REACTOME_CTLA4_INHIBITORY_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AKT1 RAC-alpha serine/threonine-protein kinase [1] -0.26[2] -0.61[3] -1.52[4] -0.78[5] -0.62[6] -0.83[7]
2 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0.46[8] 0.17[9] 0.26[10] 0.48[11] -0.05[12] -0.44[13]
3 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform -0.07[14] -0.09[15] -0.55[16] 0.01[17] 0.27[18] -0.69[19]
4 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform -0.74[20] -1.19[21] -0.94[22] -1.18[23] -1.15[24] -1.57[25]
5 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [26] 0.10[27] 0.42[28] 0.54[29] 0.16[30] 0.93[31] 0.68[32]
6 YES1 Tyrosine-protein kinase Yes [33] -1.21[34] 0.17[35] 0.56[36] -0.28[37] -0.68[38] -0.46[39]
7 PPP2R5A Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform -1.47[40] -0.69[41] 0.20[42] -0.98[43] -1.96[44] 0.05[45]
8 PPP2R5C Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform -0.65[46] 0.11[47] -0.02[48] 0.21[49] 0.16[50] -0.78[51]
9 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0.11[52] -0.53[53] 0.05[54] -0.46[55] -0.54[56] 2.35[57]
10 AKT2 RAC-beta serine/threonine-protein kinase [58] 0.61[59] 0.78[60] 1.08[61] 0.13[62] 0.06[63] 0.55[64]
11 PPP2R5D Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform 0.91[65] 0.55[66] 0.28[67] 0.56[68] 0.59[69] -0.85[70]
12 PPP2R5E Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform -0.23[71] -0.17[72] -0.46[73] 0.13[74] 0.06[75] -0.39[76]
13 LYN Tyrosine-protein kinase Lyn [77] -1.21[78] -1.50[79] -0.80[80] 0.33[81] -0.77[82] -0.57[83]
14 SRC Proto-oncogene tyrosine-protein kinase Src [84] 2.68[85] 2.55[86] 1.72[87] 1.67[88] 0.99[89] -1.43[90]
15 PPP2R5B Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform 0.43[91] 0.08[92] -0.39[93] -0.44[94] 0.87[95] -0.49[96]
16 FYN Tyrosine-protein kinase Fyn [97] 0.60[98] -8.12[99] 0.62[100] 0.74[101] 2.41[102] 0.39[103]
17 CD86 T-lymphocyte activation antigen CD86 [104] [105] [106] -5.00[107] -4.82[108] -6.71[109] 0.77[110]
18 AKT3 RAC-gamma serine/threonine-protein kinase [111] -2.19[112] -4.86[113] -4.00[114] 5.11[115] 4.21[116] 3.03[117]
19 LCK Tyrosine-protein kinase Lck [118] 2.43[119] 2.40[120] -7.43[121] -5.81[122] -5.87[123] 0.65[124]
20 CD80 T-lymphocyte activation antigen CD80 [125] [126] [127] -5.55[128] -1.88[129] -2.81[130] 2.04[131]
21 CTLA4 Cytotoxic T-lymphocyte protein 4 [132] [133] [134] [135] [136] [137] [138]
[1]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 55 50 19 31 32
[2]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 89 86
[3]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 65 68
[4]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 33 23 35
[5]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 76 57
[6]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[7]
liver AKT1
Mean 45.1
Standard deviation 25
Values 34 48 20 79
[8]
ref_hepatocyte PPP2R1A
Mean 27.9
Standard deviation 5.4
Values 23 30 23 36 28
[9]
HepG2 PPP2R1A
Mean 107
Standard deviation 6.5
Values 1.1e+02 1e+02
[10]
HepG2.C3A PPP2R1A
Mean 84.7
Standard deviation 12
Values 93 76
[11]
HuH.7 PPP2R1A
Mean 77.2
Standard deviation 6.8
Values 84 70 78
[12]
SNU475 PPP2R1A
Mean 118
Standard deviation 14
Values 1.3e+02 1.1e+02
[13]
THLE PPP2R1A
Mean 83.3
Standard deviation 16
Values 72 94
[14]
liver PPP2R1A
Mean 43.9
Standard deviation 17
Values 51 30 65 30
[15]
ref_hepatocyte PPP2CA
Mean 27.3
Standard deviation 6.4
Values 27 38 22 24 25
[16]
HepG2 PPP2CA
Mean 72.8
Standard deviation 15
Values 62 83
[17]
HepG2.C3A PPP2CA
Mean 69.2
Standard deviation 19
Values 55 83
[18]
HuH.7 PPP2CA
Mean 42.8
Standard deviation 4.9
Values 43 38 48
[19]
SNU475 PPP2CA
Mean 83.9
Standard deviation 4.1
Values 81 87
[20]
THLE PPP2CA
Mean 102
Standard deviation 13
Values 92 1.1e+02
[21]
liver PPP2CA
Mean 36.1
Standard deviation 13
Values 49 27 46 23
[22]
ref_hepatocyte PPP2CB
Mean 25.5
Standard deviation 11
Values 15 43 27 17 26
[23]
HepG2 PPP2CB
Mean 43
Standard deviation 1.5
Values 44 42
[24]
HepG2.C3A PPP2CB
Mean 30.2
Standard deviation 0.78
Values 31 30
[25]
HuH.7 PPP2CB
Mean 30.6
Standard deviation 2.8
Values 28 34 30
[26]
SNU475 PPP2CB
Mean 34.2
Standard deviation 0.1
Values 34 34
[27]
THLE PPP2CB
Mean 35.7
Standard deviation 2.6
Values 37 34
[28]
liver PPP2CB
Mean 18.3
Standard deviation 7.2
Values 28 14 19 12
[29]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[30]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[31]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[32]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[33]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[34]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[35]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[36]
ref_hepatocyte YES1
Mean 20.5
Standard deviation 18
Values 40 40 7.9 6.7 7.6
[37]
HepG2 YES1
Mean 24.9
Standard deviation 6
Values 21 29
[38]
HepG2.C3A YES1
Mean 62.3
Standard deviation 7.4
Values 57 68
[39]
HuH.7 YES1
Mean 69.8
Standard deviation 10
Values 74 77 58
[40]
SNU475 YES1
Mean 51.4
Standard deviation 2.5
Values 53 50
[41]
THLE YES1
Mean 39.7
Standard deviation 2
Values 41 38
[42]
liver YES1
Mean 31.7
Standard deviation 8
Values 27 39 23 38
[43]
ref_hepatocyte PPP2R5A
Mean 14.2
Standard deviation 11
Values 8.7 5.8 6.2 21 30
[44]
HepG2 PPP2R5A
Mean 14.4
Standard deviation 0.58
Values 14 15
[45]
HepG2.C3A PPP2R5A
Mean 23.8
Standard deviation 5
Values 27 20
[46]
HuH.7 PPP2R5A
Mean 37.7
Standard deviation 14
Values 28 54 31
[47]
SNU475 PPP2R5A
Mean 21.9
Standard deviation 3
Values 24 20
[48]
THLE PPP2R5A
Mean 11.3
Standard deviation 0.33
Values 12 11
[49]
liver PPP2R5A
Mean 31.4
Standard deviation 5.3
Values 33 37 24 32
[50]
ref_hepatocyte PPP2R5C
Mean 14.1
Standard deviation 2.7
Values 15 17 10 13 15
[51]
HepG2 PPP2R5C
Mean 25.2
Standard deviation 5.7
Values 21 29
[52]
HepG2.C3A PPP2R5C
Mean 41.3
Standard deviation 0.87
Values 41 42
[53]
HuH.7 PPP2R5C
Mean 32.2
Standard deviation 4.1
Values 31 37 29
[54]
SNU475 PPP2R5C
Mean 49.7
Standard deviation 5.7
Values 54 46
[55]
THLE PPP2R5C
Mean 48.8
Standard deviation 6.3
Values 44 53
[56]
liver PPP2R5C
Mean 17.5
Standard deviation 1.8
Values 18 20 16 16
[57]
ref_hepatocyte PPP2R1B
Mean 12
Standard deviation 3.3
Values 7 14 11 15 13
[58]
HepG2 PPP2R1B
Mean 36.3
Standard deviation 12
Values 27 45
[59]
HepG2.C3A PPP2R1B
Mean 22.5
Standard deviation 5.6
Values 19 26
[60]
HuH.7 PPP2R1B
Mean 28.7
Standard deviation 4.1
Values 32 30 24
[61]
SNU475 PPP2R1B
Mean 26.6
Standard deviation 1.2
Values 26 27
[62]
THLE PPP2R1B
Mean 25.6
Standard deviation 5.7
Values 22 30
[63]
liver PPP2R1B
Mean 130
Standard deviation 78
Values 52 1.6e+02 82 2.2e+02
[64]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 7.2 8.4 11 13 14
[65]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 48 43
[66]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 55 43
[67]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 59 41 55
[68]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 39 31
[69]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[70]
liver AKT2
Mean 33
Standard deviation 9.4
Values 24 36 27 45
[71]
ref_hepatocyte PPP2R5D
Mean 7.67
Standard deviation 1.8
Values 11 7.4 6.7 6.6 6.7
[72]
HepG2 PPP2R5D
Mean 40.3
Standard deviation 5.9
Values 36 44
[73]
HepG2.C3A PPP2R5D
Mean 30.4
Standard deviation 4.1
Values 27 33
[74]
HuH.7 PPP2R5D
Mean 21.5
Standard deviation 4.4
Values 26 17 22
[75]
SNU475 PPP2R5D
Mean 34.4
Standard deviation 4.8
Values 38 31
[76]
THLE PPP2R5D
Mean 35.6
Standard deviation 5.6
Values 32 40
[77]
liver PPP2R5D
Mean 9.05
Standard deviation 4.1
Values 11 5.8 14 5.4
[78]
ref_hepatocyte PPP2R5E
Mean 5.64
Standard deviation 2
Values 6.5 7.7 6.9 3.9 3.2
[79]
HepG2 PPP2R5E
Mean 13.5
Standard deviation 2.7
Values 12 15
[80]
HepG2.C3A PPP2R5E
Mean 13.6
Standard deviation 2.9
Values 11 16
[81]
HuH.7 PPP2R5E
Mean 9.42
Standard deviation 2.1
Values 12 9.4 7.3
[82]
SNU475 PPP2R5E
Mean 18.8
Standard deviation 1.2
Values 20 18
[83]
THLE PPP2R5E
Mean 18.2
Standard deviation 0.7
Values 18 19
[84]
liver PPP2R5E
Mean 9.17
Standard deviation 1.5
Values 11 9.6 9.4 7
[85]
ref_hepatocyte LYN
Mean 5.33
Standard deviation 4.4
Values 0.29 6.8 12 3.7 3.8
[86]
HepG2 LYN
Mean 6.48
Standard deviation 1
Values 5.8 7.2
[87]
HepG2.C3A LYN
Mean 5.11
Standard deviation 2.1
Values 3.6 6.6
[88]
HuH.7 LYN
Mean 7.08
Standard deviation 0.67
Values 7.4 7.5 6.3
[89]
SNU475 LYN
Mean 20.4
Standard deviation 4.4
Values 17 23
[90]
THLE LYN
Mean 9.65
Standard deviation 1.4
Values 8.7 11
[91]
liver LYN
Mean 7.66
Standard deviation 1.7
Values 7.2 9.4 5.5 8.6
[92]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 9.6 4.7 2.2 0.77 1.2
[93]
HepG2 SRC
Mean 66
Standard deviation 21
Values 81 51
[94]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 71 45
[95]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 28 29 26
[96]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 38 33
[97]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[98]
liver SRC
Mean 2.9
Standard deviation 1
Values 4.1 2.5 1.7 3.2
[99]
ref_hepatocyte PPP2R5B
Mean 2.1
Standard deviation 0.85
Values 1.5 2.2 2.4 3.3 1.2
[100]
HepG2 PPP2R5B
Mean 7.95
Standard deviation 0.71
Values 7.4 8.5
[101]
HepG2.C3A PPP2R5B
Mean 6.01
Standard deviation 3.4
Values 8.4 3.6
[102]
HuH.7 PPP2R5B
Mean 3.69
Standard deviation 1.6
Values 2.4 5.5 3.2
[103]
SNU475 PPP2R5B
Mean 4.72
Standard deviation 0.053
Values 4.8 4.7
[104]
THLE PPP2R5B
Mean 11.9
Standard deviation 2.7
Values 14 10
[105]
liver PPP2R5B
Mean 3.19
Standard deviation 1.1
Values 3.5 2 4.5 2.8
[106]
ref_hepatocyte FYN
Mean 2.1
Standard deviation 2.2
Values 2.2 0.039 0.23 2.6 5.5
[107]
HepG2 FYN
Mean 8.91
Standard deviation 0.7
Values 9.4 8.4
[108]
HepG2.C3A FYN
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[109]
HuH.7 FYN
Mean 7.43
Standard deviation 2.2
Values 8.9 4.8 8.5
[110]
SNU475 FYN
Mean 10.7
Standard deviation 2.5
Values 12 8.9
[111]
THLE FYN
Mean 34.5
Standard deviation 4.9
Values 38 31
[112]
liver FYN
Mean 5.84
Standard deviation 2.1
Values 8.9 4.4 5.1 5
[113]
ref_hepatocyte CD86
Mean 0.389
Standard deviation 0.38
Values 0 0 0.61 0.48 0.85
[114]
HepG2 CD86
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A CD86
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 CD86
Mean 0.0281
Standard deviation 0.02
Values 0.049 0.026 0.0094
[117]
SNU475 CD86
Mean 0.0418
Standard deviation 0.02
Values 0.028 0.056
[118]
THLE CD86
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[119]
liver CD86
Mean 1.41
Standard deviation 0.3
Values 1.2 1.9 1.2 1.3
[120]
ref_hepatocyte AKT3
Mean 0.387
Standard deviation 0.32
Values 0 0.53 0.83 0.16 0.41
[121]
HepG2 AKT3
Mean 0.238
Standard deviation 0.15
Values 0.34 0.13
[122]
HepG2.C3A AKT3
Mean 0.036
Standard deviation 0.0097
Values 0.029 0.043
[123]
HuH.7 AKT3
Mean 0.0557
Standard deviation 0.031
Values 0.049 0.09 0.028
[124]
SNU475 AKT3
Mean 40.8
Standard deviation 10
Values 48 34
[125]
THLE AKT3
Mean 22.1
Standard deviation 4.4
Values 25 19
[126]
liver AKT3
Mean 6.71
Standard deviation 4.9
Values 2.8 12 2.3 9.4
[127]
ref_hepatocyte LCK
Mean 0.319
Standard deviation 0.43
Values 0.11 0 0.49 0 0.99
[128]
HepG2 LCK
Mean 4.84
Standard deviation 4.4
Values 8 1.7
[129]
HepG2.C3A LCK
Mean 4.55
Standard deviation 0.16
Values 4.4 4.7
[130]
HuH.7 LCK
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[131]
SNU475 LCK
Mean 0.0173
Standard deviation 0.011
Values 0.0093 0.025
[132]
THLE LCK
Mean 0.0169
Standard deviation 0.0013
Values 0.018 0.016
[133]
liver LCK
Mean 1.07
Standard deviation 0.51
Values 1.2 0.49 1.7 0.91
[134]
ref_hepatocyte CD80
Mean 0.0435
Standard deviation 0.06
Values 0 0 0 0.1 0.11
[135]
HepG2 CD80
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A CD80
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 CD80
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[138]
SNU475 CD80
Mean 0.0359
Standard deviation 0.015
Values 0.046 0.025
[139]
THLE CD80
Mean 0.0192
Standard deviation 0.01
Values 0.012 0.027
[140]
liver CD80
Mean 0.381
Standard deviation 0.28
Values 0.12 0.64 0.15 0.61
[141]
ref_hepatocyte CTLA4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 CTLA4
Mean 0.00788
Standard deviation 0.0051
Values 0.011 0.0043
[143]
HepG2.C3A CTLA4
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[144]
HuH.7 CTLA4
Mean 0.00487
Standard deviation 0.0043
Values 0.0082 0.0064 0
[145]
SNU475 CTLA4
Mean 0
Standard deviation 0
Values 0 0
[146]
THLE CTLA4
Mean 0.0361
Standard deviation 0.0092
Values 0.03 0.043
[147]
liver CTLA4
Mean 0.0171
Standard deviation 0.02
Values 0 0.029 0 0.04