REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PCOLCE Procollagen C-endopeptidase enhancer 1 [1] -4.74[2] -3.88[3] -4.51[4] -5.44[5] -6.70[6] -3.74[7]
2 BMP1 Bone morphogenetic protein 1 [8] -1.94[9] -2.30[10] -3.27[11] -1.93[12] -3.25[13] -2.04[14]
3 COL4A5 Collagen alpha-5(IV) chain [15] 0.59[16] -7.57[17] -2.07[18] -1.33[19] -0.78[20] -3.62[21]
4 LOXL4 Lysyl oxidase homolog 4 [22] 2.25[23] 1.45[24] -4.31[25] -3.95[26] -6.11[27] -3.56[28]
5 COL4A2 Collagen alpha-2(IV) chain [29] -2.74[30] -1.29[31] -4.28[32] 3.15[33] 2.31[34] 2.20[35]
6 COL1A1 Collagen alpha-1(I) chain [36] 2.06[37] -4.31[38] -2.78[39] 2.96[40] 3.77[41] 3.40[42]
7 COL1A2 Collagen alpha-2(I) chain [43] -8.83[44] -7.62[45] -5.42[46] 0.94[47] 0.24[48] 3.46[49]
8 COL4A1 Collagen alpha-1(IV) chain [50] -5.41[51] -5.26[52] -4.20[53] 3.34[54] 2.38[55] 3.11[56]
9 PXDN Peroxidasin homolog [57] -6.74[58] -5.53[59] -5.93[60] -3.92[61] 2.13[62] 2.46[63]
10 COL4A6 Collagen alpha-6(IV) chain [64] 1.81[65] -6.35[66] -6.08[67] -2.63[68] 0.40[69] -4.58[70]
11 LOXL3 Lysyl oxidase homolog 3 [71] -0.54[72] 0.17[73] -1.23[74] -3.01[75] -1.49[76] -1.71[77]
12 LOXL2 Lysyl oxidase homolog 2 [78] 3.73[79] -1.48[80] -0.42[81] 3.40[82] 3.48[83] 0.55[84]
13 LOX Protein-lysine 6-oxidase [85] 5.13[86] 6.77[87] 7.13[88] 1.21[89] 4.56[90] 0.58[91]
14 LOXL1 Lysyl oxidase homolog 1 [92] -1.01[93] -2.75[94] -1.41[95] 3.00[96] 0.81[97] -2.97[98]
15 COL4A3 Collagen alpha-3(IV) chain [99] -5.97[100] -4.59[101] -3.47[102] 2.10[103] -5.86[104] 0.56[105]
16 COL4A4 Collagen alpha-4(IV) chain [106] -4.06[107] -5.77[108] -1.82[109] 4.30[110] -0.84[111] 3.05[112]
17 TLL1 Tolloid-like protein 1 [113] [114] -5.30[115] 0.73[116] -8.76[117] 0.15[118] -0.77[119]
18 TLL2 Tolloid-like protein 2 [120] -0.38[121] -1.26[122] 0.64[123] -0.36[124] -4.14[125] -1.93[126]
[1]
ref_hepatocyte PCOLCE
Mean 8.36
Standard deviation 8.3
Values 6.5 0.073 1.7 14 20
[2]
HepG2 PCOLCE
Mean 4.4
Standard deviation 0.22
Values 4.2 4.6
[3]
HepG2.C3A PCOLCE
Mean 3.24
Standard deviation 1.3
Values 4.2 2.3
[4]
HuH.7 PCOLCE
Mean 2.47
Standard deviation 1.4
Values 1.5 4.1 1.9
[5]
SNU475 PCOLCE
Mean 5.81
Standard deviation 1.9
Values 4.5 7.1
[6]
THLE PCOLCE
Mean 4.55
Standard deviation 1.1
Values 5.3 3.8
[7]
liver PCOLCE
Mean 6.9
Standard deviation 7.5
Values 5.7 2.7 18 1.4
[8]
ref_hepatocyte BMP1
Mean 4.74
Standard deviation 2
Values 3.6 8.1 4.8 3.4 3.8
[9]
HepG2 BMP1
Mean 17.4
Standard deviation 1.6
Values 19 16
[10]
HepG2.C3A BMP1
Mean 5.5
Standard deviation 0.036
Values 5.5 5.5
[11]
HuH.7 BMP1
Mean 3.31
Standard deviation 0.52
Values 3.7 2.7 3.4
[12]
SNU475 BMP1
Mean 37.7
Standard deviation 14
Values 47 28
[13]
THLE BMP1
Mean 28.1
Standard deviation 4
Values 31 25
[14]
liver BMP1
Mean 12.8
Standard deviation 3.2
Values 12 11 10 17
[15]
ref_hepatocyte COL4A5
Mean 1.22
Standard deviation 2.3
Values 5.3 0.58 0 0.069 0.15
[16]
HepG2 COL4A5
Mean 25.8
Standard deviation 4.1
Values 23 29
[17]
HepG2.C3A COL4A5
Mean 0.0365
Standard deviation 0.024
Values 0.019 0.054
[18]
HuH.7 COL4A5
Mean 1.95
Standard deviation 2.1
Values 0.85 4.4 0.63
[19]
SNU475 COL4A5
Mean 14.6
Standard deviation 6.5
Values 19 10
[20]
THLE COL4A5
Mean 39.9
Standard deviation 4.9
Values 36 43
[21]
liver COL4A5
Mean 1.09
Standard deviation 1
Values 0.4 2.6 0.59 0.78
[22]
ref_hepatocyte LOXL4
Mean 1.19
Standard deviation 0.88
Values 0.8 1 1.5 2.5 0.11
[23]
HepG2 LOXL4
Mean 79.7
Standard deviation 34
Values 1e+02 56
[24]
HepG2.C3A LOXL4
Mean 18.6
Standard deviation 6.7
Values 23 14
[25]
HuH.7 LOXL4
Mean 0.403
Standard deviation 0.33
Values 0.24 0.78 0.19
[26]
SNU475 LOXL4
Mean 2.33
Standard deviation 0.63
Values 2.8 1.9
[27]
THLE LOXL4
Mean 0.975
Standard deviation 0.16
Values 1.1 0.86
[28]
liver LOXL4
Mean 1.11
Standard deviation 0.35
Values 0.66 1.5 1.1 1.2
[29]
ref_hepatocyte COL4A2
Mean 0.513
Standard deviation 0.39
Values 0 0.18 0.81 0.78 0.8
[30]
HepG2 COL4A2
Mean 1.08
Standard deviation 0.47
Values 1.4 0.75
[31]
HepG2.C3A COL4A2
Mean 1.2
Standard deviation 0.062
Values 1.2 1.2
[32]
HuH.7 COL4A2
Mean 0.178
Standard deviation 0.11
Values 0.25 0.23 0.056
[33]
SNU475 COL4A2
Mean 137
Standard deviation 66
Values 1.8e+02 90
[34]
THLE COL4A2
Mean 144
Standard deviation 70
Values 94 1.9e+02
[35]
liver COL4A2
Mean 26
Standard deviation 16
Values 6.2 43 20 35
[36]
ref_hepatocyte COL1A1
Mean 0.396
Standard deviation 0.34
Values 0.021 0.18 0.62 0.31 0.85
[37]
HepG2 COL1A1
Mean 23.3
Standard deviation 12
Values 15 32
[38]
HepG2.C3A COL1A1
Mean 0.114
Standard deviation 0.051
Values 0.078 0.15
[39]
HuH.7 COL1A1
Mean 0.386
Standard deviation 0.18
Values 0.55 0.41 0.2
[40]
SNU475 COL1A1
Mean 93.4
Standard deviation 25
Values 76 1.1e+02
[41]
THLE COL1A1
Mean 304
Standard deviation 1.2e+02
Values 2.2e+02 3.9e+02
[42]
liver COL1A1
Mean 46
Standard deviation 44
Values 24 30 1.1e+02 19
[43]
ref_hepatocyte COL1A2
Mean 0.368
Standard deviation 0.45
Values 0 0.065 0.43 0.23 1.1
[44]
HepG2 COL1A2
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[45]
HepG2.C3A COL1A2
Mean 0.0107
Standard deviation 0.015
Values 0 0.021
[46]
HuH.7 COL1A2
Mean 0.0577
Standard deviation 0.036
Values 0.09 0.064 0.019
[47]
SNU475 COL1A2
Mean 21.3
Standard deviation 0.8
Values 21 22
[48]
THLE COL1A2
Mean 24.5
Standard deviation 0.21
Values 25 24
[49]
liver COL1A2
Mean 44.8
Standard deviation 24
Values 20 51 76 32
[50]
ref_hepatocyte COL4A1
Mean 0.353
Standard deviation 0.31
Values 0 0.11 0.76 0.43 0.46
[51]
HepG2 COL4A1
Mean 0.117
Standard deviation 0.069
Values 0.17 0.069
[52]
HepG2.C3A COL4A1
Mean 0.0526
Standard deviation 0.047
Values 0.019 0.086
[53]
HuH.7 COL4A1
Mean 0.129
Standard deviation 0.08
Values 0.19 0.16 0.037
[54]
SNU475 COL4A1
Mean 108
Standard deviation 58
Values 1.5e+02 67
[55]
THLE COL4A1
Mean 104
Standard deviation 59
Values 62 1.5e+02
[56]
liver COL4A1
Mean 33.7
Standard deviation 21
Values 8.2 58 32 36
[57]
ref_hepatocyte PXDN
Mean 0.325
Standard deviation 0.39
Values 0.052 0 0.97 0.29 0.31
[58]
HepG2 PXDN
Mean 0.043
Standard deviation 0.036
Values 0.069 0.017
[59]
HepG2.C3A PXDN
Mean 0.0404
Standard deviation 0.012
Values 0.049 0.032
[60]
HuH.7 PXDN
Mean 0.0359
Standard deviation 0.0068
Values 0.041 0.039 0.028
[61]
SNU475 PXDN
Mean 0.649
Standard deviation 0.072
Values 0.7 0.6
[62]
THLE PXDN
Mean 80.6
Standard deviation 21
Values 66 96
[63]
liver PXDN
Mean 19.8
Standard deviation 5
Values 13 24 21 21
[64]
ref_hepatocyte COL4A6
Mean 0.221
Standard deviation 0.41
Values 0.95 0.052 0.084 0.017 0
[65]
HepG2 COL4A6
Mean 11
Standard deviation 3.2
Values 8.7 13
[66]
HepG2.C3A COL4A6
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[67]
HuH.7 COL4A6
Mean 0.022
Standard deviation 0.012
Values 0.025 0.032 0.0094
[68]
SNU475 COL4A6
Mean 1.08
Standard deviation 0.73
Values 0.57 1.6
[69]
THLE COL4A6
Mean 16.5
Standard deviation 3.5
Values 14 19
[70]
liver COL4A6
Mean 0.102
Standard deviation 0.098
Values 0 0.043 0.15 0.21
[71]
ref_hepatocyte LOXL3
Mean 0.206
Standard deviation 0.22
Values 0.56 0.23 0 0.06 0.18
[72]
HepG2 LOXL3
Mean 2
Standard deviation 1.5
Values 3.1 0.93
[73]
HepG2.C3A LOXL3
Mean 1.33
Standard deviation 0.42
Values 1.6 1
[74]
HuH.7 LOXL3
Mean 0.587
Standard deviation 0.091
Values 0.48 0.62 0.66
[75]
SNU475 LOXL3
Mean 0.772
Standard deviation 0.048
Values 0.74 0.81
[76]
THLE LOXL3
Mean 4.13
Standard deviation 0.62
Values 4.6 3.7
[77]
liver LOXL3
Mean 0.694
Standard deviation 0.4
Values 0.14 0.86 0.69 1.1
[78]
ref_hepatocyte LOXL2
Mean 0.188
Standard deviation 0.13
Values 0.34 0 0.24 0.1 0.25
[79]
HepG2 LOXL2
Mean 35.2
Standard deviation 37
Values 61 9.2
[80]
HepG2.C3A LOXL2
Mean 0.387
Standard deviation 0.016
Values 0.4 0.38
[81]
HuH.7 LOXL2
Mean 0.939
Standard deviation 0.13
Values 1 0.99 0.8
[82]
SNU475 LOXL2
Mean 59.9
Standard deviation 8.1
Values 66 54
[83]
THLE LOXL2
Mean 118
Standard deviation 9.5
Values 1.3e+02 1.1e+02
[84]
liver LOXL2
Mean 3.04
Standard deviation 1.7
Values 1.2 4 5 2
[85]
ref_hepatocyte LOX
Mean 0.12
Standard deviation 0.14
Values 0.32 0 0 0.095 0.19
[86]
HepG2 LOX
Mean 59.4
Standard deviation 46
Values 92 27
[87]
HepG2.C3A LOX
Mean 75.2
Standard deviation 24
Values 92 58
[88]
HuH.7 LOX
Mean 113
Standard deviation 11
Values 1.2e+02 1.1e+02 1e+02
[89]
SNU475 LOX
Mean 8.37
Standard deviation 4.8
Values 5 12
[90]
THLE LOX
Mean 159
Standard deviation 17
Values 1.5e+02 1.7e+02
[91]
liver LOX
Mean 1.98
Standard deviation 1.1
Values 1 2.7 3.2 1
[92]
ref_hepatocyte LOXL1
Mean 0.116
Standard deviation 0.2
Values 0.052 0 0.46 0 0.065
[93]
HepG2 LOXL1
Mean 0.81
Standard deviation 0.1
Values 0.88 0.74
[94]
HepG2.C3A LOXL1
Mean 0.0989
Standard deviation 0.057
Values 0.058 0.14
[95]
HuH.7 LOXL1
Mean 0.293
Standard deviation 0.15
Values 0.15 0.45 0.28
[96]
SNU475 LOXL1
Mean 28.1
Standard deviation 18
Values 41 16
[97]
THLE LOXL1
Mean 11.4
Standard deviation 2.8
Values 9.5 13
[98]
liver LOXL1
Mean 0.163
Standard deviation 0.12
Values 0.047 0.19 0.1 0.32
[99]
ref_hepatocyte COL4A3
Mean 0.0635
Standard deviation 0.097
Values 0 0.23 0.062 0 0.024
[100]
HepG2 COL4A3
Mean 0.0143
Standard deviation 0.004
Values 0.011 0.017
[101]
HepG2.C3A COL4A3
Mean 0.0151
Standard deviation 0.0062
Values 0.019 0.011
[102]
HuH.7 COL4A3
Mean 0.0386
Standard deviation 0.023
Values 0.033 0.064 0.019
[103]
SNU475 COL4A3
Mean 8.22
Standard deviation 7.6
Values 14 2.9
[104]
THLE COL4A3
Mean 0.0618
Standard deviation 0.0046
Values 0.065 0.059
[105]
liver COL4A3
Mean 1.03
Standard deviation 0.79
Values 0.47 0.83 0.64 2.2
[106]
ref_hepatocyte COL4A4
Mean 0.0509
Standard deviation 0.081
Values 0 0.19 0.046 0.0086 0.0081
[107]
HepG2 COL4A4
Mean 0.0429
Standard deviation 0.012
Values 0.052 0.034
[108]
HepG2.C3A COL4A4
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[109]
HuH.7 COL4A4
Mean 0.0969
Standard deviation 0.052
Values 0.13 0.12 0.037
[110]
SNU475 COL4A4
Mean 30.4
Standard deviation 30
Values 52 9.1
[111]
THLE COL4A4
Mean 1.61
Standard deviation 0.54
Values 1.2 2
[112]
liver COL4A4
Mean 4.66
Standard deviation 2.8
Values 2.9 4.2 2.7 8.8
[113]
ref_hepatocyte TLL1
Mean 0.0333
Standard deviation 0.027
Values 0 0.049 0.049 0.06 0.0081
[114]
HepG2 TLL1
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A TLL1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[116]
HuH.7 TLL1
Mean 0.372
Standard deviation 0.36
Values 0.14 0.79 0.19
[117]
SNU475 TLL1
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[118]
THLE TLL1
Mean 2.09
Standard deviation 0.73
Values 1.6 2.6
[119]
liver TLL1
Mean 0.216
Standard deviation 0.11
Values 0.12 0.31 0.13 0.3
[120]
ref_hepatocyte TLL2
Mean 0.0235
Standard deviation 0.032
Values 0 0 0 0.06 0.057
[121]
HepG2 TLL2
Mean 0.254
Standard deviation 0.035
Values 0.23 0.28
[122]
HepG2.C3A TLL2
Mean 0.056
Standard deviation 0.0033
Values 0.058 0.054
[123]
HuH.7 TLL2
Mean 0.246
Standard deviation 0.13
Values 0.3 0.096 0.34
[124]
SNU475 TLL2
Mean 0.554
Standard deviation 0.18
Values 0.68 0.43
[125]
THLE TLL2
Mean 0.0751
Standard deviation 0.014
Values 0.065 0.085
[126]
liver TLL2
Mean 0.0679
Standard deviation 0.053
Values 0 0.11 0.051 0.11