REACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.29[2] | -1.33[3] | -1.22[4] | -1.57[5] | -1.19[6] | -0.67[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.85[16] | -0.58[17] | -0.85[18] | -0.72[19] | -0.81[20] | -0.22[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.62[23] | -2.17[24] | -1.82[25] | -1.43[26] | -2.04[27] | -1.17[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.43[30] | -1.79[31] | -1.91[32] | -1.22[33] | -1.57[34] | -0.79[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.52[37] | 0.68[38] | -0.66[39] | 0.41[40] | -0.10[41] | 0.23[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.07[44] | 0.23[45] | -0.86[46] | -0.84[47] | -0.14[48] | 0.07[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.41[51] | -1.15[52] | -0.14[53] | -0.86[54] | -1.04[55] | -0.23[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | -0.17[58] | 0.05[59] | 0.16[60] | 0.57[61] | 0.50[62] | -0.56[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -1.11[65] | -1.05[66] | -0.93[67] | -1.21[68] | -0.83[69] | -0.99[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.29[72] | -0.09[73] | -0.18[74] | -0.48[75] | -0.26[76] | -0.52[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.41[79] | 0.19[80] | 0.10[81] | 0.05[82] | 0.00[83] | -0.44[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.52[86] | 0.20[87] | -0.02[88] | 0.35[89] | 0.11[90] | -0.52[91] |
14 | SKP1 | S-phase kinase-associated protein 1 | [92] | -0.07[93] | 0.48[94] | -0.43[95] | 0.71[96] | 0.84[97] | 0.52[98] |
15 | PSMC3 | 26S proteasome regulatory subunit 6A | [99] | -0.55[100] | -0.56[101] | 0.04[102] | -0.85[103] | -0.71[104] | -0.05[105] |
16 | PSMA3 | Proteasome subunit alpha type-3 | [106] | -1.14[107] | -0.08[108] | -0.77[109] | -0.11[110] | -0.61[111] | -0.27[112] |
17 | PSMB6 | Proteasome subunit beta type-6 | [113] | -0.59[114] | -0.38[115] | -0.25[116] | -0.65[117] | -0.98[118] | -0.11[119] |
18 | PSMA2 | Proteasome subunit alpha type-2 | [120] | -0.67[121] | 0.34[122] | 0.66[123] | -0.16[124] | 0.16[125] | 0.11[126] |
19 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [127] | -0.15[128] | -0.08[129] | 0.10[130] | 0.55[131] | -0.05[132] | -0.21[133] |
20 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [134] | -0.24[135] | 0.19[136] | 0.04[137] | -0.54[138] | -0.12[139] | -0.39[140] |
21 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [141] | -0.07[142] | 0.23[143] | 0.35[144] | -0.26[145] | 0.44[146] | -0.36[147] |
22 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [148] | 1.46[149] | 0.70[150] | 0.76[151] | 0.85[152] | 2.08[153] | 0.67[154] |
23 | PSMC1 | 26S proteasome regulatory subunit 4 | [155] | -0.21[156] | -0.09[157] | -0.76[158] | 1.03[159] | 0.50[160] | -0.17[161] |
24 | PSMA1 | Proteasome subunit alpha type-1 | [162] | -0.03[163] | 0.42[164] | 0.46[165] | 0.61[166] | 0.05[167] | 0.32[168] |
25 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [169] | 1.59[170] | 1.66[171] | 2.66[172] | 0.68[173] | 1.41[174] | 0.55[175] |
26 | PSMC5 | 26S proteasome regulatory subunit 8 | [176] | 0.29[177] | 0.24[178] | 0.30[179] | 0.01[180] | 0.37[181] | 0.09[182] |
27 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [183] | -1.15[184] | -0.56[185] | -0.71[186] | -1.49[187] | -1.15[188] | -0.89[189] |
28 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [190] | 0.68[191] | 0.23[192] | 0.81[193] | 0.55[194] | 0.71[195] | -0.20[196] |
29 | PSMB8 | Proteasome subunit beta type-8 | [197] | -1.71[198] | -2.25[199] | -9.48[200] | 0.52[201] | -0.84[202] | -0.88[203] |
30 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [204] | -0.14[205] | 0.52[206] | 0.76[207] | 0.41[208] | 0.39[209] | -0.34[210] |
31 | PSMC4 | 26S proteasome regulatory subunit 6B | [211] | 0.29[212] | 0.37[213] | 0.29[214] | 0.04[215] | 0.10[216] | 0.14[217] |
32 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [218] | -0.87[219] | -0.33[220] | -1.43[221] | -0.59[222] | 0.17[223] | -0.45[224] |
33 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [225] | 0.33[226] | 0.50[227] | 0.98[228] | 0.47[229] | -0.08[230] | -0.26[231] |
34 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [232] | -0.49[233] | -0.35[234] | -0.68[235] | 0.09[236] | 0.10[237] | -0.34[238] |
35 | CTNNB1 | Catenin beta-1 | [239] | 2.53[240] | 2.18[241] | 3.04[242] | 1.97[243] | 2.11[244] | 2.32[245] |
36 | PSMC6 | 26S proteasome regulatory subunit 10B | [246] | -0.19[247] | 1.44[248] | 0.24[249] | 0.45[250] | 0.33[251] | 0.31[252] |
37 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [253] | 0.69[254] | 0.36[255] | 0.94[256] | 0.86[257] | 0.96[258] | 1.14[259] |
38 | PSMC2 | 26S proteasome regulatory subunit 7 | [260] | 0.44[261] | 0.90[262] | 0.66[263] | 1.25[264] | 1.02[265] | 1.19[266] |
39 | MYC | Myc proto-oncogene protein | [267] | 1.34[268] | 1.16[269] | -0.90[270] | -1.58[271] | 0.71[272] | -0.79[273] |
40 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 1.71[274] | 1.69[275] | 1.58[276] | 2.42[277] | 1.66[278] | 1.35[279] | |
41 | PSME3 | Proteasome activator complex subunit 3 | [280] | 1.67[281] | 1.45[282] | 1.11[283] | 1.28[284] | 1.49[285] | 0.76[286] |
42 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 1.18[287] | 1.44[288] | 0.76[289] | 1.95[290] | 1.98[291] | 1.11[292] | |
43 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | 0.52[293] | 0.33[294] | 0.38[295] | 0.75[296] | 0.57[297] | 0.22[298] | |
44 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [299] | 1.43[300] | 1.81[301] | 1.67[302] | 2.08[303] | 2.03[304] | 1.94[305] |
45 | PSMB10 | Proteasome subunit beta type-10 | [306] | -1.29[307] | -0.64[308] | -2.54[309] | -0.13[310] | -1.35[311] | -0.21[312] |
46 | HDAC1 | Histone deacetylase 1 | [313] | 1.42[314] | 1.59[315] | 2.24[316] | 1.86[317] | 1.56[318] | 0.75[319] |
47 | CTBP1 | C-terminal-binding protein 1 | [320] | 0.96[321] | 1.23[322] | 1.48[323] | 1.62[324] | 0.58[325] | 0.94[326] |
48 | CSNK1A1 | Casein kinase I isoform alpha | [327] | 1.25[328] | 1.40[329] | 1.13[330] | 2.04[331] | 2.06[332] | 1.90[333] |
49 | PSMA5 | Proteasome subunit alpha type-5 | [334] | 1.76[335] | 2.24[336] | 1.79[337] | 2.13[338] | 1.64[339] | 1.78[340] |
50 | PSMF1 | Proteasome inhibitor PI31 subunit | [341] | 2.14[342] | 2.24[343] | 1.03[344] | 1.14[345] | 0.85[346] | 1.72[347] |
51 | PSMB2 | Proteasome subunit beta type-2 | [348] | 1.92[349] | 1.71[350] | 2.08[351] | 2.44[352] | 2.37[353] | 2.27[354] |
52 | PSMB9 | Proteasome subunit beta type-9 | [355] | -2.09[356] | -4.65[357] | -6.97[358] | 1.69[359] | -0.64[360] | -0.63[361] |
53 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [362] | 0.30[363] | 0.84[364] | -0.16[365] | 0.31[366] | 0.70[367] | 0.60[368] |
54 | CUL1 | Cullin-1 | [369] | 0.53[370] | 1.36[371] | 0.88[372] | 1.79[373] | 1.36[374] | 1.96[375] |
55 | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | -0.21[376] | 0.84[377] | 1.52[378] | 0.96[379] | -0.25[380] | 1.85[381] | |
56 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isofor | 0.60[382] | 1.64[383] | 1.30[384] | 2.15[385] | 1.88[386] | 1.01[387] | |
57 | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | 1.36[388] | 1.00[389] | 1.37[390] | 1.48[391] | 1.18[392] | 4.14[393] | |
58 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [394] | 0.85[395] | 1.23[396] | 1.24[397] | 1.99[398] | 1.25[399] | 0.58[400] |
59 | PSME4 | Proteasome activator complex subunit 4 | [401] | 2.38[402] | 3.35[403] | 3.33[404] | 2.54[405] | 2.45[406] | 2.85[407] |
60 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | 2.16[408] | 2.08[409] | 1.60[410] | 2.50[411] | 2.30[412] | 0.94[413] | |
61 | TLE1 | Transducin-like enhancer protein 1 | [414] | 2.47[415] | 2.02[416] | 1.26[417] | 1.31[418] | 1.04[419] | 1.55[420] |
62 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [421] | 1.27[422] | 0.88[423] | 2.43[424] | 2.37[425] | 2.40[426] | 2.03[427] |
63 | FRAT2 | GSK-3-binding protein FRAT2 | [428] | 1.00[429] | 0.85[430] | 2.70[431] | -1.48[432] | -0.75[433] | 0.21[434] |
64 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isofor | 1.02[435] | 1.36[436] | 0.86[437] | 2.07[438] | 1.78[439] | 1.40[440] | |
65 | ZRANB1 | Ubiquitin thioesterase ZRANB1 | [441] | 1.17[442] | 2.24[443] | 2.08[444] | 1.26[445] | 2.61[446] | 2.77[447] |
66 | AXIN1 | Axin-1 | [448] | 2.26[449] | 2.74[450] | 1.14[451] | -7.48[452] | 1.28[453] | 0.56[454] |
67 | GSK3B | Glycogen synthase kinase-3 beta | [455] | 2.18[456] | 1.97[457] | 2.51[458] | 3.03[459] | 2.77[460] | 2.37[461] |
68 | AXIN2 | Axin-2 | [462] | 4.38[463] | 2.14[464] | -1.94[465] | 0.12[466] | -0.33[467] | -1.13[468] |
69 | TLE3 | Transducin-like enhancer protein 3 | [469] | 1.28[470] | 1.19[471] | 3.86[472] | 3.56[473] | 3.05[474] | 1.49[475] |
70 | TCF7L2 | Transcription factor 7-like 2 | [476] | 1.78[477] | 2.70[478] | 2.87[479] | 1.90[480] | 1.81[481] | 2.93[482] |
71 | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform | 1.69[483] | 1.61[484] | 0.93[485] | 1.50[486] | 2.58[487] | 1.31[488] | |
72 | BTRC | F-box/WD repeat-containing protein 1A | [489] | 2.32[490] | 3.27[491] | 2.85[492] | 1.97[493] | 2.42[494] | 2.56[495] |
73 | TCF7L1 | Transcription factor 7-like 1 | [496] | -2.14[497] | -0.18[498] | 1.98[499] | -0.61[500] | -0.57[501] | 1.50[502] |
74 | TCF7 | Transcription factor 7 | [503] | 3.35[504] | 2.16[505] | 1.18[506] | 1.37[507] | 0.98[508] | 0.84[509] |
75 | FRAT1 | Proto-oncogene FRAT1 | [510] | 1.60[511] | 1.52[512] | 3.59[513] | -1.34[514] | -0.24[515] | 1.68[516] |
76 | CTBP2 | C-terminal-binding protein 2 | [517] | -1.15[518] | -0.56[519] | 3.13[520] | 4.49[521] | 4.69[522] | 2.76[523] |
77 | APC | Adenomatous polyposis coli protein | [524] | 1.48[525] | 3.31[526] | 3.11[527] | 3.44[528] | 3.99[529] | 4.95[530] |
78 | TLE2 | Transducin-like enhancer protein 2 | [531] | -1.70[532] | -0.99[533] | 4.50[534] | -0.70[535] | 1.98[536] | 1.89[537] |
79 | TLE4 | Transducin-like enhancer protein 4 | [538] | 2.30[539] | 4.60[540] | 3.38[541] | 1.32[542] | 4.19[543] | 3.48[544] |
80 | LEF1 | Lymphoid enhancer-binding factor 1 | [545] | 3.56[546] | -3.20[547] | 4.68[548] | 2.29[549] | 0.51[550] | 2.29[551] |
81 | TLE5 | [552] | [553] | [554] | [555] | [556] | [557] | [558] | |
82 | PSMB11 | Proteasome subunit beta type-11 | [559] | [560] | [561] | [562] | [563] | [564] | [565] |
83 | AMER1 | APC membrane recruitment protein 1 | [566] | [567] | [568] | [569] | [570] | [571] | [572] |
84 | SEM1 | Putative protein SEM1, isoform 2 | [573] | [574] | [575] | [576] | [577] | [578] | [579] |
85 | PSMA8 | Proteasome subunit alpha type-7-like | [580] | [581] | [582] | [583] | [584] | [585] | [586] |