REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SAA1 | Serum amyloid A-1 protein | [1] | -15.30[2] | -15.56[3] | -10.57[4] | -13.60[5] | -4.72[6] | -0.32[7] |
2 | UBB | Polyubiquitin-B | [8] | 1.65[9] | 1.23[10] | 1.62[11] | 1.18[12] | 1.69[13] | 0.65[14] |
3 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [15] | [16] | [17] | [18] | [19] | [20] | [21] |
4 | UBC | Polyubiquitin-C | [22] | 2.09[23] | 1.98[24] | 1.98[25] | 2.03[26] | 2.07[27] | 1.10[28] |
5 | HSP90AB1 | Heat shock protein HSP 90-beta | [29] | 4.08[30] | 3.96[31] | 3.38[32] | 3.42[33] | 2.84[34] | 0.42[35] |
6 | HSP90AA1 | Heat shock protein HSP 90-alpha | [36] | 3.20[37] | 3.96[38] | 3.42[39] | 4.05[40] | 3.78[41] | 1.27[42] |
7 | HMGB1 | High mobility group protein B1 | [43] | 3.55[44] | 4.07[45] | 4.05[46] | 4.42[47] | 3.95[48] | 1.97[49] |
8 | NFKBIA | NF-kappa-B inhibitor alpha | [50] | 2.79[51] | 0.78[52] | 0.64[53] | 0.44[54] | 2.37[55] | 1.39[56] |
9 | PCBP2 | Poly(rC)-binding protein 2 | [57] | 4.15[58] | 4.05[59] | 4.64[60] | 3.82[61] | 4.00[62] | 1.37[63] |
10 | UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 | [64] | 3.03[65] | 3.13[66] | 3.60[67] | 3.22[68] | 3.74[69] | 2.38[70] |
11 | APP | Amyloid-beta A4 protein | [71] | 4.23[72] | 3.46[73] | 4.35[74] | 4.74[75] | 5.20[76] | 2.66[77] |
12 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [78] | 4.53[79] | 4.22[80] | 5.49[81] | 3.43[82] | 4.29[83] | 1.87[84] |
13 | ISG15 | Ubiquitin-like protein ISG15 | [85] | 1.69[86] | 1.72[87] | 0.84[88] | 0.66[89] | -0.43[90] | 0.13[91] |
14 | UBE2L6 | Ubiquitin/ISG15-conjugating enzyme E2 L6 | [92] | 2.10[93] | -0.61[94] | 1.29[95] | 2.91[96] | 2.39[97] | 1.83[98] |
15 | IKBKG | NF-kappa-B essential modulator | [99] | 2.96[100] | 2.89[101] | 0.88[102] | 3.11[103] | 1.95[104] | 1.92[105] |
16 | TAX1BP1 | Tax1-binding protein 1 | [106] | 3.75[107] | 4.70[108] | 5.13[109] | 4.94[110] | 4.19[111] | 3.08[112] |
17 | PIN1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | [113] | 2.81[114] | 2.65[115] | 3.13[116] | 2.30[117] | 3.49[118] | 1.16[119] |
18 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | [120] | 3.08[121] | 3.17[122] | 3.85[123] | 2.58[124] | 3.48[125] | -0.49[126] |
19 | RELA | Transcription factor p65 | [127] | 3.98[128] | 3.26[129] | 3.63[130] | 3.91[131] | 3.86[132] | 1.64[133] |
20 | UBE2K | Ubiquitin-conjugating enzyme E2 K | [134] | 4.17[135] | 4.44[136] | 4.92[137] | 4.37[138] | 4.89[139] | 2.84[140] |
21 | NFKBIB | NF-kappa-B inhibitor beta | [141] | 2.69[142] | 2.29[143] | 2.86[144] | 2.15[145] | 2.54[146] | 0.80[147] |
22 | IRF7 | Interferon regulatory factor 7 | [148] | -5.38[149] | -4.60[150] | -3.26[151] | 0.81[152] | 0.60[153] | 2.45[154] |
23 | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 | [155] | 4.48[156] | 4.96[157] | 1.94[158] | 2.75[159] | 4.76[160] | 1.50[161] |
24 | UBE2D2 | Ubiquitin-conjugating enzyme E2 D2 | [162] | 4.85[163] | 4.68[164] | 4.19[165] | 4.76[166] | 5.00[167] | 2.49[168] |
25 | IRF3 | Interferon regulatory factor 3 | [169] | 4.15[170] | 4.10[171] | 5.06[172] | 4.32[173] | 3.96[174] | 1.34[175] |
26 | FADD | FAS-associated death domain protein | [176] | 3.89[177] | 2.96[178] | 3.92[179] | 5.89[180] | 3.75[181] | 0.75[182] |
27 | ITCH | E3 ubiquitin-protein ligase Itchy homolog | [183] | 5.20[184] | 5.51[185] | 5.00[186] | 5.49[187] | 4.87[188] | 4.69[189] |
28 | CASP8 | Caspase-8 | [190] | 3.87[191] | 4.22[192] | 3.63[193] | 3.88[194] | 3.18[195] | 1.11[196] |
29 | TANK | TRAF family member-associated NF-kappa-B activator | [197] | 2.71[198] | 4.48[199] | 4.34[200] | 4.09[201] | 3.37[202] | 3.06[203] |
30 | OTUD5 | OTU domain-containing protein 5 | [204] | 4.52[205] | 3.92[206] | 5.12[207] | 4.40[208] | 4.39[209] | 1.95[210] |
31 | NKIRAS2 | NF-kappa-B inhibitor-interacting Ras-like protein 2 | [211] | 4.60[212] | 3.13[213] | 4.43[214] | 4.54[215] | 4.39[216] | 2.72[217] |
32 | TRIM4 | E3 ubiquitin-protein ligase TRIM4 | [218] | 3.56[219] | 3.54[220] | 3.96[221] | 2.65[222] | 3.31[223] | 2.93[224] |
33 | TBK1 | Serine/threonine-protein kinase TBK1 | [225] | 3.21[226] | 4.67[227] | 4.05[228] | 4.45[229] | 4.59[230] | 3.00[231] |
34 | TRIM25 | E3 ubiquitin/ISG15 ligase TRIM25 | [232] | 5.98[233] | 5.40[234] | 5.47[235] | 4.84[236] | 5.54[237] | 4.34[238] |
35 | ATG5 | Autophagy protein 5 | [239] | 3.63[240] | 4.44[241] | 4.33[242] | 4.74[243] | 4.53[244] | 3.37[245] |
36 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [246] | 4.52[247] | 3.98[248] | 4.00[249] | 3.71[250] | 4.67[251] | 2.98[252] |
37 | NKIRAS1 | NF-kappa-B inhibitor-interacting Ras-like protein 1 | [253] | 2.48[254] | 2.06[255] | 3.51[256] | 3.42[257] | 3.75[258] | 2.30[259] |
38 | TRAF2 | TNF receptor-associated factor 2 | [260] | 4.08[261] | 3.92[262] | 3.89[263] | 4.08[264] | 4.14[265] | 1.73[266] |
39 | ATG12 | Ubiquitin-like protein ATG12 | [267] | 4.28[268] | 4.96[269] | 5.13[270] | 5.42[271] | 5.25[272] | 3.96[273] |
40 | IFIH1 | Interferon-induced helicase C domain-containing protein 1 | [274] | 1.88[275] | 1.75[276] | -2.13[277] | 2.73[278] | 3.01[279] | 2.78[280] |
41 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | [281] | 4.14[282] | 4.08[283] | 4.00[284] | 5.04[285] | 4.61[286] | 4.01[287] |
42 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | [288] | 3.75[289] | 3.66[290] | 2.71[291] | 4.91[292] | 6.18[293] | 4.46[294] |
43 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [295] | 4.75[296] | 5.75[297] | 5.95[298] | 4.61[299] | 5.47[300] | 4.04[301] |
44 | DHX58 | Probable ATP-dependent RNA helicase DHX58 | [302] | 1.60[303] | 2.07[304] | -4.52[305] | 2.25[306] | 1.21[307] | 3.04[308] |
45 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [309] | 4.37[310] | 4.21[311] | 4.55[312] | 4.22[313] | 4.36[314] | 3.71[315] |
46 | DDX58 | Probable ATP-dependent RNA helicase DDX58 | [316] | 3.15[317] | 2.91[318] | 2.33[319] | 3.17[320] | 3.78[321] | 3.64[322] |
47 | SIKE1 | Suppressor of IKBKE 1 | [323] | 4.63[324] | 5.52[325] | 6.37[326] | 5.70[327] | 5.67[328] | 4.31[329] |
48 | UBA7 | Ubiquitin-like modifier-activating enzyme 7 | [330] | 3.61[331] | 3.12[332] | -1.40[333] | 5.03[334] | 4.63[335] | 3.91[336] |
49 | RNF216 | E3 ubiquitin-protein ligase RNF216 | [337] | 5.96[338] | 5.72[339] | 6.23[340] | 5.85[341] | 5.96[342] | 4.67[343] |
50 | EP300 | Histone acetyltransferase p300 | [344] | 6.57[345] | 5.95[346] | 7.08[347] | 6.53[348] | 6.63[349] | 5.28[350] |
51 | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 | [351] | 4.64[352] | 5.29[353] | 5.87[354] | 5.48[355] | 5.29[356] | 3.03[357] |
52 | MAVS | Mitochondrial antiviral-signaling protein | [358] | 8.13[359] | 7.52[360] | 7.36[361] | 7.69[362] | 7.33[363] | 5.87[364] |
53 | NLRX1 | NLR family member X1 | [365] | 5.71[366] | 4.84[367] | 3.78[368] | 5.18[369] | 4.54[370] | 3.67[371] |
54 | CREBBP | CREB-binding protein | [372] | 6.75[373] | 5.75[374] | 6.59[375] | 6.72[376] | 6.77[377] | 5.76[378] |
55 | CASP10 | Caspase-10 | [379] | 5.07[380] | 6.14[381] | 5.33[382] | 4.39[383] | 4.49[384] | 3.59[385] |
56 | RNF125 | E3 ubiquitin-protein ligase RNF125 | [386] | 1.38[387] | 2.70[388] | 3.40[389] | 2.70[390] | 1.95[391] | 4.10[392] |
57 | TRAF3 | TNF receptor-associated factor 3 | [393] | 6.74[394] | 5.94[395] | 5.78[396] | 6.79[397] | 7.25[398] | 4.45[399] |
58 | HERC5 | E3 ISG15--protein ligase HERC5 | [400] | 0.87[401] | -2.32[402] | 3.65[403] | 4.72[404] | 3.98[405] | 3.76[406] |
59 | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | [407] | 6.50[408] | 6.00[409] | 5.96[410] | 6.29[411] | 5.21[412] | 5.32[413] |
60 | TRAF6 | TNF receptor-associated factor 6 | [414] | 4.94[415] | 4.61[416] | 5.41[417] | 5.62[418] | 5.13[419] | 5.43[420] |
61 | RNF135 | E3 ubiquitin-protein ligase RNF135 | [421] | -3.46[422] | -3.28[423] | -1.77[424] | -3.52[425] | 5.45[426] | 3.39[427] |
62 | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | [428] | 5.57[429] | 5.22[430] | 4.35[431] | 6.52[432] | 6.12[433] | 2.29[434] |
63 | NLRC5 | Protein NLRC5 | [435] | 5.06[436] | 5.36[437] | 4.30[438] | 7.74[439] | 7.29[440] | 5.65[441] |
64 | S100A12 | Protein S100-A12 | [442] | [443] | [444] | [445] | [446] | [447] | 2.81[448] |
65 | AGER | Advanced glycosylation end product-specific receptor | [449] | 2.80[450] | 5.76[451] | 4.93[452] | 4.60[453] | 4.41[454] | 2.42[455] |
66 | S100B | Protein S100-B | [456] | -0.01[457] | -1.20[458] | [459] | 2.21[460] | -1.76[461] | 3.67[462] |
67 | IFNA13 | [463] | [464] | [465] | [466] | [467] | [468] | [469] | |
68 | TOMM70 | Mitochondrial import receptor subunit TOM70 | [470] | [471] | [472] | [473] | [474] | [475] | [476] |
69 | IFNA8 | Interferon alpha-8 | [477] | [478] | [479] | [480] | [481] | [482] | [483] |
70 | IFNA14 | Interferon alpha-14 | [484] | [485] | [486] | [487] | [488] | [489] | [490] |
71 | IFNA5 | Interferon alpha-5 | [491] | [492] | [493] | [494] | [495] | [496] | [497] |
72 | TKFC | Triokinase/FMN cyclase | [498] | [499] | [500] | [501] | [502] | [503] | [504] |
73 | IFNA17 | Interferon alpha-17 | [505] | [506] | [507] | [508] | [509] | [510] | [511] |
74 | IFNA21 | Interferon alpha-21 | [512] | [513] | [514] | [515] | [516] | [517] | [518] |
75 | IFNA16 | Interferon alpha-16 | [519] | [520] | [521] | [522] | [523] | [524] | [525] |
76 | IFNA4 | Interferon alpha-4 | [526] | [527] | [528] | [529] | [530] | [531] | [532] |
77 | IFNB1 | Interferon beta | [533] | [534] | [535] | [536] | [537] | [538] | [539] |
78 | IFNA6 | Interferon alpha-6 | [540] | [541] | [542] | [543] | [544] | [545] | [546] |
79 | IFNA10 | Interferon alpha-10 | [547] | [548] | [549] | [550] | [551] | [552] | [553] |
80 | IFNA1 | Interferon alpha-1/13 | [554] | [555] | [556] | [557] | [558] | [559] | [560] |
81 | IFNA7 | Interferon alpha-7 | [561] | [562] | [563] | [564] | [565] | [566] | [567] |
82 | IFNA2 | Interferon alpha-2 | [568] | [569] | [570] | [571] | [572] | [573] | [574] |