REACTOME_CYTOCHROME_C_MEDIATED_APOPTOTIC_RESPONSE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 DIABLO Diablo homolog, mitochondrial [1] -0.74[2] -0.81[3] -1.01[4] -1.07[5] -1.17[6] -1.29[7]
2 CYCS Cytochrome c [8] 0.74[9] 0.60[10] 0.79[11] 0.60[12] 1.14[13] 0.76[14]
3 APIP Methylthioribulose-1-phosphate dehydratase [15] -2.26[16] -1.87[17] -1.55[18] -2.27[19] -2.66[20] -1.78[21]
4 CASP3 Caspase-3 [22] -0.46[23] -0.11[24] -2.55[25] -1.63[26] -0.50[27] -1.36[28]
5 MAPK1 Mitogen-activated protein kinase 1 [29] 1.12[30] 0.92[31] 0.86[32] 1.11[33] 0.90[34] 1.22[35]
6 CASP7 Caspase-7 [36] -0.90[37] -1.60[38] -1.05[39] -1.63[40] -1.29[41] -1.04[42]
7 AVEN Cell death regulator Aven [43] -1.57[44] -2.17[45] -4.14[46] -1.79[47] -1.56[48] -1.76[49]
8 MAPK3 Mitogen-activated protein kinase 3 [50] 1.26[51] 0.97[52] 1.12[53] -0.31[54] -0.15[55] -1.60[56]
9 UACA Uveal autoantigen with coiled-coil domains and ankyrin repeats [57] -0.89[58] 0.98[59] 1.15[60] 2.14[61] 0.95[62] 1.22[63]
10 XIAP E3 ubiquitin-protein ligase XIAP [64] 0.93[65] 1.18[66] 1.75[67] 1.86[68] 1.42[69] 2.12[70]
11 CASP9 Caspase-9 [71] -0.43[72] 0.19[73] -0.58[74] -0.49[75] -1.04[76] -1.10[77]
12 CARD8 Caspase recruitment domain-containing protein 8 [78] -0.78[79] -0.31[80] 0.93[81] -0.03[82] 0.13[83] 0.87[84]
13 APAF1 Apoptotic protease-activating factor 1 [85] 1.07[86] 1.16[87] 1.52[88] 1.89[89] 1.13[90] 0.93[91]
[1]
ref_hepatocyte DIABLO
Mean 16.2
Standard deviation 5.1
Values 11 14 24 15 17
[2]
HepG2 DIABLO
Mean 32.4
Standard deviation 1.1
Values 32 33
[3]
HepG2.C3A DIABLO
Mean 34.5
Standard deviation 2.7
Values 33 36
[4]
HuH.7 DIABLO
Mean 26.8
Standard deviation 4.5
Values 26 23 32
[5]
SNU475 DIABLO
Mean 23.7
Standard deviation 0.05
Values 24 24
[6]
THLE DIABLO
Mean 22.5
Standard deviation 0.81
Values 22 23
[7]
liver DIABLO
Mean 13.9
Standard deviation 8.5
Values 22 7.3 21 5.8
[8]
ref_hepatocyte CYCS
Mean 14.3
Standard deviation 4.3
Values 16 19 7.5 15 14
[9]
HepG2 CYCS
Mean 79.8
Standard deviation 18
Values 67 93
[10]
HepG2.C3A CYCS
Mean 81.4
Standard deviation 39
Values 54 1.1e+02
[11]
HuH.7 CYCS
Mean 82.3
Standard deviation 19
Values 93 60 94
[12]
SNU475 CYCS
Mean 66.3
Standard deviation 0.99
Values 66 67
[13]
THLE CYCS
Mean 98.4
Standard deviation 7.6
Values 93 1e+02
[14]
liver CYCS
Mean 50.8
Standard deviation 34
Values 59 30 95 19
[15]
ref_hepatocyte APIP
Mean 13.7
Standard deviation 4.9
Values 21 15 7.6 11 14
[16]
HepG2 APIP
Mean 9.53
Standard deviation 0.68
Values 9 10
[17]
HepG2.C3A APIP
Mean 14
Standard deviation 2.8
Values 12 16
[18]
HuH.7 APIP
Mean 15.6
Standard deviation 6.5
Values 16 8.8 22
[19]
SNU475 APIP
Mean 8.67
Standard deviation 2.2
Values 10 7.1
[20]
THLE APIP
Mean 6.76
Standard deviation 0.32
Values 6.5 7
[21]
liver APIP
Mean 8.35
Standard deviation 5.9
Values 16 4.2 11 2.9
[22]
ref_hepatocyte CASP3
Mean 12.5
Standard deviation 12
Values 33 13 6.8 4.9 5.1
[23]
HepG2 CASP3
Mean 30.3
Standard deviation 8.2
Values 25 36
[24]
HepG2.C3A CASP3
Mean 43.1
Standard deviation 22
Values 27 59
[25]
HuH.7 CASP3
Mean 7.08
Standard deviation 1
Values 5.9 7.5 7.8
[26]
SNU475 CASP3
Mean 12.3
Standard deviation 0.36
Values 13 12
[27]
THLE CASP3
Mean 27.6
Standard deviation 0.68
Values 27 28
[28]
liver CASP3
Mean 10.2
Standard deviation 4.2
Values 9.5 9 16 6.1
[29]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[30]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[31]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[32]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[33]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[34]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[35]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[36]
ref_hepatocyte CASP7
Mean 10
Standard deviation 4.1
Values 7.8 14 15 7.6 6
[37]
HepG2 CASP7
Mean 17.9
Standard deviation 4
Values 15 21
[38]
HepG2.C3A CASP7
Mean 12.4
Standard deviation 4
Values 9.5 15
[39]
HuH.7 CASP7
Mean 16.1
Standard deviation 1.8
Values 15 15 18
[40]
SNU475 CASP7
Mean 9.89
Standard deviation 0.26
Values 10 9.7
[41]
THLE CASP7
Mean 12.8
Standard deviation 0.29
Values 13 13
[42]
liver CASP7
Mean 10.2
Standard deviation 3.1
Values 14 6.6 9.7 10
[43]
ref_hepatocyte AVEN
Mean 5.37
Standard deviation 2.6
Values 2.9 6 2.8 9.2 5.9
[44]
HepG2 AVEN
Mean 6.02
Standard deviation 1.2
Values 5.2 6.9
[45]
HepG2.C3A AVEN
Mean 4.47
Standard deviation 0.39
Values 4.2 4.7
[46]
HuH.7 AVEN
Mean 1.01
Standard deviation 0.28
Values 1 0.72 1.3
[47]
SNU475 AVEN
Mean 4.74
Standard deviation 1.1
Values 5.5 4
[48]
THLE AVEN
Mean 5.67
Standard deviation 1.7
Values 4.5 6.9
[49]
liver AVEN
Mean 3.31
Standard deviation 0.69
Values 4 3.1 2.4 3.6
[50]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[51]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[52]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[53]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[54]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[55]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[56]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[57]
ref_hepatocyte UACA
Mean 2.85
Standard deviation 2.7
Values 2.4 7.4 2.3 1 1
[58]
HepG2 UACA
Mean 5.11
Standard deviation 0.11
Values 5.2 5
[59]
HepG2.C3A UACA
Mean 21
Standard deviation 3.6
Values 18 24
[60]
HuH.7 UACA
Mean 21.1
Standard deviation 3
Values 20 24 19
[61]
SNU475 UACA
Mean 38.4
Standard deviation 0.9
Values 39 38
[62]
THLE UACA
Mean 17.2
Standard deviation 8.3
Values 23 11
[63]
liver UACA
Mean 13.9
Standard deviation 3.3
Values 13 17 16 9.8
[64]
ref_hepatocyte XIAP
Mean 2.63
Standard deviation 0.63
Values 2.6 3.3 2.1 1.9 3.2
[65]
HepG2 XIAP
Mean 16.7
Standard deviation 3.8
Values 14 19
[66]
HepG2.C3A XIAP
Mean 22.3
Standard deviation 5.6
Values 18 26
[67]
HuH.7 XIAP
Mean 29.4
Standard deviation 6.2
Values 34 31 22
[68]
SNU475 XIAP
Mean 29.2
Standard deviation 5.9
Values 33 25
[69]
THLE XIAP
Mean 21.9
Standard deviation 3.4
Values 19 24
[70]
liver XIAP
Mean 24
Standard deviation 7.9
Values 19 34 16 27
[71]
ref_hepatocyte CASP9
Mean 2.59
Standard deviation 1
Values 1.9 1.9 2 2.7 4.4
[72]
HepG2 CASP9
Mean 6.38
Standard deviation 0.81
Values 5.8 7
[73]
HepG2.C3A CASP9
Mean 11.1
Standard deviation 0.21
Values 11 11
[74]
HuH.7 CASP9
Mean 5.76
Standard deviation 1.5
Values 6.7 4.1 6.6
[75]
SNU475 CASP9
Mean 5.65
Standard deviation 0.92
Values 6.3 5
[76]
THLE CASP9
Mean 3.94
Standard deviation 0.43
Values 3.6 4.2
[77]
liver CASP9
Mean 2.54
Standard deviation 1.2
Values 2.4 1.9 4.2 1.6
[78]
ref_hepatocyte CARD8
Mean 2.48
Standard deviation 1.1
Values 1.5 2.2 4 3.1 1.6
[79]
HepG2 CARD8
Mean 4.79
Standard deviation 2.6
Values 2.9 6.7
[80]
HepG2.C3A CARD8
Mean 7.46
Standard deviation 0.12
Values 7.4 7.6
[81]
HuH.7 CARD8
Mean 15.7
Standard deviation 2.4
Values 18 13 16
[82]
SNU475 CARD8
Mean 7.44
Standard deviation 0.33
Values 7.2 7.7
[83]
THLE CARD8
Mean 8.44
Standard deviation 0.72
Values 7.9 8.9
[84]
liver CARD8
Mean 9.46
Standard deviation 1.7
Values 10 9.7 7.1 11
[85]
ref_hepatocyte APAF1
Mean 1.36
Standard deviation 0.48
Values 1.9 1.8 1.2 0.79 1.1
[86]
HepG2 APAF1
Mean 9.46
Standard deviation 4.9
Values 6 13
[87]
HepG2.C3A APAF1
Mean 11.3
Standard deviation 2.5
Values 9.5 13
[88]
HuH.7 APAF1
Mean 12.9
Standard deviation 2.1
Values 15 12 12
[89]
SNU475 APAF1
Mean 15.4
Standard deviation 1.9
Values 17 14
[90]
THLE APAF1
Mean 9.25
Standard deviation 1.4
Values 8.2 10
[91]
liver APAF1
Mean 5.4
Standard deviation 3.4
Values 2.4 8.5 2.5 8.2