REACTOME_CREB1_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_ADENYLATE_CYCLASE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit [1] -0.05[2] -0.01[3] -0.20[4] -0.75[5] -0.52[6] -0.43[7]
2 CALM1 Calmodulin-1 [8] -0.05[9] -0.09[10] 0.03[11] 0.93[12] 0.53[13] 0.60[14]
3 PRKACA cAMP-dependent protein kinase catalytic subunit alpha [15] -0.29[16] -0.55[17] -0.88[18] -1.13[19] -0.20[20] -1.80[21]
4 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit [22] -0.08[23] -0.47[24] 0.30[25] -0.94[26] -0.75[27] -0.87[28]
5 PRKAR1B cAMP-dependent protein kinase type I-beta regulatory subunit [29] 0.85[30] 0.22[31] -1.91[32] -4.75[33] -1.62[34] -1.19[35]
6 PRKACB cAMP-dependent protein kinase catalytic subunit beta [36] -0.96[37] -0.26[38] 0.68[39] 1.58[40] 0.77[41] 0.69[42]
7 CREB1 Cyclic AMP-responsive element-binding protein 1 [43] 1.59[44] 2.67[45] 2.83[46] 1.89[47] 2.16[48] 1.32[49]
8 ADCY1 Adenylate cyclase type 1 [50] -0.96[51] -2.91[52] -3.45[53] -2.77[54] -2.45[55] 3.97[56]
9 PRKX cAMP-dependent protein kinase catalytic subunit PRKX [57] -1.77[58] -2.08[59] 2.51[60] 0.60[61] 2.47[62] 0.42[63]
10 PRKAR2B cAMP-dependent protein kinase type II-beta regulatory subunit [64] -2.47[65] -0.72[66] 3.22[67] 4.43[68] 3.28[69] 2.29[70]
11 PRKACG cAMP-dependent protein kinase catalytic subunit gamma [71] [72] [73] [74] [75] [76] [77]
12 ADCY8 Adenylate cyclase type 8 [78] [79] [80] [81] [82] [83] [84]
[1]
ref_hepatocyte PRKAR1A
Mean 51.9
Standard deviation 38
Values 1.1e+02 62 30 19 35
[2]
HepG2 PRKAR1A
Mean 121
Standard deviation 21
Values 1.1e+02 1.4e+02
[3]
HepG2.C3A PRKAR1A
Mean 117
Standard deviation 14
Values 1.1e+02 1.3e+02
[4]
HuH.7 PRKAR1A
Mean 124
Standard deviation 6.6
Values 1.3e+02 1.3e+02 1.2e+02
[5]
SNU475 PRKAR1A
Mean 89.4
Standard deviation 19
Values 1e+02 76
[6]
THLE PRKAR1A
Mean 93.3
Standard deviation 15
Values 83 1e+02
[7]
liver PRKAR1A
Mean 111
Standard deviation 40
Values 89 1.4e+02 1.5e+02 66
[8]
ref_hepatocyte CALM1
Mean 29.2
Standard deviation 11
Values 17 40 21 28 40
[9]
HepG2 CALM1
Mean 67.9
Standard deviation 4.3
Values 65 71
[10]
HepG2.C3A CALM1
Mean 62
Standard deviation 16
Values 51 73
[11]
HuH.7 CALM1
Mean 81.9
Standard deviation 15
Values 90 64 92
[12]
SNU475 CALM1
Mean 160
Standard deviation 24
Values 1.8e+02 1.4e+02
[13]
THLE CALM1
Mean 109
Standard deviation 13
Values 1e+02 1.2e+02
[14]
liver CALM1
Mean 127
Standard deviation 70
Values 2.1e+02 80 1.7e+02 57
[15]
ref_hepatocyte PRKACA
Mean 15.8
Standard deviation 8.3
Values 7.6 11 11 27 23
[16]
HepG2 PRKACA
Mean 31.2
Standard deviation 2.7
Values 29 33
[17]
HepG2.C3A PRKACA
Mean 24.6
Standard deviation 3.5
Values 27 22
[18]
HuH.7 PRKACA
Mean 23.6
Standard deviation 5.7
Values 27 17 27
[19]
SNU475 PRKACA
Mean 21
Standard deviation 3.3
Values 23 19
[20]
THLE PRKACA
Mean 35.4
Standard deviation 5.3
Values 32 39
[21]
liver PRKACA
Mean 13.1
Standard deviation 4.9
Values 18 8.8 16 8.9
[22]
ref_hepatocyte PRKAR2A
Mean 7.11
Standard deviation 7.6
Values 6.5 20 6.5 1.3 1.4
[23]
HepG2 PRKAR2A
Mean 16.3
Standard deviation 1.9
Values 15 18
[24]
HepG2.C3A PRKAR2A
Mean 11.6
Standard deviation 4.5
Values 8.4 15
[25]
HuH.7 PRKAR2A
Mean 24
Standard deviation 9.6
Values 34 24 14
[26]
SNU475 PRKAR2A
Mean 10.7
Standard deviation 0.56
Values 11 10
[27]
THLE PRKAR2A
Mean 10.9
Standard deviation 4
Values 8.1 14
[28]
liver PRKAR2A
Mean 11.2
Standard deviation 5.7
Values 5.5 18 7.5 14
[29]
ref_hepatocyte PRKAR1B
Mean 6.04
Standard deviation 3.4
Values 7.5 11 3.5 5.3 2.7
[30]
HepG2 PRKAR1B
Mean 26.2
Standard deviation 3.9
Values 23 29
[31]
HepG2.C3A PRKAR1B
Mean 15.9
Standard deviation 0.32
Values 16 16
[32]
HuH.7 PRKAR1B
Mean 4.42
Standard deviation 1.8
Values 5.2 2.4 5.7
[33]
SNU475 PRKAR1B
Mean 0.647
Standard deviation 0.21
Values 0.79 0.5
[34]
THLE PRKAR1B
Mean 5.04
Standard deviation 0.84
Values 4.4 5.6
[35]
liver PRKAR1B
Mean 7.61
Standard deviation 2.9
Values 11 4.6 9.2 5.8
[36]
ref_hepatocyte PRKACB
Mean 2.75
Standard deviation 1.3
Values 2.1 3.1 1.4 2.4 4.8
[37]
HepG2 PRKACB
Mean 3.41
Standard deviation 1.6
Values 2.3 4.6
[38]
HepG2.C3A PRKACB
Mean 5.2
Standard deviation 0.9
Values 4.6 5.8
[39]
HuH.7 PRKACB
Mean 12.2
Standard deviation 3.4
Values 11 16 9.5
[40]
SNU475 PRKACB
Mean 23.8
Standard deviation 4.4
Values 27 21
[41]
THLE PRKACB
Mean 12.1
Standard deviation 0.96
Values 13 11
[42]
liver PRKACB
Mean 12.8
Standard deviation 2
Values 12 14 14 10
[43]
ref_hepatocyte CREB1
Mean 1.8
Standard deviation 1.2
Values 3.7 2.1 1.5 0.96 0.81
[44]
HepG2 CREB1
Mean 13.1
Standard deviation 2.8
Values 11 15
[45]
HepG2.C3A CREB1
Mean 26.1
Standard deviation 3.2
Values 24 28
[46]
HuH.7 CREB1
Mean 35.1
Standard deviation 4
Values 38 36 31
[47]
SNU475 CREB1
Mean 19.3
Standard deviation 0.081
Values 19 19
[48]
THLE CREB1
Mean 20.8
Standard deviation 2.1
Values 22 19
[49]
liver CREB1
Mean 13
Standard deviation 3.1
Values 12 16 9.3 15
[50]
ref_hepatocyte ADCY1
Mean 0.753
Standard deviation 0.8
Values 0.18 0.11 0.22 1.6 1.6
[51]
HepG2 ADCY1
Mean 0.932
Standard deviation 0.17
Values 1 0.82
[52]
HepG2.C3A ADCY1
Mean 0.227
Standard deviation 0.064
Values 0.27 0.18
[53]
HuH.7 ADCY1
Mean 0.189
Standard deviation 0.063
Values 0.18 0.26 0.13
[54]
SNU475 ADCY1
Mean 0.321
Standard deviation 0.11
Values 0.25 0.4
[55]
THLE ADCY1
Mean 0.355
Standard deviation 0.017
Values 0.34 0.37
[56]
liver ADCY1
Mean 34
Standard deviation 27
Values 8 57 14 57
[57]
ref_hepatocyte PRKX
Mean 0.643
Standard deviation 0.41
Values 0.54 1.3 0.75 0.22 0.41
[58]
HepG2 PRKX
Mean 0.454
Standard deviation 0.14
Values 0.56 0.35
[59]
HepG2.C3A PRKX
Mean 0.346
Standard deviation 0.034
Values 0.37 0.32
[60]
HuH.7 PRKX
Mean 10.1
Standard deviation 3.2
Values 13 6.7 11
[61]
SNU475 PRKX
Mean 2.81
Standard deviation 0.015
Values 2.8 2.8
[62]
THLE PRKX
Mean 9.15
Standard deviation 0.52
Values 8.8 9.5
[63]
liver PRKX
Mean 2.48
Standard deviation 1.2
Values 1.1 3.4 1.8 3.6
[64]
ref_hepatocyte PRKAR2B
Mean 0.12
Standard deviation 0.14
Values 0 0 0.21 0.078 0.31
[65]
HepG2 PRKAR2B
Mean 0.0522
Standard deviation 0.0072
Values 0.057 0.047
[66]
HepG2.C3A PRKAR2B
Mean 0.165
Standard deviation 0.097
Values 0.23 0.097
[67]
HuH.7 PRKAR2B
Mean 3.07
Standard deviation 1.2
Values 3.8 1.7 3.7
[68]
SNU475 PRKAR2B
Mean 7.46
Standard deviation 0.031
Values 7.5 7.4
[69]
THLE PRKAR2B
Mean 2.99
Standard deviation 0.15
Values 2.9 3.1
[70]
liver PRKAR2B
Mean 1.69
Standard deviation 0.7
Values 1.6 2.7 1.4 1.1
[71]
ref_hepatocyte PRKACG
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[72]
HepG2 PRKACG
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[73]
HepG2.C3A PRKACG
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 PRKACG
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[75]
SNU475 PRKACG
Mean 0
Standard deviation 0
Values 0 0
[76]
THLE PRKACG
Mean 0
Standard deviation 0
Values 0 0
[77]
liver PRKACG
Mean 0
Standard deviation 0
Values 0 0 0 0
[78]
ref_hepatocyte ADCY8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[79]
HepG2 ADCY8
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[80]
HepG2.C3A ADCY8
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 ADCY8
Mean 0
Standard deviation 0
Values 0 0 0
[82]
SNU475 ADCY8
Mean 0.0198
Standard deviation 0.015
Values 0.0093 0.03
[83]
THLE ADCY8
Mean 0.0937
Standard deviation 0.035
Values 0.12 0.069
[84]
liver ADCY8
Mean 0.0332
Standard deviation 0.041
Values 0 0.014 0.026 0.093