REACTOME_CYCLIN_D_ASSOCIATED_EVENTS_IN_G1 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.22[2] | -1.23[3] | -1.12[4] | -1.51[5] | -1.19[6] | -0.52[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.77[16] | -0.47[17] | -0.75[18] | -0.66[19] | -0.82[20] | -0.07[21] |
4 | SKP1 | S-phase kinase-associated protein 1 | [22] | 0.00[23] | 0.59[24] | -0.33[25] | 0.76[26] | 0.84[27] | 0.67[28] |
5 | CKS1B | Cyclin-dependent kinases regulatory subunit 1 | [29] | -0.75[30] | 0.04[31] | 0.71[32] | -0.03[33] | -0.31[34] | -1.70[35] |
6 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [36] | 1.66[37] | 1.76[38] | 2.76[39] | 0.74[40] | 1.41[41] | 0.70[42] |
7 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [43] | 1.82[44] | 0.62[45] | -2.11[46] | -0.72[47] | 1.70[48] | -0.47[49] |
8 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 1.78[50] | 1.80[51] | 1.68[52] | 2.48[53] | 1.66[54] | 1.50[55] | |
9 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 1.25[56] | 1.54[57] | 0.86[58] | 2.01[59] | 1.98[60] | 1.26[61] | |
10 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | 0.59[62] | 0.44[63] | 0.47[64] | 0.81[65] | 0.57[66] | 0.37[67] | |
11 | CCND1 | G1/S-specific cyclin-D1 | [68] | 4.03[69] | 1.72[70] | 2.51[71] | 3.15[72] | 1.53[73] | 2.41[74] |
12 | CDK4 | Cyclin-dependent kinase 4 | [75] | 2.31[76] | 3.09[77] | 2.67[78] | 1.45[79] | 1.96[80] | 0.52[81] |
13 | CCNH | Cyclin-H | [82] | -0.69[83] | 0.36[84] | -0.29[85] | -0.51[86] | 0.74[87] | 0.43[88] |
14 | TFDP1 | Transcription factor Dp-1 | [89] | 1.65[90] | 1.17[91] | 1.19[92] | 1.87[93] | 2.31[94] | 0.22[95] |
15 | CUL1 | Cullin-1 | [96] | 0.60[97] | 1.47[98] | 0.97[99] | 1.85[100] | 1.36[101] | 2.11[102] |
16 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [103] | 0.90[104] | 1.53[105] | 1.68[106] | 0.16[107] | 0.48[108] | 0.45[109] |
17 | CDK2 | Cyclin-dependent kinase 2 | [110] | 0.57[111] | 0.93[112] | 1.26[113] | 1.25[114] | 1.70[115] | -0.83[116] |
18 | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | 1.43[117] | 1.10[118] | 1.47[119] | 1.54[120] | 1.18[121] | 4.29[122] | |
19 | CDK7 | Cyclin-dependent kinase 7 | [123] | 0.33[124] | 1.54[125] | 1.22[126] | 0.70[127] | 0.24[128] | -0.99[129] |
20 | E2F4 | Transcription factor E2F4 | [130] | 2.11[131] | 2.42[132] | 1.40[133] | 1.69[134] | 1.54[135] | 1.11[136] |
21 | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isofor | 1.33[137] | 1.67[138] | 2.03[139] | 2.15[140] | 1.89[141] | 1.34[142] | |
22 | RBL2 | Retinoblastoma-like protein 2 | [143] | 1.82[144] | 2.86[145] | 2.87[146] | 2.50[147] | 2.07[148] | 3.50[149] |
23 | MNAT1 | CDK-activating kinase assembly factor MAT1 | [150] | 0.36[151] | 1.86[152] | 0.99[153] | 1.65[154] | 1.05[155] | 0.41[156] |
24 | LYN | Tyrosine-protein kinase Lyn | [157] | 0.12[158] | 0.13[159] | 0.62[160] | 2.32[161] | 0.94[162] | 1.38[163] |
25 | CDK6 | Cyclin-dependent kinase 6 | [164] | 3.03[165] | 3.92[166] | 2.28[167] | 2.19[168] | 2.85[169] | 3.43[170] |
26 | ABL1 | Tyrosine-protein kinase ABL1 | [171] | 3.21[172] | 2.80[173] | 3.55[174] | 3.34[175] | 3.88[176] | 2.30[177] |
27 | SRC | Proto-oncogene tyrosine-protein kinase Src | [178] | 4.01[179] | 4.18[180] | 3.14[181] | 3.67[182] | 2.70[183] | 0.51[184] |
28 | CCND3 | G1/S-specific cyclin-D3 | [185] | 1.93[186] | 1.06[187] | -0.61[188] | 4.93[189] | 3.97[190] | 2.01[191] |
29 | SKP2 | S-phase kinase-associated protein 2 | [192] | 2.29[193] | 2.95[194] | 4.04[195] | 2.53[196] | 2.48[197] | 2.44[198] |
30 | CCNE1 | G1/S-specific cyclin-E1 | [199] | 2.22[200] | 2.52[201] | 0.66[202] | 0.86[203] | 1.32[204] | -3.27[205] |
31 | RB1 | Retinoblastoma-associated protein | [206] | 2.20[207] | 2.89[208] | 3.41[209] | 3.55[210] | 3.73[211] | 2.84[212] |
32 | E2F1 | Transcription factor E2F1 | [213] | 2.93[214] | 2.98[215] | 3.06[216] | 3.13[217] | 3.43[218] | -2.26[219] |
33 | CDKN2B | Cyclin-dependent kinase 4 inhibitor B | [220] | 1.35[221] | -2.93[222] | 0.88[223] | 2.43[224] | 2.59[225] | -0.72[226] |
34 | E2F3 | Transcription factor E2F3 | [227] | 2.70[228] | 2.72[229] | 1.93[230] | 3.90[231] | 3.21[232] | 1.19[233] |
35 | CDKN2C | Cyclin-dependent kinase 4 inhibitor C | [234] | 1.20[235] | 2.01[236] | 2.11[237] | 3.45[238] | 3.43[239] | 0.55[240] |
36 | TFDP2 | Transcription factor Dp-2 | [241] | 2.89[242] | 3.77[243] | 3.74[244] | 3.66[245] | 3.74[246] | 3.71[247] |
37 | CDKN2D | Cyclin-dependent kinase 4 inhibitor D | [248] | 0.47[249] | 1.05[250] | 0.76[251] | 0.43[252] | 1.76[253] | -0.35[254] |
38 | PPP2R3B | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta | [255] | [256] | [257] | [258] | [259] | [260] | |
39 | E2F5 | Transcription factor E2F5 | [261] | 2.51[262] | 3.66[263] | 4.02[264] | 1.30[265] | -0.39[266] | -0.33[267] |
40 | CCNE2 | G1/S-specific cyclin-E2 | [268] | 1.40[269] | 1.99[270] | 1.48[271] | 4.31[272] | 4.07[273] | 1.01[274] |
41 | RBL1 | Retinoblastoma-like protein 1 | [275] | 2.76[276] | 3.82[277] | 2.40[278] | 4.08[279] | 4.27[280] | 2.04[281] |
42 | JAK2 | Tyrosine-protein kinase JAK2 | [282] | 1.21[283] | 1.39[284] | 0.91[285] | 2.03[286] | 2.49[287] | 4.07[288] |
43 | CCND2 | G1/S-specific cyclin-D2 | [289] | 4.12[290] | 2.90[291] | -3.35[292] | -3.18[293] | -0.41[294] | 3.21[295] |
44 | PTK6 | Protein-tyrosine kinase 6 | [296] | -0.14[297] | 2.26[298] | 0.46[299] | -0.39[300] | -0.95[301] | 0.78[302] |
45 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [303] | 5.07[304] | 3.02[305] | 6.38[306] | 6.48[307] | 8.12[308] | -0.79[309] |
46 | CDKN1C | Cyclin-dependent kinase inhibitor 1C | [310] | [311] | -4.08[312] | 2.57[313] | 2.44[314] | 1.67[315] | 2.82[316] |
47 | E2F2 | Transcription factor E2F2 | [317] | 5.23[318] | 6.31[319] | 5.78[320] | 5.32[321] | 5.51[322] | 2.78[323] |