REACTOME_DARPP_32_EVENTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit [1] -0.17[2] 0.00[3] -0.07[4] -0.92[5] -0.47[6] 0.02[7]
2 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [8] -0.27[9] -0.50[10] 0.50[11] 0.70[12] -1.14[13] -1.52[14]
3 CALM1 Calmodulin-1 [15] -0.17[16] -0.09[17] 0.16[18] 0.75[19] 0.58[20] 1.05[21]
4 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0.55[22] 0.42[23] 0.14[24] 0.37[25] 0.26[26] -0.42[27]
5 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.02[28] 0.16[29] -0.68[30] -0.09[31] 0.58[32] -0.67[33]
6 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform -0.64[34] -0.94[35] -1.07[36] -1.29[37] -0.84[38] -1.55[39]
7 PRKACA cAMP-dependent protein kinase catalytic subunit alpha [40] -0.41[41] -0.54[42] -0.76[43] -1.30[44] -0.16[45] -1.35[46]
8 PPP3R1 Calcineurin subunit B type 1 [47] -0.06[48] 0.17[49] -0.13[50] -0.13[51] 0.19[52] -1.72[53]
9 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0.20[54] -0.28[55] -0.07[56] -0.56[57] -0.23[58] 2.37[59]
10 PPP2R5D Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform 1.00[60] 0.81[61] 0.15[62] 0.46[63] 0.90[64] -0.83[65]
11 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit [66] -0.20[67] -0.47[68] 0.43[69] -1.12[70] -0.70[71] -0.42[72]
12 PRKAR1B cAMP-dependent protein kinase type I-beta regulatory subunit [73] 0.73[74] 0.22[75] -1.78[76] -4.93[77] -1.58[78] -0.74[79]
13 PPP3CB Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform 0.24[80] 1.08[81] 0.37[82] -0.08[83] 0.23[84] -0.72[85]
14 CDK5 Cyclin-dependent-like kinase 5 [86] -0.01[87] -0.66[88] -0.82[89] -0.21[90] -0.86[91] -1.45[92]
15 PPP3CC Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform -0.95[93] -0.77[94] -1.38[95] -1.92[96] -0.45[97] -0.51[98]
16 PPP3CA Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 0.48[99] 0.28[100] -0.12[101] 1.11[102] 1.41[103] 1.24[104]
17 PRKACB cAMP-dependent protein kinase catalytic subunit beta [105] -1.08[106] -0.26[107] 0.81[108] 1.40[109] 0.81[110] 1.14[111]
18 PDE4C cAMP-specific 3',5'-cyclic phosphodiesterase 4C [112] 2.72[113] 2.21[114] 0.50[115] -2.02[116] 0.21[117] -1.43[118]
19 PDE4A cAMP-specific 3',5'-cyclic phosphodiesterase 4A [119] 2.87[120] 1.85[121] 3.01[122] -0.23[123] 3.16[124] 0.94[125]
20 PDE4B cAMP-specific 3',5'-cyclic phosphodiesterase 4B [126] [127] [128] -6.18[129] -0.05[130] 3.16[131] 1.87[132]
21 PDE4D cAMP-specific 3',5'-cyclic phosphodiesterase 4D [133] 3.20[134] 6.39[135] 6.27[136] 3.75[137] 5.53[138] 4.16[139]
22 PRKAR2B cAMP-dependent protein kinase type II-beta regulatory subunit [140] -2.59[141] -0.72[142] 3.35[143] 4.25[144] 3.32[145] 2.75[146]
23 PPP1R1B Protein phosphatase 1 regulatory subunit 1B [147] -1.83[148] -2.66[149] -6.82[150] -4.18[151] 0.24[152] -2.85[153]
24 PRKACG cAMP-dependent protein kinase catalytic subunit gamma [154] [155] [156] [157] [158] [159] [160]
[1]
ref_hepatocyte PRKAR1A
Mean 51.9
Standard deviation 38
Values 1.1e+02 62 30 19 35
[2]
HepG2 PRKAR1A
Mean 121
Standard deviation 21
Values 1.1e+02 1.4e+02
[3]
HepG2.C3A PRKAR1A
Mean 117
Standard deviation 14
Values 1.1e+02 1.3e+02
[4]
HuH.7 PRKAR1A
Mean 124
Standard deviation 6.6
Values 1.3e+02 1.3e+02 1.2e+02
[5]
SNU475 PRKAR1A
Mean 89.4
Standard deviation 19
Values 1e+02 76
[6]
THLE PRKAR1A
Mean 93.3
Standard deviation 15
Values 83 1e+02
[7]
liver PRKAR1A
Mean 111
Standard deviation 40
Values 89 1.4e+02 1.5e+02 66
[8]
ref_hepatocyte PPP1CA
Mean 42.2
Standard deviation 7
Values 36 44 39 54 39
[9]
HepG2 PPP1CA
Mean 92
Standard deviation 5.7
Values 96 88
[10]
HepG2.C3A PPP1CA
Mean 67.5
Standard deviation 3.3
Values 65 70
[11]
HuH.7 PPP1CA
Mean 150
Standard deviation 50
Values 1.7e+02 93 1.9e+02
[12]
SNU475 PPP1CA
Mean 224
Standard deviation 25
Values 2.4e+02 2.1e+02
[13]
THLE PPP1CA
Mean 47.8
Standard deviation 8.9
Values 41 54
[14]
liver PPP1CA
Mean 31
Standard deviation 18
Values 42 17 51 15
[15]
ref_hepatocyte CALM1
Mean 29.2
Standard deviation 11
Values 17 40 21 28 40
[16]
HepG2 CALM1
Mean 67.9
Standard deviation 4.3
Values 65 71
[17]
HepG2.C3A CALM1
Mean 62
Standard deviation 16
Values 51 73
[18]
HuH.7 CALM1
Mean 81.9
Standard deviation 15
Values 90 64 92
[19]
SNU475 CALM1
Mean 160
Standard deviation 24
Values 1.8e+02 1.4e+02
[20]
THLE CALM1
Mean 109
Standard deviation 13
Values 1e+02 1.2e+02
[21]
liver CALM1
Mean 127
Standard deviation 70
Values 2.1e+02 80 1.7e+02 57
[22]
ref_hepatocyte PPP2R1A
Mean 27.9
Standard deviation 5.4
Values 23 30 23 36 28
[23]
HepG2 PPP2R1A
Mean 107
Standard deviation 6.5
Values 1.1e+02 1e+02
[24]
HepG2.C3A PPP2R1A
Mean 84.7
Standard deviation 12
Values 93 76
[25]
HuH.7 PPP2R1A
Mean 77.2
Standard deviation 6.8
Values 84 70 78
[26]
SNU475 PPP2R1A
Mean 118
Standard deviation 14
Values 1.3e+02 1.1e+02
[27]
THLE PPP2R1A
Mean 83.3
Standard deviation 16
Values 72 94
[28]
liver PPP2R1A
Mean 43.9
Standard deviation 17
Values 51 30 65 30
[29]
ref_hepatocyte PPP2CA
Mean 27.3
Standard deviation 6.4
Values 27 38 22 24 25
[30]
HepG2 PPP2CA
Mean 72.8
Standard deviation 15
Values 62 83
[31]
HepG2.C3A PPP2CA
Mean 69.2
Standard deviation 19
Values 55 83
[32]
HuH.7 PPP2CA
Mean 42.8
Standard deviation 4.9
Values 43 38 48
[33]
SNU475 PPP2CA
Mean 83.9
Standard deviation 4.1
Values 81 87
[34]
THLE PPP2CA
Mean 102
Standard deviation 13
Values 92 1.1e+02
[35]
liver PPP2CA
Mean 36.1
Standard deviation 13
Values 49 27 46 23
[36]
ref_hepatocyte PPP2CB
Mean 25.5
Standard deviation 11
Values 15 43 27 17 26
[37]
HepG2 PPP2CB
Mean 43
Standard deviation 1.5
Values 44 42
[38]
HepG2.C3A PPP2CB
Mean 30.2
Standard deviation 0.78
Values 31 30
[39]
HuH.7 PPP2CB
Mean 30.6
Standard deviation 2.8
Values 28 34 30
[40]
SNU475 PPP2CB
Mean 34.2
Standard deviation 0.1
Values 34 34
[41]
THLE PPP2CB
Mean 35.7
Standard deviation 2.6
Values 37 34
[42]
liver PPP2CB
Mean 18.3
Standard deviation 7.2
Values 28 14 19 12
[43]
ref_hepatocyte PRKACA
Mean 15.8
Standard deviation 8.3
Values 7.6 11 11 27 23
[44]
HepG2 PRKACA
Mean 31.2
Standard deviation 2.7
Values 29 33
[45]
HepG2.C3A PRKACA
Mean 24.6
Standard deviation 3.5
Values 27 22
[46]
HuH.7 PRKACA
Mean 23.6
Standard deviation 5.7
Values 27 17 27
[47]
SNU475 PRKACA
Mean 21
Standard deviation 3.3
Values 23 19
[48]
THLE PRKACA
Mean 35.4
Standard deviation 5.3
Values 32 39
[49]
liver PRKACA
Mean 13.1
Standard deviation 4.9
Values 18 8.8 16 8.9
[50]
ref_hepatocyte PPP3R1
Mean 13
Standard deviation 4.5
Values 19 16 9.2 8.1 13
[51]
HepG2 PPP3R1
Mean 32.8
Standard deviation 2.3
Values 31 34
[52]
HepG2.C3A PPP3R1
Mean 33.2
Standard deviation 2.2
Values 32 35
[53]
HuH.7 PPP3R1
Mean 29.9
Standard deviation 3.7
Values 34 29 27
[54]
SNU475 PPP3R1
Mean 39.1
Standard deviation 2.2
Values 38 41
[55]
THLE PPP3R1
Mean 37.1
Standard deviation 5.2
Values 33 41
[56]
liver PPP3R1
Mean 8.35
Standard deviation 5.9
Values 3.5 14 3 13
[57]
ref_hepatocyte PPP2R1B
Mean 12
Standard deviation 3.3
Values 7 14 11 15 13
[58]
HepG2 PPP2R1B
Mean 36.3
Standard deviation 12
Values 27 45
[59]
HepG2.C3A PPP2R1B
Mean 22.5
Standard deviation 5.6
Values 19 26
[60]
HuH.7 PPP2R1B
Mean 28.7
Standard deviation 4.1
Values 32 30 24
[61]
SNU475 PPP2R1B
Mean 26.6
Standard deviation 1.2
Values 26 27
[62]
THLE PPP2R1B
Mean 25.6
Standard deviation 5.7
Values 22 30
[63]
liver PPP2R1B
Mean 130
Standard deviation 78
Values 52 1.6e+02 82 2.2e+02
[64]
ref_hepatocyte PPP2R5D
Mean 7.67
Standard deviation 1.8
Values 11 7.4 6.7 6.6 6.7
[65]
HepG2 PPP2R5D
Mean 40.3
Standard deviation 5.9
Values 36 44
[66]
HepG2.C3A PPP2R5D
Mean 30.4
Standard deviation 4.1
Values 27 33
[67]
HuH.7 PPP2R5D
Mean 21.5
Standard deviation 4.4
Values 26 17 22
[68]
SNU475 PPP2R5D
Mean 34.4
Standard deviation 4.8
Values 38 31
[69]
THLE PPP2R5D
Mean 35.6
Standard deviation 5.6
Values 32 40
[70]
liver PPP2R5D
Mean 9.05
Standard deviation 4.1
Values 11 5.8 14 5.4
[71]
ref_hepatocyte PRKAR2A
Mean 7.11
Standard deviation 7.6
Values 6.5 20 6.5 1.3 1.4
[72]
HepG2 PRKAR2A
Mean 16.3
Standard deviation 1.9
Values 15 18
[73]
HepG2.C3A PRKAR2A
Mean 11.6
Standard deviation 4.5
Values 8.4 15
[74]
HuH.7 PRKAR2A
Mean 24
Standard deviation 9.6
Values 34 24 14
[75]
SNU475 PRKAR2A
Mean 10.7
Standard deviation 0.56
Values 11 10
[76]
THLE PRKAR2A
Mean 10.9
Standard deviation 4
Values 8.1 14
[77]
liver PRKAR2A
Mean 11.2
Standard deviation 5.7
Values 5.5 18 7.5 14
[78]
ref_hepatocyte PRKAR1B
Mean 6.04
Standard deviation 3.4
Values 7.5 11 3.5 5.3 2.7
[79]
HepG2 PRKAR1B
Mean 26.2
Standard deviation 3.9
Values 23 29
[80]
HepG2.C3A PRKAR1B
Mean 15.9
Standard deviation 0.32
Values 16 16
[81]
HuH.7 PRKAR1B
Mean 4.42
Standard deviation 1.8
Values 5.2 2.4 5.7
[82]
SNU475 PRKAR1B
Mean 0.647
Standard deviation 0.21
Values 0.79 0.5
[83]
THLE PRKAR1B
Mean 5.04
Standard deviation 0.84
Values 4.4 5.6
[84]
liver PRKAR1B
Mean 7.61
Standard deviation 2.9
Values 11 4.6 9.2 5.8
[85]
ref_hepatocyte PPP3CB
Mean 4.68
Standard deviation 1.4
Values 6.3 5.9 3.1 4 4
[86]
HepG2 PPP3CB
Mean 14.5
Standard deviation 0.038
Values 14 15
[87]
HepG2.C3A PPP3CB
Mean 22.3
Standard deviation 2.3
Values 24 21
[88]
HuH.7 PPP3CB
Mean 15.2
Standard deviation 1.8
Values 17 13 16
[89]
SNU475 PPP3CB
Mean 14.5
Standard deviation 3.6
Values 17 12
[90]
THLE PPP3CB
Mean 13.7
Standard deviation 2.2
Values 12 15
[91]
liver PPP3CB
Mean 5.99
Standard deviation 0.99
Values 5.4 7 4.9 6.7
[92]
ref_hepatocyte CDK5
Mean 4.43
Standard deviation 2.1
Values 4.3 1.4 4.6 7.2 4.7
[93]
HepG2 CDK5
Mean 11.6
Standard deviation 2.3
Values 9.9 13
[94]
HepG2.C3A CDK5
Mean 6.36
Standard deviation 1.4
Values 5.3 7.4
[95]
HuH.7 CDK5
Mean 6.32
Standard deviation 1.5
Values 6.1 4.9 8
[96]
SNU475 CDK5
Mean 12.6
Standard deviation 1.1
Values 13 12
[97]
THLE CDK5
Mean 6.09
Standard deviation 0.67
Values 5.6 6.6
[98]
liver CDK5
Mean 3.42
Standard deviation 1.7
Values 5.5 1.8 4.1 2.3
[99]
ref_hepatocyte PPP3CC
Mean 3.74
Standard deviation 2.3
Values 3 4.2 7.4 2.6 1.4
[100]
HepG2 PPP3CC
Mean 5.07
Standard deviation 0.34
Values 5.3 4.8
[101]
HepG2.C3A PPP3CC
Mean 4.97
Standard deviation 0.61
Values 5.4 4.5
[102]
HuH.7 PPP3CC
Mean 3.62
Standard deviation 1.2
Values 2.6 5 3.3
[103]
SNU475 PPP3CC
Mean 3.23
Standard deviation 0.21
Values 3.4 3.1
[104]
THLE PPP3CC
Mean 6.83
Standard deviation 0.085
Values 6.9 6.8
[105]
liver PPP3CC
Mean 5.52
Standard deviation 0.57
Values 6.1 5.9 4.8 5.3
[106]
ref_hepatocyte PPP3CA
Mean 3.28
Standard deviation 1.4
Values 2.6 5.6 2.6 2.1 3.4
[107]
HepG2 PPP3CA
Mean 12
Standard deviation 2.1
Values 11 13
[108]
HepG2.C3A PPP3CA
Mean 9.04
Standard deviation 0.97
Values 9.7 8.4
[109]
HuH.7 PPP3CA
Mean 7.59
Standard deviation 0.7
Values 8.3 7.5 7
[110]
SNU475 PPP3CA
Mean 23.2
Standard deviation 2.3
Values 22 25
[111]
THLE PPP3CA
Mean 21.8
Standard deviation 1.1
Values 21 23
[112]
liver PPP3CA
Mean 16.3
Standard deviation 7.4
Values 27 10 13 14
[113]
ref_hepatocyte PRKACB
Mean 2.75
Standard deviation 1.3
Values 2.1 3.1 1.4 2.4 4.8
[114]
HepG2 PRKACB
Mean 3.41
Standard deviation 1.6
Values 2.3 4.6
[115]
HepG2.C3A PRKACB
Mean 5.2
Standard deviation 0.9
Values 4.6 5.8
[116]
HuH.7 PRKACB
Mean 12.2
Standard deviation 3.4
Values 11 16 9.5
[117]
SNU475 PRKACB
Mean 23.8
Standard deviation 4.4
Values 27 21
[118]
THLE PRKACB
Mean 12.1
Standard deviation 0.96
Values 13 11
[119]
liver PRKACB
Mean 12.8
Standard deviation 2
Values 12 14 14 10
[120]
ref_hepatocyte PDE4C
Mean 0.435
Standard deviation 0.14
Values 0.54 0.22 0.38 0.55 0.49
[121]
HepG2 PDE4C
Mean 7.51
Standard deviation 5
Values 11 3.9
[122]
HepG2.C3A PDE4C
Mean 4.55
Standard deviation 0.23
Values 4.4 4.7
[123]
HuH.7 PDE4C
Mean 1.55
Standard deviation 0.74
Values 1 2.4 1.2
[124]
SNU475 PDE4C
Mean 0.35
Standard deviation 0.029
Values 0.33 0.37
[125]
THLE PDE4C
Mean 1.25
Standard deviation 0.59
Values 1.7 0.84
[126]
liver PDE4C
Mean 0.339
Standard deviation 0.17
Values 0.21 0.51 0.18 0.45
[127]
ref_hepatocyte PDE4A
Mean 0.339
Standard deviation 0.25
Values 0.78 0.22 0.3 0.23 0.15
[128]
HepG2 PDE4A
Mean 6.5
Standard deviation 1.7
Values 7.7 5.3
[129]
HepG2.C3A PDE4A
Mean 2.76
Standard deviation 1.3
Values 3.7 1.8
[130]
HuH.7 PDE4A
Mean 6.86
Standard deviation 0.98
Values 7.6 7.2 5.8
[131]
SNU475 PDE4A
Mean 0.942
Standard deviation 0.31
Values 1.2 0.72
[132]
THLE PDE4A
Mean 7.53
Standard deviation 0.97
Values 6.8 8.2
[133]
liver PDE4A
Mean 1.37
Standard deviation 0.93
Values 2.7 0.43 1.3 1.1
[134]
ref_hepatocyte PDE4B
Mean 0.336
Standard deviation 0.24
Values 0 0.27 0.65 0.47 0.29
[135]
HepG2 PDE4B
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A PDE4B
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 PDE4B
Mean 0.0117
Standard deviation 0.013
Values 0 0.026 0.0094
[138]
SNU475 PDE4B
Mean 1.06
Standard deviation 0.37
Values 0.8 1.3
[139]
THLE PDE4B
Mean 7.48
Standard deviation 0.95
Values 8.1 6.8
[140]
liver PDE4B
Mean 2.57
Standard deviation 1.2
Values 1.9 4.3 2.5 1.6
[141]
ref_hepatocyte PDE4D
Mean 0.124
Standard deviation 0.096
Values 0.24 0.044 0.17 0.16 0.0081
[142]
HepG2 PDE4D
Mean 2.97
Standard deviation 0.48
Values 2.6 3.3
[143]
HepG2.C3A PDE4D
Mean 23.4
Standard deviation 0.69
Values 23 24
[144]
HuH.7 PDE4D
Mean 24.1
Standard deviation 7.7
Values 22 32 17
[145]
SNU475 PDE4D
Mean 5.43
Standard deviation 1.1
Values 6.2 4.6
[146]
THLE PDE4D
Mean 14.2
Standard deviation 2.7
Values 16 12
[147]
liver PDE4D
Mean 4.66
Standard deviation 2.5
Values 3.9 6 1.5 7.2
[148]
ref_hepatocyte PRKAR2B
Mean 0.12
Standard deviation 0.14
Values 0 0 0.21 0.078 0.31
[149]
HepG2 PRKAR2B
Mean 0.0522
Standard deviation 0.0072
Values 0.057 0.047
[150]
HepG2.C3A PRKAR2B
Mean 0.165
Standard deviation 0.097
Values 0.23 0.097
[151]
HuH.7 PRKAR2B
Mean 3.07
Standard deviation 1.2
Values 3.8 1.7 3.7
[152]
SNU475 PRKAR2B
Mean 7.46
Standard deviation 0.031
Values 7.5 7.4
[153]
THLE PRKAR2B
Mean 2.99
Standard deviation 0.15
Values 2.9 3.1
[154]
liver PRKAR2B
Mean 1.69
Standard deviation 0.7
Values 1.6 2.7 1.4 1.1
[155]
ref_hepatocyte PPP1R1B
Mean 0.0962
Standard deviation 0.22
Values 0 0 0.48 0 0
[156]
HepG2 PPP1R1B
Mean 0.0709
Standard deviation 0.046
Values 0.1 0.039
[157]
HepG2.C3A PPP1R1B
Mean 0.0345
Standard deviation 0.034
Values 0.058 0.011
[158]
HuH.7 PPP1R1B
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[159]
SNU475 PPP1R1B
Mean 0.0173
Standard deviation 0.011
Values 0.0093 0.025
[160]
THLE PPP1R1B
Mean 0.284
Standard deviation 0.11
Values 0.36 0.21
[161]
liver PPP1R1B
Mean 0.0281
Standard deviation 0.021
Values 0.047 0 0.026 0.04
[162]
ref_hepatocyte PRKACG
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 PRKACG
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[164]
HepG2.C3A PRKACG
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 PRKACG
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[166]
SNU475 PRKACG
Mean 0
Standard deviation 0
Values 0 0
[167]
THLE PRKACG
Mean 0
Standard deviation 0
Values 0 0
[168]
liver PRKACG
Mean 0
Standard deviation 0
Values 0 0 0 0