REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0.05[1] -0.47[2] -0.39[3] 0.24[4] -0.77[5] 0.02[6]
2 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform -0.48[7] -0.73[8] -1.21[9] -0.22[10] -0.45[11] -0.23[12]
3 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform -1.15[13] -1.83[14] -1.60[15] -1.42[16] -1.86[17] -1.12[18]
4 CCNH Cyclin-H [19] -2.42[20] -1.91[21] -2.37[22] -2.74[23] -1.69[24] -1.06[25]
5 XPO1 Exportin-1 [26] 0.60[27] 0.97[28] 1.16[29] 1.17[30] 0.92[31] 0.73[32]
6 CDK2 Cyclin-dependent kinase 2 [33] -1.17[34] -1.34[35] -0.82[36] -0.99[37] -0.73[38] -2.32[39]
7 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform -0.30[40] -1.17[41] -0.60[42] -0.69[43] -1.25[44] 2.80[45]
8 CDK7 Cyclin-dependent kinase 7 [46] -1.40[47] -0.73[48] -0.86[49] -1.53[50] -2.19[51] -2.48[52]
9 CCNB1 G2/mitotic-specific cyclin-B1 [53] 1.09[54] 0.99[55] 1.32[56] 0.64[57] 1.28[58] -2.47[59]
10 PPME1 Protein phosphatase methylesterase 1 [60] 0.80[61] -0.26[62] -0.98[63] 0.79[64] -0.06[65] -0.32[66]
11 PPP2R2A Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform -0.40[67] -0.60[68] -0.05[69] -0.09[70] -0.53[71] -0.15[72]
12 LCMT1 Leucine carboxyl methyltransferase 1 [73] -0.01[74] -0.33[75] -0.39[76] -2.07[77] -1.82[78] -1.98[79]
13 CDK1 Cyclin-dependent kinase 1 [80] 0.50[81] 2.22[82] 1.10[83] 1.30[84] 1.79[85] -2.60[86]
14 MNAT1 CDK-activating kinase assembly factor MAT1 [87] -1.37[88] -0.41[89] -1.08[90] -0.58[91] -1.37[92] -1.08[93]
15 PLK1 Serine/threonine-protein kinase PLK1 [94] 1.74[95] 1.14[96] 1.15[97] 0.28[98] 0.98[99] -2.76[100]
16 WEE1 Wee1-like protein kinase [101] -0.45[102] -0.37[103] 0.51[104] -0.24[105] -1.05[106] -0.67[107]
17 CDC25B M-phase inducer phosphatase 2 [108] 1.11[109] 0.95[110] 0.48[111] 1.76[112] 1.58[113] 0.21[114]
18 CCNA2 Cyclin-A2 [115] 1.45[116] 2.12[117] 1.61[118] 1.04[119] 2.09[120] -1.36[121]
19 CDC25A M-phase inducer phosphatase 1 [122] 0.67[123] 0.96[124] 1.47[125] -0.62[126] 0.50[127] -2.79[128]
20 CCNB2 G2/mitotic-specific cyclin-B2 [129] 1.34[130] 1.75[131] 2.29[132] 1.56[133] 2.21[134] -1.73[135]
21 PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 0.56[136] -0.01[137] 0.28[138] -0.32[139] 0.53[140] -2.69[141]
22 FOXM1 Forkhead box protein M1 [142] 2.47[143] 2.02[144] 2.98[145] 1.94[146] 3.12[147] -0.74[148]
23 PPP2R3B Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [149] [150] [151] [152] [153] [154]
24 CDC25C M-phase inducer phosphatase 3 [155] 1.18[156] 1.99[157] 2.17[158] 0.96[159] 1.48[160] -1.55[161]
25 CCNA1 Cyclin-A1 [162] [163] -4.49[164] [165] -1.76[166] 5.31[167] [168]
[1]
ref_hepatocyte PPP2R1A
Mean 27.9
Standard deviation 5.4
Values 23 30 23 36 28
[2]
HepG2 PPP2R1A
Mean 107
Standard deviation 6.5
Values 1.1e+02 1e+02
[3]
HepG2.C3A PPP2R1A
Mean 84.7
Standard deviation 12
Values 93 76
[4]
HuH.7 PPP2R1A
Mean 77.2
Standard deviation 6.8
Values 84 70 78
[5]
SNU475 PPP2R1A
Mean 118
Standard deviation 14
Values 1.3e+02 1.1e+02
[6]
THLE PPP2R1A
Mean 83.3
Standard deviation 16
Values 72 94
[7]
liver PPP2R1A
Mean 43.9
Standard deviation 17
Values 51 30 65 30
[8]
ref_hepatocyte PPP2CA
Mean 27.3
Standard deviation 6.4
Values 27 38 22 24 25
[9]
HepG2 PPP2CA
Mean 72.8
Standard deviation 15
Values 62 83
[10]
HepG2.C3A PPP2CA
Mean 69.2
Standard deviation 19
Values 55 83
[11]
HuH.7 PPP2CA
Mean 42.8
Standard deviation 4.9
Values 43 38 48
[12]
SNU475 PPP2CA
Mean 83.9
Standard deviation 4.1
Values 81 87
[13]
THLE PPP2CA
Mean 102
Standard deviation 13
Values 92 1.1e+02
[14]
liver PPP2CA
Mean 36.1
Standard deviation 13
Values 49 27 46 23
[15]
ref_hepatocyte PPP2CB
Mean 25.5
Standard deviation 11
Values 15 43 27 17 26
[16]
HepG2 PPP2CB
Mean 43
Standard deviation 1.5
Values 44 42
[17]
HepG2.C3A PPP2CB
Mean 30.2
Standard deviation 0.78
Values 31 30
[18]
HuH.7 PPP2CB
Mean 30.6
Standard deviation 2.8
Values 28 34 30
[19]
SNU475 PPP2CB
Mean 34.2
Standard deviation 0.1
Values 34 34
[20]
THLE PPP2CB
Mean 35.7
Standard deviation 2.6
Values 37 34
[21]
liver PPP2CB
Mean 18.3
Standard deviation 7.2
Values 28 14 19 12
[22]
ref_hepatocyte CCNH
Mean 15.2
Standard deviation 4.9
Values 13 23 13 17 10
[23]
HepG2 CCNH
Mean 10.6
Standard deviation 1.9
Values 9.2 12
[24]
HepG2.C3A CCNH
Mean 17
Standard deviation 5.2
Values 13 21
[25]
HuH.7 CCNH
Mean 10.7
Standard deviation 2.1
Values 10 8.7 13
[26]
SNU475 CCNH
Mean 8.14
Standard deviation 0.45
Values 7.8 8.5
[27]
THLE CCNH
Mean 23.9
Standard deviation 3.5
Values 21 26
[28]
liver CCNH
Mean 11.4
Standard deviation 3.1
Values 13 10 14 7.6
[29]
ref_hepatocyte XPO1
Mean 13.2
Standard deviation 5.7
Values 20 19 8.6 8.1 11
[30]
HepG2 XPO1
Mean 74.7
Standard deviation 37
Values 48 1e+02
[31]
HepG2.C3A XPO1
Mean 109
Standard deviation 54
Values 71 1.5e+02
[32]
HuH.7 XPO1
Mean 107
Standard deviation 26
Values 1.3e+02 77 1.2e+02
[33]
SNU475 XPO1
Mean 106
Standard deviation 0.46
Values 1.1e+02 1.1e+02
[34]
THLE XPO1
Mean 127
Standard deviation 5.2
Values 1.2e+02 1.3e+02
[35]
liver XPO1
Mean 34
Standard deviation 14
Values 22 53 24 37
[36]
ref_hepatocyte CDK2
Mean 12.1
Standard deviation 11
Values 19 28 3.3 5.7 4.6
[37]
HepG2 CDK2
Mean 20
Standard deviation 3.4
Values 18 22
[38]
HepG2.C3A CDK2
Mean 20
Standard deviation 9.1
Values 14 26
[39]
HuH.7 CDK2
Mean 24.9
Standard deviation 12
Values 30 11 33
[40]
SNU475 CDK2
Mean 21.8
Standard deviation 2.6
Values 20 24
[41]
THLE CDK2
Mean 36.9
Standard deviation 5.3
Values 33 41
[42]
liver CDK2
Mean 3.76
Standard deviation 1.3
Values 4.4 2.3 5.2 3.2
[43]
ref_hepatocyte PPP2R1B
Mean 12
Standard deviation 3.3
Values 7 14 11 15 13
[44]
HepG2 PPP2R1B
Mean 36.3
Standard deviation 12
Values 27 45
[45]
HepG2.C3A PPP2R1B
Mean 22.5
Standard deviation 5.6
Values 19 26
[46]
HuH.7 PPP2R1B
Mean 28.7
Standard deviation 4.1
Values 32 30 24
[47]
SNU475 PPP2R1B
Mean 26.6
Standard deviation 1.2
Values 26 27
[48]
THLE PPP2R1B
Mean 25.6
Standard deviation 5.7
Values 22 30
[49]
liver PPP2R1B
Mean 130
Standard deviation 78
Values 52 1.6e+02 82 2.2e+02
[50]
ref_hepatocyte CDK7
Mean 12
Standard deviation 6.1
Values 16 14 19 5.4 5.6
[51]
HepG2 CDK7
Mean 16.9
Standard deviation 3.8
Values 14 20
[52]
HepG2.C3A CDK7
Mean 30.4
Standard deviation 2.1
Values 29 32
[53]
HuH.7 CDK7
Mean 24
Standard deviation 1.4
Values 23 24 25
[54]
SNU475 CDK7
Mean 14.9
Standard deviation 0.18
Values 15 15
[55]
THLE CDK7
Mean 13.3
Standard deviation 2.2
Values 12 15
[56]
liver CDK7
Mean 3.33
Standard deviation 1.6
Values 4.4 2.2 5 1.7
[57]
ref_hepatocyte CCNB1
Mean 8.2
Standard deviation 8.6
Values 15 20 1.8 3.1 1.3
[58]
HepG2 CCNB1
Mean 65.1
Standard deviation 21
Values 50 80
[59]
HepG2.C3A CCNB1
Mean 68.3
Standard deviation 39
Values 41 96
[60]
HuH.7 CCNB1
Mean 74.2
Standard deviation 37
Values 87 33 1e+02
[61]
SNU475 CCNB1
Mean 45.8
Standard deviation 3.3
Values 48 44
[62]
THLE CCNB1
Mean 101
Standard deviation 30
Values 80 1.2e+02
[63]
liver CCNB1
Mean 2.29
Standard deviation 1.6
Values 2.3 2.4 4.2 0.28
[64]
ref_hepatocyte PPME1
Mean 6.62
Standard deviation 3.1
Values 8.6 11 5.3 5.8 2.8
[65]
HepG2 PPME1
Mean 42.9
Standard deviation 12
Values 34 52
[66]
HepG2.C3A PPME1
Mean 23.3
Standard deviation 0.17
Values 23 23
[67]
HuH.7 PPME1
Mean 12.2
Standard deviation 2.2
Values 14 9.6 13
[68]
SNU475 PPME1
Mean 41.2
Standard deviation 9.9
Values 48 34
[69]
THLE PPME1
Mean 32.1
Standard deviation 2
Values 31 33
[70]
liver PPME1
Mean 8.22
Standard deviation 4.9
Values 11 4.5 14 3.8
[71]
ref_hepatocyte PPP2R2A
Mean 6.53
Standard deviation 3.3
Values 5.3 10 9.5 4.9 2.6
[72]
HepG2 PPP2R2A
Mean 18.4
Standard deviation 1.5
Values 17 19
[73]
HepG2.C3A PPP2R2A
Mean 18.1
Standard deviation 0.43
Values 18 18
[74]
HuH.7 PPP2R2A
Mean 23
Standard deviation 0.83
Values 22 24 23
[75]
SNU475 PPP2R2A
Mean 22
Standard deviation 1.8
Values 21 23
[76]
THLE PPP2R2A
Mean 22.9
Standard deviation 2.8
Values 25 21
[77]
liver PPP2R2A
Mean 9.13
Standard deviation 3.1
Values 13 6.3 11 7
[78]
ref_hepatocyte LCMT1
Mean 6.07
Standard deviation 3.6
Values 12 5.1 5.1 4.8 3.1
[79]
HepG2 LCMT1
Mean 22.5
Standard deviation 4.2
Values 25 20
[80]
HepG2.C3A LCMT1
Mean 20.3
Standard deviation 6.6
Values 25 16
[81]
HuH.7 LCMT1
Mean 16.9
Standard deviation 0.88
Values 16 17 17
[82]
SNU475 LCMT1
Mean 5.17
Standard deviation 0.64
Values 5.6 4.7
[83]
THLE LCMT1
Mean 8.72
Standard deviation 1.4
Values 7.7 9.7
[84]
liver LCMT1
Mean 2.39
Standard deviation 1.4
Values 2.9 1.6 4 0.99
[85]
ref_hepatocyte CDK1
Mean 5.78
Standard deviation 6.9
Values 13 14 0.06 1.6 0.72
[86]
HepG2 CDK1
Mean 30.4
Standard deviation 14
Values 21 40
[87]
HepG2.C3A CDK1
Mean 113
Standard deviation 85
Values 53 1.7e+02
[88]
HuH.7 CDK1
Mean 45.1
Standard deviation 21
Values 55 21 60
[89]
SNU475 CDK1
Mean 51.1
Standard deviation 5
Values 48 55
[90]
THLE CDK1
Mean 101
Standard deviation 11
Values 93 1.1e+02
[91]
liver CDK1
Mean 1.48
Standard deviation 1.4
Values 1 1.4 3.4 0.013
[92]
ref_hepatocyte MNAT1
Mean 5.52
Standard deviation 3.5
Values 9.2 9.1 1.4 4 3.9
[93]
HepG2 MNAT1
Mean 7.94
Standard deviation 1.1
Values 7.1 8.7
[94]
HepG2.C3A MNAT1
Mean 17.5
Standard deviation 3.6
Values 15 20
[95]
HuH.7 MNAT1
Mean 9.48
Standard deviation 1.5
Values 8.9 8.4 11
[96]
SNU475 MNAT1
Mean 13.2
Standard deviation 1.5
Values 14 12
[97]
THLE MNAT1
Mean 10.8
Standard deviation 0.19
Values 11 11
[98]
liver MNAT1
Mean 4.05
Standard deviation 2
Values 6.8 3 4.3 2.2
[99]
ref_hepatocyte PLK1
Mean 4.92
Standard deviation 5.9
Values 13 9.1 0.65 1.1 0.48
[100]
HepG2 PLK1
Mean 61.1
Standard deviation 5.4
Values 57 65
[101]
HepG2.C3A PLK1
Mean 45.5
Standard deviation 17
Values 33 58
[102]
HuH.7 PLK1
Mean 39.6
Standard deviation 20
Values 55 17 47
[103]
SNU475 PLK1
Mean 21.4
Standard deviation 1.4
Values 20 22
[104]
THLE PLK1
Mean 49.2
Standard deviation 23
Values 33 65
[105]
liver PLK1
Mean 1.13
Standard deviation 1.1
Values 1.2 0.53 2.7 0.093
[106]
ref_hepatocyte WEE1
Mean 4.87
Standard deviation 1.2
Values 5.1 4.1 6.8 3.9 4.5
[107]
HepG2 WEE1
Mean 13.3
Standard deviation 1.3
Values 14 12
[108]
HepG2.C3A WEE1
Mean 15.8
Standard deviation 0.28
Values 16 16
[109]
HuH.7 WEE1
Mean 25.2
Standard deviation 0.7
Values 24 26 26
[110]
SNU475 WEE1
Mean 14.8
Standard deviation 0.86
Values 15 14
[111]
THLE WEE1
Mean 11.9
Standard deviation 1.6
Values 11 13
[112]
liver WEE1
Mean 4.76
Standard deviation 1.4
Values 6.8 4.4 3.8 4
[113]
ref_hepatocyte CDC25B
Mean 3.7
Standard deviation 1.9
Values 5.6 4.7 1.4 4.9 1.9
[114]
HepG2 CDC25B
Mean 29.8
Standard deviation 3.6
Values 32 27
[115]
HepG2.C3A CDC25B
Mean 30.1
Standard deviation 0.9
Values 29 31
[116]
HuH.7 CDC25B
Mean 18.7
Standard deviation 7.4
Values 24 10 22
[117]
SNU475 CDC25B
Mean 44.8
Standard deviation 0.23
Values 45 45
[118]
THLE CDC25B
Mean 56.1
Standard deviation 11
Values 48 64
[119]
liver CDC25B
Mean 6.65
Standard deviation 3.5
Values 9 4.9 10 2.6
[120]
ref_hepatocyte CCNA2
Mean 3.28
Standard deviation 3.7
Values 7 7.5 0.2 1.1 0.57
[121]
HepG2 CCNA2
Mean 33.4
Standard deviation 16
Values 22 44
[122]
HepG2.C3A CCNA2
Mean 60.1
Standard deviation 42
Values 30 90
[123]
HuH.7 CCNA2
Mean 36.5
Standard deviation 15
Values 47 20 43
[124]
SNU475 CCNA2
Mean 24.1
Standard deviation 0.4
Values 24 24
[125]
THLE CCNA2
Mean 71
Standard deviation 9.4
Values 64 78
[126]
liver CCNA2
Mean 1.99
Standard deviation 1.7
Values 0.85 3.4 3.5 0.21
[127]
ref_hepatocyte CDC25A
Mean 2.04
Standard deviation 2.5
Values 6.2 2.3 1 0.26 0.37
[128]
HepG2 CDC25A
Mean 12.1
Standard deviation 2.6
Values 10 14
[129]
HepG2.C3A CDC25A
Mean 16.8
Standard deviation 9.8
Values 9.8 24
[130]
HuH.7 CDC25A
Mean 20.5
Standard deviation 10
Values 26 8.6 27
[131]
SNU475 CDC25A
Mean 4.76
Standard deviation 2.1
Values 3.3 6.2
[132]
THLE CDC25A
Mean 14.6
Standard deviation 2.2
Values 13 16
[133]
liver CDC25A
Mean 0.459
Standard deviation 0.38
Values 0.33 1 0.28 0.2
[134]
ref_hepatocyte CCNB2
Mean 1.97
Standard deviation 1.8
Values 4.5 3.3 0.37 1.1 0.63
[135]
HepG2 CCNB2
Mean 18.6
Standard deviation 2.7
Values 17 20
[136]
HepG2.C3A CCNB2
Mean 28
Standard deviation 11
Values 20 36
[137]
HuH.7 CCNB2
Mean 35
Standard deviation 14
Values 40 19 46
[138]
SNU475 CCNB2
Mean 20.8
Standard deviation 0.15
Values 21 21
[139]
THLE CCNB2
Mean 46.1
Standard deviation 8.4
Values 40 52
[140]
liver CCNB2
Mean 0.924
Standard deviation 0.76
Values 1 0.61 1.9 0.15
[141]
ref_hepatocyte PKMYT1
Mean 1.79
Standard deviation 1.3
Values 3 3.3 0.73 0.99 0.91
[142]
HepG2 PKMYT1
Mean 9.81
Standard deviation 0.77
Values 10 9.3
[143]
HepG2.C3A PKMYT1
Mean 7.51
Standard deviation 2.2
Values 6 9.1
[144]
HuH.7 PKMYT1
Mean 7.9
Standard deviation 5.1
Values 11 2 11
[145]
SNU475 PKMYT1
Mean 5.13
Standard deviation 2.1
Values 3.6 6.6
[146]
THLE PKMYT1
Mean 13.1
Standard deviation 1.4
Values 12 14
[147]
liver PKMYT1
Mean 0.433
Standard deviation 0.38
Values 0.38 0.3 0.98 0.079
[148]
ref_hepatocyte FOXM1
Mean 1.44
Standard deviation 0.69
Values 2.4 1.9 1.2 1.2 0.55
[149]
HepG2 FOXM1
Mean 29.8
Standard deviation 8.6
Values 24 36
[150]
HepG2.C3A FOXM1
Mean 24.7
Standard deviation 10
Values 18 32
[151]
HuH.7 FOXM1
Mean 41.2
Standard deviation 21
Values 59 19 46
[152]
SNU475 FOXM1
Mean 19.9
Standard deviation 1.7
Values 19 21
[153]
THLE FOXM1
Mean 63.7
Standard deviation 17
Values 52 76
[154]
liver FOXM1
Mean 1.34
Standard deviation 1
Values 1.2 0.97 2.8 0.46
[155]
ref_hepatocyte PPP2R3B
Mean 1.4
Standard deviation 0.74
Values 2.3 0.82 2.1 0.99 0.8
[156]
HepG2 PPP2R3B
Missing
[157]
HepG2.C3A PPP2R3B
Missing
[158]
HuH.7 PPP2R3B
Missing
[159]
SNU475 PPP2R3B
Missing
[160]
THLE PPP2R3B
Missing
[161]
liver PPP2R3B
Missing
[162]
ref_hepatocyte CDC25C
Mean 0.731
Standard deviation 0.89
Values 2 1.3 0.11 0.078 0.13
[163]
HepG2 CDC25C
Mean 6.16
Standard deviation 0.58
Values 5.7 6.6
[164]
HepG2.C3A CDC25C
Mean 12.2
Standard deviation 6.2
Values 7.8 17
[165]
HuH.7 CDC25C
Mean 12
Standard deviation 5.4
Values 14 5.9 16
[166]
SNU475 CDC25C
Mean 5.11
Standard deviation 0.28
Values 5.3 4.9
[167]
THLE CDC25C
Mean 10.3
Standard deviation 1.8
Values 9 12
[168]
liver CDC25C
Mean 0.389
Standard deviation 0.27
Values 0.45 0.43 0.67 0.013
[169]
ref_hepatocyte CCNA1
Mean 0.0259
Standard deviation 0.058
Values 0.13 0 0 0 0
[170]
HepG2 CCNA1
Mean 0
Standard deviation 0
Values 0 0
[171]
HepG2.C3A CCNA1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[172]
HuH.7 CCNA1
Mean 0
Standard deviation 0
Values 0 0 0
[173]
SNU475 CCNA1
Mean 0.0274
Standard deviation 0.026
Values 0.0093 0.046
[174]
THLE CCNA1
Mean 5.22
Standard deviation 2.3
Values 3.6 6.9
[175]
liver CCNA1
Mean 0
Standard deviation 0
Values 0 0 0 0