REACTOME_DEFECTIVE_CFTR_CAUSES_CYSTIC_FIBROSIS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.12[2] | -1.22[3] | -1.07[4] | -1.34[5] | -1.00[6] | -0.63[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.68[16] | -0.46[17] | -0.71[18] | -0.48[19] | -0.62[20] | -0.18[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.45[23] | -2.05[24] | -1.68[25] | -1.20[26] | -1.84[27] | -1.13[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.27[30] | -1.68[31] | -1.77[32] | -0.99[33] | -1.38[34] | -0.75[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.69[37] | 0.79[38] | -0.52[39] | 0.64[40] | 0.09[41] | 0.27[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.24[44] | 0.34[45] | -0.72[46] | -0.61[47] | 0.05[48] | 0.11[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.25[51] | -1.04[52] | 0.01[53] | -0.63[54] | -0.85[55] | -0.19[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | 0.00[58] | 0.16[59] | 0.31[60] | 0.80[61] | 0.69[62] | -0.52[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -0.95[65] | -0.94[66] | -0.79[67] | -0.97[68] | -0.63[69] | -0.95[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.45[72] | 0.02[73] | -0.03[74] | -0.25[75] | -0.07[76] | -0.48[77] |
12 | VCP | Transitional endoplasmic reticulum ATPase | [78] | 1.31[79] | 1.15[80] | 1.08[81] | 0.94[82] | 1.38[83] | 1.49[84] |
13 | PSMA6 | Proteasome subunit alpha type-6 | [85] | 1.58[86] | 0.30[87] | 0.25[88] | 0.28[89] | 0.19[90] | -0.40[91] |
14 | OS9 | Protein OS-9 | [92] | 0.32[93] | 0.84[94] | 0.58[95] | -0.17[96] | -0.05[97] | 1.21[98] |
15 | PSMA4 | Proteasome subunit alpha type-4 | [99] | -0.35[100] | 0.31[101] | 0.13[102] | 0.58[103] | 0.31[104] | -0.48[105] |
16 | PSMC3 | 26S proteasome regulatory subunit 6A | [106] | -0.38[107] | -0.45[108] | 0.19[109] | -0.62[110] | -0.52[111] | -0.01[112] |
17 | PSMA3 | Proteasome subunit alpha type-3 | [113] | -0.97[114] | 0.04[115] | -0.62[116] | 0.13[117] | -0.42[118] | -0.23[119] |
18 | PSMB6 | Proteasome subunit beta type-6 | [120] | -0.42[121] | -0.27[122] | -0.11[123] | -0.42[124] | -0.79[125] | -0.07[126] |
19 | PSMA2 | Proteasome subunit alpha type-2 | [127] | -0.50[128] | 0.46[129] | 0.81[130] | 0.08[131] | 0.35[132] | 0.15[133] |
20 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [134] | 0.01[135] | 0.03[136] | 0.25[137] | 0.78[138] | 0.15[139] | -0.17[140] |
21 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [141] | -0.07[142] | 0.31[143] | 0.18[144] | -0.31[145] | 0.07[146] | -0.35[147] |
22 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [148] | 0.10[149] | 0.34[150] | 0.50[151] | -0.03[152] | 0.63[153] | -0.32[154] |
23 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [155] | 1.63[156] | 0.81[157] | 0.90[158] | 1.08[159] | 2.28[160] | 0.71[161] |
24 | PSMC1 | 26S proteasome regulatory subunit 4 | [162] | -0.05[163] | 0.02[164] | -0.61[165] | 1.26[166] | 0.69[167] | -0.13[168] |
25 | PSMA1 | Proteasome subunit alpha type-1 | [169] | 0.13[170] | 0.53[171] | 0.61[172] | 0.84[173] | 0.24[174] | 0.36[175] |
26 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [176] | 1.76[177] | 1.77[178] | 2.81[179] | 0.91[180] | 1.61[181] | 0.59[182] |
27 | PSMC5 | 26S proteasome regulatory subunit 8 | [183] | 0.45[184] | 0.35[185] | 0.45[186] | 0.25[187] | 0.56[188] | 0.13[189] |
28 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [190] | 0.85[191] | 0.35[192] | 0.96[193] | 0.78[194] | 0.90[195] | -0.16[196] |
29 | PSMB8 | Proteasome subunit beta type-8 | [197] | -1.55[198] | -2.13[199] | -9.33[200] | 0.75[201] | -0.65[202] | -0.84[203] |
30 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [204] | 0.03[205] | 0.64[206] | 0.91[207] | 0.64[208] | 0.58[209] | -0.30[210] |
31 | PSMC4 | 26S proteasome regulatory subunit 6B | [211] | 0.45[212] | 0.49[213] | 0.44[214] | 0.27[215] | 0.29[216] | 0.18[217] |
32 | RNF5 | E3 ubiquitin-protein ligase RNF5 | [218] | -9.28[219] | -8.51[220] | -7.63[221] | -9.38[222] | -10.80[223] | -8.93[224] |
33 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [225] | -0.70[226] | -0.21[227] | -1.29[228] | -0.36[229] | 0.36[230] | -0.41[231] |
34 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [232] | 0.50[233] | 0.61[234] | 1.13[235] | 0.70[236] | 0.12[237] | -0.22[238] |
35 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [239] | -0.32[240] | -0.24[241] | -0.53[242] | 0.32[243] | 0.29[244] | -0.30[245] |
36 | PSMC6 | 26S proteasome regulatory subunit 10B | [246] | -0.03[247] | 1.55[248] | 0.39[249] | 0.68[250] | 0.52[251] | 0.35[252] |
37 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [253] | 0.86[254] | 0.47[255] | 1.08[256] | 1.09[257] | 1.15[258] | 1.18[259] |
38 | PSMC2 | 26S proteasome regulatory subunit 7 | [260] | 0.61[261] | 1.02[262] | 0.81[263] | 1.48[264] | 1.21[265] | 1.23[266] |
39 | DERL2 | Derlin-2 | [267] | -1.14[268] | -0.39[269] | -0.92[270] | -0.26[271] | -0.65[272] | 0.08[273] |
40 | PSME3 | Proteasome activator complex subunit 3 | [274] | 1.84[275] | 1.56[276] | 1.26[277] | 1.51[278] | 1.68[279] | 0.80[280] |
41 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [281] | 1.60[282] | 1.92[283] | 1.82[284] | 2.31[285] | 2.23[286] | 1.98[287] |
42 | PSMB10 | Proteasome subunit beta type-10 | [288] | -1.13[289] | -0.53[290] | -2.40[291] | 0.10[292] | -1.16[293] | -0.17[294] |
43 | PSMA5 | Proteasome subunit alpha type-5 | [295] | 1.93[296] | 2.36[297] | 1.94[298] | 2.37[299] | 1.83[300] | 1.82[301] |
44 | ERLIN1 | Erlin-1 | [302] | 1.35[303] | 2.53[304] | 2.56[305] | 0.18[306] | 1.53[307] | 2.14[308] |
45 | PSMF1 | Proteasome inhibitor PI31 subunit | [309] | 2.31[310] | 2.35[311] | 1.18[312] | 1.37[313] | 1.04[314] | 1.76[315] |
46 | ERLEC1 | Endoplasmic reticulum lectin 1 | [316] | 0.83[317] | 2.47[318] | 2.10[319] | 1.29[320] | 1.05[321] | 1.22[322] |
47 | PSMB2 | Proteasome subunit beta type-2 | [323] | 2.09[324] | 1.82[325] | 2.23[326] | 2.67[327] | 2.56[328] | 2.31[329] |
48 | DERL1 | Derlin-1 | [330] | 0.65[331] | 0.70[332] | 0.79[333] | 1.64[334] | 1.17[335] | 2.01[336] |
49 | SEL1L | Protein sel-1 homolog 1 | [337] | 1.40[338] | 1.94[339] | 1.86[340] | 2.41[341] | 1.98[342] | 4.07[343] |
50 | PSMB9 | Proteasome subunit beta type-9 | [344] | -1.92[345] | -4.54[346] | -6.83[347] | 1.92[348] | -0.44[349] | -0.59[350] |
51 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [351] | 0.46[352] | 0.96[353] | -0.01[354] | 0.55[355] | 0.89[356] | 0.64[357] |
52 | RNF185 | E3 ubiquitin-protein ligase RNF185 | [358] | 1.05[359] | 0.99[360] | 1.44[361] | 1.02[362] | 0.78[363] | 2.09[364] |
53 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [365] | 1.02[366] | 1.34[367] | 1.38[368] | 2.22[369] | 1.44[370] | 0.62[371] |
54 | ERLIN2 | Erlin-2 | [372] | 1.87[373] | 2.12[374] | 3.08[375] | 1.69[376] | 1.49[377] | 1.96[378] |
55 | PSME4 | Proteasome activator complex subunit 4 | [379] | 2.55[380] | 3.46[381] | 3.48[382] | 2.77[383] | 2.64[384] | 2.89[385] |
56 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [386] | 1.44[387] | 0.99[388] | 2.57[389] | 2.60[390] | 2.59[391] | 2.07[392] |
57 | DERL3 | Derlin-3 | [393] | -6.82[394] | -5.95[395] | -6.06[396] | -1.86[397] | -2.41[398] | 0.61[399] |
58 | CFTR | Cystic fibrosis transmembrane conductance regulator | [400] | -1.10[401] | -1.51[402] | 2.04[403] | 5.27[404] | -2.45[405] | 8.41[406] |
59 | SEM1 | Putative protein SEM1, isoform 2 | [407] | [408] | [409] | [410] | [411] | [412] | [413] |
60 | PSMA8 | Proteasome subunit alpha type-7-like | [414] | [415] | [416] | [417] | [418] | [419] | [420] |
61 | PSMB11 | Proteasome subunit beta type-11 | [421] | [422] | [423] | [424] | [425] | [426] | [427] |