REACTOME_CYCLIN_A_CDK2_ASSOCIATED_EVENTS_AT_S_PHASE_ENTRY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.35[2] | -1.36[3] | -1.16[4] | -1.56[5] | -1.23[6] | -0.52[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.91[16] | -0.61[17] | -0.80[18] | -0.70[19] | -0.85[20] | -0.07[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.68[23] | -2.20[24] | -1.77[25] | -1.42[26] | -2.08[27] | -1.02[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.50[30] | -1.82[31] | -1.86[32] | -1.21[33] | -1.61[34] | -0.65[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.46[37] | 0.65[38] | -0.61[39] | 0.42[40] | -0.14[41] | 0.38[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.01[44] | 0.20[45] | -0.81[46] | -0.83[47] | -0.18[48] | 0.21[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.48[51] | -1.18[52] | -0.08[53] | -0.85[54] | -1.08[55] | -0.08[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | -0.23[58] | 0.02[59] | 0.21[60] | 0.58[61] | 0.46[62] | -0.41[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -1.17[65] | -1.08[66] | -0.88[67] | -1.19[68] | -0.87[69] | -0.85[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.22[72] | -0.12[73] | -0.13[74] | -0.47[75] | -0.31[76] | -0.38[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.35[79] | 0.16[80] | 0.16[81] | 0.06[82] | -0.04[83] | -0.29[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.58[86] | 0.17[87] | 0.03[88] | 0.36[89] | 0.07[90] | -0.37[91] |
14 | SKP1 | S-phase kinase-associated protein 1 | [92] | -0.13[93] | 0.45[94] | -0.37[95] | 0.72[96] | 0.80[97] | 0.66[98] |
15 | PSMC3 | 26S proteasome regulatory subunit 6A | [99] | -0.61[100] | -0.59[101] | 0.10[102] | -0.84[103] | -0.75[104] | 0.10[105] |
16 | PSMA3 | Proteasome subunit alpha type-3 | [106] | -1.20[107] | -0.11[108] | -0.72[109] | -0.09[110] | -0.65[111] | -0.12[112] |
17 | PSMB6 | Proteasome subunit beta type-6 | [113] | -0.65[114] | -0.41[115] | -0.20[116] | -0.64[117] | -1.02[118] | 0.03[119] |
18 | PSMA2 | Proteasome subunit alpha type-2 | [120] | -0.73[121] | 0.31[122] | 0.71[123] | -0.14[124] | 0.12[125] | 0.26[126] |
19 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [127] | -0.22[128] | -0.11[129] | 0.15[130] | 0.56[131] | -0.09[132] | -0.07[133] |
20 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [134] | -0.30[135] | 0.16[136] | 0.09[137] | -0.53[138] | -0.16[139] | -0.24[140] |
21 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [141] | -0.13[142] | 0.20[143] | 0.40[144] | -0.25[145] | 0.40[146] | -0.22[147] |
22 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [148] | 1.40[149] | 0.67[150] | 0.81[151] | 0.86[152] | 2.04[153] | 0.82[154] |
23 | CKS1B | Cyclin-dependent kinases regulatory subunit 1 | [155] | -0.89[156] | -0.10[157] | 0.67[158] | -0.08[159] | -0.35[160] | -1.70[161] |
24 | PSMC1 | 26S proteasome regulatory subunit 4 | [162] | -0.28[163] | -0.12[164] | -0.71[165] | 1.04[166] | 0.46[167] | -0.02[168] |
25 | PSMA1 | Proteasome subunit alpha type-1 | [169] | -0.09[170] | 0.39[171] | 0.52[172] | 0.62[173] | 0.01[174] | 0.47[175] |
26 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [176] | 1.53[177] | 1.63[178] | 2.71[179] | 0.69[180] | 1.37[181] | 0.70[182] |
27 | PSMC5 | 26S proteasome regulatory subunit 8 | [183] | 0.22[184] | 0.21[185] | 0.35[186] | 0.03[187] | 0.33[188] | 0.24[189] |
28 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [190] | 0.62[191] | 0.20[192] | 0.86[193] | 0.56[194] | 0.67[195] | -0.05[196] |
29 | PSMB8 | Proteasome subunit beta type-8 | [197] | -1.78[198] | -2.28[199] | -9.43[200] | 0.53[201] | -0.89[202] | -0.74[203] |
30 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [204] | -0.20[205] | 0.49[206] | 0.82[207] | 0.42[208] | 0.34[209] | -0.19[210] |
31 | PSMC4 | 26S proteasome regulatory subunit 6B | [211] | 0.22[212] | 0.34[213] | 0.35[214] | 0.05[215] | 0.06[216] | 0.29[217] |
32 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [218] | -0.93[219] | -0.36[220] | -1.38[221] | -0.57[222] | 0.13[223] | -0.30[224] |
33 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [225] | 0.27[226] | 0.47[227] | 1.04[228] | 0.48[229] | -0.12[230] | -0.12[231] |
34 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [232] | 1.69[233] | 0.49[234] | -2.16[235] | -0.76[236] | 1.66[237] | -0.48[238] |
35 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [239] | -0.55[240] | -0.38[241] | -0.62[242] | 0.10[243] | 0.06[244] | -0.20[245] |
36 | AKT1 | RAC-alpha serine/threonine-protein kinase | [246] | 0.93[247] | 0.89[248] | -0.15[249] | 1.17[250] | 1.06[251] | 1.11[252] |
37 | PSMC6 | 26S proteasome regulatory subunit 10B | [253] | -0.26[254] | 1.41[255] | 0.30[256] | 0.46[257] | 0.28[258] | 0.46[259] |
38 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [260] | 0.63[261] | 0.33[262] | 0.99[263] | 0.87[264] | 0.92[265] | 1.28[266] |
39 | PSMC2 | 26S proteasome regulatory subunit 7 | [267] | 0.38[268] | 0.87[269] | 0.72[270] | 1.26[271] | 0.98[272] | 1.34[273] |
40 | MYC | Myc proto-oncogene protein | [274] | 1.28[275] | 1.13[276] | -0.85[277] | -1.57[278] | 0.67[279] | -0.64[280] |
41 | PSME3 | Proteasome activator complex subunit 3 | [281] | 1.61[282] | 1.42[283] | 1.17[284] | 1.29[285] | 1.45[286] | 0.90[287] |
42 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [288] | 1.37[289] | 1.78[290] | 1.72[291] | 2.09[292] | 1.99[293] | 2.09[294] |
43 | CCND1 | G1/S-specific cyclin-D1 | [295] | 3.90[296] | 1.59[297] | 2.46[298] | 3.10[299] | 1.49[300] | 2.41[301] |
44 | PSMB10 | Proteasome subunit beta type-10 | [302] | -1.36[303] | -0.67[304] | -2.49[305] | -0.12[306] | -1.39[307] | -0.06[308] |
45 | PSMA5 | Proteasome subunit alpha type-5 | [309] | 1.70[310] | 2.21[311] | 1.84[312] | 2.15[313] | 1.60[314] | 1.93[315] |
46 | PSMF1 | Proteasome inhibitor PI31 subunit | [316] | 2.08[317] | 2.21[318] | 1.08[319] | 1.16[320] | 0.81[321] | 1.87[322] |
47 | CDK4 | Cyclin-dependent kinase 4 | [323] | 2.18[324] | 2.95[325] | 2.63[326] | 1.40[327] | 1.92[328] | 0.52[329] |
48 | PSMB2 | Proteasome subunit beta type-2 | [330] | 1.86[331] | 1.68[332] | 2.13[333] | 2.45[334] | 2.33[335] | 2.41[336] |
49 | CCNH | Cyclin-H | [337] | -0.82[338] | 0.23[339] | -0.34[340] | -0.56[341] | 0.70[342] | 0.43[343] |
50 | PSMB9 | Proteasome subunit beta type-9 | [344] | -2.15[345] | -4.68[346] | -6.92[347] | 1.70[348] | -0.68[349] | -0.48[350] |
51 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [351] | 0.23[352] | 0.81[353] | -0.10[354] | 0.33[355] | 0.66[356] | 0.74[357] |
52 | TFDP1 | Transcription factor Dp-1 | [358] | 1.51[359] | 1.03[360] | 1.15[361] | 1.83[362] | 2.27[363] | 0.21[364] |
53 | CUL1 | Cullin-1 | [365] | 0.46[366] | 1.33[367] | 0.93[368] | 1.81[369] | 1.32[370] | 2.10[371] |
54 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [372] | 0.76[373] | 1.40[374] | 1.64[375] | 0.12[376] | 0.44[377] | 0.45[378] |
55 | MAX | Protein max | [379] | -0.09[380] | 0.08[381] | -0.55[382] | 0.46[383] | 0.85[384] | 0.12[385] |
56 | CDK2 | Cyclin-dependent kinase 2 | [386] | 0.43[387] | 0.79[388] | 1.21[389] | 1.20[390] | 1.66[391] | -0.83[392] |
57 | CDK7 | Cyclin-dependent kinase 7 | [393] | 0.20[394] | 1.41[395] | 1.17[396] | 0.66[397] | 0.20[398] | -1.00[399] |
58 | AKT2 | RAC-beta serine/threonine-protein kinase | [400] | 1.81[401] | 2.27[402] | 2.45[403] | 2.08[404] | 1.74[405] | 2.49[406] |
59 | E2F4 | Transcription factor E2F4 | [407] | 1.98[408] | 2.28[409] | 1.35[410] | 1.64[411] | 1.50[412] | 1.11[413] |
60 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [414] | 0.79[415] | 1.20[416] | 1.29[417] | 2.00[418] | 1.21[419] | 0.73[420] |
61 | RBBP4 | Histone-binding protein RBBP4 | [421] | 2.79[422] | 3.10[423] | 2.96[424] | 2.90[425] | 3.15[426] | 2.86[427] |
62 | RBL2 | Retinoblastoma-like protein 2 | [428] | 1.69[429] | 2.72[430] | 2.82[431] | 2.45[432] | 2.03[433] | 3.50[434] |
63 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [435] | 1.21[436] | 0.85[437] | 2.48[438] | 2.39[439] | 2.36[440] | 2.18[441] |
64 | FZR1 | Fizzy-related protein homolog | [442] | 1.60[443] | 1.43[444] | 1.56[445] | 1.26[446] | 1.71[447] | 1.98[448] |
65 | MNAT1 | CDK-activating kinase assembly factor MAT1 | [449] | 0.23[450] | 1.73[451] | 0.95[452] | 1.61[453] | 1.01[454] | 0.40[455] |
66 | LIN37 | Protein lin-37 homolog | [456] | -1.16[457] | -0.53[458] | -0.16[459] | -0.44[460] | -0.33[461] | -0.36[462] |
67 | WEE1 | Wee1-like protein kinase | [463] | 1.15[464] | 1.76[465] | 2.54[466] | 1.95[467] | 1.34[468] | 0.82[469] |
68 | CDC25B | M-phase inducer phosphatase 2 | [470] | 2.71[471] | 3.09[472] | 2.51[473] | 3.94[474] | 3.97[475] | 1.70[476] |
69 | CABLES1 | CDK5 and ABL1 enzyme substrate 1 | [477] | 2.56[478] | 1.78[479] | 1.06[480] | 1.35[481] | 0.29[482] | 1.16[483] |
70 | SKP2 | S-phase kinase-associated protein 2 | [484] | 2.16[485] | 2.81[486] | 3.99[487] | 2.48[488] | 2.44[489] | 2.43[490] |
71 | CCNE1 | G1/S-specific cyclin-E1 | [491] | 2.09[492] | 2.39[493] | 0.62[494] | 0.82[495] | 1.28[496] | -3.28[497] |
72 | CCNA2 | Cyclin-A2 | [498] | 3.05[499] | 4.26[500] | 3.64[501] | 3.23[502] | 4.48[503] | 0.13[504] |
73 | RB1 | Retinoblastoma-associated protein | [505] | 2.07[506] | 2.76[507] | 3.36[508] | 3.50[509] | 3.69[510] | 2.83[511] |
74 | LIN52 | Protein lin-52 homolog | [512] | 0.82[513] | 1.77[514] | 1.27[515] | 0.12[516] | 1.10[517] | 1.01[518] |
75 | E2F1 | Transcription factor E2F1 | [519] | 2.79[520] | 2.84[521] | 3.01[522] | 3.09[523] | 3.39[524] | -2.26[525] |
76 | CDC25A | M-phase inducer phosphatase 1 | [526] | 2.27[527] | 3.10[528] | 3.50[529] | 1.57[530] | 2.89[531] | -1.30[532] |
77 | TFDP2 | Transcription factor Dp-2 | [533] | 2.75[534] | 3.64[535] | 3.70[536] | 3.61[537] | 3.70[538] | 3.71[539] |
78 | LIN54 | Protein lin-54 homolog | [540] | 2.28[541] | 3.99[542] | 2.99[543] | 2.33[544] | 3.05[545] | 3.16[546] |
79 | E2F5 | Transcription factor E2F5 | [547] | 2.37[548] | 3.53[549] | 3.97[550] | 1.25[551] | -0.43[552] | -0.33[553] |
80 | CCNE2 | G1/S-specific cyclin-E2 | [554] | 1.27[555] | 1.86[556] | 1.44[557] | 4.26[558] | 4.03[559] | 1.00[560] |
81 | LIN9 | Protein lin-9 homolog | [561] | 1.87[562] | 3.38[563] | 4.15[564] | 4.12[565] | 3.49[566] | 1.34[567] |
82 | PTK6 | Protein-tyrosine kinase 6 | [568] | -0.27[569] | 2.13[570] | 0.41[571] | -0.43[572] | -0.99[573] | 0.78[574] |
83 | AKT3 | RAC-gamma serine/threonine-protein kinase | [575] | -0.99[576] | -3.36[577] | -2.63[578] | 7.07[579] | 5.88[580] | 4.96[581] |
84 | CCNA1 | Cyclin-A1 | [582] | [583] | -2.35[584] | [585] | 0.43[586] | 7.70[587] | [588] |
85 | SEM1 | Putative protein SEM1, isoform 2 | [589] | [590] | [591] | [592] | [593] | [594] | [595] |