REACTOME_DAG_AND_IP3_SIGNALING |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
PRKAR1A |
cAMP-dependent protein kinase type I-alpha regulatory subunit |
[1] |
-0.95[2] |
-0.73[3] |
-0.68[4] |
-0.97[5] |
-1.18[6] |
-0.58[7] |
2 |
KPNA2 |
Importin subunit alpha-1 |
[8] |
-0.25[9] |
-0.28[10] |
0.16[11] |
-0.35[12] |
0.27[13] |
-2.96[14] |
3 |
CALM1 |
Calmodulin-1 |
[15] |
-0.95[16] |
-0.82[17] |
-0.46[18] |
0.71[19] |
-0.13[20] |
0.44[21] |
4 |
AHCYL1 |
S-adenosylhomocysteine hydrolase-like protein 1 |
[22] |
-0.79[23] |
-0.60[24] |
-0.12[25] |
0.13[26] |
-0.10[27] |
-0.87[28] |
5 |
PRKACA |
cAMP-dependent protein kinase catalytic subunit alpha |
[29] |
-1.19[30] |
-1.27[31] |
-1.37[32] |
-1.35[33] |
-0.86[34] |
-1.95[35] |
6 |
CAMKK2 |
Calcium/calmodulin-dependent protein kinase kinase 2 |
[36] |
-0.46[37] |
-0.02[38] |
-0.94[39] |
-0.72[40] |
-0.92[41] |
-0.22[42] |
7 |
PRKAR2A |
cAMP-dependent protein kinase type II-alpha regulatory subunit |
[43] |
-0.97[44] |
-1.20[45] |
-0.19[46] |
-1.16[47] |
-1.41[48] |
-1.03[49] |
8 |
CAMK2D |
Calcium/calmodulin-dependent protein kinase type II subunit delta |
[50] |
-0.89[51] |
-0.49[52] |
0.93[53] |
-0.20[54] |
-1.11[55] |
0.24[56] |
9 |
PRKAR1B |
cAMP-dependent protein kinase type I-beta regulatory subunit |
[57] |
-0.05[58] |
-0.51[59] |
-2.39[60] |
-4.98[61] |
-2.28[62] |
-1.35[63] |
10 |
ITPR2 |
Inositol 1,4,5-trisphosphate receptor type 2 |
[64] |
-0.11[65] |
1.44[66] |
-0.20[67] |
-0.87[68] |
-0.84[69] |
2.69[70] |
11 |
PRKCD |
Protein kinase C delta type |
[71] |
0.07[72] |
0.42[73] |
-0.20[74] |
-1.38[75] |
-0.33[76] |
-2.24[77] |
12 |
PLCG1 |
1-phosphatidylinositol
4,5-bisphosphate phosphodiesterase gamma-1 |
2.47[78] |
2.18[79] |
1.41[80] |
1.94[81] |
1.33[82] |
-0.83[83] |
13 |
CAMK2G |
Calcium/calmodulin-dependent protein
kinase type II subunit gamma |
-0.25[84] |
1.06[85] |
0.57[86] |
0.81[87] |
0.26[88] |
-0.22[89] |
14 |
PRKACB |
cAMP-dependent protein kinase catalytic subunit beta |
[90] |
-1.86[91] |
-0.99[92] |
0.20[93] |
1.35[94] |
0.11[95] |
0.54[96] |
15 |
ADCY9 |
Adenylate cyclase type 9 |
[97] |
1.59[98] |
0.88[99] |
1.20[100] |
0.08[101] |
-0.48[102] |
1.24[103] |
16 |
PRKCA |
Protein kinase C alpha type |
[104] |
1.81[105] |
1.95[106] |
2.21[107] |
1.27[108] |
1.53[109] |
0.74[110] |
17 |
ITPR3 |
Inositol 1,4,5-trisphosphate receptor type 3 |
[111] |
4.27[112] |
3.21[113] |
1.60[114] |
1.47[115] |
3.54[116] |
-0.95[117] |
18 |
ADCY6 |
Adenylate cyclase type 6 |
[118] |
1.02[119] |
1.58[120] |
1.44[121] |
1.63[122] |
2.19[123] |
1.46[124] |
19 |
CREB1 |
Cyclic AMP-responsive element-binding protein 1 |
[125] |
0.70[126] |
1.95[127] |
2.34[128] |
1.66[129] |
1.50[130] |
1.17[131] |
20 |
ADCY1 |
Adenylate cyclase type 1 |
[132] |
-1.86[133] |
-3.64[134] |
-3.94[135] |
-2.99[136] |
-3.11[137] |
3.82[138] |
21 |
PRKCE |
Protein kinase C epsilon type |
[139] |
-0.38[140] |
-1.80[141] |
0.59[142] |
0.10[143] |
0.36[144] |
2.39[145] |
22 |
PRKX |
cAMP-dependent protein kinase catalytic subunit PRKX |
[146] |
-2.67[147] |
-2.80[148] |
2.02[149] |
0.37[150] |
1.81[151] |
0.27[152] |
23 |
CAMK2B |
Calcium/calmodulin-dependent protein kinase type II subunit beta |
[153] |
-3.56[154] |
-4.79[155] |
-7.85[156] |
-3.74[157] |
-3.21[158] |
-0.03[159] |
24 |
ADCY7 |
Adenylate cyclase type 7 |
[160] |
2.49[161] |
2.20[162] |
1.06[163] |
2.43[164] |
1.80[165] |
1.75[166] |
25 |
ITPR1 |
Inositol 1,4,5-trisphosphate receptor type 1 |
[167] |
2.11[168] |
2.09[169] |
3.15[170] |
1.97[171] |
2.74[172] |
3.48[173] |
26 |
CAMKK1 |
Calcium/calmodulin-dependent protein kinase kinase 1 |
[174] |
0.22[175] |
-0.39[176] |
-2.19[177] |
1.97[178] |
0.31[179] |
-1.09[180] |
27 |
PRKAR2B |
cAMP-dependent protein kinase type II-beta regulatory subunit |
[181] |
-3.36[182] |
-1.45[183] |
2.74[184] |
4.21[185] |
2.62[186] |
2.14[187] |
28 |
ADCY3 |
Adenylate cyclase type 3 |
[188] |
0.43[189] |
-0.72[190] |
2.51[191] |
3.86[192] |
5.28[193] |
2.34[194] |
29 |
ADCY2 |
Adenylate cyclase type 2 |
[195] |
-6.41[196] |
-4.38[197] |
-5.73[198] |
-3.61[199] |
-4.84[200] |
-5.29[201] |
30 |
NBEA |
Neurobeachin |
[202] |
2.97[203] |
2.74[204] |
0.44[205] |
1.06[206] |
3.30[207] |
3.65[208] |
31 |
PDE1B |
Calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase 1B |
-4.71[209] |
-5.59[210] |
[211] |
-1.70[212] |
-2.88[213] |
2.69[214] |
32 |
ADCY5 |
Adenylate cyclase type 5 |
[215] |
-0.87[216] |
0.22[217] |
1.15[218] |
-0.23[219] |
0.79[220] |
5.20[221] |
33 |
PRKCG |
Protein kinase C gamma type |
[222] |
-1.85[223] |
-1.08[224] |
-3.56[225] |
-1.94[226] |
-2.13[227] |
[228] |
34 |
CAMK4 |
Calcium/calmodulin-dependent protein kinase type IV |
[229] |
[230] |
-2.69[231] |
-3.45[232] |
0.57[233] |
2.53[234] |
3.07[235] |
35 |
PDE1A |
Calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase 1A |
[236] |
-1.65[237] |
2.95[238] |
5.24[239] |
1.60[240] |
5.43[241] |
36 |
ADCY4 |
Adenylate cyclase type 4 |
[242] |
-0.94[243] |
-1.91[244] |
0.63[245] |
[246] |
[247] |
7.19[248] |
37 |
GRK2 |
Beta-adrenergic receptor kinase 1 |
[249] |
[250] |
[251] |
[252] |
[253] |
[254] |
[255] |
38 |
PRKACG |
cAMP-dependent protein kinase catalytic subunit gamma |
[256] |
[257] |
[258] |
[259] |
[260] |
[261] |
[262] |
39 |
PDE1C |
Calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase 1C |
[263] |
[264] |
[265] |
[266] |
[267] |
[268] |
40 |
ADCY8 |
Adenylate cyclase type 8 |
[269] |
[270] |
[271] |
[272] |
[273] |
[274] |
[275] |
41 |
CAMK2A |
Calcium/calmodulin-dependent protein kinase type II subunit alpha |
[276] |
[277] |
[278] |
[279] |
[280] |
[281] |
[282] |
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