REACTOME_DEFECTS_IN_VITAMIN_AND_COFACTOR_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 MMADHC Methylmalonic aciduria and homocystinuria type D protein, mitochondrial -0.56[1] -0.19[2] -0.48[3] 0.32[4] 0.31[5] -1.58[6]
2 PCCB Propionyl-CoA carboxylase beta chain, mitochondrial [7] -0.57[8] -1.11[9] -2.43[10] -0.89[11] -0.68[12] -0.89[13]
3 PC Pyruvate carboxylase, mitochondrial [14] -0.52[15] -0.78[16] 0.37[17] -0.53[18] -2.81[19] 1.36[20]
4 AMN Protein amnionless [21] -2.65[22] -2.27[23] -3.43[24] -9.30[25] -9.38[26] -4.65[27]
5 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [28] 0.88[29] 0.37[30] 0.57[31] -0.05[32] 0.27[33] 0.04[34]
6 PCCA Propionyl-CoA carboxylase alpha chain, mitochondrial [35] -0.82[36] -1.19[37] -1.41[38] -2.40[39] -2.13[40] 0.35[41]
7 LMBRD1 Probable lysosomal cobalamin transporter [42] -0.66[43] -0.21[44] -0.80[45] -0.54[46] -0.22[47] -0.21[48]
8 CD320 CD320 antigen [49] 1.63[50] 0.91[51] -0.04[52] -0.35[53] 0.80[54] -3.00[55]
9 MCCC1 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial [56] -0.85[57] -1.28[58] -0.37[59] -1.37[60] -0.85[61] -0.26[62]
10 MMAB Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial [63] -1.06[64] 1.44[65] 0.76[66] -1.02[67] -1.12[68] 0.17[69]
11 BTD Biotinidase [70] -0.60[71] -0.76[72] -1.30[73] -1.29[74] -0.51[75] 0.14[76]
12 MTRR Methionine synthase reductase [77] 0.98[78] 1.19[79] 1.87[80] 1.60[81] 2.46[82] 0.43[83]
13 ABCD4 ATP-binding cassette sub-family D member 4 [84] 0.68[85] 1.55[86] 0.27[87] 1.21[88] 0.91[89] -0.03[90]
14 ACACA Acetyl-CoA carboxylase 1 [91] 3.20[92] 3.08[93] 3.95[94] 3.62[95] 3.00[96] 2.57[97]
15 MMAA Methylmalonic aciduria type A protein, mitochondrial [98] -1.88[99] -1.37[100] -0.85[101] 0.35[102] 0.60[103] 1.53[104]
16 MMACHC Methylmalonic aciduria and homocystinuria type C protein [105] 0.82[106] 0.97[107] 0.75[108] -0.23[109] 0.58[110] 0.91[111]
17 HLCS Biotin--protein ligase [112] 1.72[113] 1.50[114] 0.90[115] 2.45[116] 2.35[117] 1.64[118]
18 TCN2 Transcobalamin-2 [119] -0.59[120] -2.81[121] -0.52[122] 2.33[123] 1.81[124] 0.80[125]
19 MTR Methionine synthase [126] 3.01[127] 3.24[128] 3.35[129] 4.19[130] 3.72[131] 2.58[132]
20 CUBN Cubilin [133] 1.97[134] 3.01[135] 1.22[136] 6.35[137] 4.99[138] 3.93[139]
21 CBLIF [140] [141] [142] [143] [144] [145] [146]
22 MMUT [147] [148] [149] [150] [151] [152] [153]
[1]
ref_hepatocyte MMADHC
Mean 53.2
Standard deviation 26
Values 71 81 15 48 51
[2]
HepG2 MMADHC
Mean 47.4
Standard deviation 7.3
Values 42 53
[3]
HepG2.C3A MMADHC
Mean 75.4
Standard deviation 22
Values 60 91
[4]
HuH.7 MMADHC
Mean 60.8
Standard deviation 4
Values 65 57 60
[5]
SNU475 MMADHC
Mean 59.1
Standard deviation 1.5
Values 58 60
[6]
THLE MMADHC
Mean 57.6
Standard deviation 10
Values 50 65
[7]
liver MMADHC
Mean 43.5
Standard deviation 21
Values 63 28 61 22
[8]
ref_hepatocyte PCCB
Mean 41.7
Standard deviation 29
Values 18 27 17 67 79
[9]
HepG2 PCCB
Mean 37
Standard deviation 6.8
Values 32 42
[10]
HepG2.C3A PCCB
Mean 31.3
Standard deviation 3.5
Values 29 34
[11]
HuH.7 PCCB
Mean 12.3
Standard deviation 1.8
Values 13 10 13
[12]
SNU475 PCCB
Mean 20
Standard deviation 5
Values 24 16
[13]
THLE PCCB
Mean 22.8
Standard deviation 3.3
Values 20 25
[14]
liver PCCB
Mean 54.9
Standard deviation 21
Values 55 46 84 34
[15]
ref_hepatocyte PC
Mean 39.5
Standard deviation 46
Values 8 5.6 3.9 87 93
[16]
HepG2 PC
Mean 36.2
Standard deviation 7.4
Values 41 31
[17]
HepG2.C3A PC
Mean 37.2
Standard deviation 8
Values 43 32
[18]
HuH.7 PC
Mean 81.4
Standard deviation 7.4
Values 90 77 77
[19]
SNU475 PC
Mean 24.3
Standard deviation 13
Values 33 15
[20]
THLE PC
Mean 4.93
Standard deviation 0.64
Values 4.5 5.4
[21]
liver PC
Mean 248
Standard deviation 63
Values 1.7e+02 2.7e+02 3.2e+02 2.4e+02
[22]
ref_hepatocyte AMN
Mean 35.6
Standard deviation 50
Values 14 0.23 2.6 40 1.2e+02
[23]
HepG2 AMN
Mean 7.5
Standard deviation 1.1
Values 8.2 6.7
[24]
HepG2.C3A AMN
Mean 11.9
Standard deviation 6.3
Values 16 7.5
[25]
HuH.7 AMN
Mean 5.27
Standard deviation 1.7
Values 3.8 7.1 4.9
[26]
SNU475 AMN
Mean 0.0503
Standard deviation 0.058
Values 0.0093 0.091
[27]
THLE AMN
Mean 0.0467
Standard deviation 0.024
Values 0.03 0.064
[28]
liver AMN
Mean 3.47
Standard deviation 4.8
Values 11 1.6 0.95 0.74
[29]
ref_hepatocyte MCCC2
Mean 24.7
Standard deviation 9.8
Values 22 26 11 27 38
[30]
HepG2 MCCC2
Mean 60.1
Standard deviation 16
Values 49 71
[31]
HepG2.C3A MCCC2
Mean 51.8
Standard deviation 17
Values 40 64
[32]
HuH.7 MCCC2
Mean 58.3
Standard deviation 19
Values 74 37 63
[33]
SNU475 MCCC2
Mean 21.4
Standard deviation 2.4
Values 23 20
[34]
THLE MCCC2
Mean 26.1
Standard deviation 3.3
Values 24 28
[35]
liver MCCC2
Mean 62.1
Standard deviation 26
Values 72 46 94 36
[36]
ref_hepatocyte PCCA
Mean 17.2
Standard deviation 15
Values 9.9 6.1 3.5 37 29
[37]
HepG2 PCCA
Mean 12.9
Standard deviation 1.6
Values 12 14
[38]
HepG2.C3A PCCA
Mean 12.2
Standard deviation 0.74
Values 13 12
[39]
HuH.7 PCCA
Mean 10.3
Standard deviation 0.27
Values 10 11 10
[40]
SNU475 PCCA
Mean 2.91
Standard deviation 0.067
Values 3 2.9
[41]
THLE PCCA
Mean 3.46
Standard deviation 0.45
Values 3.1 3.8
[42]
liver PCCA
Mean 53.8
Standard deviation 7.3
Values 49 58 62 47
[43]
ref_hepatocyte LMBRD1
Mean 15.7
Standard deviation 6.8
Values 15 14 6.8 17 26
[44]
HepG2 LMBRD1
Mean 13.1
Standard deviation 1.1
Values 12 14
[45]
HepG2.C3A LMBRD1
Mean 22
Standard deviation 0.015
Values 22 22
[46]
HuH.7 LMBRD1
Mean 14.4
Standard deviation 3.1
Values 13 18 12
[47]
SNU475 LMBRD1
Mean 9.65
Standard deviation 3.6
Values 12 7.1
[48]
THLE LMBRD1
Mean 11.8
Standard deviation 1
Values 11 13
[49]
liver LMBRD1
Mean 33.3
Standard deviation 16
Values 52 25 41 16
[50]
ref_hepatocyte CD320
Mean 15.2
Standard deviation 13
Values 8.4 9.5 38 12 7.7
[51]
HepG2 CD320
Mean 61.9
Standard deviation 11
Values 69 54
[52]
HepG2.C3A CD320
Mean 46.2
Standard deviation 6.6
Values 42 51
[53]
HuH.7 CD320
Mean 23.6
Standard deviation 10
Values 27 12 32
[54]
SNU475 CD320
Mean 10.7
Standard deviation 0.022
Values 11 11
[55]
THLE CD320
Mean 23.2
Standard deviation 0.08
Values 23 23
[56]
liver CD320
Mean 4.65
Standard deviation 3.5
Values 7.5 1.9 7.9 1.3
[57]
ref_hepatocyte MCCC1
Mean 13.4
Standard deviation 8.4
Values 5.1 14 4.4 21 22
[58]
HepG2 MCCC1
Mean 9.8
Standard deviation 2
Values 8.4 11
[59]
HepG2.C3A MCCC1
Mean 8.89
Standard deviation 0.017
Values 8.9 8.9
[60]
HuH.7 MCCC1
Mean 16.5
Standard deviation 1.3
Values 16 15 18
[61]
SNU475 MCCC1
Mean 4.59
Standard deviation 1.2
Values 5.4 3.7
[62]
THLE MCCC1
Mean 6.51
Standard deviation 0.64
Values 6.1 7
[63]
liver MCCC1
Mean 27.2
Standard deviation 5.9
Values 27 28 34 20
[64]
ref_hepatocyte MMAB
Mean 11.5
Standard deviation 12
Values 6.1 2.6 1.9 18 29
[65]
HepG2 MMAB
Mean 7.28
Standard deviation 1.8
Values 6 8.5
[66]
HepG2.C3A MMAB
Mean 50.5
Standard deviation 17
Values 62 39
[67]
HuH.7 MMAB
Mean 31
Standard deviation 2.8
Values 29 30 34
[68]
SNU475 MMAB
Mean 5.06
Standard deviation 1.2
Values 5.9 4.2
[69]
THLE MMAB
Mean 4.65
Standard deviation 0.9
Values 4 5.3
[70]
liver MMAB
Mean 31.6
Standard deviation 24
Values 43 10 61 13
[71]
ref_hepatocyte BTD
Mean 8.84
Standard deviation 10
Values 2.1 1.8 1.1 15 24
[72]
HepG2 BTD
Mean 7.7
Standard deviation 0.5
Values 7.4 8.1
[73]
HepG2.C3A BTD
Mean 8.4
Standard deviation 0.021
Values 8.4 8.4
[74]
HuH.7 BTD
Mean 5.74
Standard deviation 0.4
Values 5.5 6.2 5.5
[75]
SNU475 BTD
Mean 3.22
Standard deviation 0.56
Values 3.6 2.8
[76]
THLE BTD
Mean 5.46
Standard deviation 0.75
Values 4.9 6
[77]
liver BTD
Mean 23.9
Standard deviation 2
Values 23 24 26 21
[78]
ref_hepatocyte MTRR
Mean 6.08
Standard deviation 1.7
Values 3.7 7.4 5.1 8 6.2
[79]
HepG2 MTRR
Mean 15.8
Standard deviation 4.2
Values 13 19
[80]
HepG2.C3A MTRR
Mean 22.3
Standard deviation 4.3
Values 19 25
[81]
HuH.7 MTRR
Mean 35.5
Standard deviation 8.3
Values 42 26 38
[82]
SNU475 MTRR
Mean 16.4
Standard deviation 3.1
Values 14 19
[83]
THLE MTRR
Mean 29.4
Standard deviation 7.2
Values 34 24
[84]
liver MTRR
Mean 20.1
Standard deviation 4.3
Values 21 20 25 14
[85]
ref_hepatocyte ABCD4
Mean 5.56
Standard deviation 3.4
Values 3.8 2.3 3.4 8.6 9.7
[86]
HepG2 ABCD4
Mean 11.7
Standard deviation 1.2
Values 13 11
[87]
HepG2.C3A ABCD4
Mean 26.3
Standard deviation 6.6
Values 31 22
[88]
HuH.7 ABCD4
Mean 10.7
Standard deviation 2
Values 10 9 13
[89]
SNU475 ABCD4
Mean 11.5
Standard deviation 0.23
Values 12 11
[90]
THLE ABCD4
Mean 9.15
Standard deviation 0.94
Values 9.8 8.5
[91]
liver ABCD4
Mean 13.3
Standard deviation 4.7
Values 18 8.8 17 9.6
[92]
ref_hepatocyte ACACA
Mean 3.02
Standard deviation 0.95
Values 4.3 3.2 1.7 3.2 2.7
[93]
HepG2 ACACA
Mean 36.5
Standard deviation 4.8
Values 33 40
[94]
HepG2.C3A ACACA
Mean 41.2
Standard deviation 13
Values 50 32
[95]
HuH.7 ACACA
Mean 74.7
Standard deviation 16
Values 89 78 57
[96]
SNU475 ACACA
Mean 33.2
Standard deviation 14
Values 43 23
[97]
THLE ACACA
Mean 21.2
Standard deviation 5
Values 18 25
[98]
liver ACACA
Mean 44
Standard deviation 21
Values 21 70 35 50
[99]
ref_hepatocyte MMAA
Mean 2.58
Standard deviation 1.4
Values 0.53 1.6 3.4 3.7 3.6
[100]
HepG2 MMAA
Mean 0.922
Standard deviation 0.37
Values 0.66 1.2
[101]
HepG2.C3A MMAA
Mean 1.6
Standard deviation 0.69
Values 1.1 2.1
[102]
HuH.7 MMAA
Mean 2.27
Standard deviation 0.28
Values 2.6 2.3 2
[103]
SNU475 MMAA
Mean 2.93
Standard deviation 0.84
Values 3.5 2.3
[104]
THLE MMAA
Mean 3.42
Standard deviation 0.2
Values 3.3 3.6
[105]
liver MMAA
Mean 18.2
Standard deviation 6.6
Values 24 14 23 11
[106]
ref_hepatocyte MMACHC
Mean 2.46
Standard deviation 2.5
Values 1.2 0.4 0.38 5.1 5.2
[107]
HepG2 MMACHC
Mean 5.75
Standard deviation 1.4
Values 4.8 6.7
[108]
HepG2.C3A MMACHC
Mean 7.79
Standard deviation 1.7
Values 6.6 9
[109]
HuH.7 MMACHC
Mean 6.61
Standard deviation 1.3
Values 7.9 5.3 6.6
[110]
SNU475 MMACHC
Mean 1.87
Standard deviation 0.26
Values 1.7 2.1
[111]
THLE MMACHC
Mean 3.23
Standard deviation 0.96
Values 2.5 3.9
[112]
liver MMACHC
Mean 11.3
Standard deviation 3.2
Values 15 7.2 11 11
[113]
ref_hepatocyte HLCS
Mean 2.02
Standard deviation 0.54
Values 1.6 1.6 1.9 2 2.9
[114]
HepG2 HLCS
Mean 8.73
Standard deviation 0.85
Values 8.1 9.3
[115]
HepG2.C3A HLCS
Mean 9.23
Standard deviation 0.52
Values 8.9 9.6
[116]
HuH.7 HLCS
Mean 5.98
Standard deviation 0.68
Values 6.7 5.8 5.4
[117]
SNU475 HLCS
Mean 9.79
Standard deviation 2.9
Values 12 7.7
[118]
THLE HLCS
Mean 9.03
Standard deviation 1.3
Values 8.1 9.9
[119]
liver HLCS
Mean 15.4
Standard deviation 3.7
Values 12 20 16 14
[120]
ref_hepatocyte TCN2
Mean 1.75
Standard deviation 1.6
Values 0.3 1.1 0.65 2.6 4
[121]
HepG2 TCN2
Mean 1.53
Standard deviation 0.2
Values 1.4 1.7
[122]
HepG2.C3A TCN2
Mean 0.402
Standard deviation 0.16
Values 0.52 0.29
[123]
HuH.7 TCN2
Mean 1.94
Standard deviation 0.14
Values 2.1 1.9 1.9
[124]
SNU475 TCN2
Mean 7.84
Standard deviation 2.8
Values 9.8 5.9
[125]
THLE TCN2
Mean 5.39
Standard deviation 1.5
Values 4.3 6.5
[126]
liver TCN2
Mean 7.47
Standard deviation 4.1
Values 13 4.5 8.3 4.1
[127]
ref_hepatocyte MTR
Mean 1.43
Standard deviation 1
Values 2.9 2.1 1.2 0.53 0.48
[128]
HepG2 MTR
Mean 15.2
Standard deviation 4.2
Values 12 18
[129]
HepG2.C3A MTR
Mean 21.8
Standard deviation 0.68
Values 22 21
[130]
HuH.7 MTR
Mean 23.2
Standard deviation 4.8
Values 29 21 20
[131]
SNU475 MTR
Mean 23.4
Standard deviation 7.7
Values 29 18
[132]
THLE MTR
Mean 16.5
Standard deviation 1
Values 17 16
[133]
liver MTR
Mean 20.9
Standard deviation 9.9
Values 12 34 14 24
[134]
ref_hepatocyte CUBN
Mean 0.0112
Standard deviation 0.0085
Values 0.021 0.018 0 0.0086 0.0081
[135]
HepG2 CUBN
Mean 0.058
Standard deviation 0.009
Values 0.052 0.064
[136]
HepG2.C3A CUBN
Mean 0.146
Standard deviation 0.055
Values 0.18 0.11
[137]
HuH.7 CUBN
Mean 0.0417
Standard deviation 0.0065
Values 0.049 0.039 0.037
[138]
SNU475 CUBN
Mean 0.813
Standard deviation 0.66
Values 0.34 1.3
[139]
THLE CUBN
Mean 0.313
Standard deviation 0.059
Values 0.35 0.27
[140]
liver CUBN
Mean 0.416
Standard deviation 0.32
Values 0.12 0.61 0.18 0.75
[141]
ref_hepatocyte CBLIF
Missing
[142]
HepG2 CBLIF
Missing
[143]
HepG2.C3A CBLIF
Missing
[144]
HuH.7 CBLIF
Missing
[145]
SNU475 CBLIF
Missing
[146]
THLE CBLIF
Missing
[147]
liver CBLIF
Missing
[148]
ref_hepatocyte MMUT
Missing
[149]
HepG2 MMUT
Missing
[150]
HepG2.C3A MMUT
Missing
[151]
HuH.7 MMUT
Missing
[152]
SNU475 MMUT
Missing
[153]
THLE MMUT
Missing
[154]
liver MMUT
Missing