REACTOME_DEFECTS_IN_COBALAMIN_B12_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 MMADHC Methylmalonic aciduria and homocystinuria type D protein, mitochondrial -0.48[1] -0.42[2] -0.32[3] 0.17[4] -0.01[5] -0.75[6]
2 AMN Protein amnionless [7] -2.57[8] -2.50[9] -3.27[10] -9.45[11] -9.70[12] -3.82[13]
3 LMBRD1 Probable lysosomal cobalamin transporter [14] -0.58[15] -0.44[16] -0.64[17] -0.69[18] -0.53[19] 0.62[20]
4 CD320 CD320 antigen [21] 1.71[22] 0.68[23] 0.12[24] -0.49[25] 0.49[26] -2.17[27]
5 MMAB Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial [28] -0.98[29] 1.21[30] 0.92[31] -1.17[32] -1.43[33] 0.99[34]
6 MTRR Methionine synthase reductase [35] 1.06[36] 0.95[37] 2.03[38] 1.45[39] 2.15[40] 1.26[41]
7 ABCD4 ATP-binding cassette sub-family D member 4 [42] 0.76[43] 1.32[44] 0.43[45] 1.06[46] 0.60[47] 0.79[48]
8 MMAA Methylmalonic aciduria type A protein, mitochondrial [49] -1.80[50] -1.61[51] -0.69[52] 0.20[53] 0.28[54] 2.36[55]
9 MMACHC Methylmalonic aciduria and homocystinuria type C protein [56] 0.91[57] 0.74[58] 0.91[59] -0.38[60] 0.26[61] 1.73[62]
10 TCN2 Transcobalamin-2 [63] -0.51[64] -3.04[65] -0.36[66] 2.18[67] 1.50[68] 1.63[69]
11 MTR Methionine synthase [70] 3.09[71] 3.01[72] 3.51[73] 4.05[74] 3.40[75] 3.40[76]
12 CUBN Cubilin [77] 2.05[78] 2.78[79] 1.39[80] 6.20[81] 4.68[82] 4.75[83]
13 CBLIF [84] [85] [86] [87] [88] [89] [90]
14 MMUT [91] [92] [93] [94] [95] [96] [97]
[1]
ref_hepatocyte MMADHC
Mean 53.2
Standard deviation 26
Values 71 81 15 48 51
[2]
HepG2 MMADHC
Mean 47.4
Standard deviation 7.3
Values 42 53
[3]
HepG2.C3A MMADHC
Mean 75.4
Standard deviation 22
Values 60 91
[4]
HuH.7 MMADHC
Mean 60.8
Standard deviation 4
Values 65 57 60
[5]
SNU475 MMADHC
Mean 59.1
Standard deviation 1.5
Values 58 60
[6]
THLE MMADHC
Mean 57.6
Standard deviation 10
Values 50 65
[7]
liver MMADHC
Mean 43.5
Standard deviation 21
Values 63 28 61 22
[8]
ref_hepatocyte AMN
Mean 35.6
Standard deviation 50
Values 14 0.23 2.6 40 1.2e+02
[9]
HepG2 AMN
Mean 7.5
Standard deviation 1.1
Values 8.2 6.7
[10]
HepG2.C3A AMN
Mean 11.9
Standard deviation 6.3
Values 16 7.5
[11]
HuH.7 AMN
Mean 5.27
Standard deviation 1.7
Values 3.8 7.1 4.9
[12]
SNU475 AMN
Mean 0.0503
Standard deviation 0.058
Values 0.0093 0.091
[13]
THLE AMN
Mean 0.0467
Standard deviation 0.024
Values 0.03 0.064
[14]
liver AMN
Mean 3.47
Standard deviation 4.8
Values 11 1.6 0.95 0.74
[15]
ref_hepatocyte LMBRD1
Mean 15.7
Standard deviation 6.8
Values 15 14 6.8 17 26
[16]
HepG2 LMBRD1
Mean 13.1
Standard deviation 1.1
Values 12 14
[17]
HepG2.C3A LMBRD1
Mean 22
Standard deviation 0.015
Values 22 22
[18]
HuH.7 LMBRD1
Mean 14.4
Standard deviation 3.1
Values 13 18 12
[19]
SNU475 LMBRD1
Mean 9.65
Standard deviation 3.6
Values 12 7.1
[20]
THLE LMBRD1
Mean 11.8
Standard deviation 1
Values 11 13
[21]
liver LMBRD1
Mean 33.3
Standard deviation 16
Values 52 25 41 16
[22]
ref_hepatocyte CD320
Mean 15.2
Standard deviation 13
Values 8.4 9.5 38 12 7.7
[23]
HepG2 CD320
Mean 61.9
Standard deviation 11
Values 69 54
[24]
HepG2.C3A CD320
Mean 46.2
Standard deviation 6.6
Values 42 51
[25]
HuH.7 CD320
Mean 23.6
Standard deviation 10
Values 27 12 32
[26]
SNU475 CD320
Mean 10.7
Standard deviation 0.022
Values 11 11
[27]
THLE CD320
Mean 23.2
Standard deviation 0.08
Values 23 23
[28]
liver CD320
Mean 4.65
Standard deviation 3.5
Values 7.5 1.9 7.9 1.3
[29]
ref_hepatocyte MMAB
Mean 11.5
Standard deviation 12
Values 6.1 2.6 1.9 18 29
[30]
HepG2 MMAB
Mean 7.28
Standard deviation 1.8
Values 6 8.5
[31]
HepG2.C3A MMAB
Mean 50.5
Standard deviation 17
Values 62 39
[32]
HuH.7 MMAB
Mean 31
Standard deviation 2.8
Values 29 30 34
[33]
SNU475 MMAB
Mean 5.06
Standard deviation 1.2
Values 5.9 4.2
[34]
THLE MMAB
Mean 4.65
Standard deviation 0.9
Values 4 5.3
[35]
liver MMAB
Mean 31.6
Standard deviation 24
Values 43 10 61 13
[36]
ref_hepatocyte MTRR
Mean 6.08
Standard deviation 1.7
Values 3.7 7.4 5.1 8 6.2
[37]
HepG2 MTRR
Mean 15.8
Standard deviation 4.2
Values 13 19
[38]
HepG2.C3A MTRR
Mean 22.3
Standard deviation 4.3
Values 19 25
[39]
HuH.7 MTRR
Mean 35.5
Standard deviation 8.3
Values 42 26 38
[40]
SNU475 MTRR
Mean 16.4
Standard deviation 3.1
Values 14 19
[41]
THLE MTRR
Mean 29.4
Standard deviation 7.2
Values 34 24
[42]
liver MTRR
Mean 20.1
Standard deviation 4.3
Values 21 20 25 14
[43]
ref_hepatocyte ABCD4
Mean 5.56
Standard deviation 3.4
Values 3.8 2.3 3.4 8.6 9.7
[44]
HepG2 ABCD4
Mean 11.7
Standard deviation 1.2
Values 13 11
[45]
HepG2.C3A ABCD4
Mean 26.3
Standard deviation 6.6
Values 31 22
[46]
HuH.7 ABCD4
Mean 10.7
Standard deviation 2
Values 10 9 13
[47]
SNU475 ABCD4
Mean 11.5
Standard deviation 0.23
Values 12 11
[48]
THLE ABCD4
Mean 9.15
Standard deviation 0.94
Values 9.8 8.5
[49]
liver ABCD4
Mean 13.3
Standard deviation 4.7
Values 18 8.8 17 9.6
[50]
ref_hepatocyte MMAA
Mean 2.58
Standard deviation 1.4
Values 0.53 1.6 3.4 3.7 3.6
[51]
HepG2 MMAA
Mean 0.922
Standard deviation 0.37
Values 0.66 1.2
[52]
HepG2.C3A MMAA
Mean 1.6
Standard deviation 0.69
Values 1.1 2.1
[53]
HuH.7 MMAA
Mean 2.27
Standard deviation 0.28
Values 2.6 2.3 2
[54]
SNU475 MMAA
Mean 2.93
Standard deviation 0.84
Values 3.5 2.3
[55]
THLE MMAA
Mean 3.42
Standard deviation 0.2
Values 3.3 3.6
[56]
liver MMAA
Mean 18.2
Standard deviation 6.6
Values 24 14 23 11
[57]
ref_hepatocyte MMACHC
Mean 2.46
Standard deviation 2.5
Values 1.2 0.4 0.38 5.1 5.2
[58]
HepG2 MMACHC
Mean 5.75
Standard deviation 1.4
Values 4.8 6.7
[59]
HepG2.C3A MMACHC
Mean 7.79
Standard deviation 1.7
Values 6.6 9
[60]
HuH.7 MMACHC
Mean 6.61
Standard deviation 1.3
Values 7.9 5.3 6.6
[61]
SNU475 MMACHC
Mean 1.87
Standard deviation 0.26
Values 1.7 2.1
[62]
THLE MMACHC
Mean 3.23
Standard deviation 0.96
Values 2.5 3.9
[63]
liver MMACHC
Mean 11.3
Standard deviation 3.2
Values 15 7.2 11 11
[64]
ref_hepatocyte TCN2
Mean 1.75
Standard deviation 1.6
Values 0.3 1.1 0.65 2.6 4
[65]
HepG2 TCN2
Mean 1.53
Standard deviation 0.2
Values 1.4 1.7
[66]
HepG2.C3A TCN2
Mean 0.402
Standard deviation 0.16
Values 0.52 0.29
[67]
HuH.7 TCN2
Mean 1.94
Standard deviation 0.14
Values 2.1 1.9 1.9
[68]
SNU475 TCN2
Mean 7.84
Standard deviation 2.8
Values 9.8 5.9
[69]
THLE TCN2
Mean 5.39
Standard deviation 1.5
Values 4.3 6.5
[70]
liver TCN2
Mean 7.47
Standard deviation 4.1
Values 13 4.5 8.3 4.1
[71]
ref_hepatocyte MTR
Mean 1.43
Standard deviation 1
Values 2.9 2.1 1.2 0.53 0.48
[72]
HepG2 MTR
Mean 15.2
Standard deviation 4.2
Values 12 18
[73]
HepG2.C3A MTR
Mean 21.8
Standard deviation 0.68
Values 22 21
[74]
HuH.7 MTR
Mean 23.2
Standard deviation 4.8
Values 29 21 20
[75]
SNU475 MTR
Mean 23.4
Standard deviation 7.7
Values 29 18
[76]
THLE MTR
Mean 16.5
Standard deviation 1
Values 17 16
[77]
liver MTR
Mean 20.9
Standard deviation 9.9
Values 12 34 14 24
[78]
ref_hepatocyte CUBN
Mean 0.0112
Standard deviation 0.0085
Values 0.021 0.018 0 0.0086 0.0081
[79]
HepG2 CUBN
Mean 0.058
Standard deviation 0.009
Values 0.052 0.064
[80]
HepG2.C3A CUBN
Mean 0.146
Standard deviation 0.055
Values 0.18 0.11
[81]
HuH.7 CUBN
Mean 0.0417
Standard deviation 0.0065
Values 0.049 0.039 0.037
[82]
SNU475 CUBN
Mean 0.813
Standard deviation 0.66
Values 0.34 1.3
[83]
THLE CUBN
Mean 0.313
Standard deviation 0.059
Values 0.35 0.27
[84]
liver CUBN
Mean 0.416
Standard deviation 0.32
Values 0.12 0.61 0.18 0.75
[85]
ref_hepatocyte CBLIF
Missing
[86]
HepG2 CBLIF
Missing
[87]
HepG2.C3A CBLIF
Missing
[88]
HuH.7 CBLIF
Missing
[89]
SNU475 CBLIF
Missing
[90]
THLE CBLIF
Missing
[91]
liver CBLIF
Missing
[92]
ref_hepatocyte MMUT
Missing
[93]
HepG2 MMUT
Missing
[94]
HepG2.C3A MMUT
Missing
[95]
HuH.7 MMUT
Missing
[96]
SNU475 MMUT
Missing
[97]
THLE MMUT
Missing
[98]
liver MMUT
Missing