REACTOME_DEFECTIVE_INTRINSIC_PATHWAY_FOR_APOPTOSIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SOD2 Superoxide dismutase [Mn], mitochondrial [1] -3.43[2] -2.47[3] -3.45[4] -4.59[5] -2.47[6] -1.05[7]
2 PRDX1 Peroxiredoxin-1 [8] 0.01[9] -0.37[10] -0.10[11] -0.35[12] -0.90[13] -0.35[14]
3 YWHAE 14-3-3 protein epsilon [15] 0.26[16] 0.67[17] 0.86[18] 0.55[19] 0.59[20] 0.23[21]
4 PRDX2 Peroxiredoxin-2 [22] 0.53[23] 0.93[24] 0.73[25] -1.37[26] -0.22[27] 0.87[28]
5 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0.45[29] 0.55[30] 0.29[31] -0.61[32] -0.67[33] -0.06[34]
6 LMNA Prelamin-A/C [35] 1.36[36] 1.11[37] -0.43[38] 1.93[39] 1.16[40] 0.81[41]
7 CAPNS1 Calpain small subunit 1 [42] 0.95[43] 0.99[44] 0.69[45] 0.62[46] 0.64[47] -0.67[48]
8 APP Amyloid-beta A4 protein [49] 1.88[50] 1.63[51] 2.13[52] 2.19[53] 2.60[54] 1.92[55]
9 JUN Transcription factor AP-1 [56] 1.01[57] -0.23[58] -0.12[59] -0.29[60] 0.28[61] -0.03[62]
10 CAPN2 Calpain-2 catalytic subunit [63] 0.73[64] -0.37[65] -3.16[66] 2.63[67] 2.19[68] 0.61[69]
11 CAPN1 Calpain-1 catalytic subunit [70] 2.03[71] 1.14[72] 1.58[73] 1.78[74] 1.44[75] 1.43[76]
12 CAST Calpastatin [77] 1.42[78] 2.14[79] 2.41[80] 2.36[81] 1.80[82] 2.58[83]
13 GOLGA2 Golgin subfamily A member 2 [84] 2.19[85] 2.60[86] 2.97[87] 2.34[88] 2.04[89] 1.90[90]
14 LMNB1 Lamin-B1 [91] 2.48[92] 2.82[93] 2.71[94] 2.72[95] 2.37[96] -0.42[97]
15 TP53 Cellular tumor antigen p53 [98] 3.14[99] 3.00[100] 3.60[101] 2.70[102] 2.37[103] 1.74[104]
16 CDK5 Cyclin-dependent-like kinase 5 [105] 1.74[106] 1.34[107] 1.23[108] 2.04[109] 0.83[110] 0.90[111]
17 CDC25B M-phase inducer phosphatase 2 [112] 3.37[113] 3.85[114] 3.06[115] 4.13[116] 4.29[117] 2.12[118]
18 FOXO3 Forkhead box protein O3 [119] 1.95[120] 2.34[121] 2.82[122] 1.81[123] 3.05[124] 4.11[125]
19 CDC25A M-phase inducer phosphatase 1 [126] 2.93[127] 3.86[128] 4.05[129] 1.75[130] 3.21[131] -0.88[132]
20 BCL2L11 Bcl-2-like protein 11 [133] 3.01[134] 3.31[135] 3.48[136] 3.27[137] 2.25[138] 3.77[139]
21 CDC25C M-phase inducer phosphatase 3 [140] 3.43[141] 4.89[142] 4.76[143] 3.33[144] 4.19[145] 0.36[146]
22 CDK5R1 Cyclin-dependent kinase 5 activator 1 [147] 3.59[148] 3.66[149] 3.66[150] 3.38[151] 2.75[152] 1.41[153]
23 CDKN2A Cyclin-dependent kinase inhibitor 2A [154] 5.58[155] 3.65[156] 6.90[157] 6.62[158] 8.40[159] -0.37[160]
24 FASLG Tumor necrosis factor ligand superfamily member 6 [161] -2.31[162] -0.14[163] -4.27[164] [165] [166] 2.37[167]
25 CAPNS2 Calpain small subunit 2 [168] [169] [170] [171] [172] [173] [174]
[1]
ref_hepatocyte SOD2
Mean 955
Standard deviation 9.9e+02
Values 59 1.9e+03 2.2e+03 4e+02 2.7e+02
[2]
HepG2 SOD2
Mean 69.3
Standard deviation 2.2
Values 68 71
[3]
HepG2.C3A SOD2
Mean 97.8
Standard deviation 3.8
Values 1e+02 95
[4]
HuH.7 SOD2
Mean 53.1
Standard deviation 23
Values 44 79 36
[5]
SNU475 SOD2
Mean 27.5
Standard deviation 11
Values 20 35
[6]
THLE SOD2
Mean 133
Standard deviation 14
Values 1.2e+02 1.4e+02
[7]
liver SOD2
Mean 191
Standard deviation 1.1e+02
Values 56 3.2e+02 1.9e+02 2e+02
[8]
ref_hepatocyte PRDX1
Mean 510
Standard deviation 1.8e+02
Values 8.1e+02 5.4e+02 3.8e+02 4.7e+02 3.5e+02
[9]
HepG2 PRDX1
Mean 400
Standard deviation 16
Values 3.9e+02 4.1e+02
[10]
HepG2.C3A PRDX1
Mean 224
Standard deviation 81
Values 1.7e+02 2.8e+02
[11]
HuH.7 PRDX1
Mean 288
Standard deviation 1.1e+02
Values 3.2e+02 1.7e+02 3.7e+02
[12]
SNU475 PRDX1
Mean 278
Standard deviation 25
Values 3e+02 2.6e+02
[13]
THLE PRDX1
Mean 212
Standard deviation 14
Values 2e+02 2.2e+02
[14]
liver PRDX1
Mean 165
Standard deviation 1.3e+02
Values 2.8e+02 55 2.8e+02 42
[15]
ref_hepatocyte YWHAE
Mean 195
Standard deviation 97
Values 2.2e+02 3.6e+02 1.6e+02 1.3e+02 1.2e+02
[16]
HepG2 YWHAE
Mean 183
Standard deviation 1.8
Values 1.8e+02 1.8e+02
[17]
HepG2.C3A YWHAE
Mean 175
Standard deviation 29
Values 1.5e+02 2e+02
[18]
HuH.7 YWHAE
Mean 215
Standard deviation 62
Values 2.1e+02 1.5e+02 2.8e+02
[19]
SNU475 YWHAE
Mean 197
Standard deviation 19
Values 2.1e+02 1.8e+02
[20]
THLE YWHAE
Mean 227
Standard deviation 21
Values 2.1e+02 2.4e+02
[21]
liver YWHAE
Mean 94.2
Standard deviation 60
Values 1.3e+02 52 1.6e+02 36
[22]
ref_hepatocyte PRDX2
Mean 101
Standard deviation 50
Values 1.1e+02 43 57 1.6e+02 1.3e+02
[23]
HepG2 PRDX2
Mean 114
Standard deviation 4
Values 1.1e+02 1.2e+02
[24]
HepG2.C3A PRDX2
Mean 108
Standard deviation 14
Values 99 1.2e+02
[25]
HuH.7 PRDX2
Mean 101
Standard deviation 26
Values 1e+02 74 1.3e+02
[26]
SNU475 PRDX2
Mean 27
Standard deviation 1.6
Values 26 28
[27]
THLE PRDX2
Mean 67.2
Standard deviation 5.1
Values 64 71
[28]
liver PRDX2
Mean 76.4
Standard deviation 48
Values 1.1e+02 39 1.2e+02 32
[29]
ref_hepatocyte C1QBP
Mean 101
Standard deviation 47
Values 85 1.2e+02 1.7e+02 84 44
[30]
HepG2 C1QBP
Mean 108
Standard deviation 11
Values 1.2e+02 1e+02
[31]
HepG2.C3A C1QBP
Mean 83.6
Standard deviation 25
Values 66 1e+02
[32]
HuH.7 C1QBP
Mean 74.6
Standard deviation 24
Values 79 49 96
[33]
SNU475 C1QBP
Mean 45.6
Standard deviation 3
Values 44 48
[34]
THLE C1QBP
Mean 48.9
Standard deviation 16
Values 37 60
[35]
liver C1QBP
Mean 40
Standard deviation 24
Values 55 22 66 17
[36]
ref_hepatocyte LMNA
Mean 84.6
Standard deviation 77
Values 62 2.2e+02 65 42 33
[37]
HepG2 LMNA
Mean 170
Standard deviation 28
Values 1.9e+02 1.5e+02
[38]
HepG2.C3A LMNA
Mean 103
Standard deviation 24
Values 1.2e+02 86
[39]
HuH.7 LMNA
Mean 38.1
Standard deviation 0.77
Values 38 39 37
[40]
SNU475 LMNA
Mean 223
Standard deviation 30
Values 2.4e+02 2e+02
[41]
THLE LMNA
Mean 146
Standard deviation 49
Values 1.1e+02 1.8e+02
[42]
liver LMNA
Mean 61.5
Standard deviation 29
Values 59 45 1e+02 39
[43]
ref_hepatocyte CAPNS1
Mean 65.1
Standard deviation 35
Values 39 47 1.3e+02 67 47
[44]
HepG2 CAPNS1
Mean 98.1
Standard deviation 7.2
Values 93 1e+02
[45]
HepG2.C3A CAPNS1
Mean 73
Standard deviation 2.8
Values 75 71
[46]
HuH.7 CAPNS1
Mean 63.4
Standard deviation 20
Values 77 40 73
[47]
SNU475 CAPNS1
Mean 69.1
Standard deviation 23
Values 85 53
[48]
THLE CAPNS1
Mean 78.6
Standard deviation 12
Values 70 87
[49]
liver CAPNS1
Mean 16.9
Standard deviation 9.7
Values 28 8.4 22 9.1
[50]
ref_hepatocyte APP
Mean 58.3
Standard deviation 28
Values 31 1e+02 46 51 59
[51]
HepG2 APP
Mean 167
Standard deviation 49
Values 2e+02 1.3e+02
[52]
HepG2.C3A APP
Mean 102
Standard deviation 27
Values 1.2e+02 83
[53]
HuH.7 APP
Mean 154
Standard deviation 13
Values 1.6e+02 1.7e+02 1.4e+02
[54]
SNU475 APP
Mean 184
Standard deviation 28
Values 2e+02 1.6e+02
[55]
THLE APP
Mean 273
Standard deviation 68
Values 2.3e+02 3.2e+02
[56]
liver APP
Mean 91
Standard deviation 73
Values 32 1.7e+02 28 1.3e+02
[57]
ref_hepatocyte JUN
Mean 42.9
Standard deviation 25
Values 26 30 66 73 20
[58]
HepG2 JUN
Mean 67.5
Standard deviation 36
Values 93 42
[59]
HepG2.C3A JUN
Mean 20.6
Standard deviation 11
Values 28 13
[60]
HuH.7 JUN
Mean 23.9
Standard deviation 19
Values 11 46 14
[61]
SNU475 JUN
Mean 24.2
Standard deviation 4.1
Values 21 27
[62]
THLE JUN
Mean 40.2
Standard deviation 4.7
Values 37 44
[63]
liver JUN
Mean 17.4
Standard deviation 8.4
Values 25 24 8.4 12
[64]
ref_hepatocyte CAPN2
Mean 29.4
Standard deviation 32
Values 7.1 73 54 6.8 5.7
[65]
HepG2 CAPN2
Mean 38
Standard deviation 7
Values 33 43
[66]
HepG2.C3A CAPN2
Mean 12.9
Standard deviation 0.41
Values 13 13
[67]
HuH.7 CAPN2
Mean 1.99
Standard deviation 1.5
Values 1.4 3.7 0.94
[68]
SNU475 CAPN2
Mean 126
Standard deviation 7.5
Values 1.3e+02 1.2e+02
[69]
THLE CAPN2
Mean 104
Standard deviation 11
Values 97 1.1e+02
[70]
liver CAPN2
Mean 18.6
Standard deviation 4.9
Values 17 20 25 13
[71]
ref_hepatocyte CAPN1
Mean 26.6
Standard deviation 9.2
Values 18 36 36 26 17
[72]
HepG2 CAPN1
Mean 84.9
Standard deviation 1.9
Values 84 86
[73]
HepG2.C3A CAPN1
Mean 33.2
Standard deviation 4.1
Values 36 30
[74]
HuH.7 CAPN1
Mean 48.1
Standard deviation 5.2
Values 54 45 45
[75]
SNU475 CAPN1
Mean 63.3
Standard deviation 24
Values 80 47
[76]
THLE CAPN1
Mean 55.9
Standard deviation 16
Values 45 67
[77]
liver CAPN1
Mean 29.7
Standard deviation 11
Values 40 16 36 27
[78]
ref_hepatocyte CAST
Mean 22.7
Standard deviation 9.6
Values 15 39 23 19 18
[79]
HepG2 CAST
Mean 47.6
Standard deviation 3.7
Values 45 50
[80]
HepG2.C3A CAST
Mean 56.5
Standard deviation 4.5
Values 60 53
[81]
HuH.7 CAST
Mean 73.1
Standard deviation 8
Values 82 72 66
[82]
SNU475 CAST
Mean 80.9
Standard deviation 4
Values 84 78
[83]
THLE CAST
Mean 61.2
Standard deviation 2.8
Values 59 63
[84]
liver CAST
Mean 56.1
Standard deviation 14
Values 67 52 68 38
[85]
ref_hepatocyte GOLGA2
Mean 8.29
Standard deviation 1.2
Values 9.3 7.3 9.5 8.7 6.7
[86]
HepG2 GOLGA2
Mean 29.5
Standard deviation 0.28
Values 29 30
[87]
HepG2.C3A GOLGA2
Mean 28.5
Standard deviation 12
Values 37 20
[88]
HuH.7 GOLGA2
Mean 39.4
Standard deviation 3.7
Values 42 41 35
[89]
SNU475 GOLGA2
Mean 29
Standard deviation 6.1
Values 33 25
[90]
THLE GOLGA2
Mean 26.3
Standard deviation 6.7
Values 22 31
[91]
liver GOLGA2
Mean 12.8
Standard deviation 3.7
Values 11 16 8.7 16
[92]
ref_hepatocyte LMNB1
Mean 7.95
Standard deviation 9.7
Values 25 7.4 2.1 2.1 3.3
[93]
HepG2 LMNB1
Mean 34.6
Standard deviation 12
Values 26 43
[94]
HepG2.C3A LMNB1
Mean 31.6
Standard deviation 15
Values 21 42
[95]
HuH.7 LMNB1
Mean 31.5
Standard deviation 13
Values 36 16 42
[96]
SNU475 LMNB1
Mean 36.2
Standard deviation 1.2
Values 37 35
[97]
THLE LMNB1
Mean 31.8
Standard deviation 13
Values 22 41
[98]
liver LMNB1
Mean 2.45
Standard deviation 2.4
Values 0.54 5.6 0.69 3
[99]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 5.5 3.7 6.2 5.5 5.5
[100]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[101]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 23 25
[102]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 50 20 46
[103]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 28 19
[104]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[105]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 9 5 9.5 5.6
[106]
ref_hepatocyte CDK5
Mean 4.43
Standard deviation 2.1
Values 4.3 1.4 4.6 7.2 4.7
[107]
HepG2 CDK5
Mean 11.6
Standard deviation 2.3
Values 9.9 13
[108]
HepG2.C3A CDK5
Mean 6.36
Standard deviation 1.4
Values 5.3 7.4
[109]
HuH.7 CDK5
Mean 6.32
Standard deviation 1.5
Values 6.1 4.9 8
[110]
SNU475 CDK5
Mean 12.6
Standard deviation 1.1
Values 13 12
[111]
THLE CDK5
Mean 6.09
Standard deviation 0.67
Values 5.6 6.6
[112]
liver CDK5
Mean 3.42
Standard deviation 1.7
Values 5.5 1.8 4.1 2.3
[113]
ref_hepatocyte CDC25B
Mean 3.7
Standard deviation 1.9
Values 5.6 4.7 1.4 4.9 1.9
[114]
HepG2 CDC25B
Mean 29.8
Standard deviation 3.6
Values 32 27
[115]
HepG2.C3A CDC25B
Mean 30.1
Standard deviation 0.9
Values 29 31
[116]
HuH.7 CDC25B
Mean 18.7
Standard deviation 7.4
Values 24 10 22
[117]
SNU475 CDC25B
Mean 44.8
Standard deviation 0.23
Values 45 45
[118]
THLE CDC25B
Mean 56.1
Standard deviation 11
Values 48 64
[119]
liver CDC25B
Mean 6.65
Standard deviation 3.5
Values 9 4.9 10 2.6
[120]
ref_hepatocyte FOXO3
Mean 2.79
Standard deviation 0.38
Values 3.3 2.7 2.3 2.8 2.9
[121]
HepG2 FOXO3
Mean 8.44
Standard deviation 1
Values 7.7 9.2
[122]
HepG2.C3A FOXO3
Mean 8
Standard deviation 2.4
Values 9.7 6.3
[123]
HuH.7 FOXO3
Mean 11.9
Standard deviation 3.6
Values 13 15 7.9
[124]
SNU475 FOXO3
Mean 6.76
Standard deviation 0.76
Values 7.3 6.2
[125]
THLE FOXO3
Mean 17.9
Standard deviation 3.1
Values 16 20
[126]
liver FOXO3
Mean 20
Standard deviation 5.5
Values 24 21 12 23
[127]
ref_hepatocyte CDC25A
Mean 2.04
Standard deviation 2.5
Values 6.2 2.3 1 0.26 0.37
[128]
HepG2 CDC25A
Mean 12.1
Standard deviation 2.6
Values 10 14
[129]
HepG2.C3A CDC25A
Mean 16.8
Standard deviation 9.8
Values 9.8 24
[130]
HuH.7 CDC25A
Mean 20.5
Standard deviation 10
Values 26 8.6 27
[131]
SNU475 CDC25A
Mean 4.76
Standard deviation 2.1
Values 3.3 6.2
[132]
THLE CDC25A
Mean 14.6
Standard deviation 2.2
Values 13 16
[133]
liver CDC25A
Mean 0.459
Standard deviation 0.38
Values 0.33 1 0.28 0.2
[134]
ref_hepatocyte BCL2L11
Mean 1.6
Standard deviation 0.72
Values 2.4 0.45 1.7 2 1.5
[135]
HepG2 BCL2L11
Mean 10.1
Standard deviation 0.76
Values 11 9.5
[136]
HepG2.C3A BCL2L11
Mean 9.01
Standard deviation 0.3
Values 8.8 9.2
[137]
HuH.7 BCL2L11
Mean 10.8
Standard deviation 1
Values 11 12 9.7
[138]
SNU475 BCL2L11
Mean 10.7
Standard deviation 3
Values 13 8.6
[139]
THLE BCL2L11
Mean 5.92
Standard deviation 0.75
Values 5.4 6.4
[140]
liver BCL2L11
Mean 9.03
Standard deviation 4.2
Values 7.8 6.5 6.5 15
[141]
ref_hepatocyte CDC25C
Mean 0.731
Standard deviation 0.89
Values 2 1.3 0.11 0.078 0.13
[142]
HepG2 CDC25C
Mean 6.16
Standard deviation 0.58
Values 5.7 6.6
[143]
HepG2.C3A CDC25C
Mean 12.2
Standard deviation 6.2
Values 7.8 17
[144]
HuH.7 CDC25C
Mean 12
Standard deviation 5.4
Values 14 5.9 16
[145]
SNU475 CDC25C
Mean 5.11
Standard deviation 0.28
Values 5.3 4.9
[146]
THLE CDC25C
Mean 10.3
Standard deviation 1.8
Values 9 12
[147]
liver CDC25C
Mean 0.389
Standard deviation 0.27
Values 0.45 0.43 0.67 0.013
[148]
ref_hepatocyte CDK5R1
Mean 0.325
Standard deviation 0.3
Values 0.85 0.33 0.17 0.15 0.12
[149]
HepG2 CDK5R1
Mean 3.05
Standard deviation 0.82
Values 3.6 2.5
[150]
HepG2.C3A CDK5R1
Mean 2.32
Standard deviation 0.57
Values 1.9 2.7
[151]
HuH.7 CDK5R1
Mean 2.5
Standard deviation 0.94
Values 3 1.4 3.1
[152]
SNU475 CDK5R1
Mean 2.35
Standard deviation 0.21
Values 2.2 2.5
[153]
THLE CDK5R1
Mean 1.69
Standard deviation 0.024
Values 1.7 1.7
[154]
liver CDK5R1
Mean 0.358
Standard deviation 0.31
Values 0.19 0.39 0.077 0.78
[155]
ref_hepatocyte CDKN2A
Mean 0.323
Standard deviation 0.62
Values 1.4 0 0 0.13 0.065
[156]
HepG2 CDKN2A
Mean 12.1
Standard deviation 5.5
Values 16 8.2
[157]
HepG2.C3A CDKN2A
Mean 2.29
Standard deviation 0.19
Values 2.1 2.4
[158]
HuH.7 CDKN2A
Mean 23.3
Standard deviation 9
Values 24 14 32
[159]
SNU475 CDKN2A
Mean 21.9
Standard deviation 6.8
Values 27 17
[160]
THLE CDKN2A
Mean 84.5
Standard deviation 8.9
Values 78 91
[161]
liver CDKN2A
Mean 0.103
Standard deviation 0.079
Values 0.21 0.071 0.1 0.026
[162]
ref_hepatocyte FASLG
Mean 0.0683
Standard deviation 0.15
Values 0 0 0 0 0.34
[163]
HepG2 FASLG
Mean 0.0107
Standard deviation 0.0091
Values 0.017 0.0043
[164]
HepG2.C3A FASLG
Mean 0.035
Standard deviation 0.019
Values 0.049 0.021
[165]
HuH.7 FASLG
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[166]
SNU475 FASLG
Mean 0
Standard deviation 0
Values 0 0
[167]
THLE FASLG
Mean 0
Standard deviation 0
Values 0 0
[168]
liver FASLG
Mean 0.145
Standard deviation 0.073
Values 0.19 0.043 0.21 0.15
[169]
ref_hepatocyte CAPNS2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 CAPNS2
Mean 0.0272
Standard deviation 0.022
Values 0.011 0.043
[171]
HepG2.C3A CAPNS2
Mean 0
Standard deviation 0
Values 0 0
[172]
HuH.7 CAPNS2
Mean 0
Standard deviation 0
Values 0 0 0
[173]
SNU475 CAPNS2
Mean 0.0623
Standard deviation 0.055
Values 0.023 0.1
[174]
THLE CAPNS2
Mean 0.0169
Standard deviation 0.0013
Values 0.018 0.016
[175]
liver CAPNS2
Mean 0.0479
Standard deviation 0.056
Values 0 0.086 0 0.11