1.04[40] | 1.63[41] | 0.87[42] |
7 | KPNA2 | Importin subunit alpha-1 | [43] | 2.22[44] | 2.01[45] | 2.30[46] | 2.10[47] | 2.61[48] | -0.27[49] |
8 | BABAM1 | BRISC and BRCA1-A complex member 1 | [50] | 0.62[51] | 0.74[52] | 1.40[53] | 0.54[54] | 0.99[55] | 0.05[56] |
9 | UBE2N | Ubiquitin-conjugating enzyme E2 N | [57] | 2.13[58] | 2.52[59] | 1.11[60] | 1.88[61] | 1.56[62] | 0.80[63] |
10 | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2 | [64] | -0.01[65] | 0.91[66] | 1.16[67] | 1.64[68] | 1.22[69] | 0.92[70] |
11 | PPP5C | Serine/threonine-protein phosphatase 5 | [71] | 1.49[72] | 1.25[73] | 1.46[74] | 1.72[75] | 2.08[76] | 1.28[77] |
12 | UBE2I | SUMO-conjugating enzyme UBC9 | [78] | 2.73[79] | 2.32[80] | 2.47[81] | 1.89[82] | 2.24[83] | 0.97[84] |
13 | BAP1 | Ubiquitin carboxyl-terminal hydrolase BAP1 | [85] | 2.53[86] | 2.62[87] | 1.52[88] | 2.03[89] | 2.62[90] | 1.91[91] |
14 | BAZ1B | Tyrosine-protein kinase BAZ1B | [92] | 2.65[93] | 2.78[94] | 2.49[95] | 3.77[96] | 3.46[97] | 2.78[98] |
15 | MAPK8 | Mitogen-activated protein kinase 8 | [99] | 0.00[100] | 1.32[101] | -0.04[102] | 0.66[103] | 0.30[104] | 1.01[105] |
16 | KAT5 | Histone acetyltransferase KAT5 | [106] | 0.66[107] | 0.99[108] | -0.28[109] | 0.73[110] | 0.43[111] | 0.45[112] |
17 | SMARCA5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfa | 2.76[113] | 3.25[114] | 3.31[115] | 3.41[116] | 3.77[117] | 3.07[118] | |
18 | NBN | Nibrin | [119] | 1.03[120] | 2.12[121] | 1.64[122] | 3.07[123] | 1.97[124] | 2.79[125] |
19 | CHEK2 | Serine/threonine-protein kinase Chk2 | [126] | 1.54[127] | 1.90[128] | 2.06[129] | 1.32[130] | 0.73[131] | -1.76[132] |
20 | TP53 | Cellular tumor antigen p53 | [133] | 3.08[134] | 2.55[135] | 3.08[136] | 2.86[137] | 2.31[138] | 1.48[139] |
21 | UIMC1 | BRCA1-A complex subunit RAP80 | [140] | 1.82[141] | 1.96[142] | 2.17[143] | 1.64[144] | 1.57[145] | 1.23[146] |
22 | BRCC3 | Lys-63-specific deubiquitinase BRCC36 | [147] | 0.98[148] | 1.83[149] | 0.88[150] | 1.34[151] | 1.29[152] | 1.96[153] |
23 | KDM4A | Lysine-specific demethylase 4A | [154] | 2.76[155] | 2.24[156] | 2.36[157] | 2.82[158] | 2.69[159] | 2.61[160] |
24 | ABL1 | Tyrosine-protein kinase ABL1 | [161] | 3.67[162] | 2.98[163] | 3.54[164] | 3.64[165] | 4.10[166] | 2.46[167] |
25 | RAD50 | DNA repair protein RAD50 | [168] | 1.60[169] | 3.64[170] | 2.55[171] | 2.83[172] | 3.11[173] | 3.73[174] |
26 | PIAS4 | E3 SUMO-protein ligase PIAS4 | [175] | 1.69[176] | 1.12[177] | 1.63[178] | 1.04[179] | 0.93[180] | 1.11[181] |
27 | RNF8 | E3 ubiquitin-protein ligase RNF8 | [182] | 2.78[183] | 2.77[184] | 1.19[185] | 2.84[186] | 2.11[187] | 1.43[188] |
28 | RNF168 | E3 ubiquitin-protein ligase RNF168 | [189] | 1.83[190] | 2.39[191] | 3.15[192] | 1.64[193] | 2.59[194] | 3.61[195] |
29 | MDC1 | Mediator of DNA damage checkpoint protein 1 | [196] | 3.93[197] | 4.25[198] | 4.35[199] | 4.46[200] | 4.17[201] | 2.97[202] |
30 | KDM4B | Lysine-specific demethylase 4B | [203] | 4.21[204] | 3.70[205] | 4.13[206] | 3.09[207] | 3.17[208] | 3.46[209] |
31 | BRCA1 | Breast cancer type 1 susceptibility protein | [210] | 3.11[211] | 4.27[212] | 4.43[213] | 3.71[214] | 4.02[215] | 3.20[216] |
32 | APBB1 | Amyloid-beta A4 precursor protein-binding family B member 1 | [217] | 0.72[218] | -2.96[219] | 2.69[220] | 3.55[221] | 3.00[222] | 1.67[223] |
33 | HERC2 | E3 ubiquitin-protein ligase HERC2 | [224] | 3.90[225] | 3.51[226] | 3.83[227] | 4.65[228] | 4.50[229] | 5.69[230] |
34 | TP53BP1 | TP53-binding protein 1 | [231] | 4.02[232] | 3.44[233] | 4.17[234] | 5.50[235] | 4.74[236] | 3.80[237] |
35 | EYA3 | Eyes absent homolog 3 | [238] | 3.30[239] | 3.45[240] | 3.68[241] | 3.57[242] | 3.51[243] | 3.80[244] |
36 | ATM | Serine-protein kinase ATM | [245] | 4.47[246] | 5.99[247] | 5.48[248] | 5.72[249] | 4.99[250] | 6.51[251] |
37 | BARD1 | BRCA1-associated RING domain protein 1 | [252] | 2.76[253] | 3.66[254] | 3.44[255] | 4.26[256] | 4.13[257] | 3.39[258] |
38 | EYA2 | Eyes absent homolog 2 | [259] | -5.94[260] | [261] | [262] | 0.95[263] | -5.26[264] | 0.21[265] |
39 | EYA4 | Eyes absent homolog 4 | [266] | 3.23[267] | 2.73[268] | 10.64[269] | 13.04[270] | 10.77[271] | 6.51[272] |
40 | H2BC17 | [273] | [274] | [275] | [276] | [277] | [278] | [279] | |
41 | H2BC21 | [280] | [281] | [282] | [283] | [284] | [285] | [286] | |
42 | H4C6 | [287] | [288] | [289] | [290] | [291] | [292] | [293] | |
43 | H4C14 | [294] | [295] | [296] | [297] | [298] | [299] | [300] | |
44 | H2BC4 | [301] | [302] | [303] | [304] | [305] | [306] | [307] | |
45 | ABRAXAS | BRCA1-A complex subunit Abraxas 1 | [308] | [309] | [310] | [311] | [312] | [313] | [314] |
46 | MRE11 | Double-strand break repair protein MRE11 | [315] | [316] | [317] | [318] | [319] | [320] | [321] |
47 | NSD2 | Histone-lysine N-methyltransferase NSD2 | [322] | [323] | [324] | [325] | [326] | [327] | [328] |
48 | H2AX | [329] | [330] | [331] | [332] | [333] | [334] | [335] | |
49 | H2BC11 | [336] | [337] | [338] | [339] | [340] | [341] | [342] | |
50 | H4C2 | [343] | [344] | [345] | [346] | [347] | [348] | [349] | |
51 | H2BC13 | [350] | [351] | [352] | [353] | [354] | [355] | [356] | |
52 | H2BC12 | [357] | [358] | [359] | [360] | [361] | [362] | [363] | |
53 | H2BC14 | [364] | [365] | [366] | [367] | [368] | [369] | [370] | |
54 | H2BC8 | [371] | [372] | [373] | [374] | [375] | [376] | [377] | |
55 | H4C15 | [378] | [379] | [380] | [381] | [382] | [383] | [384] | |
56 | H4C1 | [385] | [386] | [387] | [388] | [389] | [390] | [391] | |
57 | H2BC5 | [392] | [393] | [394] | [395] | [396] | [397] | [398] | |
58 | EYA1 | Eyes absent homolog 1 | [399] | [400] | [401] | [402] | [403] | [404] | [405] |
59 | H2BC7 | [406] | [407] | [408] | [409] | [410] | [411] | [412] | |
60 | H2BC9 | [413] | [414] | [415] | [416] | [417] | [418] | [419] | |
61 | H4-16 | [420] | [421] | [422] | [423] | [424] | [425] | [426] | |
62 | H4C13 | [427] | [428] | [429] | [430] | [431] | [432] | [433] | |
63 | H2BC3 | [434] | [435] | [436] | [437] | [438] | [439] | [440] | |
64 | H4C3 | [441] | [442] | [443] | [444] | [445] | [446] | [447] | |
65 | BABAM2 | BRISC and BRCA1-A complex member 2 | [448] | [449] | [450] | [451] | [452] | [453] | [454] |
66 | H2BS1 | [455] | [456] | [457] | [458] | [459] | [460] | [461] | |
67 | H4C9 | [462] | [463] | [464] | [465] | [466] | [467] | [468] | |
68 | H4C12 | [469] | [470] | [471] | [472] | [473] | [474] | [475] | |
69 | H2BU1 | [476] | [477] | [478] | [479] | [480] | [481] | [482] | |
70 | H2BC6 | [483] | [484] | [485] | [486] | [487] | [488] | [489] | |
71 | H2BC10 | [490] | [491] | [492] | [493] | [494] | [495] | [496] | |
72 | H4C5 | [497] | [498] | [499] | [500] | [501] | [502] | [503] | |
73 | H2BC1 | [504] | [505] | [506] | [507] | [508] | [509] | [510] | |
74 | H4C8 | [511] | [512] | [513] | [514] | [515] | [516] | [517] | |
75 | H4C4 | [518] | [519] | [520] | [521] | [522] | [523] | [524] | |
76 | H4C11 | [525] | [526] | [527] | [528] | [529] | [530] | [531] | |
77 | H3-4 | [532] | [533] | [534] | [535] | [536] | [537] | [538] | |
78 | H2BC15 | [539] | [540] | [541] | [542] | [543] | [544] | [545] |