REACTOME_DEGRADATION_OF_GLI1_BY_THE_PROTEASOME | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.08[2] | -1.15[3] | -0.98[4] | -1.36[5] | -0.99[6] | -0.46[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.63[16] | -0.40[17] | -0.61[18] | -0.50[19] | -0.62[20] | -0.01[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.40[23] | -1.99[24] | -1.58[25] | -1.22[26] | -1.84[27] | -0.96[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.22[30] | -1.61[31] | -1.67[32] | -1.01[33] | -1.38[34] | -0.59[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.74[37] | 0.86[38] | -0.42[39] | 0.62[40] | 0.10[41] | 0.44[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.28[44] | 0.41[45] | -0.62[46] | -0.63[47] | 0.06[48] | 0.27[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.20[51] | -0.97[52] | 0.11[53] | -0.65[54] | -0.84[55] | -0.02[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | 0.04[58] | 0.23[59] | 0.40[60] | 0.78[61] | 0.70[62] | -0.35[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -0.90[65] | -0.87[66] | -0.69[67] | -0.99[68] | -0.63[69] | -0.79[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.50[72] | 0.09[73] | 0.06[74] | -0.27[75] | -0.07[76] | -0.32[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.63[79] | 0.36[80] | 0.35[81] | 0.26[82] | 0.20[83] | -0.23[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.30[86] | 0.38[87] | 0.22[88] | 0.56[89] | 0.31[90] | -0.31[91] |
14 | SKP1 | S-phase kinase-associated protein 1 | [92] | 0.14[93] | 0.66[94] | -0.19[95] | 0.92[96] | 1.04[97] | 0.72[98] |
15 | PSMC3 | 26S proteasome regulatory subunit 6A | [99] | -0.34[100] | -0.38[101] | 0.29[102] | -0.64[103] | -0.51[104] | 0.16[105] |
16 | PSMA3 | Proteasome subunit alpha type-3 | [106] | -0.92[107] | 0.10[108] | -0.53[109] | 0.11[110] | -0.41[111] | -0.07[112] |
17 | PSMB6 | Proteasome subunit beta type-6 | [113] | -0.37[114] | -0.20[115] | -0.01[116] | -0.44[117] | -0.78[118] | 0.09[119] |
18 | PSMA2 | Proteasome subunit alpha type-2 | [120] | -0.46[121] | 0.52[122] | 0.90[123] | 0.06[124] | 0.36[125] | 0.32[126] |
19 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [127] | 0.06[128] | 0.09[129] | 0.34[130] | 0.76[131] | 0.15[132] | -0.01[133] |
20 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [134] | -0.02[135] | 0.37[136] | 0.28[137] | -0.33[138] | 0.08[139] | -0.18[140] |
21 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [141] | 0.14[142] | 0.41[143] | 0.59[144] | -0.05[145] | 0.64[146] | -0.16[147] |
22 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [148] | 1.67[149] | 0.88[150] | 1.00[151] | 1.06[152] | 2.28[153] | 0.88[154] |
23 | PSMC1 | 26S proteasome regulatory subunit 4 | [155] | 0.00[156] | 0.08[157] | -0.52[158] | 1.24[159] | 0.70[160] | 0.04[161] |
24 | PSMA1 | Proteasome subunit alpha type-1 | [162] | 0.18[163] | 0.59[164] | 0.70[165] | 0.82[166] | 0.25[167] | 0.53[168] |
25 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [169] | 1.80[170] | 1.83[171] | 2.90[172] | 0.89[173] | 1.61[174] | 0.76[175] |
26 | PSMC5 | 26S proteasome regulatory subunit 8 | [176] | 0.50[177] | 0.42[178] | 0.54[179] | 0.23[180] | 0.57[181] | 0.29[182] |
27 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [183] | -0.93[184] | -0.38[185] | -0.47[186] | -1.28[187] | -0.95[188] | -0.69[189] |
28 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [190] | 0.90[191] | 0.41[192] | 1.05[193] | 0.76[194] | 0.91[195] | 0.01[196] |
29 | PSMB8 | Proteasome subunit beta type-8 | [197] | -1.50[198] | -2.07[199] | -9.24[200] | 0.73[201] | -0.65[202] | -0.68[203] |
30 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [204] | 0.07[205] | 0.70[206] | 1.01[207] | 0.62[208] | 0.58[209] | -0.13[210] |
31 | PSMC4 | 26S proteasome regulatory subunit 6B | [211] | 0.50[212] | 0.55[213] | 0.54[214] | 0.25[215] | 0.29[216] | 0.34[217] |
32 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [218] | -0.65[219] | -0.15[220] | -1.19[221] | -0.38[222] | 0.37[223] | -0.25[224] |
33 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [225] | 0.54[226] | 0.68[227] | 1.22[228] | 0.68[229] | 0.12[230] | -0.06[231] |
34 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [232] | -0.28[233] | -0.17[234] | -0.44[235] | 0.30[236] | 0.30[237] | -0.14[238] |
35 | PSMC6 | 26S proteasome regulatory subunit 10B | [239] | 0.02[240] | 1.62[241] | 0.49[242] | 0.66[243] | 0.52[244] | 0.52[245] |
36 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [246] | 0.90[247] | 0.54[248] | 1.18[249] | 1.07[250] | 1.16[251] | 1.34[252] |
37 | PSMC2 | 26S proteasome regulatory subunit 7 | [253] | 0.66[254] | 1.08[255] | 0.90[256] | 1.46[257] | 1.22[258] | 1.39[259] |
38 | PSME3 | Proteasome activator complex subunit 3 | [260] | 1.88[261] | 1.63[262] | 1.35[263] | 1.49[264] | 1.69[265] | 0.96[266] |
39 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [267] | 1.64[268] | 1.99[269] | 1.91[270] | 2.29[271] | 2.23[272] | 2.15[273] |
40 | PSMB10 | Proteasome subunit beta type-10 | [274] | -1.08[275] | -0.46[276] | -2.30[277] | 0.08[278] | -1.15[279] | 0.00[280] |
41 | PSMA5 | Proteasome subunit alpha type-5 | [281] | 1.97[282] | 2.42[283] | 2.03[284] | 2.35[285] | 1.84[286] | 1.99[287] |
42 | PSMF1 | Proteasome inhibitor PI31 subunit | [288] | 2.35[289] | 2.42[290] | 1.27[291] | 1.35[292] | 1.04[293] | 1.93[294] |
43 | PSMB2 | Proteasome subunit beta type-2 | [295] | 2.13[296] | 1.89[297] | 2.32[298] | 2.65[299] | 2.56[300] | 2.47[301] |
44 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [302] | 0.96[303] | 0.91[304] | 0.93[305] | 0.95[306] | 1.45[307] | 0.63[308] |
45 | PSMB9 | Proteasome subunit beta type-9 | [309] | -1.87[310] | -4.47[311] | -6.73[312] | 1.90[313] | -0.44[314] | -0.42[315] |
46 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [316] | 0.51[317] | 1.02[318] | 0.08[319] | 0.52[320] | 0.90[321] | 0.80[322] |
47 | CUL1 | Cullin-1 | [323] | 0.74[324] | 1.54[325] | 1.12[326] | 2.00[327] | 1.56[328] | 2.16[329] |
48 | NUMB | Protein numb homolog | [330] | 0.68[331] | 1.88[332] | 1.03[333] | 1.69[334] | 1.77[335] | 1.63[336] |
49 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [337] | 1.06[338] | 1.41[339] | 1.48[340] | 2.20[341] | 1.45[342] | 0.79[343] |
50 | ITCH | E3 ubiquitin-protein ligase Itchy homolog | [344] | 2.47[345] | 3.12[346] | 2.41[347] | 2.95[348] | 2.18[349] | 3.58[350] |
51 | PSME4 | Proteasome activator complex subunit 4 | [351] | 2.59[352] | 3.53[353] | 3.57[354] | 2.75[355] | 2.65[356] | 3.05[357] |
52 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [358] | 1.48[359] | 1.06[360] | 2.67[361] | 2.58[362] | 2.59[363] | 2.23[364] |
53 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [365] | 0.29[366] | 1.19[367] | 2.50[368] | 3.65[369] | 2.42[370] | 3.12[371] |
54 | BTRC | F-box/WD repeat-containing protein 1A | [372] | 2.54[373] | 3.45[374] | 3.09[375] | 2.18[376] | 2.62[377] | 2.76[378] |
55 | SUFU | Suppressor of fused homolog | [379] | 2.58[380] | 2.72[381] | 3.69[382] | 2.64[383] | 3.06[384] | 1.78[385] |
56 | GLI1 | Zinc finger protein GLI1 | [386] | -0.52[387] | -0.55[388] | 2.71[389] | 0.33[390] | 2.84[391] | 2.38[392] |
57 | PSMB11 | Proteasome subunit beta type-11 | [393] | [394] | [395] | [396] | [397] | [398] | [399] |
58 | PSMA8 | Proteasome subunit alpha type-7-like | [400] | [401] | [402] | [403] | [404] | [405] | [406] |
59 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [407] | [408] | [409] | [410] | [411] | [412] | [413] |
60 | SEM1 | Putative protein SEM1, isoform 2 | [414] | [415] | [416] | [417] | [418] | [419] | [420] |