REACTOME_DEFECTS_IN_BIOTIN_BTN_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PCCB Propionyl-CoA carboxylase beta chain, mitochondrial [1] -0.65[2] -0.83[3] -2.58[4] -0.73[5] -0.28[6] -1.42[7]
2 PC Pyruvate carboxylase, mitochondrial [8] -0.60[9] -0.50[10] 0.23[11] -0.37[12] -2.41[13] 0.84[14]
3 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [15] 0.81[16] 0.65[17] 0.42[18] 0.12[19] 0.67[20] -0.49[21]
4 PCCA Propionyl-CoA carboxylase alpha chain, mitochondrial [22] -0.90[23] -0.91[24] -1.56[25] -2.24[26] -1.72[27] -0.17[28]
5 MCCC1 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial [29] -0.92[30] -1.00[31] -0.51[32] -1.21[33] -0.44[34] -0.79[35]
6 BTD Biotinidase [36] -0.67[37] -0.49[38] -1.44[39] -1.12[40] -0.10[41] -0.38[42]
7 ACACA Acetyl-CoA carboxylase 1 [43] 3.12[44] 3.36[45] 3.81[46] 3.79[47] 3.41[48] 2.05[49]
8 HLCS Biotin--protein ligase [50] 1.64[51] 1.78[52] 0.75[53] 2.61[54] 2.76[55] 1.12[56]
[1]
ref_hepatocyte PCCB
Mean 41.7
Standard deviation 29
Values 18 27 17 67 79
[2]
HepG2 PCCB
Mean 37
Standard deviation 6.8
Values 32 42
[3]
HepG2.C3A PCCB
Mean 31.3
Standard deviation 3.5
Values 29 34
[4]
HuH.7 PCCB
Mean 12.3
Standard deviation 1.8
Values 13 10 13
[5]
SNU475 PCCB
Mean 20
Standard deviation 5
Values 24 16
[6]
THLE PCCB
Mean 22.8
Standard deviation 3.3
Values 20 25
[7]
liver PCCB
Mean 54.9
Standard deviation 21
Values 55 46 84 34
[8]
ref_hepatocyte PC
Mean 39.5
Standard deviation 46
Values 8 5.6 3.9 87 93
[9]
HepG2 PC
Mean 36.2
Standard deviation 7.4
Values 41 31
[10]
HepG2.C3A PC
Mean 37.2
Standard deviation 8
Values 43 32
[11]
HuH.7 PC
Mean 81.4
Standard deviation 7.4
Values 90 77 77
[12]
SNU475 PC
Mean 24.3
Standard deviation 13
Values 33 15
[13]
THLE PC
Mean 4.93
Standard deviation 0.64
Values 4.5 5.4
[14]
liver PC
Mean 248
Standard deviation 63
Values 1.7e+02 2.7e+02 3.2e+02 2.4e+02
[15]
ref_hepatocyte MCCC2
Mean 24.7
Standard deviation 9.8
Values 22 26 11 27 38
[16]
HepG2 MCCC2
Mean 60.1
Standard deviation 16
Values 49 71
[17]
HepG2.C3A MCCC2
Mean 51.8
Standard deviation 17
Values 40 64
[18]
HuH.7 MCCC2
Mean 58.3
Standard deviation 19
Values 74 37 63
[19]
SNU475 MCCC2
Mean 21.4
Standard deviation 2.4
Values 23 20
[20]
THLE MCCC2
Mean 26.1
Standard deviation 3.3
Values 24 28
[21]
liver MCCC2
Mean 62.1
Standard deviation 26
Values 72 46 94 36
[22]
ref_hepatocyte PCCA
Mean 17.2
Standard deviation 15
Values 9.9 6.1 3.5 37 29
[23]
HepG2 PCCA
Mean 12.9
Standard deviation 1.6
Values 12 14
[24]
HepG2.C3A PCCA
Mean 12.2
Standard deviation 0.74
Values 13 12
[25]
HuH.7 PCCA
Mean 10.3
Standard deviation 0.27
Values 10 11 10
[26]
SNU475 PCCA
Mean 2.91
Standard deviation 0.067
Values 3 2.9
[27]
THLE PCCA
Mean 3.46
Standard deviation 0.45
Values 3.1 3.8
[28]
liver PCCA
Mean 53.8
Standard deviation 7.3
Values 49 58 62 47
[29]
ref_hepatocyte MCCC1
Mean 13.4
Standard deviation 8.4
Values 5.1 14 4.4 21 22
[30]
HepG2 MCCC1
Mean 9.8
Standard deviation 2
Values 8.4 11
[31]
HepG2.C3A MCCC1
Mean 8.89
Standard deviation 0.017
Values 8.9 8.9
[32]
HuH.7 MCCC1
Mean 16.5
Standard deviation 1.3
Values 16 15 18
[33]
SNU475 MCCC1
Mean 4.59
Standard deviation 1.2
Values 5.4 3.7
[34]
THLE MCCC1
Mean 6.51
Standard deviation 0.64
Values 6.1 7
[35]
liver MCCC1
Mean 27.2
Standard deviation 5.9
Values 27 28 34 20
[36]
ref_hepatocyte BTD
Mean 8.84
Standard deviation 10
Values 2.1 1.8 1.1 15 24
[37]
HepG2 BTD
Mean 7.7
Standard deviation 0.5
Values 7.4 8.1
[38]
HepG2.C3A BTD
Mean 8.4
Standard deviation 0.021
Values 8.4 8.4
[39]
HuH.7 BTD
Mean 5.74
Standard deviation 0.4
Values 5.5 6.2 5.5
[40]
SNU475 BTD
Mean 3.22
Standard deviation 0.56
Values 3.6 2.8
[41]
THLE BTD
Mean 5.46
Standard deviation 0.75
Values 4.9 6
[42]
liver BTD
Mean 23.9
Standard deviation 2
Values 23 24 26 21
[43]
ref_hepatocyte ACACA
Mean 3.02
Standard deviation 0.95
Values 4.3 3.2 1.7 3.2 2.7
[44]
HepG2 ACACA
Mean 36.5
Standard deviation 4.8
Values 33 40
[45]
HepG2.C3A ACACA
Mean 41.2
Standard deviation 13
Values 50 32
[46]
HuH.7 ACACA
Mean 74.7
Standard deviation 16
Values 89 78 57
[47]
SNU475 ACACA
Mean 33.2
Standard deviation 14
Values 43 23
[48]
THLE ACACA
Mean 21.2
Standard deviation 5
Values 18 25
[49]
liver ACACA
Mean 44
Standard deviation 21
Values 21 70 35 50
[50]
ref_hepatocyte HLCS
Mean 2.02
Standard deviation 0.54
Values 1.6 1.6 1.9 2 2.9
[51]
HepG2 HLCS
Mean 8.73
Standard deviation 0.85
Values 8.1 9.3
[52]
HepG2.C3A HLCS
Mean 9.23
Standard deviation 0.52
Values 8.9 9.6
[53]
HuH.7 HLCS
Mean 5.98
Standard deviation 0.68
Values 6.7 5.8 5.4
[54]
SNU475 HLCS
Mean 9.79
Standard deviation 2.9
Values 12 7.7
[55]
THLE HLCS
Mean 9.03
Standard deviation 1.3
Values 8.1 9.9
[56]
liver HLCS
Mean 15.4
Standard deviation 3.7
Values 12 20 16 14