REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PLG | Plasminogen | [1] | -12.67[2] | -10.27[3] | -2.50[4] | -13.08[5] | -11.29[6] | -0.45[7] |
2 | A2M | Alpha-2-macroglobulin | [8] | -0.92[9] | 0.52[10] | -1.91[11] | -9.66[12] | -10.35[13] | 0.82[14] |
3 | CTSB | Cathepsin B | [15] | -0.39[16] | -0.68[17] | -1.48[18] | -2.31[19] | -1.35[20] | -1.15[21] |
4 | CTSD | Cathepsin D | [22] | -0.92[23] | -1.29[24] | -1.02[25] | -0.78[26] | -2.58[27] | -0.58[28] |
5 | FN1 | Fibronectin | [29] | 2.58[30] | 2.34[31] | 2.48[32] | 2.02[33] | 2.34[34] | 1.15[35] |
6 | TIMP1 | Metalloproteinase inhibitor 1 | [36] | -3.14[37] | -4.48[38] | -11.41[39] | -2.86[40] | -1.16[41] | -1.19[42] |
7 | BSG | Basigin | [43] | -0.15[44] | 0.09[45] | 0.48[46] | -1.00[47] | -0.30[48] | -2.17[49] |
8 | CAPNS1 | Calpain small subunit 1 | [50] | -1.47[51] | -1.44[52] | -1.34[53] | -1.69[54] | -1.55[55] | -3.59[56] |
9 | COL18A1 | Collagen alpha-1(XVIII) chain | [57] | -0.40[58] | -0.85[59] | -0.35[60] | -0.48[61] | -4.06[62] | 0.06[63] |
10 | FURIN | Furin | [64] | 0.71[65] | -2.75[66] | -0.34[67] | -2.17[68] | -1.59[69] | 0.51[70] |
11 | HTRA1 | Serine protease HTRA1 | [71] | -6.47[72] | -10.26[73] | -4.36[74] | -1.29[75] | -1.06[76] | -1.29[77] |
12 | CAPN2 | Calpain-2 catalytic subunit | [78] | -1.69[79] | -2.80[80] | -5.18[81] | 0.33[82] | 0.00[83] | -2.31[84] |
13 | SPP1 | Osteopontin | [85] | 2.26[86] | 1.32[87] | -6.94[88] | 1.00[89] | -6.95[90] | -2.22[91] |
14 | CAPN1 | Calpain-1 catalytic subunit | [92] | -0.39[93] | -1.28[94] | -0.45[95] | -0.52[96] | -0.75[97] | -1.49[98] |
15 | KLKB1 | Plasma kallikrein | [99] | -9.57[100] | -6.39[101] | -7.15[102] | -13.08[103] | -11.60[104] | -0.82[105] |
16 | LAMC2 | Laminin subunit gamma-2 | [106] | -9.24[107] | -10.19[108] | -8.66[109] | -5.87[110] | -4.60[111] | -7.47[112] |
17 | LAMB3 | Laminin subunit beta-3 | [113] | -3.72[114] | -6.29[115] | -4.60[116] | -1.56[117] | -2.40[118] | -3.52[119] |
18 | CAST | Calpastatin | [120] | -0.99[121] | -0.29[122] | 0.39[123] | 0.06[124] | -0.39[125] | -0.34[126] |
19 | NCSTN | Nicastrin | [127] | 0.43[128] | -0.12[129] | 0.28[130] | 0.19[131] | 0.19[132] | -0.75[133] |
20 | ADAM9 | Disintegrin and metalloproteinase domain-containing protein 9 | [134] | 0.43[135] | 1.21[136] | 1.33[137] | 1.13[138] | 1.58[139] | -1.48[140] |
21 | CD44 | CD44 antigen | [141] | -7.98[142] | -9.19[143] | -2.52[144] | 0.86[145] | 1.43[146] | -2.43[147] |
22 | CASP3 | Caspase-3 | [148] | -0.78[149] | 0.18[150] | -2.12[151] | -1.79[152] | -0.68[153] | -1.95[154] |
23 | TMPRSS6 | Transmembrane protease serine 6 | [155] | -2.70[156] | -1.35[157] | -5.96[158] | -10.38[159] | -8.43[160] | -0.26[161] |
24 | CDH1 | Cadherin-1 | [162] | 0.20[163] | 0.97[164] | 1.75[165] | -4.07[166] | -8.20[167] | 0.42[168] |
25 | MMP1 | Interstitial collagenase | [169] | -6.08[170] | -9.56[171] | [172] | -2.65[173] | -2.99[174] | -13.27[175] |
26 | NID1 | Nidogen-1 | [176] | 0.52[177] | 0.78[178] | 3.21[179] | -0.02[180] | 0.42[181] | 1.30[182] |
27 | MMP3 | Stromelysin-1 | [183] | -5.43[184] | -10.06[185] | -12.19[186] | -2.64[187] | -5.58[188] | -9.47[189] |
28 | CTSS | Cathepsin S | [190] | -3.46[191] | -2.52[192] | -4.59[193] | -1.82[194] | -4.54[195] | -0.48[196] |
29 | LAMC1 | Laminin subunit gamma-1 | [197] | 2.43[198] | 0.98[199] | 1.96[200] | 2.87[201] | 2.63[202] | 0.09[203] |
30 | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 | [204] | 0.07[205] | 0.84[206] | 1.11[207] | 0.38[208] | 0.91[209] | -0.34[210] |
31 | MMP15 | Matrix metalloproteinase-15 | [211] | 0.80[212] | 1.17[213] | 1.19[214] | -1.31[215] | -0.66[216] | -0.56[217] |
32 | TIMP2 | Metalloproteinase inhibitor 2 | [218] | 1.30[219] | -0.75[220] | -2.32[221] | 2.19[222] | 3.02[223] | -1.29[224] |
33 | COL9A3 | Collagen alpha-3(IX) chain | [225] | 1.90[226] | 1.18[227] | -2.66[228] | -4.65[229] | -6.44[230] | -6.29[231] |
34 | PSEN1 | Presenilin-1 | [232] | 0.14[233] | 0.65[234] | 0.46[235] | 0.36[236] | 0.35[237] | -0.14[238] |
35 | CAPN5 | Calpain-5 | [239] | -3.07[240] | -3.57[241] | -0.32[242] | -1.58[243] | -0.03[244] | -0.04[245] |
36 | ADAM15 | Disintegrin and metalloproteinase domain-containing protein 15 | [246] | 0.79[247] | 0.44[248] | 1.35[249] | 1.24[250] | 2.03[251] | -0.72[252] |
37 | CAPN7 | Calpain-7 | [253] | -0.84[254] | 0.59[255] | 1.81[256] | -0.36[257] | 0.10[258] | 0.20[259] |
38 | ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17 | [260] | -0.24[261] | -0.07[262] | -0.09[263] | 0.84[264] | 0.09[265] | -1.06[266] |
39 | BMP1 | Bone morphogenetic protein 1 | [267] | -0.18[268] | -1.39[269] | -1.82[270] | 1.22[271] | 0.75[272] | -0.22[273] |
40 | MMP10 | Stromelysin-2 | [274] | -7.24[275] | -11.37[276] | [277] | -9.08[278] | [279] | [280] |
41 | LAMB1 | Laminin subunit beta-1 | [281] | 3.00[282] | 2.85[283] | 4.44[284] | 4.49[285] | 3.79[286] | 1.19[287] |
42 | MMP14 | Matrix metalloproteinase-14 | [288] | 0.14[289] | -0.15[290] | 2.08[291] | -0.18[292] | 4.47[293] | -1.65[294] |
43 | CAPN10 | Calpain-10 | [295] | -0.27[296] | 0.86[297] | 0.31[298] | -0.72[299] | -0.65[300] | -1.35[301] |
44 | COL6A1 | Collagen alpha-1(VI) chain | [302] | -0.67[303] | -2.28[304] | 1.42[305] | 2.57[306] | 3.17[307] | 1.72[308] |
45 | CAPN3 | Calpain-3 | [309] | -4.40[310] | -2.27[311] | -3.37[312] | -6.32[313] | -4.25[314] | -0.69[315] |
46 | LAMA5 | Laminin subunit alpha-5 | [316] | 4.01[317] | 3.49[318] | 3.37[319] | 5.11[320] | 2.76[321] | 1.61[322] |
47 | COL16A1 | Collagen alpha-1(XVI) chain | [323] | 0.86[324] | 0.40[325] | -7.72[326] | -1.52[327] | -0.92[328] | -2.74[329] |
48 | ADAMTS1 | A disintegrin and metalloproteinase with thrombospondin motifs 1 | [330] | -4.10[331] | -7.66[332] | 1.11[333] | -2.22[334] | 1.37[335] | 1.00[336] |
49 | MMP24 | Matrix metalloproteinase-24 | [337] | -0.62[338] | -0.41[339] | -1.10[340] | 1.70[341] | -0.76[342] | -1.30[343] |
50 | MMP19 | Matrix metalloproteinase-19 | [344] | -3.63[345] | -4.72[346] | -5.34[347] | -2.75[348] | -0.34[349] | -2.48[350] |
51 | MMP12 | Macrophage metalloelastase | [351] | [352] | [353] | [354] | -2.62[355] | -10.60[356] | -6.84[357] |
52 | COL4A5 | Collagen alpha-5(IV) chain | [358] | 2.35[359] | -6.66[360] | -0.62[361] | 1.81[362] | 3.21[363] | -1.81[364] |
53 | COL5A2 | Collagen alpha-2(V) chain | [365] | -2.13[366] | -1.80[367] | 6.39[368] | 5.90[369] | 5.31[370] | 1.79[371] |
54 | COL9A2 | Collagen alpha-2(IX) chain | [372] | 2.86[373] | 2.59[374] | 1.99[375] | -0.02[376] | -3.24[377] | -4.53[378] |
55 | TPSAB1 | Tryptase alpha/beta-1 | [379] | -2.34[380] | [381] | [382] | [383] | [384] | -1.88[385] |
56 | COL5A3 | Collagen alpha-3(V) chain | [386] | -4.94[387] | -4.94[388] | -0.23[389] | -2.60[390] | -4.59[391] | -0.10[392] |
57 | CAPN12 | Calpain-12 | [393] | -3.31[394] | 1.48[395] | 2.08[396] | -3.72[397] | -4.53[398] | 1.24[399] |
58 | COL6A2 | Collagen alpha-2(VI) chain | [400] | -1.46[401] | -4.15[402] | 1.32[403] | 4.15[404] | 4.39[405] | 2.95[406] |
59 | MMP9 | Matrix metalloproteinase-9 | [407] | -3.64[408] | -4.40[409] | -6.55[410] | -2.33[411] | -4.77[412] | -1.28[413] |
60 | DCN | Decorin | [414] | -7.25[415] | -8.70[416] | -5.57[417] | 0.64[418] | 4.92[419] | 4.56[420] |
61 | CTSG | Cathepsin G | [421] | [422] | [423] | [424] | [425] | [426] | -3.31[427] |
62 | SCUBE1 | Signal peptide, CUB and EGF-like domain-containing protein 1 | [428] | -4.30[429] | [430] | -9.26[431] | -0.84[432] | -9.32[433] | -2.02[434] |
63 | COL4A2 | Collagen alpha-2(IV) chain | [435] | -0.98[436] | -0.38[437] | -2.83[438] | 6.29[439] | 6.31[440] | 4.01[441] |
64 | HSPG2 | Basement membrane-specific heparan sulfate proteoglycan core protein | 6.70[442] | 5.23[443] | 5.87[444] | 5.15[445] | 5.43[446] | 5.23[447] | |
65 | COL3A1 | Collagen alpha-1(III) chain | [448] | -1.91[449] | -3.22[450] | -0.59[451] | 9.06[452] | 7.39[453] | 6.46[454] |
66 | COL1A1 | Collagen alpha-1(I) chain | [455] | 3.82[456] | -3.40[457] | -1.34[458] | 6.11[459] | 7.76[460] | 5.21[461] |
67 | LAMA3 | Laminin subunit alpha-3 | [462] | 2.61[463] | 2.74[464] | -1.05[465] | 3.59[466] | 1.00[467] | 0.39[468] |
68 | COL7A1 | Collagen alpha-1(VII) chain | [469] | 1.97[470] | 5.23[471] | 2.51[472] | 4.89[473] | 3.96[474] | -0.86[475] |
69 | COL1A2 | Collagen alpha-2(I) chain | [476] | -7.07[477] | -6.70[478] | -3.97[479] | 4.08[480] | 4.23[481] | 5.28[482] |
70 | ADAM8 | Disintegrin and metalloproteinase domain-containing protein 8 | [483] | -3.98[484] | -2.48[485] | 1.00[486] | -1.21[487] | -0.38[488] | 0.67[489] |
71 | MMP11 | Stromelysin-3 | [490] | 1.94[491] | 3.18[492] | 4.29[493] | 1.07[494] | -0.68[495] | -2.02[496] |
72 | COL4A1 | Collagen alpha-1(IV) chain | [497] | -3.65[498] | -4.35[499] | -2.75[500] | 6.49[501] | 6.38[502] | 4.93[503] |
73 | ELN | Elastin | [504] | -2.66[505] | -0.14[506] | -8.26[507] | -2.99[508] | -4.63[509] | 2.23[510] |
74 | ADAMTS4 | A disintegrin and metalloproteinase with thrombospondin motifs 4 | [511] | 1.91[512] | 2.57[513] | -2.37[514] | -1.83[515] | -0.41[516] | 0.66[517] |
75 | CMA1 | Chymase | [518] | -5.76[519] | -7.25[520] | [521] | -8.63[522] | [523] | -3.51[524] |
76 | CAPN8 | Calpain-8 | [525] | -3.01[526] | [527] | -4.41[528] | -6.93[529] | [530] | -6.92[531] |
77 | COL4A6 | Collagen alpha-6(IV) chain | [532] | 3.57[533] | -5.43[534] | -4.63[535] | 0.51[536] | 4.40[537] | -2.76[538] |
78 | MMP7 | Matrilysin | [539] | -0.49[540] | -2.99[541] | [542] | 1.65[543] | -3.50[544] | -0.43[545] |
79 | MMP2 | 72 kDa type IV collagenase | [546] | 2.52[547] | -4.18[548] | -2.66[549] | 6.54[550] | 6.21[551] | 2.79[552] |
80 | ADAMTS9 | A disintegrin and metalloproteinase with thrombospondin motifs 9 | [553] | -1.14[554] | 4.51[555] | 5.45[556] | 4.61[557] | 8.12[558] | 3.48[559] |
81 | CTSK | Cathepsin K | [560] | 0.06[561] | 2.34[562] | 2.13[563] | 2.18[564] | 2.16[565] | 1.98[566] |
82 | COL17A1 | Collagen alpha-1(XVII) chain | [567] | 0.74[568] | -3.78[569] | -3.02[570] | -1.95[571] | -0.33[572] | -1.48[573] |
83 | COL15A1 | Collagen alpha-1(XV) chain | [574] | -2.28[575] | -6.13[576] | [577] | 2.31[578] | -1.63[579] | -0.25[580] |
84 | ADAMTS8 | A disintegrin and metalloproteinase with thrombospondin motifs 8 | [581] | -7.27[582] | [583] | -5.57[584] | -6.22[585] | -4.82[586] | -2.13[587] |
85 | COL2A1 | Collagen alpha-1(II) chain | [588] | -0.33[589] | 2.73[590] | 5.45[591] | -3.25[592] | -3.40[593] | [594] |
86 | CAPN13 | Calpain-13 | [595] | -6.32[596] | [597] | [598] | [599] | [600] | -5.45[601] |
87 | FBN1 | Fibrillin-1 | [602] | 2.14[603] | 0.50[604] | 3.29[605] | 5.44[606] | 8.52[607] | 6.25[608] |
88 | COL12A1 | Collagen alpha-1(XII) chain | [609] | -0.51[610] | -2.54[611] | 4.87[612] | 9.90[613] | 6.83[614] | 4.06[615] |
89 | COL6A3 | Collagen alpha-3(VI) chain | [616] | -0.78[617] | -3.05[618] | -3.23[619] | 6.52[620] | 7.29[621] | 6.67[622] |
90 | MMP25 | Matrix metalloproteinase-25 | [623] | -0.84[624] | -0.25[625] | 0.14[626] | 0.22[627] | 0.82[628] | 2.01[629] |
91 | COL14A1 | Collagen alpha-1(XIV) chain | [630] | -1.11[631] | -0.47[632] | 9.53[633] | 4.20[634] | -0.44[635] | 6.16[636] |
92 | COL25A1 | Collagen alpha-1(XXV) chain | [637] | [638] | -2.98[639] | [640] | -6.47[641] | -1.06[642] | 3.16[643] |
93 | ADAMTS1 | A disintegrin and metalloproteinase with thrombospondin motifs 16 | -1.70[644] | -5.35[645] | 0.83[646] | 4.89[647] | -5.44[648] | -1.02[649] | |
94 | COL4A3 | Collagen alpha-3(IV) chain | [650] | -4.21[651] | -3.68[652] | -2.02[653] | 5.24[654] | -1.86[655] | 2.38[656] |
95 | COL4A4 | Collagen alpha-4(IV) chain | [657] | -2.31[658] | -4.85[659] | -0.37[660] | 7.45[661] | 3.16[662] | 4.87[663] |
96 | ELANE | Neutrophil elastase | [664] | [665] | [666] | -2.83[667] | -2.55[668] | -5.02[669] | 0.91[670] |
97 | COL13A1 | Collagen alpha-1(XIII) chain | [671] | -3.73[672] | [673] | -4.78[674] | -0.30[675] | 2.88[676] | -0.17[677] |
98 | COL5A1 | Collagen alpha-1(V) chain | [678] | 2.51[679] | -0.81[680] | 0.72[681] | 10.20[682] | 9.36[683] | 5.97[684] |
99 | FBN2 | Fibrillin-2 | [685] | 0.24[686] | [687] | -3.20[688] | 3.45[689] | 6.39[690] | 2.72[691] |
100 | COL11A2 | Collagen alpha-2(XI) chain | [692] | 0.53[693] | 2.38[694] | 2.07[695] | 3.99[696] | 1.80[697] | 1.71[698] |
101 | TLL1 | Tolloid-like protein 1 | [699] | [700] | -4.38[701] | 2.18[702] | -5.62[703] | 4.15[704] | 1.05[705] |
102 | KLK7 | Kallikrein-7 | [706] | -0.24[707] | 0.19[708] | -0.39[709] | -0.96[710] | -0.95[711] | -3.12[712] |
103 | MMP8 | Neutrophil collagenase | [713] | [714] | [715] | [716] | [717] | -2.81[718] | 1.91[719] |
104 | SCUBE3 | Signal peptide, CUB and EGF-like domain-containing protein 3 | [720] | -0.54[721] | 0.23[722] | 0.87[723] | 6.50[724] | -0.65[725] | 2.77[726] |
105 | MMP17 | Matrix metalloproteinase-17 | [727] | 5.19[728] | 5.78[729] | 7.20[730] | 1.96[731] | 5.55[732] | -1.69[733] |
106 | TLL2 | Tolloid-like protein 2 | [734] | 1.38[735] | -0.35[736] | 2.09[737] | 2.79[738] | -0.14[739] | -0.12[740] |
107 | FBN3 | Fibrillin-3 | [741] | 2.68[742] | 6.00[743] | 3.90[744] | -3.93[745] | [746] | -0.41[747] |
108 | SPOCK3 | Testican-3 | [748] | [749] | [750] | -3.85[751] | -4.44[752] | 3.49[753] | 1.52[754] |
109 | COL9A1 | Collagen alpha-1(IX) chain | [755] | -3.47[756] | [757] | [758] | -4.49[759] | [760] | -2.23[761] |
110 | CAPN6 | Calpain-6 | [762] | [763] | [764] | [765] | 1.22[766] | [767] | 2.37[768] |
111 | MMP20 | Matrix metalloproteinase-20 | [769] | 3.40[770] | 3.70[771] | [772] | -1.50[773] | -3.87[774] | -3.53[775] |
112 | COL11A1 | Collagen alpha-1(XI) chain | [776] | -0.52[777] | [778] | -1.24[779] | 5.32[780] | 2.75[781] | -0.87[782] |
113 | COL23A1 | Collagen alpha-1(XXIII) chain | [783] | -1.21[784] | [785] | [786] | -2.80[787] | [788] | 2.67[789] |
114 | COL8A1 | Collagen alpha-1(VIII) chain | [790] | -1.66[791] | -0.59[792] | 0.48[793] | 4.00[794] | 10.17[795] | 4.91[796] |
115 | CAPN14 | Calpain-14 | [797] | -2.84[798] | [799] | [800] | 0.09[801] | 0.71[802] | -0.72[803] |
116 | BCAN | Brevican core protein | [804] | 7.29[805] | 7.76[806] | 6.24[807] | 6.46[808] | 4.52[809] | 1.57[810] |
117 | COL8A2 | Collagen alpha-2(VIII) chain | [811] | 4.89[812] | 3.34[813] | 4.89[814] | 3.59[815] | 5.43[816] | 3.66[817] |
118 | COL19A1 | Collagen alpha-1(XIX) chain | [818] | -1.24[819] | [820] | 4.32[821] | 1.37[822] | 0.04[823] | 4.60[824] |
119 | ADAMTS5 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | [825] | [826] | [827] | 2.64[828] | 2.66[829] | 9.32[830] | 8.81[831] |
120 | KLK2 | Kallikrein-2 | [832] | [833] | [834] | [835] | [836] | [837] | [838] |
121 | CAPN11 | Calpain-11 | [839] | [840] | [841] | [842] | [843] | [844] | [845] |
122 | COL10A1 | Collagen alpha-1(X) chain | [846] | [847] | [848] | [849] | [850] | [851] | [852] |
123 | COL6A6 | Collagen alpha-6(VI) chain | [853] | [854] | [855] | [856] | [857] | [858] | [859] |
124 | COL26A1 | Collagen alpha-1(XXVI) chain | [860] | [861] | [862] | [863] | [864] | [865] | [866] |
125 | CTSL | Cathepsin L1 | [867] | [868] | [869] | [870] | [871] | [872] | [873] |
126 | CAPN15 | Calpain-15 | [874] | [875] | [876] | [877] | [878] | [879] | [880] |
127 | MMP16 | Matrix metalloproteinase-16 | [881] | [882] | [883] | [884] | [885] | [886] | [887] |
128 | PRSS2 | Trypsin-2 | [888] | [889] | [890] | [891] | [892] | [893] | [894] |
129 | CTSV | Cathepsin L2 | [895] | [896] | [897] | [898] | [899] | [900] | [901] |
130 | CTRB1 | Chymotrypsinogen B | [902] | [903] | [904] | [905] | [906] | [907] | [908] |
131 | ACAN | Aggrecan core protein | [909] | [910] | [911] | [912] | [913] | [914] | [915] |
132 | COL6A5 | Collagen alpha-5(VI) chain | [916] | [917] | [918] | [919] | [920] | [921] | [922] |
133 | PHYKPL | 5-phosphohydroxy-L-lysine phospho-lyase | [923] | [924] | [925] | [926] | [927] | [928] | [929] |
134 | OPTC | Opticin | [930] | [931] | [932] | [933] | [934] | [935] | [936] |
135 | ADAMTS1 | A disintegrin and metalloproteinase with thrombospondin motifs 18 | [937] | [938] | [939] | [940] | [941] | [942] | |
136 | MMP13 | Collagenase 3 | [943] | [944] | [945] | [946] | [947] | [948] | [949] |
137 | PRSS1 | Trypsin-1 | [950] | [951] | [952] | [953] | [954] | [955] | [956] |
138 | CAPNS2 | Calpain small subunit 2 | [957] | [958] | [959] | [960] | [961] | [962] | [963] |
139 | CTRB2 | Chymotrypsinogen B2 | [964] | [965] | [966] | [967] | [968] | [969] | [970] |
140 | CAPN9 | Calpain-9 | [971] | [972] | [973] | [974] | [975] | [976] | [977] |